ライフサイエンスコーパス: RNA synthesis

1 1, which plays important regulatory roles in RNA synthesis.

2 protein in PRRSV infection to regulate viral RNA synthesis.

3 viral polyprotein, but is required for viral RNA synthesis.

4 s of RNA polymerase II to DNA and consequent RNA synthesis.

5 ational drug design efforts to inhibit viral RNA synthesis.

6 rus, encodes a V protein that inhibits viral RNA synthesis.

7 The P protein of MuV is critical for viral RNA synthesis.

8 stood process that makes the RdRp capable of RNA synthesis.

9 ng the fraction of HCV genomes available for RNA synthesis.

10 asmic membranes that serve as sites of viral RNA synthesis.

11 while increasing the fraction available for RNA synthesis.

12 (TopA), inhibiting both DNA replication and RNA synthesis.

13 th elongating RNAPII and the leading edge of RNA synthesis.

14 at controls both the abortive and productive RNA synthesis.

15 uncoated particles were active in initiating RNA synthesis.

16 d result in changes in virus replication and RNA synthesis.

17 iscrimination against 2'-fluoro-dNTPs during RNA synthesis.

18 and a short template sequence for subgenomic RNA synthesis.

19 sit into the elongation phase for processive RNA synthesis.

20 A complex, the functional template for viral RNA synthesis.

21 anslation, eliminates miR-122 stimulation of RNA synthesis.

22 losteric site is not always available during RNA synthesis.

23 the NP-RNA complex, thereby regulating viral RNA synthesis.

24 ng that telaprevir exerts a direct effect on RNA synthesis.

25 e the requirements of nsp3 domains for viral RNA synthesis.

26 al oligomerization domain and enhances viral RNA synthesis.

27 ing the RdRp greatly affects its ability for RNA synthesis.

28 mplish the initiation and then elongation of RNA synthesis.

29 osphorylation plays a critical role in viral RNA synthesis.

30 tiation of the subgenomic RNAs and efficient RNA synthesis.

31 particles are produced as a result of viral RNA synthesis.

32 ant to understand the mechanism of norovirus RNA synthesis.

33 ADRP plays an essential role in coronavirus RNA synthesis.

34 e there gene expression, DNA duplication and RNA synthesis.

35 their gene expression, DNA duplication, and RNA synthesis.

36 ential for coronavirus genomic or subgenomic RNA synthesis.

37 ese stalled RNAPs is essential for efficient RNA synthesis.

38 osphoprotein (P) that is important for viral RNA synthesis.

39 ing both primed initiation and elongation of RNA synthesis.

40 sid of NSVs serves as the template for viral RNA synthesis.

41 the dsRNA template, leading to asymmetrical RNA synthesis.

42 ypermethylation and with a decrease in total RNA synthesis.

43 ins, P(XD) and N(TAIL) is required for viral RNA synthesis.

44 of a viral peptide (VPg) as primer for viral RNA synthesis.

45 s duplex translocation and primase-dependent RNA synthesis.

46 and RNA [(-)RNA] synthesis and subsequent (+)RNA synthesis.

47 of MuV-P-T101 plays a negative role in viral RNA synthesis.

48 thereby resulting in slow shut-off of viral RNA synthesis.

49 templates for translation to using them for RNA synthesis.

50 a large fraction of them are not involved in RNA synthesis.

51 0:1, suggesting a significant variability in RNA synthesis.

52 roles of Ser/Thr residues of MuV P in viral RNA synthesis.

53 replication complexes and the initiation of RNA synthesis.

54 esicle, is proportional to the rate of viral RNA synthesis.

55 ased DLPs and their efficiency in initiating RNA synthesis.

56 the importance of glycosphingolipids in HCV RNA synthesis.

57 d/or position the RNAP clamp domain to allow RNA synthesis.

58 and ribonucleotide pools needed for DNA and RNA synthesis.

59 g used here as a model system for pre-biotic RNA synthesis.

60 id not demonstrate a role for these sites in RNA synthesis.

61 for S/T residues that are critical for viral RNA synthesis.

62 orylation sites that are important for viral RNA synthesis.

63 n attenuated HCV infectivity and impeded HCV RNA synthesis.

