ライフサイエンスコーパス: RNA virus

1 our knowledge, never before reported for an RNA virus.

2 virus (ZIKV) is an emerging, mosquito-borne RNA virus.

3 n incoming genomic RNA from a positive-sense RNA virus.

4 sed by reovirus, a prototype double-stranded RNA virus.

5 merase (L) of non-segmented, negative-strand RNA viruses.

6 ay triggered by membrane fusion of enveloped RNA viruses.

7 e to the study of packaging signals in other RNA viruses.

8 es are among the least characterized enteric RNA viruses.

9 G-I detects double-stranded RNA derived from RNA viruses.

10 strategy to control cytoplasmic-replicating RNA viruses.

11 production and impaired control of enveloped RNA viruses.

12 and dZcchc7, as antiviral against a panel of RNA viruses.

13 slow-evolving DNA viruses and fast-evolving RNA viruses.

14 iate host defense against a range of DNA and RNA viruses.

15 activation and implicate DAI as a sensor of RNA viruses.

16 s a key host factor mediating replication of RNA viruses.

17 ms of life, while also serving as genomes in RNA viruses.

18 chnology for simplified diagnostic tests for RNA viruses.

19 RNA polymerases of diverse positive-stranded RNA viruses.

20 Ai pathway, which in many organisms controls RNA viruses.

21 -fold increase in fidelity compared to other RNA viruses.

22 nic viral persistence for some small DNA and RNA viruses.

23 ses but has an unexplored role in control of RNA viruses.

24 t may bypass the wide genetic variability of RNA viruses.

25 d viruses are positive-sense single-stranded RNA viruses.

26 ble replication organelles induced by other +RNA viruses.

27 is an effective antiviral drug against many RNA viruses.

28 nucleotide selectivity are conserved across RNA viruses.

29 cation of several different types of DNA and RNA viruses.

30 ensures both the stability and variation of RNA viruses.

31 sure both the stability and the variation of RNA viruses.

32 ally important for highly adaptable small (+)RNA viruses.

33 extreme susceptibility to common respiratory RNA viruses.

34 nt mutations in the evolution and fitness of RNA viruses.

35 I (RIG-I) senses the RNA genomes of several RNA viruses.

36 to the Potyviridae family of positive-strand RNA viruses.

37 ses to inhibit replication of positive-sense RNA viruses.

38 ions that govern assembly of other segmented RNA viruses.

39 tate replication of specific positive-strand RNA viruses.

40 dae) are enveloped negative-sense tripartite RNA viruses.

41 e important for replication of plus-stranded RNA viruses.

42 d synthetic amines inhibit pDC activation by RNA viruses.

43 NCE Most viral evolutionary studies focus on RNA viruses.

44 n the detection and control of infections by RNA viruses.

45 ineffective against a range of other DNA and RNA viruses.

46 A modifications in modulating life cycles of RNA viruses.

47 bgenus harbor the double-stranded Leishmania RNA virus 1 (LRV-1), previously identified in isolates f

48 The presence of the endogenous Leishmania RNA virus 1 (LRV1) replicating stably within some parasi

49 that a double-stranded RNA virus, Leishmania RNA virus 1 (LRV1), nested within L. guyanensis parasite

50 bor the double-stranded RNA virus Leishmania RNA virus 1 (LRV1), which has been associated with incre

51 arbor a viral endosymbiont called Leishmania RNA virus 1 (LRV1).

52 Many RNA viruses also encode helicases, which are sometimes c

53 is exceptionally vulnerable to infection by RNA viruses and provides a conceptual framework for the

54 Due to their high genomic variability, RNA viruses and retroviruses present a unique opportunit

55 Because of their high mutation rates, RNA viruses and retroviruses replicate close to the thre

56 interaction between positive-strand RNA [(+)RNA] viruses and cellular membranes that contribute to t

57 Brome mosaic virus (BMV) is an RNA virus, and its three genomic RNAs are encapsidated i

58 ackievirus B3 (CVB3) being a single-stranded RNA virus, and the recent evidence that the NOD2 target,

59 against a broad range of emerging enveloped RNA viruses, and should be further explored as potential

60 RNA viruses, and the multiple, seminal mentors who taugh

61 tide composition of HIV-1, and perhaps other RNA viruses, appears to have adapted to evade this host

