ライフサイエンスコーパス: RNA-dependent RNA polymerase

1 inhibitors of norovirus 3C-like protease and RNA dependent RNA polymerase.

2 ld have arisen as a secondary function of an RNA-dependent RNA polymerase.

3 al agent specifically targeting HCV NS5B, an RNA-dependent RNA polymerase.

4 virus replication, the methyltransferase and RNA-dependent RNA polymerase.

5 n plants by a process typically requiring an RNA-dependent RNA polymerase.

6 d but is suggested to target influenza virus RNA-dependent RNA polymerase.

7 targeting an assembly interface of the viral RNA-dependent RNA polymerase.

8 (PIV5) is an essential cofactor of the viral RNA-dependent RNA polymerase.

9 transferase, cysteine protease, helicase and RNA-dependent RNA polymerase.

10 segments, the nucleocapsid protein, and the RNA-dependent RNA polymerase.

11 ication of CHS7 and CHS8 secondary siRNAs by RNA-dependent RNA polymerase.

12 s requires two mutations in the gene for the RNA-dependent RNA polymerase.

13 ation of the peptide primer VPg by the viral RNA-dependent RNA polymerase.

14 etermine the recognition of viral RNA by the RNA-dependent RNA polymerase.

15 mechanistic understanding of NS5B, the viral RNA-dependent RNA polymerase.

16 te in access to the genomic RNA by the viral RNA-dependent-RNA polymerase.

17 ovirus 3D(pol) are a common feature of viral RNA-dependent RNA polymerases.

18 primers to characterize activities of DNA or RNA-dependent RNA polymerases.

19 small interfering RNAs (siRNAs) by multiple RNA-dependent RNA polymerases.

20 ys involving several distinct Argonautes and RNA-dependent RNA polymerases.

21 ogenetic analysis of amino acid sequences of RNA-dependent RNA polymerases.

22 idelity of DNA-dependent DNA polymerases and RNA-dependent RNA polymerases.

23 ering near a highly conserved motif in viral RNA-dependent RNA polymerases.

24 troviral RTs but remarkably similar to viral RNA-dependent RNA polymerases.

25 e exonic-siRNAs (ex-siRNAs) are generated by RNA-dependent RNA Polymerase 1 (RdRP1) and dicer-like 2

26 e guided by siRNAs whose biogenesis requires RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) and DICER-LIKE 3 (

27 requires nuclear RNA polymerase IV (Pol IV), RNA-dependent RNA polymerase 2 (RDR2) and DICER-like 3 (

28 -dependent nat-siRNAs were also dependent on RNA-dependent RNA polymerase 2 (RDR2) and plant-specific

29 enous siRNAs in Arabidopsis are dependent on RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) for their biogenes

30 silencing DICER-LIKE3 (DCL3) in tobacco and RNA-dependent RNA polymerase 2 (RDR2) in potato cause a

31 DNA templates by RNA polymerase IV (PolIV), RNA-dependent RNA polymerase 2 (RDR2), DICER-LIKE 3 (DCL

32 of a physical association between JMJ24 and RNA-dependent RNA polymerase 2 (RDR2), which represents

33 RNAs are globally reduced by mutation of the RNA-dependent RNA polymerase 2 encoded by modifier of pa

34 A mutation in RNA-dependent RNA polymerase 2, another essential gene f

35 ical, concerted action of RNA POLYMERASE IV, RNA-DEPENDENT RNA POLYMERASE-2, and DICER-LIKE-4.

36 Transgenic expression of the RNA-dependent RNA polymerase 3D(pol) inhibited infection

37 The RNA-dependent RNA polymerase 3D(pol) is required for the

38 rame of poliovirus (PV) RNA allows the viral RNA-dependent RNA polymerase 3D(Pol) to catalyze the con

39 analysis of cis and trans activities of the RNA-dependent RNA polymerase 3D.

