ライフサイエンスコーパス: RNA silencing

1 bitors (pseudosubstrate or small interfering RNA silencing).

2 kinase R(PKR)-mediated immune response, and RNA silencing.

3 suppressor proteins that interfere with host RNA silencing.

4 SR) that can neutralize the effectiveness of RNA silencing.

5 artment required for siRNA amplification and RNA silencing.

6 d RNAs that can serve to initiate or amplify RNA silencing.

7 ase RM62, a protein previously implicated in RNA silencing.

8 9 suppressor mutants are very susceptible to RNA silencing.

9 and disarm the host's essential effector of RNA silencing.

10 ring time control and has been implicated in RNA silencing.

11 mily proteins, are the central components in RNA silencing.

12 using specific pharmacologic inhibitors and RNA silencing.

13 es; RDRs 1, 2 and 6 have roles in anti-viral RNA silencing.

14 w that all four DCLs contribute to antiviral RNA silencing.

15 ith a remarkably high fidelity for efficient RNA silencing.

16 in the initiation and maintenance phases of RNA silencing.

17 P713 mutant that lacks the p29 suppressor of RNA silencing.

18 We also implicate DRB4 in antiviral RNA silencing.

19 d by the hypovirus-encoded p29 suppressor of RNA silencing.

20 NA replication and to act as a suppressor of RNA silencing.

21 short interfering RNAs (siRNAs) to suppress RNA silencing.

22 ng RNAs that are known to be associated with RNA silencing.

23 optosis when endogenous SfIAP was ablated by RNA silencing.

24 how that p37, the viral coat protein, blocks RNA silencing.

25 , including the expression of suppressors of RNA silencing.

26 or piRNAs in protecting essential genes from RNA silencing.

27 rocessing, and suppression of host antiviral RNA silencing.

28 roteins are involved in RISC function during RNA silencing.

29 he endomembrane system in various aspects of RNA silencing.

30 nation of these results is the phenomenon of RNA silencing, a group of RNA-based processes that produ

31 ed RNA (dsRNA) binding protein that inhibits RNA silencing, a major antiviral defense pathway in inse

32 in mammals, revealing that DUSP11-dependent RNA silencing activities are shared among diverse metazo

33 C3PO and PLCbeta raises the possibility that RNA silencing activity can affect the ability of PLCbeta

34 g pocket of the Dicer-2 PAZ domain decreased RNA silencing activity in vivo, showing the importance o

35 iphosphatase activity of DUSP11 promotes the RNA silencing activity of viral microRNAs (miRNAs) deriv

36 To enhance stringency, we employed RNA silencing alone and together with transcriptional re

37 ss this issue, we combined short interfering RNA silencing and a high-throughput imaging assay to ide

38 tory signaling cascades as well as antiviral RNA silencing and autophagy.

39 y to assess aphid performance on Arabidopsis RNA silencing and defence pathway mutants.

40 plant viruses, geminiviruses are targeted by RNA silencing and encode suppressor proteins such as AL2

41 the production of noncoding transcripts for RNA silencing and genome defense.

42 r-RIG-I family protein that is essential for RNA silencing and germline development in nematodes.

43 ts and of assessing the extent of non-coding RNA silencing and histone H4K16 deacetylation.

44 cant progress has been made in understanding RNA silencing and how viruses counter this apparently ub

45 or their ability to undergo RdDM, transitive RNA silencing and maintenance of PTGS.

46 Sp1/Sp3 RNA silencing and mithramycin A treatment significantly

47 at went relatively unnoticed in the realm of RNA silencing and nonviral immune responses.

48 Through RNA silencing and over-expression experiments, we discov

49 Significantly, using Hic-5 small hairpin RNA silencing and overexpression systems, we show that H

50 Experiments using small interfering RNA silencing and pharmacological inhibition demonstrate

51 CPSF100 was reported to play a role in RNA silencing and promote flowering in Arabidopsis.

52 Using RNA silencing and receptor antagonists, we demonstrated

53 ts endogenous messenger RNAs from undergoing RNA silencing and uncovered an unexpected role of the ca

54 resistance proteins, transcription factors, RNA silencing, and splicing-associated proteins.

