ライフサイエンスコーパス: RNA-induced silencing complex

1 ions in the formation of a stable Piwi RISC (RNA-induced silencing complex).

2 y a ribonucleoprotein complex known as RISC (RNA-induced silencing complex).

3 bodies and bind to Argonaute proteins of the RNA induced silencing complex.

4 helicase, and it is also a component of the RNA-induced silencing complex.

5 , an essential step in the activation of the RNA-induced silencing complex.

6 he degradation of the target mRNA within the RNA-induced silencing complex.

7 n between the 3'-untranslated region and the RNA-induced silencing complex.

8 for the siRNA and biased strand loading into RNA-induced silencing complex.

9 so involved in loading and activation of the RNA-induced silencing complex.

10 and transfers the processed products to the RNA-induced silencing complex.

11 P) functions downstream to pass siRNA to the RNA-induced silencing complex.

12 that are subsequently incorporated into the RNA-induced silencing complex.

13 plex dictate which strand is loaded into the RNA-induced silencing complex.

14 erference (RNAi) is carried out by RISC, the RNA-induced silencing complex.

15 that regulate gene expression as part of the RNA-induced silencing complex.

16 investigated represents a functional minimal RNA-induced silencing complex.

17 ute 2 (AGO2), the catalytic component of the RNA-induced silencing complex.

18 nted miR-155 activity without saturating the RNA-induced silencing complex.

19 g RNA-binding proteins and components of the RNA-induced silencing complex.

20 knockout mice deficient in components of the RNA-induced silencing complex.

21 As by Drosha and more efficient formation of RNA-induced silencing complexes.

22 any mRNAs and non-coding RNAs are cleaved by RNA-induced silencing complexes.

23 caque TRIM5alpha did, however, provide siRNA-RNA-induced silencing complex access to HIV-1 genomic RN

24 -142 efficiently recruits the APC mRNA to an RNA-induced silencing complex, activates the canonical W

25 set of miR-499 target mRNAs to cardiomyocyte RNA-induced silencing complexes, altering steady-state c

26 een for microRNAs that were recruited to the RNA-induced silencing complex and differentially express

27 (Ago) proteins are the key component of the RNA-induced silencing complex and mediate RNA interferen

28 ic small interfering RNAs (siRNAs) enter the RNA-induced silencing complex and one strand guides clea

29 Genome-wide RNA-induced silencing complex and RNA sequencing identif

30 lanks complex is unlike previously described RNA-induced silencing complexes and associates with the

31 binds Argonaute2, a central component of the RNA-induced silencing complex, and miR-146a, a microRNA

32 detectable by Northern blot, are loaded into RNA-induced silencing complexes, and can effectively and

33 These proteins assemble into functional RNA-induced silencing complexes as transfection of small

34 When an siRNA or miRNA proceeds through the RNA-induced silencing complex assembly pathway, only one

35 ile intermediate during the miRNA biogenesis/RNA-induced silencing complex assembly, miRNA*, was belo

36 ssociation with AGO1, either during or after RNA-induced silencing complex assembly.

37 Here we show that human RISC (RNA-induced silencing complex) associates with a multipr

38 centration in plasma and liver, the temporal RNA-induced silencing complex binding profiles, mRNA red

39 sequences, indicating in planta miRNA-guided RNA-induced silencing complex cleavage of the recombinan

40 trated a novel interaction between the major RNA-induced silencing complex component Argounaute-2 (Ag

41 nique that identifies the mRNAs bound to the RNA-induced silencing complex component protein Argonaut

42 was identified by immunoprecipitation of the RNA-induced silencing complex components AIN-1 and AIN-2

43 The RNA-induced silencing complex, comprising Argonaute and

44 ng specific stoichiometric associations with RNA-induced silencing complex constituents argonaute-2 (

45 The results reveal the requirement of RNA-induced silencing complex constituents in the mitoch

46 in vitro Drosha/Dicer processing, and (iii) RNA-induced silencing complex-dependent targeting of wil

47 e for formation of nuclear-programmed active RNA induced silencing complexes directly in the nucleus.

48 hat they function, at least in part, via the RNA-induced silencing complex effector Ago1.

49 ow that Nsf is specifically recruited to the RNA-induced silencing complex following induction of miR

50 ality in reconstituted, catalytically active RNA-induced silencing complexes following the incorporat

51 is an essential functional component in the RNA-induced silencing complex for miRNA-mediated gene si

52 Argonautes are recruited with miRNAs into an RNA-induced silencing complex for mRNA recognition (Figu

53 degradation of the unwound sense strand and RNA-induced silencing complex formation, suggesting that

54 roRNAs exist mainly in high molecular weight RNA-induced silencing complexes (HMW-RISC) associated wi

55 enriched through immunoprecipitation of the RNA-induced silencing complex identified several transcr

56 Dicer and facilitates loading of miRNA onto RNA-induced silencing complexes, identifying a new role

57 type 2a RNA with miR-181c was observed in an RNA-induced silencing complex in Huh7.5 cells.

