ライフサイエンスコーパス: RNA splicing

1 d, and many disease-causing mutations affect RNA splicing.

2 nd-to-last nucleotide of exon 2 and possibly RNA splicing.

3 omplex genes, via aberrant transcription and RNA splicing.

4 ir C termini as a consequence of alternative RNA splicing.

5 l role in RNA metabolism by facilitating pre-RNA splicing.

6 tophagy, global transcriptional control, and RNA splicing.

7 trimethylation, nucleosome positioning, and RNA splicing.

8 failure, presumably through altering cardiac RNA splicing.

9 icases, we examined cancer-specific roles in RNA splicing.

10 ylation at splice acceptor sites may inhibit RNA splicing.

11 chromatin remodeler could indirectly affect RNA splicing.

12 o humans that are reported to have a role in RNA splicing.

13 ns are orthologues of proteins implicated in RNA splicing.

14 ed to regulate gene expression by modulating RNA splicing.

15 xcept for some encoding proteins involved in RNA splicing.

16 nd E7 expression is regulated by alternative RNA splicing.

17 pression of approximately 50 genes governing RNA splicing.

18 to excise a minimal length of the intron in RNA splicing.

19 tified its selective role as an inhibitor of RNA splicing.

20 ated for RNA sequencing (RNA-Seq) because of RNA splicing.

21 (snRNAs) are essential factors in messenger RNA splicing.

22 l processes such as chromatin remodeling and RNA splicing.

23 events through the regulation of alternative RNA splicing.

24 Top1 cleavage complexes (Top1cc), can alter RNA splicing.

25 number of functions, including regulation of RNA splicing.

26 r trafficking, mitochondrial metabolism, and RNA splicing.

27 phenotype in the first family and disrupted RNA splicing.

28 xpress together with IgM through alternative RNA splicing.

29 srupted cis elements necessary for efficient RNA splicing.

30 nal elements that affect gene expression and RNA splicing.

31 at the levels of viral DNA transcription and RNA splicing.

32 specific role for Jmjd6 in the regulation of RNA splicing.

33 vesicular trafficking, DNA damage repair and RNA splicing.

34 nd nuclear export, in addition to modulating RNA splicing.

35 eptor-mediated transcription and alternative RNA splicing.

36 assembly of the snRNP complexes required for RNA splicing.

37 F and DSX M) are formed due to sex-specific RNA splicing.

38 reviously implicated in the control of HIV-1 RNA splicing.

39 ydroxyvitamin D (1,25(OH)2D) with subsequent RNA splicing.

40 w role for this central kinase in regulating RNA splicing.

41 B cell receptors (BCRs) through alternative RNA splicing.

42 while not impairing full-length SON-mediated RNA splicing.

43 proteins involved in nucleotide binding and RNA splicing.

44 abundance of several proteins that regulate RNA splicing.

45 cripts resulting from erroneous SON-mediated RNA splicing.

46 ene expression, chromatin accessibility, and RNA splicing.

47 nELAVL target binding, and altered neuronal RNA splicing.

48 nition factor U2AF1 alter its normal role in RNA splicing.

49 er they caused abnormal ABCB11 pre-messenger RNA splicing, abnormal processing of BSEP protein, or al

50 -requiring enzyme 1alpha-dependent messenger RNA splicing (activation) of X-box-binding protein-1 (XB

51 The RNA splicing activity is not affected by these mutations

52 has adopted an extremely efficient secondary RNA splicing activity that is beneficial to its host, ba

53 on, environmental factors and drugs modulate RNA splicing, affording new opportunities for the treatm

54 n human disease and defects in pre-messenger RNA splicing/alternative splicing are accumulating.

55 ct failed to splice reporter RNA in in vitro RNA splicing analyses.

56 intronic and 3' UTR binding regulates human RNA splicing and abundance.

57 strate that bZIP60 in plants is activated by RNA splicing and afford opportunities for monitoring and

58 s (RTs) function in both intron mobility and RNA splicing and are evolutionary predecessors of retrot

59 are predicted to influence gene expression, RNA splicing and cell proliferation.

