ライフサイエンスコーパス: RNA-binding

1 entatricopeptide repeat motifs in PRORP2 for RNA binding.

2 ormational change induced by single-stranded RNA binding.

3 are highly flexible, but essential for tight RNA binding.

4 e retention of POS-1, which depends on POS-1 RNA binding.

5 d retention within the nucleus even prior to RNA binding.

6 l biological function, such as prediction of RNA-binding ability.

7 RelQ's enzymatic and RNA binding activities are subject to intricate alloster

8 owever, the affinity and specificity of this RNA binding activity has not been well characterized, wh

9 We also show that the RNA binding activity of the Rbfox family protein is cruc

10 essive accumulation of iron-response element RNA-binding activity, whose disruption reduces cell grow

11 reduction in IRP1 and IRP2 protein level and RNA-binding activity.

12 Small-angle X-ray scattering, NMR and RNA-binding analyses further reveal that the C-terminal

13 r topoisomerase for mRNAs, and requires both RNA binding and catalytic activity to promote neurodevel

14 irst time the dynamic connection between FTO RNA binding and demethylation activity that influences s

15 Using biochemical assays for RNA binding and duplex unwinding, we show that JFH-1 NS3

16 for this regulatory mechanism, because both RNA binding and enzymatic activity are abolished by dele

17 CHDC is triggered upon target RNA binding and quickly generate amplified signals.

18 hat screen, DDX21, is tested for protein and RNA binding and subsequent enzymatic activities in the c

19 Together, these findings indicate that the RNA-binding and mRNA-stabilizing functions of Hsp70 are

20 Identifying the RNA-binding and putative catalytic sites within the DWV

21 between CCUG repeat and minimally structured RNA binding appear to be due to the ability to modify bo

22 For FUS, previous studies defined RNA binding as mediated by its well-folded domains; howe

23 f FMRP with one candidate, RhoC, by in vitro RNA binding assays.

24 ns in CPSF30, we identify using quantitative RNA-binding assays an N-terminal lysine/arginine-rich mo

25 sgenes by employing the bacterial tryptophan RNA-binding attenuation protein (TRAP), which binds its

26 yptophan ligands to the homo-undecameric trp RNA-binding Attenuation Protein from Bacillus stearother

27 This suggested the possibility that RNA binding by Hsp70 might mimic features of its peptide

28 Inactivation of IRP1 RNA binding by iron primarily involves insertion of a [4

29 l can be transformed into a groove prone for RNA binding by large rearrangements of the C-terminal do

30 ome subunits, and recent findings of altered RNA binding by mutant U2AF1 proteins, we suggest that af

31 We conclude that RNA binding by Set1 contributes to both chromatin associ

32 RNA binding by SMAD has the potential to affect numerous

33 tro to determine the ligand requirements for RNA binding by SMAD3.

34 DNA ligand, suggesting a biological role for RNA binding by SMAD3.

35 Upon target RNA binding by the interference complex, its Cas10 subun

36 rprisingly, we also find that m(6)A disrupts RNA binding by the stress granule proteins G3BP1/2, USP1

37 suggesting a possible role for regulation of RNA binding by tyrosine kinase signaling.

38 of the inter-RRM interaction or the loss of RNA binding capacity of either RRM impairs splicing repr

39 In uninfected cells, the impaired RNA-binding capacity of Y315A was evident by a shift of

40 terferon-stimulated gene (ISG) with possible RNA-binding capacity, is an important restriction factor

41 Here, we report a detailed analysis of the RNA binding characteristics of intrinsically disordered

42 on that contains an open, positively charged RNA binding cleft that is primed for productive interact

43 RNA-binding-defective mutants demonstrate clear separati

44 Deletion analysis of the sigmaNS RNA binding domain and G3BP1 RNA (RRM) and ribosomal (RG

45 valent interactions with the double stranded RNA binding domain and the basic region underlie the abi

46 RNA intermediate, and mutations in the pTRS1 RNA binding domain did not affect PKR binding or inhibit

47 RGG/RG domains are the second most common RNA binding domain in the human genome, yet their RNA-bi

48 polymerase (RNAP) beta subunit is a part of RNA binding domain in transcription complex.

49 The SFPQ*NONO complex contains an RNA binding domain, and prior work has demonstrated dive

50 cognition Motif (RRM) is the most ubiquitous RNA binding domain.

51 eta is specifically targeted to mRNAs by its RNA binding domain.