40 The fidelity of the poliovirus RNA-dependent RNA polymerase (3D(pol)) plays a direct ro

41 , we proposed a model wherein the poliovirus RNA-dependent RNA polymerase (3D(pol)) uses a reiterativ

42 ructures, located in the region encoding the RNA-dependent RNA polymerase, 3D(pol), by site-directed

43 within the Picornaviridae family express an RNA-dependent RNA polymerase, 3D(pol), that is required

44 The poliovirus RNA-dependent RNA polymerase, 3Dpol, replicates the vira

45 In plants, SGS3 and RNA-dependent RNA polymerase 6 (RDR6) are required to co

46 element mRNAs into small RNAs guided by the RNA-dependent RNA polymerase 6 (RDR6) protein and is the

47 However, DCL2 facilitates the recruitment of RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) to ARGONAUTE 1-der

48 Maintenance of PTGS requires RNA-dependent RNA polymerase 6 (RDR6), and may be associ

49 econdary short interfering RNAs (siRNAs) via RNA-DEPENDENT RNA POLYMERASE 6 (RDR6), DCL4 and ARGONAUT

50 entified: RNA Polymerase IV (PolIV)-RdDM and RNA-dependent RNA Polymerase 6 (RDR6)-RdDM.

51 ents are converted to double-stranded RNA by RNA-dependent RNA polymerase 6 (RDR6).

52 o enzymes involved in PTGS, Dicer-like 4 and RNA-dependent RNA polymerase 6, are localized in the nuc

53 showed that cleavage by nta-miR6019 triggers RNA-dependent RNA polymerase 6- and ribonuclease Dicer-l

54 secondary siRNAs in a manner that depends on RNA-dependent RNA polymerase 6.

55 ple copies of a major structural protein, an RNA-dependent RNA polymerase, a hexameric NTPase, and an

56 ple copies of a major structural protein, an RNA-dependent RNA polymerase, a hexameric NTPase, and an

57 ple copies of a major structural protein, an RNA-dependent RNA polymerase, a hexameric NTPase, and an

58 hin P90, focus formation required the entire RNA-dependent RNA polymerase (aa 1700 to 2116).

59 NRDE-3 binds siRNAs generated by RNA-dependent RNA polymerases acting on messenger RNA te

60 roles for ncRNAs, as well as a novel Pol II RNA-dependent RNA polymerase activity that regulates an

61 DENV RNA-dependent RNA polymerase, an attractive target for d

62 g of heterotypic segments by influenza virus RNA-dependent RNA polymerase, an inhibitory effect of vi

63 tem-loop A (5' SLA) interacts with the viral RNA-dependent RNA polymerase and promotes RNA synthesis,

64 nt RNA polymerase and a DNA ligase to act as RNA-dependent RNA polymerase and RNA ligase, respectivel

65 nalysis of regions of the genes encoding the RNA-dependent RNA polymerase and the S domain of the cap

66 ce gene was identified, shown to code for an RNA-dependent RNA polymerase and to be allelic with Ty-3

67 ve identified fidelity determinants in viral RNA-dependent RNA polymerases and have shown that RNA vi

68 Are the unwinding activities of RNA-dependent RNA polymerases and of ribosomes different

69 iral replicase, on the activity of the viral RNA-dependent RNA polymerase, and an inhibitory effect o

70 ns-acting short interfering RNA3 pathway, an RNA-dependent RNA polymerase, and an XH/XP domain-contai

71 RNA1 encodes the RNA-dependent RNA polymerase, and RNA2 encodes the capsi

72 Benzothiadiazine inhibitors of the HCV NS5B RNA-dependent RNA polymerase are an important class of n

73 Viral RNA-dependent RNA polymerases are considered to be low-f

74 ding genes encoding Argonaute, Dicer, and an RNA-dependent RNA polymerase-are all required for both m

75 s meiotic silencing machinery are related to RNA-dependent RNA polymerases, Argonautes and Dicers, su

76 s require a common set of protein types like RNA-dependent RNA polymerases, Argonautes and Dicers.

77 hod allows accurate fitting of the monomeric RNA-dependent RNA polymerase bound at the threefold axis

78 on-nucleoside organic inhibitor of the viral RNA-dependent RNA polymerase by means of high-throughput

79 Their viral RNA-dependent RNA polymerase can induce local conformati

80 ily release the RNA genome so that the viral RNA-dependent RNA polymerase can use it as the template

81 RNA-dependent RNA polymerase complex (RDRC) and Dicer ac

82 lysine 9 (H3K9) methylation and recruits the RNA-dependent RNA polymerase complex (RDRC) to promote d

83 0 nM by inhibiting the action of the virus's RNA-dependent RNA polymerase complex (RdRp).