55 have important functions in suppressing the RNA silencing antiviral defense response and in viral RN

56 for an Argonaute gene in the induction of an RNA silencing antiviral defense response and the promoti

57 Dicer gene dcl2, required for the RNA silencing antiviral defense response in the chestnut

58 the C. parasitica Dicer gene dcl2-dependent RNA-silencing antiviral defense response.

59 Using gene deletion and small interference RNA silencing approach, we investigated the role of P-Re

60 , we conducted a genome-wide screen using an RNA-silencing approach and an assay for huntingtin prote

61 Argonaute (Ago) proteins function in RNA silencing as components of the RNA-induced silencing

62 role for Aub, independent of its function in RNA silencing, as a component of a nos mRNA localization

63 n evolutionary conserved protein involved in RNA silencing, as an antiviral gene against RNA viruses

64 Similarly, RNA silencing, as well as the overexpression of a benefi

65 y control and its role in the suppression of RNA silencing at endogenous genes and discuss the mechan

66 RNA silencing at the transcriptional and posttranscripti

67 including components of antiviral pathways (RNA silencing, autophagy, JAK/STAT, Toll, and Imd) and v

68 geting by Dicer-like enzymes, the first host RNA-silencing barrier.

69 in needed for virus assembly, suppression of RNA silencing-based antiviral defense, and long-distance

70 tional regulation of gene expression and the RNA silencing-based antiviral defense.

71 essors of RNA silencing (VSRs) to counteract RNA silencing-based host defenses.

72 keratinocytes by targeted small interfering RNA silencing before S. aureus exposure blocked the incr

73 s for the observed qualitative difference in RNA silencing between 21- and 22-nucleotide secondary si

74 Trpv4-small interfering RNA silencing blocked effects of Trpv4 activators by 70%

75 than 2,000 C. elegans genes are targeted for RNA silencing by the mutator complex, a specialized smal

76 t premature delivery can be controlled using RNA silencing, by hydrodynamic transfection of E15 mice

77 RNA silencing can be initiated by endogenous or exogenou

78 onaute (Ago), the catalytic component of the RNA silencing complex, was suggested as the central mech

79 PMV coinfections, expression of an antiviral RNA silencing component, SILENCING DEFECTIVE3, was suppr

80 epresses the transcriptional induction of an RNA silencing component.

81 e, and specific pharmacologic inhibitors and RNA-silencing confirmed that FPR contributes significant

82 Stigma-specific RNA-silencing constructs were used to suppress the expre

83 own-regulation of TRAIL by small interfering RNA silencing decreased MS275-mediated Adriamycin-induce

84 minant negative constructs and short hairpin RNA silencing demonstrated a role for MYO5A and MYO5B in

85 re known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and a

86 rget transcripts may be a general feature of RNA-silencing effector complexes.

87 ression of these Phytophthora suppressors of RNA silencing enhances plant susceptibility to both a vi

88 The tug of war between RNA surveillance and RNA silencing ensures the appropriate partitioning of en

89 ng H2S levels, including enzymatic knockout, RNA silencing, enzymatic inhibition, and use of small mo

90 e have discovered a role for the Arabidopsis RNA silencing enzyme DICER-LIKE 4 (DCL4) in transcriptio

91 Nuclear RNA polymerase V (Pol V) is an RNA silencing enzyme recently shown to generate noncodin

92 RNA silencing experiments revealed the link between AR s

93 l lines MTLn3 and MCF-7 is further proven by RNA silencing experiments that yield COS-7 showing lower

94 s of YAP in HCC cells via overexpression and RNA silencing experiments.

95 e expression in human tissues, and conducted RNA-silencing experiments for one novel association.

96 nase (MAPK)-dependent phosphorylation of the RNA-silencing factor HIV TAR-RNA-binding protein (TRBP)

97 of combining transcriptional repression and RNA silencing for stringent reduction of gene expression

98 RNA silencing functions as an antiviral defense through

99 formation, cell connectivity was reduced by RNA silencing gap junction Cx43.

100 In Caenorhabditis elegans, RNA silencing guided by primary siRNAs is inefficient an

101 RNA silencing has the potential to simultaneously alter

102 Stem cells and RNA silencing have emerged as areas of intense interest

103 oms to cause disease and are consistent with RNA silencing having key roles in host defense.