64 dentify residues that are critical for viral RNA synthesis.

65 ed new residues of PB1 that are critical for RNA synthesis.

66 pseudoknot may participate in regulation of RNA synthesis.

67 ly of the viral replicase complex, and viral RNA synthesis.

68 role in any clay mineral-catalyzed prebiotic RNA synthesis.

69 essential laboratory technique for enzymatic RNA synthesis.

70 two to three nucleotides after kilobases of RNA synthesis.

71 polymerase (RdRp) (3D(pol)) catalyzes viral RNA synthesis.

72 iral polymerase NS5 to initiate minus-strand RNA synthesis.

73 e for RNA capping and a polymerase for viral RNA synthesis.

74 the viral replicase complex to boost progeny RNA synthesis.

75 iomyocytes, indicative of impaired ribosomal RNA synthesis.

76 Inhibition is relieved upon 6S RNA-templated RNA synthesis.

77 to modestly enhance viral pregenomic 3.5-kb RNA synthesis.

78 the promoter DNA while moving downstream for RNA synthesis.

79 r binding, bending and melting, and abortive RNA synthesis.

80 were interchangeable without affecting viral RNA synthesis.

81 R101A) or completely destroyed (G12L) viral RNA synthesis.

82 polymerase uses it as the template for viral RNA synthesis.

83 which is required for ribozyme activity and RNA synthesis.

84 of nascent transcript during negative-strand RNA synthesis.

85 fically impede intracellular influenza virus RNA synthesis.

86 g general transcription factors to stimulate RNA synthesis.

87 disperse based on the presence or absence of RNA synthesis.

88 S selection involves DNA scrunching prior to RNA synthesis.

89 ength TRIM56 by specifically targeting viral RNA synthesis.

90 virus, that has a unique mechanism of viral RNA synthesis.

91 viruses suggests that the CP also regulates RNA synthesis.

92 structural analyses of spherules engaged in RNA synthesis.

93 al replication machinery for efficient viral RNA synthesis.

94 st transcription machinery in favor of viral RNA synthesis, a process that is blocked by NSC95397.

95 A-binding protein Rim1 severely inhibits the RNA synthesis activity of Rpo41, but not the Rpo41-Mtf1

96 pound does not inhibit back priming, another RNA synthesis activity of the RSV polymerase.

97 f repair DNA synthesis) and RRS (recovery of RNA synthesis after DNA damage).

98 e PCR (qPCR) analyses revealed reduced viral RNA synthesis and a steepened transcription gradient in

99 how here that PIs can directly inhibit viral RNA synthesis and also block a late stage in virus assem

100 scontinuous to continuous extension of PRRSV RNA synthesis and also offer a new potential anti-PRRSV

101 lear actin filaments correlates with reduced RNA synthesis and altered chromatin organization.

102 function in the TH form as a general acid in RNA synthesis and as a general base in RNA hydrolysis.

103 two mutations (G37L and P112A) reduced viral RNA synthesis and blocked virion assembly.

104 rt steps essential for mitochondrial DNA and RNA synthesis and breakdown.

105 thematical model of the kinetic interplay of RNA synthesis and CTS and parameterized it with diverse

106 ze replication complexes at PD for localized RNA synthesis and directional trafficking of the virus b

107 icular stomatitis virus reveal insights into RNA synthesis and distinctive mRNA capping mechanisms of

108 te that Spt5 is crucial for a normal rate of RNA synthesis and distribution of RNAPII over transcript

109 h initiates growth by increasing protein and RNA synthesis and fatty acid metabolism, while decreasin

110 2 sub-domain is required for efficient viral RNA synthesis and growth of SVV, but not for IRES functi

111 The precise roles of the TL/TH in RNA synthesis and hydrolysis remain unclear.

112 ances our understanding of influenza A virus RNA synthesis and identifies the initiation platform of

113 ances our understanding of Influenza A virus RNA synthesis and identifies the initiation platform of

114 ts in its decreased activity both in de novo RNA synthesis and in extending a short primer.