84 pecifically impairs the function of the hRSV RNA-dependent RNA polymerase complex notably by reducing

85 this mechanism have been identified: 1) the RNA-dependent RNA polymerase complex RdRC, 2) the Argona

86 lymerase basic 2 (PB2) proteins comprise the RNA-dependent RNA polymerase complex responsible for vir

87 of polymerase lattices within the multimeric RNA-dependent RNA polymerase complex should facilitate a

88 logs were shown to block the activity of the RNA-dependent RNA-polymerase complex of RSV.

89 s is transcribed and replicated by the viral RNA-dependent RNA polymerase, composed of the subunits P

90 f viral RNA synthesis by the recombinant MNV RNA-dependent RNA polymerase, confirming that the stem-l

91 Influenza virus RNA-dependent RNA polymerase consists of three viral pro

92 The vesicular stomatitis virus (VSV) RNA-dependent RNA polymerase consists of two viral prote

93 f PIV5, the catalytic component of the viral RNA-dependent RNA polymerase, contains six domains that

94 nd comprises a methyltransferase (MTase) and RNA dependent RNA polymerase domain.

95 ociated N protein in the architecture of the RNA-dependent RNA polymerase domain of L.

96 alternative substrate inhibitor of the NS5B RNA-dependent RNA polymerase during HCV replication.

97 nd two other endo-siRNA pathway members, the RNA-dependent RNA polymerase EGO-1 and the helicase DRH-

98 that in C. elegans the Argonaute CSR-1, the RNA-dependent RNA polymerase EGO-1, the Dicer-related he

99 L protein, an RNA-dependent RNA polymerase, encoded in the L segment,

100 us (HCV) replication as it carries the viral RNA-dependent RNA polymerase enzymatic activity.

101 The RNA-dependent RNA polymerase enzyme NS5B represents one

102 viruses replicate by using a virally encoded RNA-dependent RNA polymerase enzyme that has low fidelit

103 nhibitor of the HCV nonstructural protein 5B RNA-dependent RNA polymerase enzyme, was recently approv

104 protease/helicase and NS5 methyltransferase/RNA-dependent RNA polymerase form part of the viral repl

105 of foot-and-mouth disease virus (FMDV), the RNA-dependent RNA polymerase, forms fibrils in vitro.

106 lete match to the nucleotide sequence of the RNA-dependent RNA polymerase from Drosophila X virus (DX

107 The purified RNA-dependent RNA polymerase from poliovirus self-assemb

108 presteady-state kinetics and fidelity for an RNA-dependent RNA polymerase from the Flaviviridae famil

109 The RNA-dependent RNA polymerase from the Hepatitis C Virus

110 P is also essential for RNA-dependent RNA polymerase function.

111 The RNA-dependent RNA polymerase, glycoprotein precursor, nu

112 The HCV RNA-dependent RNA polymerase has emerged as one of the k

113 logical salt conditions, HCV NS5BDelta21, an RNA-dependent RNA polymerase, has poor affinity for the

114 atches the transcript generated by the viral RNA-dependent RNA polymerase in cells.

115 ability and poor activity of the avian virus RNA-dependent RNA polymerase in human cells.

116 psid must be accessible by the virus-encoded RNA-dependent RNA polymerase in order to serve as the te

117 a A virus mRNAs are transcribed by the viral RNA-dependent RNA polymerase in the cell nucleus before

118 bonucleosides form a novel class of HCV NS5B RNA-dependent RNA polymerase inhibitors, displaying EC50

119 include new NS3/4A protease inhibitors, NS5B RNA-dependent RNA polymerase inhibitors, NS5A inhibitors

120 pecifically, we show that the Nodamura virus RNA-dependent RNA polymerase interacts with the outer mi

121 Influenza virus mRNA synthesis by the RNA-dependent RNA polymerase involves binding and cleava

122 The NS5B RNA-dependent RNA polymerase is an attractive target for

123 his context, heterotrimeric viral PA/PB1/PB2 RNA-dependent RNA polymerase is an attractive target for

124 on of the endonuclease activity of influenza RNA-dependent RNA polymerase is attractive for the devel

125 The RNA-dependent RNA polymerase is responsible for genome r

126 is translocated by the single subunit viral RNA-dependent RNA polymerases is not yet understood.