62 Plant positive-strand (+)RNA viruses are intracellular infectious agents that reo

63 lthough helicases encoded by positive-strand RNA viruses are necessary for RNA genome replication, th

64 RNA viruses are one of the fastest-evolving biological e

65 However, since RNA viruses are prone to high mutation rates, the possib

66 Our results show that RNA viruses are some of the most important components of

67 Segmented RNA viruses are ubiquitous pathogens, which include infl

68 Both negative-sense RNA viruses are vulnerable to VHHs uniquely specific for

69 clear division between the rates of DNA and RNA viruses as well as reverse-transcribing viruses coul

70 s.IMPORTANCE Measles virus is a paradigmatic RNA virus, as the antigenic composition of the vaccinati

71 ously, a stochastic model of single-stranded RNA virus assembly was created to model the cooperative

72 ne regulation, RNA-protein interactions, and RNA virus assembly.

73 RNA viruses associated with honeybees represent a potent

74 Coronaviruses (CoVs) stand out among RNA viruses because of their unusually large genomes ( a

75 s (EBOV) is a single-stranded negative-sense RNA virus belonging to the Filoviridae family.

76 Positive-strand RNA viruses build extensive membranous replication compa

77 ed AMPK inhibits the replication of numerous RNA viruses but enhances the entry of vaccinia virus.

78 led to impaired antiviral responses against RNA viruses, but not against DNA viruses.

79 omote infection of several mammalian enteric RNA viruses, but the mechanisms and consequences are unc

80 st a number of positive- and negative-strand RNA viruses by enhancing type I IFN induction.

81 ettmann et al. provides insight as to how an RNA virus can persistently coexist in a protozoan with R

82 Certain RNA viruses can cross species barriers and cause disease

83 Packaging and capsid assembly in RNA viruses can involve interactions between capsid prot

84 genus Cytorhabdovirus Although both DNA and RNA viruses can trigger the biogenesis of virus-derived

85 Non-segmented, (-)RNA viruses cause serious human diseases.

86 RNA viruses cause significant human pathology and are re

87 This arthropod-borne positive-strand RNA virus causes acute and fatal encephalitis in many ma

88 Ebolavirus (EBOV), an enveloped filamentous RNA virus causing severe hemorrhagic fever, enters cells

89 RNA viruses co-opt a large number of cellular proteins t

90 The terminal ends in the genome of RNA viruses contain features that regulate viral replica

91 Our data suggest that RNA viruses contributed up to 65% of the total virioplan

92 These findings generalize the concept of RNA virus dependence on cellular miRNAs and connect viru

93 tion complexes for all known positive-strand RNA viruses depends on the extensive remodeling of host

94 Replication of plus-stranded RNA [(+)RNA] viruses depends on the availability of coopted host

95 We find that the RNA viruses differ in the number and properties of their

96 phic location played a major role in shaping RNA virus diversity, and several viruses discovered here

97 at during sickness behavior, single-stranded RNA viruses, double-stranded RNA ligands, and IFNs share

98 teins of non-segmented negative strand (NNS) RNA viruses (e.g. rabies, measles, Ebola) contains five

99 Here we show that frameshifting in a model RNA virus, encephalomyocarditis virus, is trans-activate

100 viral translation and replication.IMPORTANCE RNA viruses encode a limited set of viral proteins to mo

101 Positive-sense RNA viruses encode RNA-dependent RNA polymerases (RdRps)

102 Negative-strand RNA viruses encode their own polymerases to perform each

103 Lassa virus (LASV) is an enveloped RNA virus endemic to West Africa and responsible for sev

104 DNA genomes, but recent studies suggest that RNA viruses, especially those with positive-sense, singl

105 Predicting and constraining RNA virus evolution require understanding the molecular

106 Although RNA viruses exhibit a high frequency of host jumps, majo

107 RNA viruses exhibit a variety of genome organization str

108 RNA viruses exist in genetically diverse populations due

109 ecting and characterising members of diverse RNA virus families within a human plasma background, som

110 rategy among positive-sense, single-stranded RNA viruses for bypassing the host cell requirement of a

111 ing (-1 PRF) is used by many positive-strand RNA viruses for translation of required products.