115 of 10-del ZIKV may be due to decreased viral RNA synthesis and increased sensitivity to type-1-interf

116 glycolytic pathway dramatically reduced DENV RNA synthesis and infectious virion production, revealin

117 RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformationa

118 linkages occur sporadically in non-enzymatic RNA synthesis and may have aided prebiotic RNA replicati

119 viral polymerase, thereby diminishing viral RNA synthesis and modulating EBOV replication.

120 3, which is critically involved in ribosomal RNA synthesis and mRNA translation.

121 of a variety of tools and methods for guide RNA synthesis and mutant identification.

122 interaction and abrogate both viral genomic RNA synthesis and N-mediated translation strategy withou

123 hibitor of IRF3 activation; thus, both viral RNA synthesis and nuclear export are required for IFN in

124 ents in tissue culture cells show that viral RNA synthesis and nuclear export are required to activat

125 tein (RNP) complexes that are substrates for RNA synthesis and packaging into virus particles.

126 dentified S/T residues of P critical for MuV RNA synthesis and phosphorylation sites that are importa

127 Our results explain how p58C participates in RNA synthesis and primer length counting and also indica

128 h of our knowledge about the fundamentals of RNA synthesis and processing come from ensemble in vitro

129 nts of the gene expression machinery such as RNA synthesis and processing factors.

130 involved in cell adhesion, cytoskeleton, and RNA synthesis and processing.

131 ere acute respiratory syndrome (SARS)-CoV an RNA synthesis and proofreading pathway through associati

132 sport, on cellular metabolism and on DNA and RNA synthesis and repair.

133 RNA synthesis and replication of the members of the Flav

134 Recent studies show the processes of RNA synthesis and RNA processing to be spatio-temporally

135 f promoter recognition, promoter activation, RNA synthesis and RNA processing, and it is known that S

136 udies did not distinguish between changes in RNA synthesis and RNA turnover and did not address the r

137 hrough a process that required de novo viral RNA synthesis and shifted the ratio of viral dsRNA/ssRNA

138 results show that ATM and p53 regulate both RNA synthesis and stability as well as enhancer element

139 The combinatory analysis of both RNA synthesis and stability using Bru-Seq and BruChase-S

140 Assays were designed to measure active viral RNA synthesis and steady-state RNA abundance, polyprotei

141 te experimental pipeline for high-throughput RNA synthesis and structure mapping.

142 nstrate that our compounds can block de novo RNA synthesis and that effect is dependent on a chemical

143 s into the molecular mechanisms of norovirus RNA synthesis and the sequences that determine the recog

144 on, PIs and APHIs can block NS3 functions in RNA synthesis and virus assembly, in addition to inhibit

145 nating diverse viral processes such as viral RNA synthesis and virus egress.

146 involves complementary minus-strand RNA [(-)RNA] synthesis and subsequent (+)RNA synthesis.

147 ations at every step can cause variations in RNA synthesis, and affect physiology and differentiation

148 Promoters initiate RNA synthesis, and enhancers stimulate promoter activity

149 d, such as primase binding to DnaB helicase, RNA synthesis, and SS B antigen (SSB) displacement durin

150 V genomes, we found that telaprevir inhibits RNA synthesis as early as 12 h at high but clinically re

151 ork leads to a better understanding of viral RNA synthesis as well as to potential novel strategies t

152 We report an in vitro RNA synthesis assay for the RNA-dependent RNA polymerase

153 pite genomic deletions but that the impaired RNA synthesis associated with terminally deleted viruses

154 1 polymerase and shows diminished growth and RNA synthesis at 39 degrees C compared to that at 31 deg

155 to UV, which supports the notion that faulty RNA synthesis at damaged sites is harmful to the cell fi

156 erate RPR evolution, and allow RPR-catalysed RNA synthesis at near physiological (>/=1 mM) Mg(2+) con

157 eprogrammed upon stress, we measured nascent RNA synthesis at nucleotide-resolution, and profiled his

158 s form a large complex that is necessary for RNA synthesis at replication sites.

159 After RNA synthesis at the local region is completed, the vira

160 NA bubble and enters into abortive cycles of RNA synthesis before escaping the promoter to transit in

161 nB P1 open complex, scrunching occurs before RNA synthesis begins.

162 cell death was cell autonomous and required RNA synthesis but not viral DNA replication.