58 mbers (Tnrc6a/b/c) are key components of the RNA-induced silencing complex in microRNA (miRNA)-mediat

59 The slicer activity of the RNA-induced silencing complex is associated with argonau

60 unforeseen increase in siRNA loading to the RNA-induced silencing complex, likely due to the unique

61 slated region of SOX2 mRNA together with the RNA-induced silencing complex miR145.

62 ulates expression of three components of the RNA-induced silencing complex, namely Dicer, Argonaute 1

63 iated by the RNA-protein effector complexes (RNA-induced silencing complex or RISC).

64 The presence of RNA-induced silencing complex proteins in these compartm

65 We asked whether the Argonaute (Ago)/RNA-induced silencing complex, providing the mRNA "slice

66 We propose that the RNA-induced silencing complex reprogramming occurs durin

67 The slicer activity of the RNA-induced silencing complex resides within its Argonau

68 The RNA induced silencing complex (RISC) contains at its cor

69 us in HSB2 cells and are associated with the RNA induced silencing complex (RISC) machinery.

70 d into Argonaute, the central protein in the RNA Induced Silencing Complex (RISC) that silences messe

71 for transport and for incorporation into the RNA induced silencing complex (RISC).

72 hen loaded into Argonaute1 (Ago1) within the RNA-induced silencing complex (RISC) [19, 20].

73 junctions recruit the core components of the RNA-induced silencing complex (RISC) Ago2, GW182, and PA

74 on of small interfering RNAs (siRNAs) by the RNA-induced silencing complex (RISC) and its precursor,

75 A (aiRNA) of 15 bp was incorporated into the RNA-induced silencing complex (RISC) and mediated sequen

76 fferent siRNAs may lead to saturation of the RNA-induced silencing complex (RISC) and to the degradat

77 ed into Argonaute (AGO) proteins to form the RNA-induced silencing complex (RISC) and used as guides

78 Complexes in the Drosophila RNA-induced silencing complex (RISC) assembly pathway ca

79 labile intermediate in the miRNA biogenesis/RNA-induced silencing complex (RISC) assembly pathway, m

80 During RNA-induced silencing complex (RISC) assembly the guide

81 ched variants in parallel in gene silencing, RNA-induced silencing complex (RISC) assembly, stability

82 ered the recruitment of TOP2A transcripts to RNA-induced silencing complex (RISC) components and to c

83 The cytoplasmic RNA-induced silencing complex (RISC) contains dsRNA bind

84 omain containing 1 (SND1), a nuclease in the RNA-induced silencing complex (RISC) facilitating RNAi-m

85 Utilizing antisense and siRNA-mediated RNA-induced silencing complex (RISC) gene reduction we s

86 Furthermore, RNA-induced silencing complex (RISC) immunoprecipitation

87 RNA-induced silencing complex (RISC) is composed of miRN

88 cally regulated and its interaction with the RNA-induced silencing complex (RISC) is compromised in M

89 hich these fragments are associated with the RNA-induced silencing complex (RISC) is mostly unknown.

90 nding of microRNA (miRNA) to mRNA within the RNA-induced silencing complex (RISC) leads to either tra

91 ns (C. elegans), the interaction between the RNA-induced silencing complex (RISC) loaded with primary

92 tle is known about whether components of the RNA-induced silencing complex (RISC) mediate the biogene

93 ated RNAs associated with Argonaute 2 in the RNA-induced silencing complex (RISC) of cyclosporine A (

94 The RNA-induced silencing complex (RISC) or the RISC complex

95 hod for miRNA target discovery that combined RNA-induced silencing complex (RISC) purification with m

96 , like RNA viruses, are also targeted by the RNA-induced silencing complex (RISC) remains controversi

97 Assembly of the RNA-induced silencing complex (RISC) requires formation

98 ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzymatic

99 r activation due in part to induction of the RNA-induced silencing complex (RISC) scaffold protein GW

100 n-cleavage-based gene repression through the RNA-induced silencing complex (RISC) that consists of on

101 RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to c-Myc mRNA and m

102 s RNA into siRNAs and miRNAs, which direct a RNA-induced silencing complex (RISC) to cleave mRNA or b

103 ral-derived siRNAs are incorporated into the RNA-induced silencing complex (RISC) to guide degradatio

104 tides in length and helps load them into the RNA-induced silencing complex (RISC) to guide the cleava