104 class genes are required for siRNA-mediated RNA silencing in both germline and somatic cells, but th

105 Our analysis reveals that the miRNA-mediated RNA silencing in C. reinhardtii differs from that of hig

106 RNA silencing in Caenorhabditis elegans is transmitted b

107 ss referred to as RNA interference (RNAi) or RNA silencing in diverse organisms.

108 RNA-induced silencing complexes that mediate RNA silencing in eukaryotes.

109 RNA silencing in flowering plants generates a signal tha

110 r candidates were evaluated by small hairpin RNA silencing in HepaRG cells; the ability of receptor e

111 e production of proteins or the induction of RNA silencing in herbaceous plants.

112 lity of this mechanism in genome defense and RNA silencing in higher eukaryotes is suggested.

113 Our experiments reveal that RNA silencing in HIV-1 infected human cells severely att

114 Likewise, CD39 RNA silencing in HMC-1 increased ATP-induced renin relea

115 essing the untapped therapeutic potential of RNA silencing in humans.

116 another ENU allele and by small interfering RNA silencing in insulinoma cells.

117 Similarly, LSP1-targeted small interfering RNA silencing in murine endothelial cells mitigated mRNA

118 he contrary, inhibition of p53 expression by RNA silencing in non-malignant human lung epithelial (Be

119 e plant pathogen Phytophthora sojae suppress RNA silencing in plants by inhibiting the biogenesis of

120 RNA silencing in plants is a multivalent antiviral defen

121 RNA silencing in plants serves as a potent antiviral def

122 ce for a link between genomic imprinting and RNA silencing in plants.

123 encing caused by lack of piRNAs, we restored RNA silencing in RNAi-defective animals in the presence

124 d SUPPRESSOR OF GENE SILENCING3, implicating RNA silencing in the control of cuticular wax deposition

125 n, and biological function of miRNA-mediated RNA silencing in the model algal species,Chlamydomonas r

126 w that the YFV capsid (YFC) protein inhibits RNA silencing in the mosquito Aedes aegypti by interferi

127 In plants the role of RNA silencing in viral RNA degradation is well establish

128 The sequence-specific nature of systemic RNA silencing indicates that a nucleic acid is a compone

129 An expanded model of RNA silencing indicates that multiple turnover by revers

130 Plant viral suppressors of RNA silencing induce developmental defects similar to th

131 l workshop on ''Induction and Suppression of RNA Silencing: Insights from Plant Viral Infections'' wa

132 RNA silencing is a complex, highly conserved mechanism m

133 RNA silencing is a conserved eukaryotic gene expression

134 RNA silencing is a conserved regulatory mechanism in fun

135 RNA silencing is a genome defense mechanism used by many

136 While RNA silencing is a potent antiviral defense in plants, w

137 RNA silencing is a process triggered by 21-24 small RNAs

138 RNA silencing is an important antiviral mechanism in div

139 Target recognition in RNA silencing is governed by the "seed sequence" of a gu

140 while in other potyviruses the suppressor of RNA silencing is HCPro, we show here that P1N-PISPO exhi

141 bidopsis Dicer-like mutants, indicating that RNA silencing is responsible for Arabidopsis nonhost res

142 In plants, RNA silencing is triggered by the production of double-s

143 a either pharmacological blockade or in vivo RNA silencing led to decreased OPCs maturation and failu

144 Many factors involved in RNA silencing localize to protein- and RNA-rich nuclear

145 Plant RNA silencing machinery enlists four primary classes of

146 l RNA, as well as by directly inhibiting the RNA silencing machinery.

147 timuli can be modulated by components of the RNA silencing machinery.-Philip, F., Sahu, S., Golebiews

148 clear genomes seem to have lost entirely the RNA-silencing machinery or have retained only a basic se

149 sulted in the isolation of components of the RNA-silencing machinery, RNA-DEPENDENT RNA POLYMERASE1 a

150 ed to disrupt higher-order structure and the RNA-silencing machinery.

151 (AGOs) are known to be key components of the RNA silencing mechanism in eukaryotes that, among other

152 mponents could provide not only insight into RNA silencing mechanism in soybean and sorghum but also

153 lated group of helicases is required for the RNA-silencing mechanism in Caenorhabditis elegans.