60 The minimized bI4 intron was active in RNA splicing and contrasts with previous proposals that

61 rylation sites involved in transcription and RNA splicing and decreased abundance of enzymes in lipid

62 ovel pathways in MDS pathogenesis, including RNA splicing and epigenetic regulation of gene expressio

63 e data identify a specific role for ZRSR2 in RNA splicing and highlight dysregulated splicing of U12-

64 criptase, which function together to promote RNA splicing and intron mobility via reverse splicing of

65 ermined that RBFox1 is a potent regulator of RNA splicing and is required for a conserved splicing pr

66 and have uncovered a potential role for the RNA splicing and localization machinery in regulating CL

67 itination at damaged DNA, but also regulates RNA splicing and mitotic spindle formation in its integr

68 as cellular maintenance pathways, including RNA splicing and nuclear-cytoplasmic transport have been

69 These tumor-specific mutations alter UPF1 RNA splicing and perturb NMD, leading to upregulated lev

70 lions of protein variants due to alternative RNA splicing and post-translational modifications, and v

71 The RNA splicing and processing endonuclease from Nanoarchae

72 ed by post-translational modification (PTM), RNA splicing and proteolysis.

73 These mutations induce defects in RNA splicing and represent a new class of mutations in m

74 in a variety of cellular processes including RNA splicing and resistance to agents that cause DNA int

75 specific recombination, telomere resolution, RNA splicing and retrohoming of mobile introns.

76 large, autocatalytic ribozymes that catalyze RNA splicing and retrotransposition.

77 An analysis of RNA splicing and RNA editing of selected RNA species dem

78 f a deep connection between the mechanism of RNA splicing and small-RNA-mediated gene silencing, the

79 ved in other functions such as modulation of RNA splicing and specific regulation of gene expression,

80 complexes that are crucial to pre-messenger RNA splicing and telomere maintenance, respectively.

81 ulation factor IX, and is predicted to alter RNA splicing and to lead to production of a truncated fo

82 of IMP1, which corrects the defects in IGF2 RNA splicing and translation.

83 olved in the regulation of transcription and RNA splicing and transport, and it has functional homolo

84 utionalized' for non-conflict roles, e.g. in RNA-splicing and in RNAi systems (e.g. in kinetoplastids

85 32, 30, 27, and 14 kDa) through differential RNA splicing, and alternative promoters and translationa

86 DNA replication and repair to transcription, RNA splicing, and metabolism.

87 sequencing confirmed the effect of hDBR1 on RNA splicing, and metabolite profiling supported the obs

88 at multiple levels, including transcription, RNA splicing, and mRNA stability.

89 imate link across telomere biology, aberrant RNA splicing, and myeloid progenitor differentiation.

90 f RNA metabolism, including rRNA biogenesis, RNA splicing, and polyadenylation.

91 orylates acinus, an SR protein essential for RNA splicing, and redistributes it from the nuclear spec

92 esent in proteins involved in transcription, RNA splicing, and signal transduction, and often exist i

93 d minor spliceosome, the factors controlling RNA splicing, and the role of alternative splicing in ca

94 d include DNA supercoiling, DNA replication, RNA splicing, and transcription.

95 enhance our understanding of transcription, RNA splicing, and translation.

96 roteins resulting in disruption of messenger RNA splicing; and (ii) licensing of expanded C9orf72 pre

97 Alterations in RNA splicing are associated with cancer, but it is not c

98 ions, genomic rearrangements, and defects in RNA splicing are included among the most sensitive acces

99 al process of gene regulation, and errors in RNA splicing are known to be associated with a variety o

100 ear protein that regulates transcription and RNA splicing, are the defining histopathological feature

101 The double mutant knocks out the RNA-splicing arm of the UPR signaling pathway.

102 Alternative RNA splicing (AS) regulates proteome diversity, includin

103 oding RNA binding proteins, particularly the RNA splicing-associated SR genes.

104 to downregulate gene expression or to modify RNA splicing, but antisense technology has not previousl

105 ols (odds ratio 1.26-1.9); it did not affect RNA splicing, but it was in strong linkage disequilibriu

106 at inhibition of transcription initiation or RNA splicing, but not translation, leads to spindle defe

107 RNA and influences both gene expression and RNA splicing, but these actions do not appear to be link

108 provide new insights into the regulation of RNA splicing by Akt isoforms through phosphorylation of

109 ogether, this study identifies regulation of RNA splicing by RBFox1 as an important player in transcr

110 The effect of the c.5461-10T-->C variant on RNA splicing by reverse-transcription polymerase chain r

111 As a result of chimeric RNA splicing, cad2 mRNA from bm1-das1 contains a 409-bp

112 Altered RNA splicing caused by this polymorphism gives rise to a

113 anscriptional regulation, DNA damage repair, RNA splicing, cell differentiation, and metastasis.