127 (mediator of paramutation1), which encodes a RNA-dependent RNA polymerase, is absolutely required for

128 , which encodes a protein closely related to RNA-dependent RNA polymerases, is absolutely required fo

129 The multifunctional RNA-dependent RNA polymerase L protein of vesicular stom

130 The RNA-dependent RNA polymerase L protein of vesicular stom

131 The RNA-dependent RNA polymerase L protein of vesicular stom

132 RNA complex constitutes the template for the RNA-dependent RNA polymerase L, which engages the nucleo

133 on between arenavirus nucleoprotein (NP) and RNA-dependent RNA polymerase (L protein), the two trans-

134 een the hemagglutinin-neuraminidase (HN) and RNA-dependent RNA polymerase (L) genes of the PIV5 genom

135 ion protein 35 (VP35), glycoprotein (GP) and RNA-dependent RNA polymerase (L) proteins.

136 MuV RNA-dependent RNA polymerase minimally consists of the p

137 ocoris ostravirus 1) with a highly divergent RNA-dependent RNA polymerase missed by conventional BLAS

138 Our data uncover a new role for the viral RNA-dependent RNA polymerase NS5B and p7 proteins in con

139 our results demonstrate a novel role for the RNA-dependent RNA polymerase NS5B in HCV assembly.

140 rs of the viral enzymes NS3 protease and the RNA-dependent RNA polymerase NS5B.

141 eries of non-nucleoside boron-containing HCV RNA-dependent RNA polymerase (NS5B) inhibitors are descr

142 the surface of the thumb domain of the viral RNA-dependent RNA polymerase (NS5B).

143 ular targets for anti-HCV drugs is the viral RNA-dependent RNA polymerase, NS5B.

144 entary sequence of which codes for the viral RNA-dependent RNA polymerase (NS7).

145 nsp14 associates with the CoV RNA-dependent RNA polymerase (nsp12-RdRp), and nsp14-Exo

146 The Sindbis virus RNA-dependent RNA polymerase nsP4 possesses an amino-ter

147 Initiation of RNA synthesis by RNA-dependent RNA polymerases occurs when a phosphodiest

148 e inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B.

149 The RNA-dependent RNA polymerase of influenza virus consists

150 The RNA-dependent RNA polymerase of viruses belonging to the

151 al clamp, conferring steric hindrance on the RNA-dependent RNA polymerases of diverse positive-strand

152 ver the 5-fold vertices, and monomers of the RNA-dependent RNA polymerase (P2) attach to the inner su

153 One attractive target is the RNA-dependent RNA polymerase PA subunit.

154 mals may have replaced an ancient eukaryotic RNA-dependent RNA polymerase pathway to control transpos

155 ithin the N-terminal 270 amino acids and the RNA-dependent RNA polymerase (POL) activity within amino

156 at the local region is completed, the viral RNA-dependent RNA polymerase processes downstream, and t

157 products corresponding to virion-associated RNA-dependent RNA polymerase protein (RdRp), glycoprotei

158 tein mu2 and further influenced by the viral RNA-dependent RNA polymerase protein, lambda3, depending

159 with enzymatic activity, the viral large (L) RNA-dependent RNA polymerase protein.

160 The FHV RNA-dependent RNA polymerase, protein A, is the only vir

161 To inhibit the HCV NS5B RNA-dependent RNA polymerase, PSI-7851 must be metaboliz

162 The production of qiRNAs requires the RNA-dependent RNA polymerase QDE-1, the Werner and Bloom

163 Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key

164 olymerases Pol IV and Pol V and the putative RNA-dependent RNA polymerase RDR2.

165 A mutation in the RNA-dependent RNA polymerase RDR6, which functions in tr

166 l PPIs including the homodimerization of the RNA dependent RNA polymerase (RdRp), the self-interactio

167 h the only protein present is the poliovirus RNA dependent RNA polymerase (RdRp), which recapitulates

168 Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp) (3D(pol)) catalyzes

169 nce the amplification of the viral siRNAs by RNA-dependent RNA polymerase (RdRP) 1 (RDR1) and RDR6 an

170 s have suggested that multiple copies of the RNA-dependent RNA polymerase (RdRp) 3D are involved in t

171 lication, contributing methyltransferase and RNA-dependent RNA polymerase (RdRP) activities.