112 Ribosome recoding is used by RNA viruses for translational readthrough or frameshifti

113 tified the complete genomes of 24 species of RNA viruses from a diverse range of viral families and o

114 2S slow-releasing donor GYY4137 on enveloped RNA viruses from Ortho-, Filo-, Flavi- and Bunyavirus fa

115 irus (HEV), a single-stranded positive-sense RNA virus, generally causes self-limiting acute viral he

116 Responsibility for replication fidelity in RNA viruses has been attributed to the RNA-dependent RNA

117 RNA viruses have evolutionarily fine-tuned replication f

118 h mutation rates and more compact genomes of RNA viruses have inspired the investigation of populatio

119 ved RNA structures, within distantly related RNA viruses, have acquired different roles in the virus

120 particularly single-stranded, positive-sense RNA viruses, have been a research focus in plant virolog

121 n this study, we observed that two different RNA viruses, HCV and Sendai, cause inhibition of ras-rel

122 e are able to detect three major blood-borne RNA viruses - HIV, HCV and HEV.

123 A novel RNA virus, human hepegivirus-1 (HHpgV-1), was also detec

124 RNA viruses impact honey bee health and contribute to el

125 n of necroptosis following infection with an RNA virus.IMPORTANCE An appreciation of how cell death p

126 ortant insights into the ecology of mosquito RNA viruses.IMPORTANCE Studies of virus ecology have gen

127 us (PIV) is a negative-sense single-stranded RNA virus in the Paramyxoviridae family.

128 We surveyed RNA viruses in 52 cultured monoxenous relatives of the h

129 he prevalence and pathogen loads of multiple RNA viruses in co-occurring managed honeybee (Apis melli

130 The huge diversity of negative-sense RNA viruses in insects, spiders and other arthropods sug

131 Hepatitis C virus (HCV) is unique among RNA viruses in its ability to establish chronic infectio

132 ytic activity of AGO2 inhibits IAV and other RNA viruses in mature mammalian cells, in an interferon-

133 markedly inhibited the replication of avian RNA viruses in ovo.

134 e a glimpse into how DNA viruses differ from RNA viruses in their evolutionary dynamics and identify

135 previously in warmer waters, the majority of RNA viruses in these Antarctic RNA virus metagenomes had

136 previous efforts to characterize blood-borne RNA viruses in wild primates across sub-Saharan Africa,

137 The Picornaviridae are a diverse family of RNA viruses including many pathogens of medical and vete

138 Signatures for DNA and RNA viruses including oncogenic viruses, gram positive a

139 or many positive-sense single-stranded RNA (+RNA) viruses including human pathogens hepatitis C virus

140 of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenaviruses, and co

141 roduction and antiviral control of enveloped RNA viruses, including influenza A virus (IAV).

142 Mosquitoes harbor a high diversity of RNA viruses, including many that impact human health.

143 tic ferrets are commonly used to study other RNA viruses, including members of the order Mononegavira

144 mine levels has a negative effect on diverse RNA viruses, including several viruses involved in recen

145 uired for the replication of several DNA and RNA viruses, including some of the most challenging huma

146 estriction factor of several positive-strand RNA viruses, including three members of the family Flavi

147 Our result thus supports the notion that RNA virus indirectly activates a DNA-specific innate imm

148 Plus-stranded RNA viruses induce membrane deformations in infected cel

149 It is well established that positive-sense RNA viruses induce significant membrane rearrangements i

150 e normally nuclear, infection by cytoplasmic RNA viruses induces their export, forming a cytoplasmic

151 Single-stranded (ss) RNA viruses infect all domains of life.

152 In RNA-virus infected cells, IRF-3's transcriptional activa

153 ptor molecule for Itch to target MAVS during RNA virus infection and thus restrict virus-induced apop

154 The host response to RNA virus infection consists of an intrinsic innate immu

155 eceptors (RLRs) play a major role in sensing RNA virus infection to initiate and modulate antiviral i

156 TAX1BP1 undergoes degradation during RNA virus infection, and loss of TAX1BP1 is associated w

157 s (RLRs) are critical for protection against RNA virus infection, and their activities must be string

158 Upon RNA virus infection, LRRC25 specifically binds to ISG15-

159 initiation of the innate immune response to RNA virus infection.