114 l program and activating genes essential for RNA splicing, cell migration, controlled cellular prolif

115 tation-chip studies, analysis of alternative RNA splicing, characterization of the methylation state

116 nt lessons learned in this emerging field of RNA splicing chemistry and chemical biology.

117 mologous to DDB1, and is a component of SF3b RNA splicing complex and STAGA/TFTC transcription comple

118 egulatory proteins controlling pre-messenger RNA splicing contain serine:arginine (SR) repeats.

119 arget of FUS-R521C-associated DNA damage and RNA splicing defects in mice.

120 tions, typically affecting genes involved in RNA splicing, dictate future trajectories of disease evo

121 identified mutations in genes implicated in RNA splicing, DNA modification, chromatin regulation, an

122 trates and is involved in DNA transcription, RNA splicing, DNA repair, cell differentiation, and meta

123 P1), as a prominent regulator of alternative RNA splicing during heart failure.

124 ght RNA ligase that catalyzes unconventional RNA splicing during the mammalian UPR.

125 been shown to sequester proteins involved in RNA splicing, editing, nuclear export and nucleolar func

126 dings suggest that c-jun directly attenuates RNA splicing efficiency, which may be of broad biologic

127 Mobile group I introns are RNA splicing elements that have been invaded by endonucl

128 We identified two RNA splicing enhancers and their binding proteins (U2AF6

129 al protein kinase (PK)/ribonuclease, IRE1, a RNA splicing enzyme, and another involving membrane-asso

130 ited number of cellular processes, including RNA splicing, epigenetic and traditional transcriptional

131 ce variants demonstrated a key role for this RNA splicing event in the resistance of cells to anoikis

132 rganisms, for example, detecting alternative RNA splicing events and oncogenic chromosomal rearrangem

133 we identify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressiv

134 covering and quantifying circular and linear RNA splicing events at both annotated and un-annotated e

135 did not detect cryptic promoter activity or RNA splicing events that could account for downstream ci

136 TP53 undergoes multiple RNA-splicing events, resulting in at least nine mRNA tra

137 A methylation of RNA has profound effects on RNA splicing, export, stability, and translation.

138 ucyl-tRNA synthetase (LeuRS) is an essential RNA splicing factor for yeast mitochondrial introns.

139 To investigate the pathogenesis of the RNA splicing factor forms of RP, the authors generated a

140 may be the primary cell type affected in the RNA splicing factor forms of RP.

141 Application of MISO implicated the RNA splicing factor hnRNP H1 in the regulation of altern

142 the maize U2AF(35) Related Protein (URP), an RNA splicing factor involved in both U2 and U12 splicing

143 f Casp9 via the phosphorylation state of the RNA splicing factor SRp30a via serines 199, 201, 227, an

144 L4-33K is a virus-encoded alternative RNA splicing factor which activates splicing of viral la

145 , we report that SON, previously known as an RNA splicing factor, controls MLL complex-mediated trans

146 ng ER-associated transcription factors and a RNA splicing factor, IRE1b.

147 Initially discovered as a potential RNA splicing factor, SFPQ was later shown to have homolo

148 st report suggesting that MCM7 is a critical RNA splicing factor, thus giving significant new insight

149 olyglutamine-binding protein 1 (PQBP1) is an RNA-splicing factor that, when mutated, in humans causes

150 Mutations in RNA splicing factors are the single most common class of

151 These toxic RNAs alter the activities of RNA splicing factors resulting in alternative splicing m

152 Under ADT conditions, recruitment of several RNA splicing factors to the 3' splicing site for AR-V7 w

153 f TOP1 to RNAPIIo and for the recruitment of RNA splicing factors to the actively transcribed chromat

154 The loss of genes that encode RNA splicing factors weakens cancer cells in a way that

155 he primary cell affected by mutations in the RNA splicing factors, and these changes occur at an earl

156 ar components, chromatin remodeling factors, RNA splicing factors, RNA granule components and the mac

157 n of function by disrupting the functions of RNA splicing factors, such as MBNL1 and CELF1, leading t

158 3/Las1 as a unique member of the RNaseL/Ire1 RNA splicing family.