172 but not silibinin inhibited genotype 2a NS5B RNA-dependent RNA polymerase (RdRp) activity at concentr

173 with the accumulation of vRNA and a bias in RNA-dependent RNA polymerase (RdRp) activity from transc

174 merase, which has also been reported to have RNA-dependent RNA polymerase (RdRP) activity.

175 NA polymerase II core elongator complex, has RNA-dependent RNA polymerase (RdRP) activity.

176 of two extensively interacting subunits: an RNA-dependent RNA polymerase (RdRP) and an NTPase VP4.

177 These activities include an RNA-dependent RNA polymerase (RdRP) and an RNA endonucle

178 his compound is an efficient substrate of PV RNA-dependent RNA polymerase (RdRP) and is incorporated

179 eEF1A) in control of activation of the viral RNA-dependent RNA polymerase (RdRp) and regulation of th

180 wo conserved amino acid substitutions in the RNA-dependent RNA polymerase (RdRp) and six in the capsi

181 n with defined termini, containing the viral RNA-dependent RNA polymerase (RdRp) at one end and a loo

182 The viral RNA-dependent RNA polymerase (RdRp) causes the TSS/surro

183 Recently, we demonstrated that the viral RNA-dependent RNA polymerase (RdRP) complex can be an op

184 DRH-3 is a core component of RNA-dependent RNA polymerase (RdRP) complexes essential

185 pped dsRNAs, the largest of which encodes an RNA-dependent RNA polymerase (RdRP) containing a unique

186 -terminal methyltransferase and a C-terminal RNA-dependent RNA polymerase (RdRp) domain.

187 ich the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into o

188 scovered that knockdown of either csr-1, the RNA-dependent RNA polymerase (RdRP) ego-1, or the dicer-

189 e hepatitis C virus (HCV) NS5B protein is an RNA-dependent RNA polymerase (RdRp) essential for replic

190 These include the sequestration of the RNA-dependent RNA polymerase (RdRp) for functions other

191 fficiently used as primers by the hantaviral RNA-dependent RNA polymerase (RdRp) for transcription in

192 on sequencing using primers specific for the RNA-dependent RNA polymerase (RDRP) gene.

193 sid (ORF2) genes and occasionally within the RNA-dependent RNA polymerase (RdRP) gene.

194 The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) has been proposed to

195 methyltransferase is physically linked to an RNA-dependent RNA polymerase (RdRp) in the flaviviral NS

196 Based on the in vitro NS5B RNA-dependent RNA polymerase (RdRp) inhibition in the lo

197 which the respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp) initiates mRNA trans

198 The viral RNA-dependent RNA polymerase (RdRp) is essential for mul

199 RNA-dependent RNA polymerase (RdRp) is essential to vira

200 cleotide incorporation fidelity of the viral RNA-dependent RNA polymerase (RdRp) is important for mai

201 The RNA-dependent RNA polymerase (RdRp) of hepatitis C virus

202 The RNA-dependent RNA polymerase (RdRP) of nonsegmented nega

203 a cell-based assay for RNA synthesis by the RNA-dependent RNA polymerase (RdRp) of noroviruses, we p

204 port an in vitro RNA synthesis assay for the RNA-dependent RNA polymerase (RdRP) of rabies virus (RAB

205 The reliance of the viral RNA-dependent RNA polymerase (RdRP) on host factors make

206 ruses (IAV) acquired through the error-prone RNA-dependent RNA polymerase (RdRP) or through genetic r

207 Based on the partial RNA-dependent RNA polymerase (RdRp) region, they cluster

208 a distinct class of siRNAs synthesized by an RNA-dependent RNA polymerase (RdRP) requires the PIR-1 p

209 In this context, the viral RNA-dependent RNA polymerase (RdRP) subunits assembly ha

210 onal analysis of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) template channel ide

211 S) in C. elegans also involves RRF-1, a worm RNA-dependent RNA polymerase (RdRP) that is known to pro

212 ny eukaryotic organisms encode more than one RNA-dependent RNA polymerase (RdRP) that probably emerge

