ライフサイエンスコーパス: ROR gamma

1 ge-specific nuclear receptors, ROR alpha and ROR gamma.

2 containing large genomic fragments encoding ROR gamma.

3 a process that is dependent on STAT3 but not ROR-gamma.

4 and pointed to a potential receptor target, ROR-gamma.

5 arranged V alpha 14J alpha 18 transgene into ROR gamma(0/0) mice results in functional iNKT cells.

6 , introgression of a Bcl-x(L) transgene into ROR gamma(0/0) mice, which promotes survival and permits

7 acid receptor-related orphan receptor gamma (ROR gamma)0/0 thymi, which accumulate immature single-po

8 mouse homologue of the orphan receptor, RZR/ROR gamma, a member of the nuclear receptor superfamily,

9 dent, while the expression of Rev-Erb alpha, Ror gamma and both Cryptochome (Cry1 and Cry2) genes was

10 The effect of CR on Rev-Erb alpha, Ror gamma and Cry1 gene expression was sex dependent.

11 d the chromosomal localization of both mouse ROR gamma and human ROR gamma (HGMW-approved symbol RORC

12 we determined the genomic structure of mouse ROR gamma and the chromosomal localization of both mouse

13 ding retinoid-related orphan receptor gamma (ROR-gamma) and IL-23 receptor (IL-23R) produced abundant

14 ROR-gamma antagonists also markedly diminish genome-wide

15 ROR-gamma antagonists suppress the expression of both AR

16 Finally, ROR-gamma antagonists suppressed tumor growth in multipl

17 RORalpha and ROR gamma are expressed in human skin and serve as recep

18 Taken together, these results establish ROR-gamma as a key player in CRPC by acting upstream of

19 The ROR gamma-binding specificity was further defined by mut

20 Furthermore, ROR alpha and ROR gamma coexpression synergistically led to greater Th

21 was shown to regulate Th17 differentiation; ROR gamma deficiency, however, did not completely abolis

22 In ontogeny, retinoic acid orphan receptor (ROR)gamma-dependent lymphoid tissue inducer (LTi) cells

23 mplified in metastatic CRPC tumors, and that ROR-gamma drives AR expression in the tumors.

24 escence in situ hybridization that the mouse ROR gamma gene is located on chromosome 3, in a region t

25 The genomic structure of the mouse ROR gamma gene was derived from the analysis of P1 vecto

26 The results demonstrate that the ROR gamma genes are located in chromosomal regions that

27 Double deficiencies in ROR alpha and ROR gamma globally impaired Th17 generation and complete

28 calization of both mouse ROR gamma and human ROR gamma (HGMW-approved symbol RORC).

29 bit the transactivation induced by GAL4(DBD)-ROR gamma in fibroblast D1 cells suggesting that these r

30 ROR alpha 1 and ROR gamma inhibit the transactivation induced by GAL4(DB

31 ROR gamma is expressed as two mRNAs, 2.3 and 3.0 kb in s

32 acid receptor-related orphan receptor gamma (ROR-gamma) is overexpressed and amplified in metastatic

33 inoic acid receptor-related orphan receptor (ROR)-gamma mediate the lineage specification.

34 The amino acid sequence of mouse ROR gamma (mROR gamma) is highly homologous to that of h

35 SiRNAs targeting other regions of ROR-gamma not only confirmed the observed reporter activ

36 The discovered negative effect of ROR-gamma on the degradation of the toxic Abeta peptides

37 ck of retinoic acid-related orphan receptor (ROR) gamma or alpha expression in mice significantly red

38 ROR-gamma recruits nuclear receptor coactivator 1 and 3

39 Analysis of the ROR gamma-response element using in vitro synthesized RO

40 -response element using in vitro synthesized ROR gamma revealed that it binds as a monomer to respons

41 nt expression in DP thymocytes, suggest that ROR gamma t controls these distinct phenotypic features

42 Our data suggest that down-regulation of ROR gamma t expression in thymocytes is essential for th

43 ic expression of the orphan nuclear receptor ROR gamma t in mature T cells down-regulates their surfa

44 Furthermore, ectopic expression of ROR gamma t inhibits the proliferation of mature and imm

45 be partially due to the inhibitory effect of ROR gamma t on c-Rel transcription.

46 The ROR gamma t transgene inhibits IL-2 production by mature

47 lated orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 ce

48 ation, including the orphan nuclear receptor ROR gamma t, the IL-1 receptor, and the IL-23 receptor.

49 the Th1 mixture expressed T-bet, whereas no ROR-gamma t was detected in Th1 incubated with Th17 mixt

50 lopment is absolutely dependent on Runx1 and ROR(gamma)t, transcription factors that influence, but a

51 ROR gamma was able to activate RORE-dependent transcript

52 The human ROR gamma was mapped to chromosome region 1q21.

53 acid receptor-related orphan receptor gamma (ROR gamma) was shown to regulate Th17 differentiation; R

54 s Foxp3 expression, which requires STAT3 and ROR-gamma, which is encoded by Rorc.

55 gamma) is highly homologous to that of human ROR gamma, with an overall identity of 88%.