105 er to generate mature miRNAs that direct the RNA-induced silencing complex (RISC) to messenger RNAs w

106 sis, mature miRNAs are incorporated into the RNA-induced silencing complex (RISC) where they interact

107 ls, this microRNA can be associated with the RNA-induced silencing complex (RISC) which is required f

108 The miRNA is incorporated into the RNA-Induced Silencing Complex (RISC) with Argonaute prot

109 l infection via poly-ADP-ribosylation of the RNA-induced silencing complex (RISC), a core component o

110 ner for Dicer and a crucial component of the RNA-induced silencing complex (RISC), a critical element

111 RNAi is mediated by RNA-induced silencing complex (RISC), a sequence-specifi

112 four major steps: assembly of siRNA with the RNA-induced silencing complex (RISC), activation of the

113 RNA metabolism, including components of the RNA-induced silencing complex (RISC), and colocalize wit

114 (hAgo2), the catalytic core component of the RNA-induced silencing complex (RISC), can be recruited t

115 nd degradation in a process mediated by Ago2/RNA-induced silencing complex (RISC), certain siRNAs hav

116 Argonaute 2 (Ago2), a key component of the RNA-induced silencing complex (RISC), has been shown to

117 naute-2 protein (Ago2), a major component of RNA-induced silencing complex (RISC), has been viewed as

118 rgonaute proteins, the catalytic core of the RNA-induced silencing complex (RISC), in the conserved R

119 P2rx7 mRNA was selectively uploaded into the RNA-induced silencing complex (RISC), suggesting microRN

120 te proteins and small RNAs together form the RNA-induced silencing complex (RISC), the central effect

121 alyze which HSV-1 miRNAs are loaded into the RNA-induced silencing complex (RISC), the key effector o

122 that the central catalytic component of the RNA-induced silencing complex (RISC), the nuclease Argon

123 (siRNAs) by Dicer and incorporated into the RNA-induced silencing complex (RISC), triggers gene sile

124 ctional machinery of the RNAi pathway is the RNA-induced silencing complex (RISC), wherein Argonaute2

125 tic engine of RNA interference (RNAi) is the RNA-induced silencing complex (RISC), wherein the endori

126 Argonaute proteins lie at the heart of the RNA-induced silencing complex (RISC), wherein they use s

127 ds, then assembled with proteins to form the RNA-induced silencing complex (RISC), which catalyzes ta

128 ic gene regulatory mechanism mediated by the RNA-induced silencing complex (RISC), which is composed

129 ut are defective in the production of active RNA-induced silencing complex (RISC), which mediates tar

130 rough a ribonucleoprotein complex called the RNA-induced silencing complex (RISC), which, in mammals,

131 Targeted gene silencing by RNAi requires the RNA-induced silencing complex (RISC), whose core compone

132 Only one siRNA strand assembles into the RNA-induced silencing complex (RISC), with preference gi

133 -stranded RNAs (dsRNAs) and interaction with RNA-induced silencing complex (RISC)-associated AGO1/AGO

134 s C virus (HCV) replication by recruiting an RNA-induced silencing complex (RISC)-like complex contai

135 srPSTVds were biologically active in guiding RNA-induced silencing complex (RISC)-mediated cleavage,

136 A new study shows how RNA-induced silencing complex (RISC)-mediated posttransc

137 are being actively down-regulated in miRNA- RNA-induced silencing complex (RISC)-messengerRNA (mRNA)

138 NoV B2 binds to pre-Dicer substrate RNA and RNA-induced silencing complex (RISC)-processed RNAs and

139 from association with the miR-1293-specified RNA-induced silencing complex (RISC).

140 e effector of RNA interference (RNAi) is the RNA-induced silencing complex (RISC).

141 gonaute2 (Ago2), a critical component of the RNA-induced silencing complex (RISC).

142 t strand is preferentially assembled into an RNA-induced silencing complex (RISC).

143 assemble into Argonaute proteins to form the RNA-induced silencing complex (RISC).

144 (dAgo1) or human Argonaute-2 (hAgo2) of the RNA-induced silencing complex (RISC).

145 fer further insights into the working of the RNA-induced silencing complex (RISC).

146 be major groove steric effects in the active RNA-induced silencing complex (RISC).

147 and the action of proteins assembled in the RNA-induced silencing complex (RISC).

148 lease, and Gemin3 helicase-components of the RNA-induced silencing complex (RISC).

149 f VIG, a part of the Drosophila melanogaster RNA-induced silencing complex (RISC).

150 ed from translational inhibition mediated by RNA-induced silencing complex (RISC).

151 cer presumably to prevent programming of the RNA-induced silencing complex (RISC).