159 nalyses revealed that both drugs altered E1A RNA splicing (favoring the production of 13S over 12S RN

160 n with global effects on gene expression and RNA splicing fidelity.

161 Although its function in RNA splicing for effective cell cycle progression and ge

162 s, severely crippling or ablating the native RNA splicing function.

163 Mutations in the RNA splicing gene SF3B1 are found in >80% of patients wi

164 (45% of primary cohort), while mutations in RNA splicing genes are rare (2% of primary cohort).

165 matic mutations in epigenetic regulators and RNA splicing genes frequently constitute isolated diseas

166 -regulated genes, there was an enrichment of RNA splicing genes.

167 Alternative RNA splicing greatly expands the repertoire of proteins

168 natural product and synthetic modulators of RNA splicing has opened new access to this field, allowi

169 osome assembly; however, its precise role in RNA splicing has remained unclear.

170 discovery in 1977, the study of alternative RNA splicing has revealed a plethora of mechanisms that

171 ng factors contributing to HPV18 alternative RNA splicing have been discovered in this study for the

172 Together, these data demonstrate a role for RNA splicing homeostasis in dietary restriction longevit

173 equencing and analysis of global alternative RNA splicing identified that the mRNA splicing of cytopl

174 termines strain-specific differences in cell RNA splicing.IMPORTANCE Efficient viral replication requ

175 ous mutations in SMC3 or SMC1A that affected RNA splicing in 2 independent patients with combined CdL

176 rations of H3K36me3 associated with aberrant RNA splicing in a SETD2 mutant RCC and SETD2 knockout ce

177 ue U1 snRNP pathology and implicate abnormal RNA splicing in AD pathogenesis.

178 Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significan

179 KDM5B, modulates RNAPII elongation rates and RNA splicing in ES cells.

180 ich underscore the importance of fine-tuning RNA splicing in hematopoiesis.

181 d demonstrate the importance of SON-mediated RNA splicing in human development.

182 be naturally disabled by aberrant messenger RNA splicing in Rfv3-susceptible strains.

183 ere are many important examples of regulated RNA splicing in Saccharomyces cerevisiae Here, we report

184 e, there are important examples of regulated RNA splicing in Saccharomyces cerevisiae, such as splici

185 rom the full-length enzyme and was active in RNA splicing in vitro.

186 ine-rich (SR) proteins involved in messenger RNA splicing, including the splicing factor SRm300 (SRRM

187 Alternative pre-messenger RNA splicing influences development, physiology and dise

188 after treating virus-infected cells with the RNA splicing inhibitor spliceostatin A to prevent M2 mRN

189 In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a

190 spliceosome, catalyzing precursor-messenger RNA splicing, involves multiple RNA-protein remodeling s

191 RNA splicing is a major contributor to total transcripto

192 The evolution of RNA splicing is a prime example of the Darwinian functio

193 Alternative RNA splicing is an essential process to yield proteomic

194 RNA splicing is an increasingly recognized regulator of

195 ur laboratory previously reported that Bcl-x RNA splicing is dysregulated in a large percentage of hu

196 ereby molecular manipulation of premessenger RNA splicing is engineered to yield genetic correction,

197 ar cloning of Rgh3 suggests that alternative RNA splicing is needed for cell differentiation, develop

198 We suggest that RNA splicing is of particular importance for plant respo

199 RNA splicing is required to remove introns from pre-mRNA

200 e propose a model wherein a modest effect on RNA splicing is sufficient to mediate the CD33 associati

201 Alternative messenger RNA splicing is the main reason that vast mammalian prot

202 The RNA splicing landscape of PCa across racial populations

203 Although this 3'-P RNA splicing ligase activity was detected almost three d

204 crystal structures of Pyrococcus horikoshii RNA-splicing ligase RtcB in complex with Mn(2+) alone (R

205 The dependence of adenovirus on the host pre-RNA splicing machinery for expression of its complete ge

206 urrent somatic mutation of SRSF2, one of the RNA splicing machinery genes, has been identified in a s

207 s affecting genes encoding components of the RNA splicing machinery in hematological malignancies.