160 AC6 knockout mice were highly susceptible to RNA virus infections compared to wild-type mice.

161 interactions in the context of 15 different RNA virus infections, including several clinically relev

162 imary triggers of antiviral immunity in many RNA virus infections.

163 are associated with many factors, including RNA virus infections.

164 data are consistent with the hypothesis that RNA viruses influence diatom bloom dynamics in Antarctic

165 ommon feature of infection by positive-sense RNA virus is the modification of host cell cytoplasmic m

166 combination in single-strand, positive-sense RNA viruses is a poorly understand mechanism responsible

167 High diversity of within-host populations of RNA viruses is an important aspect of their biology, sin

168 host immune response to vaginal exposure to RNA viruses is required to combat sexual transmission of

169 rus, an approximately 10.7-kb positive-sense RNA virus, is the most common arthropod-communicated pat

170 in infected cells of several positive-strand RNA viruses, is initially inactive.

171 We characterize a multicomponent RNA virus isolated from mosquitoes, designated Guaico Cu

172 e nidoviruses, such as coronaviruses (CoVs), RNA viruses lack proofreading and thus are dependent on

173 iannia) parasites harbor the double-stranded RNA virus Leishmania RNA virus 1 (LRV1), which has been

174 Recently, we reported that a double-stranded RNA virus, Leishmania RNA virus 1 (LRV1), nested within

175 Similar to the enveloped RNA viruses, membrane fusion stimulates interferon produ

176 e majority of RNA viruses in these Antarctic RNA virus metagenomes had +ssRNA genomes most closely re

177 at the boundary between the rates of DNA and RNA viruses might not be as clear as previously thought.

178 All positive-sense RNA viruses modify host cytoplasmic membranes for viral

179 raziliensis (>25%) contain a double-stranded RNA virus named Leishmaniavirus 1 (LRV1), which has also

180 amage generated early during infection by an RNA virus, namely, dengue virus (DENV).

181 two very distinct but representative DNA and RNA viruses, namely, T4 and influenza.

182 As with any other RNA virus, Newcastle disease virus is expected to evolve

183 evidence that assembly of a single-stranded RNA virus occurs via a packaging signal-mediated mechani

184 ype 3 (PIV3), a nonsegmented negative-strand RNA virus of the Paramyxoviridae family and a major caus

185 n enveloped, single-stranded, negative-sense RNA virus of the Paramyxoviridae family.

186 bacteriophage MS2 and as proposed for other RNA viruses of plants, animals, and human.

187 a on the interaction of the chIFN-kappa with RNA viruses of poultry and public health importance.

188 Many RNA viruses of vertebrates that are not substrates for D

189 (Culicoides spp.), known to transmit several RNA viruses of veterinary importance, have revealed infe

190 DNA/RNA viruses often hijack the cellular factors resident i

191 Almost no proteins from RNA viruses or known gene transfer agents were detected,

192 kingdoms, for instance between nonretroviral RNA viruses or ssDNA viruses and host genomes or between

193 MP primer set for bacteriophage MS2 (a model RNA virus particle).

194 a powerful new natural animal model to study RNA virus persistence in the male reproductive tract.

195 Cis-acting RNA structures in the genomes of RNA viruses play critical roles in viral infection, yet

196 Recent phylogenetic analyses indicate that RNA virus populations carry a significant deleterious mu

197 RNA virus populations will undergo processes of mutation

198 lutionized the study of genetically variable RNA virus populations, but for phylogenetic and evolutio

199 nd re-emerging infectious diseases caused by RNA viruses pose a critical public health threat.

200 Positive-sense RNA viruses pose increasing health and economic concerns

201 RNA viruses present a significant hazard to human health

202 RNA viruses present an extraordinary threat to human hea

203 may be high and in the case of at least one RNA virus, prevalence is higher in wild bumblebees than

204 This suggested that negative-strand RNA viruses produce little, if any, dsRNA or that more e

205 RNA viruses rapidly diversify into quasispecies of relat

206 Positive-strand RNA (+RNA) viruses rearrange cellular membranes during replica

207 Our study demonstrates that diverse RNA viruses rely on the polyamine pathway for replicatio

208 , but the effects of m(6)A on this segmented RNA virus remain unclear.