163 romycin blocks miR-122-mediated increases in RNA synthesis, but independently enhances RNA synthesis

164 ral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3' and 5' vRNA en

165 Although NEP stimulates viral RNA synthesis by binding to the viral polymerase, its fu

166 ngation factor that assists in DNA-templated RNA synthesis by cellular RNA polymerases (RNAP).

167 RNA synthesis by even a single virus particle can initia

168 Thus, RNA synthesis by even a single, uncoated particle can in

169 largely responsible for inhibition of viral RNA synthesis by generating recombinant viruses that lac

170 dimer of polalpha (p180DeltaN-p70) inhibited RNA synthesis by primase.

171 Detection of increased negative-strand RNA synthesis by real time RT-PCR for the NS3:N570A muta

172 of P, suggesting that NP can regulate viral RNA synthesis by regulating phosphorylation of P.

173 in RNA synthesis, but independently enhances RNA synthesis by releasing ribosomes from viral genomes.

174 ays a critical role in V inhibition of viral RNA synthesis by the N-terminal domain.

175 RNA synthesis by the prototype coronavirus mouse hepatit

176 ce is sufficient for the initiation of viral RNA synthesis by the recombinant MNV RNA-dependent RNA p

177 le-based blocking of Hsp70 function inhibits RNA synthesis by the tombusvirus RdRp in vitro.

178 e that the use of dsRNA as a template for (+)RNA synthesis by the viral replicase is facilitated by r

179 We detected RNA synthesis by uncoated particles as early as 15 min a

180 ize to viroplasms, which are the sites of RV RNA synthesis, by expressing the mutant form as a green

181 steady-state transposon mRNA levels, nascent RNA synthesis, chromatin state, and small RNA abundance.

182 , NS5A inhibitors were slow to inhibit viral RNA synthesis compared with protease or polymerase inhib

183 Long RNA synthesis (constrained to be single round) occurs on

184 The fidelity of RNA synthesis depends on both accurate template-mediated

185 NA polymerase can use it as the template for RNA synthesis during both transcription and replication.

186 mplate N are also required for initiation of RNA synthesis, extending our knowledge of ribonucleoprot

187 presents a prime example for the coupling of RNA synthesis, folding, and regulation.

188 anscribed discontinuously as short bursts of RNA synthesis followed by longer silent periods.

189 ic defect of VCP/p97 enhance the recovery of RNA synthesis following UVR, whereas both VCP/p97 and pr

190 ome replication, by inhibiting initiation of RNA synthesis from the promoter.

191 lasma of rodents and humans, is critical for RNA synthesis, glycogen deposition, and many other essen

192 and regioselectivity, no enzymatic route for RNA synthesis had been described.

193 date, the mechanism of norovirus subgenomic RNA synthesis has not been characterized.

194 promoter role by restricting non-productive RNA synthesis in a Pol II CTD S2P-specific manner.

195 ltisubunit RNA polymerases (RNAPs) carry out RNA synthesis in all domains life.

196 ption factor Gre, that increases fidelity of RNA synthesis in bacteria.

197 We show that Sal inhibits RNA synthesis in cells and that mutations that confer Sa

198 ate reductase (DHFR), were unable to recover RNA synthesis in CSB-deficient cells, transcription was

199 2',4'-diF-rUTP inhibited RNA synthesis in dinucleotide-primed reactions, although

200 eir close proximity by PLA demonstrates that RNA synthesis in individual cells resumes about 30-45 mi

201 ency of the compound, which suppressed viral RNA synthesis in infected cells.

202 "DNA scrunching" that occurs concurrent with RNA synthesis in initial transcription.

203 Using this approach, HDACi have induced HIV RNA synthesis in latently infected cells from some patie

204 nscription elongation complexes and modulate RNA synthesis in response to translation, processing, an

205 Depletion of GTP inhibits ribosomal RNA synthesis in T cells by inhibiting transcription ini

206 This strategy is likely to avoid viral RNA synthesis in the cytosol that would rapidly lead to

207 at PB1 proline 651 is critical for efficient RNA synthesis in vitro and in cell culture.

208 olymerase (RdRp), exhibits poorly processive RNA synthesis in vitro, at odds with the efficient repli

209 ich enables a more efficiently elongation of RNA synthesis in vitro.