213 RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique p

214 Hantavirus RNA-dependent RNA polymerase (RdRp) uses a capped RNA pr

215 However, genes for RNA-dependent RNA polymerase (RdRp), a hallmark of posit

216 Key to the viral life cycle is the RNA-dependent RNA polymerase (RdRp), a heterotrimeric co

217 ndrial membrane-targeting, self-interaction, RNA-dependent RNA polymerase (RdRp), and RNA capping dom

218 re dengue genome for interactions with viral RNA-dependent RNA polymerase (RdRp), and we identified t

219 influenza virus genome mainly depend on its RNA-dependent RNA polymerase (RdRP), composed of the PA,

220 SARS-CoV nsp12, the canonical RNA-dependent RNA polymerase (RdRp), exhibits poorly pro

221 or negative-strand RNA synthesis by the TBSV RNA-dependent RNA polymerase (RdRp), followed by templat

222 ral (HCV) genome is accomplished by the NS5B RNA-dependent RNA polymerase (RdRp), for which mechanist

223 ion of the downstream ORF, which encodes the RNA-dependent RNA polymerase (RdRp), has been proposed t

224 re, we show that transient expression of HCV RNA-dependent RNA polymerase (RdRp), NS5B, in mouse live

225 which encode a putative coat protein and an RNA-dependent RNA polymerase (RdRp), respectively.

226 The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (RdRp), the viral p33 RNA c

227 etween mitochondrial membranes and the viral RNA-dependent RNA polymerase (RdRp), which is mediated b

228 The virus-coded RNA-dependent RNA polymerase (RdRp), which is responsibl

229 component of the VRC is the virally encoded RNA-dependent RNA polymerase (RdRp), which should be act

230 A expression with a concomitant depletion of RNA-dependent RNA polymerase (RdRP)-derived secondary sm

231 and replication of the viral genome by viral RNA-dependent RNA polymerase (RdRp).

232 s is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRP).

233 tide misincorporation frequency of the viral RNA-dependent RNA polymerase (RdRp).

234 sid protein (N-RNA), and associated with the RNA-dependent RNA polymerase (RdRP).

235 espread conformational shift upon binding to RNA-dependent RNA polymerase (RdRp).

236 l-based assay for the human NoV GII.4 strain RNA-dependent RNA polymerase (RdRp).

237 requires the ERI-1 exonuclease and the RRF-3 RNA-dependent RNA polymerase (RdRP).

238 They all make their own RNA-dependent RNA polymerase (RdRp).

239 hich are known as inhibitors of the HCV NS5B RNA-dependent RNA polymerase (RdRp).

240 on the regulation of VP1, the virus-encoded RNA-dependent RNA polymerase (RdRp).

241 (siRNAs) are amplified from target mRNAs by RNA-dependent RNA polymerase (RdRP).

242 via template switching by the virus-encoded RNA-dependent RNA polymerase (RdRP).

243 ction might reflect the failure of the viral RNA-dependent RNA polymerase (RdRp; VP1) to recognize an

244 RNA viruses encoding high- or low-fidelity RNA-dependent RNA polymerases (RdRp) are attenuated.

245 addition to RTs, also includes certain viral RNA-dependent RNA polymerases (RdRP) synthesizing RNA on

246 bed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp).

247 optimization of non-nucleoside dengue viral RNA-dependent-RNA polymerase (RdRp) inhibitors are descr

248 in, which comprises three enzymatic domains (RNA-dependent RNA polymerase [RdRp], polyribonucleotidyl

249 RNA-dependent RNA polymerases (RdRps) are key to the rep

250 RNA-dependent RNA polymerases (RdRps) are used by RNA vi

251 RNA-dependent RNA polymerases (RdRps) are used by RNA vi

252 Positive-sense RNA viruses encode RNA-dependent RNA polymerases (RdRps) essential for geno

253 Recombinant RNA-dependent RNA polymerases (RdRps) from the human nor

254 All viral RNA-dependent RNA polymerases (RdRps) have a conserved s

255 The RNA-dependent RNA polymerases (RdRPs) of Cystoviridae ba

256 f human and animal pathogens whose essential RNA-dependent RNA polymerases (RdRPs) share a structural

257 uding plants, fungi, and nematodes, cellular RNA-dependent RNA polymerases (RdRPs) use AGO targets as

258 mplification of initial silencing signals by RNA-dependent RNA polymerases (RdRPs).