208 ic mutations of SF3B1 and other genes of the RNA splicing machinery in patients with myelodysplastic

209 dary-type AML carrying mutations in genes of RNA splicing machinery, TP53-mutated AML, or de novo AML

210 in SRRM2 (also called SRm300) is part of the RNA splicing machinery.

211 ordered and regulated assembly of the cell's RNA-splicing machinery by the survival motor neurons com

212 Here, we discuss how insights from RNA splicing maps of different RBPs inform the mechanist

213 global effects of RBPs on splicing to create RNA splicing maps.

214 ts suggest that induction of excessive HIV-1 RNA splicing may be a novel strategy to inhibit virus re

215 Alternative RNA splicing may provide unique opportunities to identif

216 Here, we provide an overview of RNA splicing mechanisms followed by a discussion of dise

217 tronic mutation as the molecular basis for a RNA splicing-mediated RAF inhibitor resistance mechanism

218 suggest a novel model wherein SNP-modulated RNA splicing modulates CD33 function and, thereby, AD ri

219 udemycin E is an analog of the pre-messenger RNA splicing modulator FR901464 and its derivative splic

220 nd are mediators of molecular functions like RNA splicing, mRNA decay, and translation control.

221 s, chromatin, long noncoding RNAs (lncRNAs), RNA splicing, nuclear topology and the 3D conformation o

222 When messenger RNA splicing occurs co-transcriptionally, the potential

223 We investigated the effect on pre-messenger RNA splicing of 14 ATP8B1 mutations at exon-intron bound

224 ese molecular defects result from inadequate RNA splicing of a specific set of cell-cycle-related gen

225 In this manuscript, we demonstrated that RNA splicing of AR-V7 in response to ADT was closely ass

226 ore, we investigated whether the alternative RNA splicing of Bcl-x pre-mRNA was modulated by MDA-7/IL

227 en 1q21-amplified ILF2 and the regulation of RNA splicing of DNA repair genes may be exploited to opt

228 NMDA receptors are modulated by alternative RNA splicing of GluN1.

229 ese cells is IgD, which, through alternative RNA splicing of H chain transcripts, begins to be coexpr

230 es important observations on how alternative RNA splicing of HPV18 pre-mRNAs is subject to regulation

231 vide the first evidence that the alternative RNA splicing of HPV18 pre-mRNAs is subject to regulation

232 Jmjd6 is shown to change alternative RNA splicing of some, but not all, of the endogenous and

233 r culturing cells at 32 degrees C suppressed RNA splicing of the CD44 variant v8-v10 and increased ex

234 onucleotide drug that modifies pre-messenger RNA splicing of the SMN2 gene and thus promotes increase

235 RNA splicing of U12-type introns functions in human cell

236 n of HPV18 genes is regulated by alternative RNA splicing of viral polycistronic pre-mRNAs to produce

237 Controlling RNA splicing opens up possibilities for the synthetic bi

238 te degradation of target mRNAs or to inhibit RNA splicing or translation of several genes of P. falci

239 have been used increasingly for redirecting RNA splicing particularly in therapeutic applications su

240 sterase and 3'-phosphate ligase steps of the RNA splicing pathway.

241 Here, we show that alterations in RNA splicing patterns across the human transcriptome tha

242 RNA splicing plays a critical role in the programming of

243 Based on this finding, we hypothesized that RNA splicing plays a role in mediating vWF expression in

244 first time a chemical-based interrogation of RNA splicing processes.

245 n/cytoskeletal protein binding, RNA binding, RNA splicing/processing, chromatin modifying, intracellu

246 tates with a protein involved in chloroplast RNA splicing prompted us to investigate a role for APO1

247 aling, chromatin, and epigenomic regulation; RNA splicing; protein homeostasis; metabolism; and linea

248 S69 connects histone H3.3K36me3 to regulated RNA splicing, providing significant, important insights

249 es DDX5 and RNA helicase A (RHA) that alters RNA-splicing ratios.

250 3ss) is an essential early step in mammalian RNA splicing reactions, but the processes involved are u

251 copies of a 5'CUG/3'GUC motif that binds the RNA splicing regulator muscleblind-like 1 protein (MBNL1

252 is caused when the expanded repeats bind the RNA splicing regulator Muscleblind-like 1 protein (MBNL1

253 Traditionally recognized as an RNA splicing regulator, heterogeneous nuclear ribonucleo

254 d identified a muscle-specific isoform of an RNA splicing regulator, RBFox1 (also known as A2BP1), as

255 We further identify BS69 association with RNA splicing regulators, including the U5 snRNP componen

256 with mutations in genes encoding chromatin, RNA-splicing regulators, or both (in 18% of patients); A

257 In a yeast strain in which the RNA splicing-related functions of Mss116p are dispensabl

258 residues in arginine-serine-rich domains of RNA splicing-related proteins.