210 bly of the viral replicase complex and viral RNA synthesis in vitro.

211 tive transcription is a noncanonical form of RNA synthesis in which a nucleotide specified by a singl

212 1-beta-d-ribofurandoside (DRB), a reversible RNA synthesis inhibitor, also prevented eCB-LTD.

213 pplication of actinomycin D, an irreversible RNA synthesis inhibitor, or 5,6-dichlorobenzimidazole 1-

214 ow the formation of spherules enhances viral RNA synthesis is also not understood, although it is ass

215 zyme predominantly used for in vitro run-off RNA synthesis is bacteriophage T7 RNA polymerase.

216 Influenza A virus RNA synthesis is catalyzed by the viral polymerase compr

217 Coronavirus RNA synthesis is connected with the formation of double-

218 e of the multiple levels at which Flavivirus RNA synthesis is controlled.

219 space of transcription intermediates during RNA synthesis is important to understand riboswitch func

220 Customized RNA synthesis is in demand for biological and biotechnol

221 viral ribonucleoproteins that catalyse viral RNA synthesis is inhibited, causing decreased viral prot

222 ce linking membrane morphogenesis with viral RNA synthesis is lacking.

223 Coronavirus RNA synthesis is performed by a replication-transcriptio

224 -replication through RNA-catalysed templated RNA synthesis is thought to have supported a primordial

225 hed a peak titer similar to and demonstrated RNA synthesis kinetics comparable to those seen with WT-

226 chanistic insights into the workings of this RNA synthesis machine.

227 elements define boundaries for both DNA and RNA synthesis machineries.

228 The RNA synthesis machinery of non-segmented negative-sense

229 ctivity directly and that IHF represses ltxA RNA synthesis mainly by blocking Mlc binding.

230 For the initiation of RNA synthesis, most RdRps use either a primer-dependent

231 For the initiation of RNA synthesis, most RdRps use either a primer-dependent

232 Here, we show that, after initiation of RNA synthesis, non-specific interaction of sigma(70) reg

233 ranscription elongation and that recovery of RNA synthesis occurred as a wave in the 5'-3' direction

234 levels in Xrn1-depleted cells, with enhanced RNA synthesis occurring before heightened protein synthe

235 After sigma70 binding, further RNA synthesis occurs as DNA is drawn (or 'scrunched') in

236 Rapid RNA synthesis of comprehensive single mutant libraries a

237 affect transcription and how the recovery of RNA synthesis of large genes are particularly delayed by

238 KSHV RTA may bind to MyD88 RNA, suppresses RNA synthesis of MyD88, and inhibits IL-1-mediated signa

239 MyD88 expression at the RNA level, inhibits RNA synthesis of MyD88, and may bind MyD88 RNA.

240 The DRMs could support viral RNA synthesis on both the endogenous and exogenous templ

241 extensively activity at the stage of initial RNA synthesis on sigma(54)-regulated promoters.

242 termini of the V protein that inhibit viral RNA synthesis: one at the very N terminus of V and the s

243 These domains may play direct roles in RNA synthesis, or they may have evolved for other purpos

244 we found that TSS scanning does not require RNA synthesis, our results revealed that transcription i

245 This marine enzyme catalyses RNA synthesis over a wider range of temperature and sali

246 edly potentiates the inhibition of ribosomal RNA synthesis, PCNA expression, and T-cell activation in

247 Understanding of RNA synthesis priming in eukaryotes is currently limited

248 er drugs requires a detailed analysis of DNA/RNA synthesis processes.

249 t it inhibits a step common to both of these RNA synthesis processes.

250 pression and lipidation that is dependent on RNA synthesis, protein translation, and the methyltransf

251 r QDE-1(Ncr) counterpart favoring processive RNA synthesis, QDE-1(Tte) and QDE-1(Mth) produce predomi

252 nificantly block initiation or elongation of RNA synthesis; rather, they block the transition from in

253 I2) do not block initiation or elongation of RNA synthesis; rather, they block the transition from th

254 the dialyzer for small-volume non-enzymatic RNA synthesis reactions inside fatty acid vesicles.