209 lepidopteran innate immune response against RNA viruses remains poorly understood, while in other in

210 ver, the impact of TRIM56 on negative-strand RNA viruses remains unclear.

211 e in restricting infection by negative-sense RNA viruses remains unclear.

212 Positive strand RNA viruses replicate via a virally encoded RNA-dependen

213 viruses, similarly to animal positive-strand RNA viruses, replicate in membrane-bound viral replicase

214 e ability of IFIT1 to inhibit negative-sense RNA virus replication and pathogenesis both in vitro and

215 RNA virus replication by plant viral RdRPs occurs inside

216 ew mechanistic insights into positive-strand RNA virus replication compartment structure, assembly, f

217 important roles of co-opted host proteins in RNA virus replication have been appreciated for a decade

218 the past as a model to study negative-strand RNA virus replication.

219 equirements for host gene suppression versus RNA virus replication.

220 iviruses are positive-sense, single-stranded RNA viruses responsible for millions of human infections

221 ed coding capacity that is characteristic of RNA viruses, rotavirus dedicates substantial resources t

222 airs sequenced at highly variable depth from RNA virus samples.

223 rived dendritic cells using a nonintegrating RNA virus, Sendai virus.

224 atitis C virus (HCV) are two positive-strand RNA viruses sharing a similar biology, but causing oppos

225 erases, with mutations in RdRps for multiple RNA viruses shown to alter fidelity and attenuate virus

226 MuV is a negative strand RNA virus, similar to rabies virus or Ebola virus, that

227 Plant positive-strand RNA viruses, similarly to animal positive-strand RNA vir

228 the adaptability of genome-scale deoptimized RNA viruses, stability studies can yield improved synthe

229 As from two additional families of mammalian RNA viruses stall and repress XRN1.

230 Thus, enveloped RNA viruses stimulate a cGAS-independent STING pathway,

231 All positive-sense RNA viruses studied to date modify host membranes to hel

232 During infection, positive-strand RNA viruses subvert cellular machinery involved in RNA m

233 detects and responds to infection by deadly RNA viruses such as influenza, and Hepatitis C.

234 e the origins and spread of rapidly mutating RNA viruses, such as influenza, Ebola, human immunodefic

235 RNA viruses, such as poliovirus, have a great evolutiona

236 s required to overcome barriers to infection.RNA viruses, such as polioviruses, have a great evolutio

237 mRNAs of nonsegmented negative-strand (NNS) RNA viruses, such as VSV, possess a fully methylated cap

238 The emergence of mosquito-borne RNA viruses, such as West Nile virus (WNV), is facilitat

239 l evidence on positive sense single-stranded RNA viruses suggests that the CP also regulates RNA synt

240 pesvirus Workshop (IHW), the Positive-Strand RNA Virus Symposium (PSR), and the Gordon Research Confe

241 ncephalitis virus (VEEV) is a mosquito-borne RNA virus that causes low mortality but high morbidity r

242 virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case

243 e agent, measles virus, is a small enveloped RNA virus that infects a broad range of cells during inf

244 engue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans e

245 debate whether infection by IAV or any other RNA virus that infects humans induces and/or suppresses

246 Influenza A virus (IAV) is an RNA virus that is cytotoxic to most cell types in which

247 Hepatitis C virus (HCV) is an enveloped RNA virus that modifies intracellular trafficking proces

248 HCV is an RNA virus that, unlike hepatitis B virus, is unable to i

249 negative-sense, nonsegmented single-stranded RNA viruses that account for a significant number of hum

250 onenveloped, positive-sense, single-stranded RNA viruses that are a leading cause of viral gastroente

251 s (WEEV) are arthropod-borne positive-strand RNA viruses that are capable of causing acute and fatal

252 oviruses are a diverse group of nonenveloped RNA viruses that are continuously evolving.

253 ed protein fold found in several plus-strand RNA viruses that binds to the small molecule ADP-ribose.

254 In contrast to other positive-strand RNA viruses that block IFN induction by targeting MAVS f

255 uman noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gas

256 Flaviviruses are single-stranded RNA viruses that cause a wide range of illnesses.

257 nonenveloped, positive-sense single-stranded RNA viruses that cause gastrointestinal illness.