52 xport of M1 mRNA required both an intact NS1 RNA-binding domain and effector domain.

53 In particular, the catalytic domain and the RNA-binding domain can move around a central hinge.

54 recognition motif (RRM) is the most abundant RNA-binding domain in eukaryotes, and it plays versatile

55 re domain of eIF4G plus an adjacent probable RNA-binding domain mediate translation initiation.

56 protein kinase R (PKR) independently of its RNA-binding domain.

57 other topoisomerases, contains a distinctive RNA-binding domain; and deletion of this domain diminish

58 te of GRIA2 Furthermore, the double-stranded RNA binding domains of ADAR3 are required for repression

59 partners by the combinatorial use of several RNA binding domains.

60 nsion also enables the identification of the RNA-binding domains of RBPs.

61 antages over classic methods for determining RNA-binding domains: it produces proteome-wide, high-res

62 Here, using chiCRAC we measure the global RNA-binding dynamics of the yeast transcription terminat

63 RNA-binding events often take place at pockets on protei

64 We validated that mRNA of MEX3D (mex-3 RNA binding family member D) was lower in NF1-iN cells b

65 PrgU has an RNA-binding fold, and prgB-prgU gene pairs are widely di

66 tational analysis confirms the importance of RNA binding for IFIT1 restriction of a human coronavirus

67 understanding the physiological function of RNA binding has been hampered by the lack of separation-

68 Disruption of the RNA-binding hinge region also prevented formation of sub

69 utation of key amino acids involved in Z-DNA/RNA binding in ZBP1's ZBDs prevented necroptosis upon in

70 lated RNA via oligo(dT), it will not provide RNA-binding information on proteins interacting exclusiv

71 C3H separation-of-function mutants show that RNA binding is required for cytoplasmic localization, pa

72 eacetylates PABP1 and deactivates its poly(A)RNA binding, leading to nuclear accumulation of PABP1 an

73 The structure reveals an unusual RNA-binding mode in which two APOBEC3H molecules at oppo

74 requires its PABP-interaction domain and the RNA-binding module which we show is sensitive to poly(A)

75 the crystal structures of the Seb1 CTD- and RNA-binding modules.

76 RNA binding motif protein 25 (RBM25) is a putative splic

77 indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiq

78 ur understanding of binding partners and PAN RNA binding motifs remains incomplete.

79 recognition patterns, as well as the protein-RNA binding motifs, are then identified and analyzed.

80 eraction that enlists both of the N-terminal RNA-binding motifs of the protein with separate surfaces

81 ic modifiers that bind RNA without canonical RNA-binding motifs.

82 ding RNA motifs rationalizes the promiscuous RNA binding of PRC2, and their enrichment at Polycomb ta

83 ent in unspliced and partially spliced viral RNA; binding of the RRE by the viral Rev protein induces

84 ed with a nuclear localization signal, to an RNA binding peptide from bacteriophage lambda.

85 We first construct a similarity network of RNA-binding pockets based on a non-sequential-order stru

86 structure alignment strategy, the consensus RNA-binding pockets in each group are identified.

87 y using network community decomposition, the RNA-binding pockets on protein surfaces are clustered in

88 Large-scale RNA-binding pockets on protein surfaces are grouped by m

89 ces long-range perturbations that affect the RNA-binding properties of the polymerase.

90 inding domain in the human genome, yet their RNA-binding properties remain poorly understood.

91 only used antibiotics, many of which exhibit RNA-binding properties, on the widespread T-box riboswit

92 s a model system that SMN interacts with the RNA binding protein (RBP) HuD in motoneurons in vivo dur

93 mes, allowing identification of differential RNA binding protein (RBP) recognition sites.

94 wing Sarcoma protein (EWS) is a multifaceted RNA binding protein (RBP) with established roles in tran

95 d an in vitro system based on expressing the RNA binding protein 6 to obtain infectious metacyclics a

96 We identify the CsrA RNA binding protein as being responsible for this, and s

97 lts suggest potential involvement of HuR/TTP RNA binding protein axis in regulation of inflammation i

98 he gene encoding this ubiquitously expressed RNA binding protein causes a specific form of muscular d

99 b1, but not Ccnb2, mRNAs is dependent on the RNA binding protein CPEB1.