259 quires an siRNA amplification step involving RNA-dependent RNA polymerases (RdRPs).

260 te for the absence of piRNAs, both involving RNA-dependent RNA polymerases (RdRPs).

261 oduction of double-stranded RNAs (dsRNAs) by RNA-DEPENDENT RNA POLYMERASEs (RDRs) and proceeds throug

262 Cellular RNA-dependent RNA polymerases (RDRs) catalyze synthesis

263 A conserved family of eukaryotic RNA-dependent RNA polymerases (RDRs) initiates or amplif

264 e Dicer-like 1 (DCL1) but do not require any RNA-dependent RNA Polymerases (RDRs) or RNA Polymerase I

265 ral genome or via the action of host-encoded RNA-dependent RNA polymerases (RDRs).

266 s (AGOs), dsRNA-binding proteins (DRBs), and RNA-dependent RNA polymerases (RDRs).

267 Hepatitis C virus (HCV) RNA-dependent RNA polymerase replicates the viral genomi

268 NS5B is the RNA-dependent RNA polymerase responsible for replicating

269 The C-terminal domain is an RNA-dependent RNA polymerase responsible for viral RNA s

270 NA) genome, which is replicated by the viral RNA-dependent RNA polymerase (RNAP).

271 re that is recognized and bound by the viral RNA-dependent RNA polymerase (RNAP); however, no 3D stru

272 The RDE-10/RDE-11 complex and the RNA-dependent RNA polymerase RRF-1 then engage the targe

273 independent of rde-4 but likely requires the RNA-dependent RNA polymerase RRF-1, suggesting a critica

274 The viral RNA-dependent RNA polymerases show a conserved structure

275 findings further our understanding of viral RNA-dependent RNA polymerase structure-function relation

276 nit, and the RDRC complex, which contains an RNA-dependent RNA polymerase subunit.

277 c RNA whose appearance is independent of the RNA-dependent RNA polymerase, suggesting that the telome

278 sfected sgmRNA contains an internally placed RNA-dependent RNA polymerase template-switching donor si

279 Non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase that catalyzes replication

280 (HCV) non-structural protein 5B (NS5B) is an RNA-dependent RNA polymerase that is essentially require

281 Nonstructural protein 9 (Nsp9) is the RNA-dependent RNA polymerase that plays a critical role

282 RSV has an RNA-dependent RNA polymerase that transcribes and replic

283 such as influenza, encode large, multidomain RNA-dependent RNA polymerases that can both transcribe a

284 1 (PA-PB1) subunits of influenza virus (Flu) RNA-dependent RNA polymerase, this paper is devoted to t

285 siRNAs, which are specifically recognized by RNA-dependent RNA polymerases to make double-stranded RN

286 tered inside the nucleocapsid when the viral RNA-dependent RNA polymerase uses it as the template for

287 agment screen on the dengue virus serotype 3 RNA-dependent RNA polymerase using x-ray crystallography

288 wn to specifically colocalize with the viral RNA-dependent RNA polymerase VP1, the capsid protein VP2

289 l double-stranded RNA (dsRNA) genome and the RNA-dependent RNA polymerase VP1.

290 me and RNA processing enzymes, including the RNA-dependent RNA polymerase (VP1).

291 e-stranded RNA (dsRNA) genome, the rotavirus RNA-dependent RNA polymerase, VP1, must recognize viral

292 dies have revealed the position of the viral RNA-dependent RNA polymerase, VP1, within the inner caps

293 The viral RNA-dependent RNA polymerase (vRdRp) of paramyxovirus co

294 The viral RNA-dependent RNA polymerases (vRdRps) of nonsegmented,

295 s, identified in the p7 polypeptide and NS5B RNA-dependent RNA polymerase, were sufficient to increas

296 lyzed by the NS5B (nonstructural protein 5B) RNA-dependent RNA polymerase, which is a major target of

297 P forms the viral RNA-dependent RNA polymerase with the large protein (L).

298 nhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all H

299 generated a SINV expressing nsP4, the viral RNA-dependent RNA polymerase, with an in-frame 3xFlag ep

300 ty in RNA viruses has been attributed to the RNA-dependent RNA polymerases, with mutations in RdRps f