152 iRNA) guide degradation of target RNA by the RNA-induced silencing complex (RISC).

153 (guide) strand to enhance its binding to the RNA-induced silencing complex (RISC).

154 This protein synthesis is regulated by the RNA-induced silencing complex (RISC).

155 nce is implemented through the action of the RNA-induced silencing complex (RISC).

156 endonuclease, Argonaute2 (Ago2), within the RNA-induced silencing complex (RISC).

157 ) proteins constitute a key component of the RNA-induced silencing complex (RISC).

158 y a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC).

159 estruction is catalyzed by the siRNA-guided, RNA-induced silencing complex (RISC).

160 nts of the RNA interference effector complex RNA-induced silencing complex (RISC).

161 is carried out by the small double-stranded RNA-induced silencing complex (RISC).

162 ausing the transcripts to be degraded by the RNA-induced silencing complex (RISC).

163 ute 2 (AGO2), the catalytic component of the RNA-induced silencing complex (RISC).

164 ent gene silencing approach controlled by an RNA-induced silencing complex (RISC).

165 nction in RNA silencing as components of the RNA-induced silencing complex (RISC).

166 (Ago) proteins, essential components of the RNA-induced silencing complex (RISC).

167 plexes devoid of essential components of the RNA-induced silencing complex (RISC).

168 reby constitute the central component of the RNA-induced silencing complex (RISC).

169 regulatory mechanism that is mediated by the RNA-induced silencing complex (RISC).

170 rfering RNAs (siRNAs) that are active in the RNA-induced silencing complex (RISC).

171 RNAs (siRNAs) before incorporation into the RNA-induced silencing complex (RISC).

172 Other proteins of the RNA-induced silencing complex (RISC; SND1, PACT, and FXR

173 phosphorylated forms that may associate with RNA-induced silencing complexes (RISC).

174 mmon set of cellular proteins (Dicer and the RNA-induced silencing complex [RISC]) to elicit RNA inte

175 F1A is a novel component of the Ago2-centred RNA-induced silencing complexes (RISCs) and augments Ago

176 bclasses of 26G RNAs that sort into specific RNA-induced silencing complexes (RISCs) and differential

177 ximately 22 nt noncoding RNAs, assemble into RNA-induced silencing complexes (RISCs) and localize to

178 ack structures, miRNAs are incorporated into RNA-induced silencing complexes (RISCs) before targeting

179 y of microRNA ribonucleoproteins (miRNPs) or RNA-induced silencing complexes (RISCs) is essential for

180 bsequently, siRNAs are incorporated into the RNA-induced silencing complexes (RISCs) that contain Arg

181 eotide (nt) small RNAs (sRNAs) to constitute RNA-induced silencing complexes (RISCs) to regulate gene

182 RNA interference (RNAi) is mediated by RNA-induced silencing complexes (RISCs), which are guide

183 family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be pr

184 ed onto Argonaute proteins they can form the RNA-induced silencing complexes (RISCs), which mediate R

185 (Ago)-containing effector complexes known as RNA-induced silencing complexes (RISCs), which they guid

186 go) proteins are essential components of the RNA-induced silencing complexes (RISCs).

187 aute (Ago), GW182, and FXR1 proteins to form RNA-induced silencing complexes (RISCs).

188 engines of miRNA-directed gene silencing are RNA-induced silencing complexes (RISCs).

189 ) or small interfering RNAs (siRNAs) forming RNA-induced silencing complexes (RISCs/miRNPs).

190 We performed unbiased RNA-induced silencing complex sequencing on wild-type an

191 go2 immunoprecipitation with RNA sequencing (RNA-induced silencing complex sequencing) was used for u

192 The loaded AGO-containing RNA-induced silencing complex specifically recognizes a

193 double-stranded RNAs is incorporated into an RNA-induced silencing complex that can either suppress p

194 ute proteins form the functional core of the RNA-induced silencing complexes that mediate RNA silenci

195 ger strands and facilitate the activation of RNA-induced silencing complex, the effector complex of R

196 and 5-phosphate is required for loading into RNA-induced silencing complex, the synthetic addition of

197 his prevents the programming of an antiviral RNA-induced silencing complex to avoid viral RNA degrada

198 They guide RNA-induced silencing complexes to complementary target

199 MicroRNAs (miRNAs) guide RNA-induced silencing complexes to target RNAs based on

200 Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequ

201 exosomes, deadenylases, decapping complexes, RNA-induced silencing complexes) to the 3'-untranslated

202 amount of siRNA at its site of action RISC (RNA-induced silencing complex) were evaluated using endo

203 ease activity, including that conferred by a RNA-induced silencing complex, which is likely the cause