100 We identified TDP-43, a DNA-RNA binding protein encoded by the Tardbp gene, as a str

101 ed interactions within a set of 14 conserved RNA binding protein genes, generating all possible singl

102 on RNAi or CRISPR approaches implicated the RNA binding protein HuR in preserving survival under nut

103 TDP-43 is a well known RNA binding protein involved in the pathogenesis of Amyo

104 The repeat transcripts sequester the RNA binding protein Muscleblind-like protein 1 (MBNL1) a

105 The protein kinase Ime2 and RNA binding protein Rim4 are general regulators of meiot

106 y retained introns are enriched for specific RNA binding protein sites and are often retained in clus

107 Moreover, UPF1 and its interaction with the RNA binding protein STAU2 are necessary for proper trans

108 s, and are linked neuropathologically by the RNA binding protein TDP-43 (TAR DNA binding protein-43 k

109 Carbon Storage Regulator A (CsrA) is an RNA binding protein that acts as a global regulator of d

110 we identified Musashi2 (MSI2), an oncogenic RNA binding protein that is required for blast crisis CM

111 fied a neural progenitor cell (NPC)-specific RNA binding protein that may underlie the high levels of

112 , including stress granules that contain the RNA binding protein Tia1.

113 otein 1 (PABPN1) is a ubiquitously expressed RNA binding protein vital for multiple steps in RNA meta

114 Thus, these studies identify Zfp106 as an RNA binding protein with important implications for ALS.

115 te amount of a binding motif for the quaking RNA binding protein, a sequence we show can significantl

116 nal control of GLUT1 mRNA is dependent of an RNA binding protein, CPEB1, and its binding elements in

117 oneurons in vivo that SMN interacts with the RNA binding protein, HuD.

118 The RNA binding protein, LARP1, has been proposed to functio

119 s exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic aggregates

120 ces the AtRAP gene, which encodes a putative RNA binding protein.

121 Cold-inducible RNA-binding protein (CIRP), released into the circulatio

122 ry elements that are controlled by the viral RNA-binding protein (RBP) NS1.

123 ry-Protein 1 (Esrp1) is a cell-type specific RNA-binding protein (RBP) that is essential for mammalia

124 Human Dicer associates with HIV TAR RNA-binding protein (TRBP) or protein activator of PKR (

125 rylation of the RNA-silencing factor HIV TAR-RNA-binding protein (TRBP) promotes binding and stabiliz

126 Transactivation response element RNA-binding protein (TRBP; TARBP2) is known to play impo

127 We find that the Apicomplexan-specific ALBA4 RNA-binding protein acts to regulate development of the

128 global Ub screen, we identified hnRNPA1, an RNA-binding protein and auxiliary splicing factor, as a

129 ter 2 h of hypoxic exposure might deactivate RNA-binding protein BRF1, hence resulting in the selecti

130 An RNA-binding protein called PABPC1 has an important role

131 Reinduction of a nuclear RNA-binding protein CELF1 (CUGBP Elav-like family member

132 In this study, we show that the cytosolic RNA-binding protein clustered mitochondria homologue (CL

133 use of age-dependent aggregation of Whi3, an RNA-binding protein controlling S-phase entry.

134 The vertebrate-conserved RNA-binding protein DND1 is required for the survival of

135 Analysis of RNA-binding protein footprints revealed that G quadruple

136 RBPs TAR-DNA binding protein 43 (TDP-43) and RNA-binding protein FUS cause amyotrophic lateral sclero

137 The RNA-binding protein FUS participates in several RNA bios

138 Neuronal inclusions of aggregated RNA-binding protein fused in sarcoma (FUS) are hallmarks

139 Cytoplasmic inclusions of the RNA-binding protein fused in sarcoma (FUS) represent one

140 istribution of cytoplasmic PLK-1 couples two RNA-binding protein gradients, thereby partitioning the

141 We identify the RNA-binding protein hnRNPK as the principal XR-PID bindi

142 Here we report that HRPU-2, an RNA-binding protein homologous to mammalian heterogeneou

143 ports overwhelmingly support the role of the RNA-binding protein Hu antigen R (HuR) as a positive reg

144 The RNA-binding protein HuR functions to promote the stabili

145 The RNA-binding protein HuR regulates the stability and tran

146 rometry, we further uncovered binding of the RNA-binding protein HuR to the -44 region, where it acts

147 HuR is an RNA-binding protein implicated in immune homeostasis and

148 Here, we demonstrate that ASFV-DP is a novel RNA-binding protein implicated in the regulation of mRNA

149 mes, exerting a non-canonical function as an RNA-binding protein in the translation of ER-destined mR

150 ll restricted intracellular antigen-1) is an RNA-binding protein involved in splicing and translation

151 The cancer-associated RNA-binding protein La is posttranslationally modified b

152 enhancer region of these genes by binding to RNA-binding protein Matrin 3 that, in turn, associates w

153 We found that expression of the RNA-binding protein Mex3a labels a slowly cycling subpop

154 e of transcription, by the YTH domain of the RNA-binding protein Mmi1 and degraded by the nuclear exo

155 wth by the combined action of the YTH-family RNA-binding protein Mmi1 and the nuclear exosome.