258 Arenaviruses are enveloped negative-strand RNA viruses that cause significant human disease.

259 aviridae is a large family of positive-sense RNA viruses that contains numerous human and animal path

260 order Nidovirales, arenaviruses are the only RNA viruses that encode an ExoN, which functions to degr

261 Coronaviruses are positive-sense RNA viruses that generate double-stranded RNA (dsRNA) in

262 Alphaviruses are small enveloped RNA viruses that infect cells via clathrin-mediated endo

263 reoviruses) are nonenveloped double-stranded RNA viruses that infect most mammalian species, includin

264 Coronaviruses (CoVs) are positive-sense RNA viruses that infect numerous mammalian and avian spe

265 an unconventional mRNA capping enzyme of NNS RNA viruses that is distinct from the eukaryotic mRNA ca

266 heterogeneity is a common characteristic of RNA viruses that is often referred to as sub-populations

267 nstrate here that some mammalian reoviruses, RNA viruses that replicate strictly in the cytoplasm, ex

268 RNA silencing, as an antiviral gene against RNA viruses that uses an retinoic acid-inducible gene I-

269 For many nonenveloped RNA viruses the requirements for this critical part of t

270 In a negative strand RNA virus, the genomic RNA is sequestered inside the nuc

271 ts antiviral actions against positive-strand RNA viruses, the anti-influenza virus activity of TRIM56

272 Positive-strand RNA viruses, the largest genetic class of viruses, inclu

273 In the picornavirus family of nonenveloped RNA viruses, the requirements for genome packaging remai

274 r nsp10 adds to the uniqueness of CoVs among RNA viruses: The MTase domain presents a new fold that d

275 Easily adapted to sequence any RNA virus, this technology illustrates the utility of ne

276 Human cells detect RNA viruses through a set of helicases called RIG-I-like

277 RIG-I is a key cytosolic sensor that detects RNA viruses through its C-terminal region and activates

278 One way for RNA viruses to accomplish this is to target the cellular

279 Ribosome recoding is used by RNA viruses to enable ribosomes to extend translation pa

280 Coronaviruses (CoVs) are the only known RNA viruses to encode a proofreading exonuclease (nsp14-

281 dinucleotide suppression in HIV-1 and other RNA viruses to evade host antiviral defenses.

282 mentalization and membranous environment for RNA viruses to flourish, creating the need for an RNA-ta

283 ependent RNA polymerases (RdRps) are used by RNA viruses to replicate and transcribe their RNA genome

284 ependent RNA polymerases (RdRps) are used by RNA viruses to replicate and transcribe their RNA genome

285 ular stomatitis virus (VSV, a prototypic NNS RNA virus) to examine participation of these motifs in m

286 of the resistance of poliovirus, a small (+)RNA virus, to brefeldin A (BFA), a drug targeting a cell

287 Similarly to other (+)RNA viruses, tomato bushy stunt virus (TBSV) induces maj

288 Pea enation mosaic virus (PEMV)--a plant RNA virus transmitted exclusively by aphids--causes dise

289 RNA viruses typically have high mutation rates, resultin

290 ability studies can yield improved synthetic RNA virus vaccine candidates.

291 apoptosis in response to infection with the RNA viruses vesicular stomatitis virus and Sendai virus

292 RNA-seq was more sensitive for RNA viruses whereas PVG PCR detected more DNA viruses.

293 However, DWV is just one of many insect RNA viruses which infect a wide range of hosts.

294 on of various positive-sense single stranded RNA viruses, which hijack this cellular enzyme to remode

295 Orthomyxoviruses are an important family of RNA viruses, which include the various influenza viruses

296 rhagic fever virus (CCHFV), a negative-sense RNA virus with a 5'-monophosphorylated genome, is a high

297 ar trafficking of HCV and multiple unrelated RNA viruses with a high barrier to resistance.

298 viruses more efficient than that in smaller RNA viruses with error-prone replication, as seen via si

299 ic microRNA (miRNA)-122, the interactions of RNA viruses with host miRNAs remain poorly characterized

300 f enveloped, negative-sense, single-stranded RNA viruses with significant economic and public health