255 The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irrad

256 bstantial reductions in both UV survival and RNA synthesis recovery.

257 A polymerase (RdRp) for functions other than RNA synthesis, regulatory interactions with other viral

258 lethal mutations in cell division cycle and RNA synthesis related genes, revealing 660 suppressor in

259 ylation of the M2-1 protein upregulates hMPV RNA synthesis, replication, and pathogenesis in vivo IMP

260 shortly after virus entry but prior to viral RNA synthesis/replication.

261 x 10(-5)) indicate high accuracy/fidelity of RNA synthesis resembling those of replicative DNA polyme

262 Therefore, instead of concurrent DNA and RNA synthesis, respectively, on the leading and lagging

263 TRIM25 inhibition of viral RNA synthesis results from its binding to viral ribonucl

264 RNA synthesis resumed fully at the 3'-end of genes after

265 stream binding factor recruitment, ribosomal RNA synthesis, ribonucleotide levels, and affects riboso

266 reported on an integrated, one-pot ribosomal RNA synthesis (rRNA), ribosome assembly, and translation

267 ication complex by NS5BDelta21, resulting in RNA synthesis stimulation by helicase.

268 RNA synthesis strongly activates the innate immune respo

269 rization and play an essential role in viral RNA synthesis, suggesting a novel mechanism for viral RN

270 ces an increase in total precursor messenger RNA synthesis, suggesting an increased burden on the cor

271 n contrast, the APHI could partially inhibit RNA synthesis, suggesting that the allosteric site is no

272 e not well understood, in part because viral RNA synthesis takes place within enzyme complexes associ

273 rgest RNA viruses, have a complex program of RNA synthesis that entails genome replication and transc

274 To ensure processive RNA synthesis, the viral polymerase L in complex with it

275 though both compounds slightly reduced viral RNA synthesis, they significantly impaired assembly of i

276 TRIM25 inhibits viral RNA synthesis through a direct mechanism that is indepen

277 al capsid and carry out endogenous messenger RNA synthesis through a transcriptional enzyme complex (

278 polymerase remodel the nucleocapsid to allow RNA synthesis to occur efficiently.

279 nergy is generated per translocation step of RNA synthesis to overcome OC stability and drive escape.

280 monitoring steady-state RNA levels, rates of RNA synthesis, transcription initiation and RNA polymera

281 into preinitiation complexes that can begin RNA synthesis upon binding of NTPs (nucleoside triphosph

282 and RNA, inhibition of OGT impaired nascent RNA synthesis upon T cell activation.

283 We studied RNA synthesis using an in situ run-on assay and found ri

284 stigated the roles of P(O) and P(C) in viral RNA synthesis using mutational analysis and a minigenome

285 Comparative global analysis of RNA synthesis vs steady state levels revealed that micro

286 Moreover, nascent RNA synthesis was observed in the interchromatin regions

287 interactions between L domains during viral RNA synthesis, we exchanged each of the four distinct re

288 es by de novo RNA priming, the first step of RNA synthesis where RNAP accepts two initiating ribonucl

289 f the coronavirus genome requires continuous RNA synthesis, whereas transcription is a discontinuous

290 irus (VSV), a prototype, supports a model of RNA synthesis whereby N is displaced from the template t

291 on of Swi6 during S phase allows a period of RNA synthesis which programs the RNAi machinery to maint

292 mplete cycle of replication and asymmetrical RNA synthesis, which is a hallmark of (+)-strand RNA vir

293 box binding protein (TBP) leads to increased RNA synthesis, which together with R-loop accumulation r

294 t-recruitment' roles in promoter melting and RNA synthesis, which were revealed by studying the pre-i

295 rus-induced replication complexes to promote RNA synthesis, while DnaJB6 associates with capsid prote

296 s mutations in the L segment decreased viral RNA synthesis, while those in the M segment delayed prog

297 An understanding of viral RNA synthesis will allow the design of better vaccines a

298 M) Mg(2+) concentrations, enabling templated RNA synthesis within membranous protocells.

299 To mimic the result of RNA synthesis within non-growing protocells, we co-encap

300 prior to capsid assembly and double-stranded RNA synthesis within viral inclusion bodies (VIBs).