156 1 and revealed the clinical relevance of the RNA-binding protein MSI2 in breast cancer.

157 Here we report that the neural RNA-binding protein Musashi-1 (MSI1) interacts with the

158 Knockdown of translation of the RNA-binding protein Nanos2 by morpholino antisense oligo

159 FMRP is a RNA-binding protein predominantly resident in cytoplasm.

160 Here we have shown that the RNA-binding protein PSPC1, a component of the paraspeckl

161 igration, which requires the Pumilio-related RNA-binding protein Puf118.

162 Absence of SR-like RNA-binding protein Slr1 slows hyphal formation and decr

163 all patients with ALS have aggregates of the RNA-binding protein TDP-43 in their brains and spinal co

164 is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression throug

165 RBM10 is an RNA-binding protein that plays an essential role in deve

166 The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements i

167 gile X mental retardation protein (FMRP), an RNA-binding protein that regulates local protein transla

168 Yeast Ssd1 is an RNA-binding protein that shuttles between the nucleus an

169 We have identified the RNA-binding protein Tristetraprolin (TTP) as a negative

170 Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer

171 Our results indicate that the RNA-binding protein YBX1, which is required for the sort

172 We identified the RNA-binding protein Zfp36l1 as an FXR target gene and de

173 e the interactions between HuR, a ubiquitous RNA-binding protein, and Ago2, a core effector of the mi

174 mental retardation autosomal homolog 1), an RNA-binding protein, are critical to maintain proper car

175 e Qbeta replication), a bacterial Lsm family RNA-binding protein, chaperones RNA-RNA interactions bet

176 translation machinery and interacts with an RNA-binding protein, FMRP, to promote synapse formation;

177 neonatal-specific expression of an oncofetal RNA-binding protein, IGF2BP3, which prevented the destab

178 Neuronal protein 3.1 (P311), a conserved RNA-binding protein, represents the first documented pro

179 codes a ubiquitously expressed polyadenosine RNA-binding protein, ZC3H14 (Zinc finger CysCysCysHis do

180 end 1 (Dnd1), a vertebrate-specific germline RNA-binding protein.

181 in, a ubiquitously expressed multifunctional RNA-binding protein.

182 igen B [SSB]) is an abundant multifunctional RNA-binding protein.

183 of FMR1, a conserved, ubiquitously expressed RNA-binding protein.

184 the LC domain of the fused in sarcoma (FUS) RNA-binding protein.

185 HCC samples revealed that a large numbers of RNA binding proteins (RBPs) are dysregulated and that RB

186 RNA binding proteins (RBPs) regulate the lives of all RN

187 RNA binding proteins (RBPs), in turn, are important regu

188 a role for tau in regulating the biology of RNA binding proteins (RBPs).

189 nto ribonucleoprotein particles (RNPs) where RNA binding proteins ensure mRNA silencing and provide a

190 a rich genetic interaction landscape between RNA binding proteins in maintaining organismal health, a

191 ure human circRNA is associated with diverse RNA binding proteins reflecting its endogenous splicing

192 alize to all RNA-protein interaction as some RNA binding proteins specifically recognize more complex

193 7SL1, an endogenous RNA normally shielded by RNA binding proteins SRP9/14.

194 and micro RNA target sites, binding sites of RNA binding proteins, and N6-methyladenosine.

195 ow that Zfp106 interacts with multiple other RNA binding proteins, including the ALS-associated facto

196 e 3'UTRome as binding sites for microRNAs or RNA binding proteins, or during alternative polyadenylat

197 A-modified RNAs to low-complexity regions in RNA binding proteins.

198 ced genes, PES4 and MIP6, encoding predicted RNA binding proteins.

199 ble overlap in protein composition including RNA binding proteins.

200 all members of the hnRNP A and D families of RNA binding proteins.