154 icularly RNA viruses, plants have evolved an RNA-silencing mechanism relying on the generation by Dic

155 Plants use RNA silencing mechanisms and produce short-interfering R

156 in plant antiviral immune responses, beyond RNA silencing mechanisms-advances that went relatively u

157 spects of eukaryotic life, primarily through RNA silencing mechanisms.

158 ing interactions between HIV-1 and host cell RNA silencing mechanisms.

159 RNA-silencing mechanisms control many aspects of gene re

160 ans by Orsay virus but is not active against RNA silencing mediated by microRNAs.

161 In eukaryotes, RNA silencing, mediated by small interfering RNAs, is an

162 We suggest that RNA silencing-mediated translation repression plays a st

163 l rDNA (encoding 18S, 5.8S and 26S ribosomal RNA) silencing (nucleolar dominance) and rRNA gene dosag

164 n contrast to the prevalent presumption that RNA silencing occurs in the cytosol, emerging evidence r

165 Small interfering RNA silencing of A20 prevents tolerance, whereas ectopic

166 this study, we report that small interfering RNA silencing of AID in plasmacytoma dramatically increa

167 muscle motor endplates and small interfering RNA silencing of ALG14 results in reduced cell-surface e

168 RNA silencing of BAG3 led to a marked reduction in Mcl-1

169 Selective RNA silencing of betaftz-f1 in Inka cells prevents ETH r

170 Short hairpin RNA silencing of Bnip3 inhibited apoptosis of the core c

171 oporin CAN/Nup214 in infected cells and that RNA silencing of CAN/Nup214 delays the onset of viral DN

172 Finally, using pharmacologic and RNA silencing of CHK1 or the associated MYC-related mech

173 ssing was minimally reduced by short hairpin RNA silencing of CTSC.

174 RNA silencing of DDX1 provided strong evidence that DDX1

175 express both TRAIL receptors, short hairpin RNA silencing of DR5 but not DR4 attenuated TRAIL-mediat

176 Short hairpin RNA silencing of either HDAC2 or HDAC4 is sufficient to

177 RNA silencing of either Stim1 or Orai1 essentially aboli

178 Lentiviral-mediated small-hairpin RNA silencing of endogenous Hic-5 reduced TGF-beta respo

179 ifen, which is reversed by small interfering RNA silencing of FGFR1, suggesting that FGFR1 overexpres

180 RNA silencing of four of these glutaredoxin genes (AtGRX

181 Interestingly, RNA silencing of GATA-1 alone had no impact on EDN expre

182 While small interfering RNA silencing of HIF-1alpha mRNA and abolition of HIF-1a

183 In both cases, RNA silencing of Homer 1a but not control RNA interferen

184 Furthermore, short hairpin RNA silencing of inflammasome components abrogated hyper

185 Intracellular Ca(2+) chelation and RNA silencing of IP(3) receptors prevented preconditioni

186 Short hairpin RNA silencing of kindlin-2, but not c-Src, blocked sprou

187 Small interfering RNA silencing of MyD88 prevented an LPS-induced increase

188 RNA silencing of p53 up-regulated RGS13 expression in B

189 ity by 3-aminobenzamide or small interfering RNA silencing of PARP-1 expression significantly increas

190 RNA silencing of Period 1 dramatically decreased express

191 RNA silencing of PPARdelta abrogated the inhibitory effe

192 ndered Arabidopsis more susceptible, whereas RNA silencing of RTP1 led to enhanced resistance to P. p

193 However, small interfering RNA silencing of Smad1 invoked proliferative responses t

194 through its ability to bind TRAX and reverse RNA silencing of specific genes, plays a key role in swi

195 d alphaSMA synthesis markedly decreased upon RNA silencing of SRF and myocardin.

196 Small interfering RNA silencing of TFIIA gamma markedly reduces levels of

197 Consistently, short interfering RNA silencing of the 70-kDa ribosomal S6 kinase 1 (S6K1)

198 Finally, small interfering RNA silencing of the EGFR diminished SLS-induced egr-1 m

199 ession, our data support the hypothesis that RNA silencing of the host gene contributed to expulsion

200 Plant RNA silencing operates via RNA-directed DNA-methylation

201 activity inside HMC-1 cells by short hairpin RNA silencing or CTS-specific pharmacologic inhibitors s

202 ected protein (i.e. TF) by small interfering RNA silencing or ligation with a function-blocking antib

203 ulations in ArPIKfyve/Sac3 protein levels by RNA silencing or overexpression in several mammalian cel

204 This gene silencing process is known as RNA silencing or RNA interference (RNAi) and, in plants

205 nterfering RNAs direct antiviral immunity by RNA silencing or RNA interference.