259 ng factors contributing to HPV18 alternative RNA splicing remain unknown.

260 Alternative pre-messenger RNA splicing remodels the human transcriptome in a spati

261 rated as two isoform families by alternative RNA splicing, represented by VEGF-A165a and VEGF-A165b.

262 identified in cardiomyopathy patients alter RNA splicing, representing a 50% increase in the numbers

263 RNA splicing represents a post-transcriptional mechanism

264 y while studying transcription, translation, RNA splicing, ribosome biogenesis, and more recently, di

265 fect genetic instability, promoter activity, RNA splicing, RNA stability, and neurite mRNA localizati

266 Driver mutant genes include those of RNA splicing (SF3B1, SRSF2, U2AF1, and ZRSR2), DNA methy

267 tes evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensa

268 ndividual transcripts, alternative messenger RNA splicing, single-nucleotide polymorphisms, repeat se

269 m(6)A is thought to regulate RNA splicing, stability, translation, and secondary stru

270 Minigene RNA splicing studies in BV2 microglial cells established

271 ntially makes it vulnerable to modulators of RNA splicing, such as digoxin and digitoxin.

272 tions by modulating dystrophin pre-messenger RNA splicing, such that functional dystrophin protein is

273 activation disrupts RNA metabolism including RNA splicing, surveillance and transport pathways.

274 nown whether there is a corresponding set of RNA splicing switches.

275 in processes such as chromatin modification, RNA splicing, T- and B-cell activation, and NF-kappaB si

276 atio-temporally coordinated, indicating that RNA splicing takes place in the context of chromatin.

277 ed additional changes in gene expression and RNA splicing that may underlie the effects of this mutat

278 ntiation from neural stem cells and mediates RNA splicing through interactions with polypyrimidine tr

279 eins that regulate alternative pre-messenger RNA splicing, thus implicating a functionally distinct g

280 pre-mRNAs that are regulated by alternative RNA splicing to produce a repertoire of viral transcript

281 uman TACI undergoes alternative messenger (m)RNA splicing to produce isoforms with 1 or 2 ligand-bind

282 ted role of RBM3 in linking stress-regulated RNA splicing to tumorigenesis, with potential prognostic

283 is a 4-exon gene that undergoes alternative RNA splicing to yield 3 mRNAs with 5' different untransl

284 Here by using a combination of RNA splicing, transcription, and protein chemistry techn

285 fect promoter activity, genetic instability, RNA splicing, translation, and neurite mRNA localization

286 V1), RHOA/cytoskeleton remodeling (ARHGEF3), RNA splicing (U2AF1), T-cell receptor signaling (PTPRN2,

287 lation at the level of nuclear actin export, RNA splicing, ubiquitination, and other upstream process

288 essential targets included genes involved in RNA splicing, ubiquitination, transcription, translation

289 suggest that a conserved role in chloroplast RNA splicing underlies the physiological defects describ

290 rine carotid arteries by posttranscriptional RNA splicing unique to platelets.

291 ion of Bcl-x(L) is regulated at the level of RNA splicing via alternative 5' splice site selection wi

292 DEK accumulation and altered TPM RNA splicing were also detected in FBXW7 mutant human co

293 rameters of retinal function, structure, and RNA splicing were analyzed.

294 involved in regulation of transcription and RNA splicing were enriched in the group of cell types wi

295 ation, proteolysis, DNA-damage response, and RNA splicing were identified as important modulators of

296 of protein-coding messenger RNAs (mRNAs) via RNA splicing, whereby the spliceosome removes non-coding

297 esses in eukaryotic gene expression, such as RNA splicing, which can cause a pre-mRNA to produce one

298 a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes in over

299 scores how strongly genetic variants affect RNA splicing, whose alteration contributes to many disea

300 ic mechanisms linking aberrant pre-messenger RNA splicing with liver damage, fibrosis, and HCC.