201 l opposing temporal gradients of Imp and Syp RNA-binding proteins (descending and ascending, respecti

202 Downregulation of oo18 RNA-binding proteins (ORBs) in any of these MBONs impair

203 olves nuclear retention of expansion RNAs by RNA-binding proteins (RBPs) and an acute phase in which

204 ) granules are enriched in specific RNAs and RNA-binding proteins (RBPs) and mediate critical cellula

205 ukaryotic mRNA decay is tightly modulated by RNA-binding proteins (RBPs) and microRNAs (miRNAs).

206 RNA-binding proteins (RBPs) are important regulators of

207 RNA-binding proteins (RBPs) are involved in mRNA splicin

208 We extend our technology to yeast RNA-binding proteins (RBPs) by tracking their propensity

209 RNA-binding proteins (RBPs) control the fate of nearly e

210 MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) critically regulate gene exp

211 g, in a proteome-wide manner, the regions of RNA-binding proteins (RBPs) engaged in native interactio

212 The mammalian MSI family of RNA-binding proteins (RBPs) have important roles as onco

213 Characterizing the binding behaviors of RNA-binding proteins (RBPs) is important for understandi

214 The identity of the RNA-binding proteins (RBPs) that govern cancer stem cell

215 RNA-binding proteins (RBPs), in addition to their functi

216 ealed that motor-neuron disease (MND)-linked RNA-binding proteins (RBPs), TDP-43, FUS, and hnRNPA2B1,

217 tionally regulated by cellular microRNAs and RNA-binding proteins (RBPs).

218 lation via interactions of G4 with potential RNA-binding proteins (RBPs).

219 )A 'writer'), not only specifically bound by RNA-binding proteins (the m(6)A 'readers'), but also rem

220 simonious regulatory model consisting of two RNA-binding proteins and four microRNAs that modulate th

221 ts have shown key interactions between these RNA-binding proteins and other regulatory elements, such

222 ge class of condensates that are enriched in RNA-binding proteins and RNA molecules.

223 Herein, we discuss various RNA-binding proteins and their unique contributions to f

224 Many RNA-binding proteins are methylated, and we previously d

225 They also suggest that globally acting RNA-binding proteins are more common in bacteria than cu

226 in genes that encode ubiquitously expressed RNA-binding proteins cause tissue specific disease.

227 We propose a mechanism whereby diverse RNA-binding proteins directly recruit PABP, in a non-pol

228 tional and post-transcriptional processes by RNA-binding proteins for maintaining cellular identity a

229 Many RNA-binding proteins have been reported to play a functi

230 Lin28 RNA-binding proteins have evolutionarily conserved roles

231 ribonucleoprotein complex that involves the RNA-binding proteins HnrnpK and PCBP1 and regulates loca

232 Ctn RNA shows enhanced interaction with the RNA-binding proteins HuR and PARN [Poly(A) specific ribo

233 The ubiquitous expression of RNA-binding proteins in a wide variety of cell types and

234 scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes,

235 ompare the expression of splicing-regulatory RNA-binding proteins in human islets, brain, and other h

236 ost-transcriptional control by microRNAs and RNA-binding proteins in the cytoplasm.

237 Different sets of RNA-binding proteins interact with primary miRs (pri-miR

238 lls, diverse stresses trigger coalescence of RNA-binding proteins into stress granules.

239 repeat (PPR) proteins are a large family of RNA-binding proteins involved in RNA metabolism in plant

240 CCUG repeats bind and sequester a family of RNA-binding proteins known as Muscleblind-like 1, 2, and

241 roglia, regulated in part by neuron-specific RNA-binding proteins NOVA2 and PTBP2.

242 RNA-binding proteins of the Musashi (Msi) have been impl

243 RNA-binding proteins of the ZFP36 family are best known

244 RNA-binding proteins play a key role in post-transcripti

245 RNA-binding proteins play a key role in shaping gene exp

246 Rbfox RNA-binding proteins play important roles in the regulat

247 Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the form

248 e demonstrate that the levels of Imp and Syp RNA-binding proteins regulate NB decommissioning.

249 The functions of many bacterial RNA-binding proteins remain obscure because of a lack of

250 of mRNA-specific translational activation by RNA-binding proteins remain poorly understood.

251 ol, operating post-transcriptionally via the RNA-binding proteins RsmA, RsmE and RsmI, is unraveled.