206 of syntaxin 5 function by small interfering RNA silencing or treatment with cyclized Retro-2 strongl

207 h as DNA methylation, histone modifications, RNA silencing, or a combination.

208 V1-EP713 hypovirus lacking the suppressor of RNA silencing p29 than to wild-type CHV1-EP713.

209 -1/EP721 were unrelated to the suppressor of RNA silencing, p29, encoded by the two viruses.

210 s resolve several key steps in the antiviral RNA silencing pathway and provide a basis for further in

211 evidences suggest that various components of RNA silencing pathway are involved in plant defense mach

212 ertebrate animals and plants, the mosquito's RNA silencing pathway comprises its primary antiviral de

213 r, these results have revealed a specialized RNA silencing pathway involving DCL2, AGO2, and HEN1 tha

214 The RNA silencing pathway is an intracellular innate respons

215 ange in expression of a key component of the RNA silencing pathway is associated with both vegetative

216 d, a detailed understanding of the antiviral RNA silencing pathway is just emerging.

217 ute and Piwi proteins are key players in the RNA silencing pathway, with the former interacting with

218 ests this protein affects the miRNA-mediated RNA silencing pathway.

219 which represents an evolved property of the RNA silencing pathway.

220 not correlate with a higher induction of the RNA-silencing pathway.

221 ications for nodavirus interaction with cell RNA silencing pathways and other aspects of virus contro

222 RdRP paralogs often participate in distinct RNA silencing pathways and show characteristic repertoir

223 xogenous RNAi, but their roles in endogenous RNA silencing pathways are not well-understood.

224 ntroversies related to the potential role of RNA silencing pathways as a defense against HIV-1 infect

225 Although at least four distinct endogenous RNA silencing pathways have been thoroughly characterize

226 RNA silencing pathways in Arabidopsis include five doubl

227 te (AGO) proteins are critical components of RNA silencing pathways that bind small RNAs and mediate

228 ective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to com

229 te (Ago) proteins are important effectors in RNA silencing pathways, but they must interact with othe

230 are proposed to primarily act via endogenous RNA silencing pathways.

231 short (s)RNAs, the central component of all RNA silencing pathways.

232 the molecular mechanisms that are central to RNA silencing pathways.

233 e evolved specialized functions for distinct RNA silencing pathways.

234 nto the mechanisms operating at the heart of RNA-silencing pathways.

235 al and morphological analyses, combined with RNA silencing, pharmacologic inhibition, and BACE2 overe

236 Therefore, it remains to be resolved whether RNA silencing plays a significant part in defending plan

237 In cells, Hmox1 or Nfe2l2 RNA silencing prevented IL-10 and IL-1Ra up-regulation,

238 evolved virulence proteins that target host RNA silencing processes to promote infection.

239 s in the organism by the inhibition of small RNA silencing processes.

240 Here we report that the viral suppressor of RNA silencing protein P0 triggers AGO1 degradation by th

241 We review current links between RNA silencing, recovery and tolerance, and present a mod

242 AgTreT1 RNA silencing reduces the hemolymph trehalose concentrat

243 After an infectious blood meal, AgTreT1 RNA silencing reduces the number of P. falciparum oocyst

244 RNA silencing refers to a collection of gene regulatory

245 dividual AGOs yet the role played by many in RNA silencing-related antiviral defense is largely unkno

246 inding complex that contributes to essential RNA silencing-related pathways in the male germ line.

247 This indicates that a very robust antiviral RNA-silencing response was induced against all three vir

248 However, the extent to which RNA silencing restricts virus host range has been diffic

249 IL1B rapidly induced DUSP1 expression and RNA silencing revealed a transient role in feedback inhi

250 ck an analogous siRNA biogenesis pathway, an RNA silencing role for the mammalian PIR-1 homolog (dual

251 These data extend the significance of an RNA silencing signal to embrace epigenetics and transcri

252 egans can transport endogenous and exogenous RNA silencing signals between many different tissues via

253 OV) counters RNAi by encoding suppressors of RNA silencing (SRSs), we screened all EBOV proteins usin

254 e subcellular location of small RNA-mediated RNA silencing still needs to be defined.