252 First, we find that two RNA-binding proteins specifically expressed in germ cell

253 d by effector proteins that are recruited by RNA-binding proteins that bind to 3'-UTR cis-elements.

254 Also, novel putative DNA/RNA-binding proteins that it predicts share similar subc

255 eoprotein U (hnRNP U) belongs to a family of RNA-binding proteins that play important roles in contro

256 This removal is controlled in part by RNA-binding proteins that regulate alternative splicing

257 ectrometry identified numerous non-canonical RNA-binding proteins that stabilize ribozyme folding; th

258 ultiple neurite-targeted non-coding RNAs and RNA-binding proteins with potential regulatory roles.

259 RATIONALE: RBPs (RNA-binding proteins) have been described to be expresse

260 mologs FASTKD1-5 are architecturally related RNA-binding proteins, each having a different function i

261 rmed by elongated DMPK transcripts sequester RNA-binding proteins, leading to mis-splicing of numerou

262 igned using a new dataset with both DNA- and RNA-binding proteins, regression that penalizes cross-pr

263 repeat) domain-containing-2 (nhl-2), encode RNA-binding proteins, thus delineating a previously unkn

264 otein-modifying enzymes, receptors, ligands, RNA-binding proteins, transcription factors and co-facto

265 TRs have enriched binding motifs for several RNA-binding proteins, which implies extensive translatio

266 XR1P) is a member of the fragile X family of RNA-binding proteins, which includes FMRP and FXR2P.

267 yotic, membrane, toxic, and multisubunit DNA/RNA-binding proteins.

268 to cardiac disease, such as those involving RNA-binding proteins.

269 dramatically alters its affinity for cognate RNA-binding proteins.

270 sets of RNA regulators such as microRNAs and RNA-binding proteins.

271 t also more accurately predicts the DNA- and RNA-binding proteins.

272 The dimerization of Nab2 induced by RNA binding provides a basis for understanding its funct

273 tyltransferase (HAT) assays, we show that an RNA binding region in the HAT domain of CBP-a regulatory

274 The three steps include 1) the prediction of RNA binding regions on protein, 2) the prediction of pro

275 The ability to predict RNA-binding regions recognized by RBPs using whole-trans

276 released fractions are used to determine the RNA-binding regions.

277 ich PrgU proteins represent a novel class of RNA-binding regulators that act to mitigate toxicity acc

278 ical approaches, we found that high-affinity RNA binding requires at least 30 nucleotides of RNA sequ

279 sRNA, while non-canonical Type B dsRBDs lack RNA-binding residues and instead interact with other pro

280 forms state-of-the-art predictors of DNA- or RNA-binding residues on a benchmark test dataset by subs

281 predicts and discriminates between DNA- and RNA-binding residues.

282 rminal helicase cassettes, while 12 binds an RNA-binding site inside the N-terminal cassette.

283 support a model where the density of shared RNA binding sites around a target exon, rather than diff

284 However, far fewer SLM2 and Sam68 RNA binding sites flank the Neurexin2 AS4 exon, compared

285 ther than different paralog-specific protein-RNA binding sites, controls functional target specificit

286 families of paralogs with indistinguishable RNA binding sites.

287 pplied to HeLa cells, RBDmap uncovered 1,174 RNA-binding sites in 529 proteins, many of which were pr

288 starts to efficiently delineate the complete RNA-binding sites.

289 pid biogenesis via SRPK2, a key regulator of RNA-binding SR proteins.

290 based on gene sets derived from protein and RNA binding studies, RNA-interference, a murine smoking

291 d RNP2 consensus sequences, which coordinate RNA binding - suggesting a possible role for regulation

292 r dynamics simulations and show that the RRM RNA binding surface exists in different states and that

293 ent aromatic side-chain conformations at the RNA-binding surface allow for high- or low-affinity bind

294 ion of Nop15 in the pre-ribosome exposes the RNA-binding surface to recognize the base of its stem-lo

295 alpha-helical region obscures its canonical RNA-binding surface.

296 t mRNA modification, is also detrimental for RNA binding, thus revealing a potentially synergistic ro

297 ophenyl moiety extends into a portion of the RNA binding tunnel that typically contains the adenosine

298 IT1 forms a water-filled, positively charged RNA-binding tunnel with a separate hydrophobic extension

299 y of pppGpp binding, (p)ppGpp synthesis, and RNA binding unites two archetypal regulatory paradigms w

300 The RNA-binding Zinc-finger protein 106 (ZFP106) detected in