255 RNA silencing studies in microvascular endothelial cells

256 K2-null MCs showed impaired responses to Ag, RNA silencing studies on other MC types indicated a domi

257 Overexpression and RNA silencing studies revealed that GPx8 is involved in

258 reveal a further layer of complexity of the RNA silencing suppression activity within the Potyvirida

259 These findings identify RNA silencing suppression as a common strategy used by p

260 Our results identify common features between RNA silencing suppression of plant and animal viruses.

261 ant viruses counter this host restriction by RNA silencing suppressor (RSS) activity of a double-stra

262 VP35 is also an RNA silencing suppressor (RSS).

263 es viral accumulation by targeting the viral RNA silencing suppressor helper-component proteinase (HC

264 nce for a mechanism by which a virus-encoded RNA silencing suppressor represses the transcriptional i

265 nthamiana revealed that P1N-PISPO acts as an RNA silencing suppressor, a role normally associated wit

266 ntermeasure, many viruses have evolved viral RNA silencing suppressors (RSS) that tightly, and presum

267 s indicate that prokaryotes possess a unique RNA silencing system that functions by homology-dependen

268 , which are known to have a highly effective RNA silencing system.

269 A new high-throughput RNA-silencing system has been developed for use in the r

270 kdown of p53 expression by small interfering RNA silencing technology significantly repressed the cap

271 omembrane system is an integral component of RNA silencing that has been long overlooked and predict

272 nimal kingdoms and suppress a common step in RNA silencing that is downstream of small RNA maturation

273 We also discuss RNA silencing that occurs between organisms.

274 uses has been found to encode suppressors of RNA silencing, the mechanisms by which flaviviruses anta

275 ave an important role in gene regulation and RNA silencing therapy, but it is challenging to detect t

276 A proviral role to subvert RNA silencing through binding of these host RNP proteins

277 upporting the notion that TCV VSR suppresses RNA silencing through directly interacting with AGO2.

278 ngly, we found that DCL1 represses antiviral RNA silencing through negatively regulating the expressi

279 We used RNA silencing to ablate factors required for multiplicat

280 Dicer enzymes function at the core of RNA silencing to defend against exogenous RNA or to regu

281 The importance of RNA silencing to HSV-1 replication was confirmed by a si

282 Many organisms including plants use RNA silencing to regulate development and physiology, an

283 ved in calcium signalling was carried out by RNA silencing to validate the new strategy and has provi

284 binding protein that controls flowering and RNA silencing, to control the expression of alternativel

285 tance (R) and other defence-related genes by RNA silencing, viral infections incite perturbations of

286 Here we describe a viral suppressor of RNA silencing (VSR) encoded by the prototype flavivirus,

287 t viruses are known to encode suppressors of RNA silencing (VSR) that can neutralize the effectivenes

288 o target PVX lacking its viral suppressor of RNA silencing (VSR), P25, but that only AGO2 and AGO5 ar

289 Viruses express viral suppressors of RNA silencing (VSRs) to counteract RNA silencing-based h

290 ific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense.

291 ing by encoding diverse viral suppressors of RNA silencing (VSRs).

292 Using human-specific small interfering RNA silencing, we could demonstrate that an extra copy o

293 5,7-trihydroxyflavone (apigenin), as well as RNA silencing, we found that the invasive phenotype of M

294 Without SID-3, cells perform RNA silencing well but import dsRNA poorly.

295 like (DCL) genes and other genes involved in RNA silencing were cloned into a vector under an estroge

296 IP(3) receptor antagonist Xestospongin C and RNA silencing were used to investigate preconditioning m

297 elected endogenous RNAs are degraded through RNA silencing, which is a genome defense mechanism used

298 nisms for plant antiviral immunity relies on RNA silencing, which is often suppressed by co-evolving

299 own to be directly associated with anti-TBSV RNA silencing, while its inactivation does not influence

300 rtion of ORF A, functions as a suppressor of RNA silencing, while protease p48, derived from the N-te