ライフサイエンスコーパス: RPTP

1 RPTP-kappa also reduced epidermal growth factor-dependen

2 RPTP-kappa directly counters intrinsic EGFR tyrosine kin

3 RPTP-kappa expression in both GFP-labeled dorsal root ga

4 RPTP-kappa induction is dependent on activation of trans

5 RPTP-kappa is proteolytically processed to isoforms that

6 RPTP-kappa levels increased in keratinocytes as cells re

7 RPTPs are type-I integral membrane proteins which contai

8 RPTPs in general are still "orphan receptors" because, w

9 PTPmu is a RPTP that mediates cell aggregation and is expressed at

10 proteins with tyrosine phosphatase activity (RPTPs).

11 es that there are likely to be no additional RPTPs encoded in the fly genome.

12 cell in the leech, express high levels of an RPTP called HmLAR2 [6,7].

13 this is the first direct demonstration of an RPTP's influence on the actin cytoskeleton.

14 n particular by the family of Wnt kinase and RPTP phosphatase signaling pathways.

15 orting the model for regulation of CD45, and RPTPs in general.

16 complex signaling interplay between RTKs and RPTPs.

17 Interestingly, another RPTP, Ptp69D, promotes dendritic growth of C4da neurons

18 pends on the phosphatase activity of another RPTP, PTP69D.

19 ptor-type protein tyrosine phosphatase beta (RPTP-beta) specifically dephosphorylates Met and thereby

20 partially because the ligands recognized by RPTPs at growth cone choice points have not been identif

21 g cascade that could be modulated in vivo by RPTPs such as DPTP10D.

22 results suggest that in unstimulated cells, RPTP beta/zeta is intrinsically active and functions as

23 s the biological activity of a CD45 chimeric RPTP and the catalytic activity of an isolated RPTPsigma

24 lamus, are expanded in size; a complementary RPTP(delta) domain in ventral thalamus is correspondingl

25 ose, treatment of cells results in decreased RPTP retention, showing that galectin-1 binding contribu

26 tified cells throughout the CNS that display RPTP-kappa promoter activity.

27 ed with in ovo electroporation to knock down RPTP expression levels in the embryonic chick lumbar spi

28 tp4E is the only widely expressed Drosophila RPTP, and is the last of the six fly RPTPs to be genetic

29 has been demonstrated for certain Drosophila RPTPs.

30 Five of the six Drosophila RPTPs have C. elegans counterparts, and three of the six

31 Recent findings show that Drosophila RPTPs play key roles in guiding retinal axons and in pre

32 ein tyrosine phosphatase (PTP) family (i.e., RPTP kappa, RPTPmu, NU-3, SHP, and 3CH134) are completel

33 These results demonstrate that each RPTP exerts a unique regulatory fingerprint of RTK tyros

34 We observed that each RPTP induced a unique fingerprint of tyrosyl phosphoryla

35 the epidermal growth factor receptor (EGFR)-RPTP CD45 chimera (EGFR-CD45) in T cell signal transduct

36 ng those that do not normally express either RPTP, suggesting that the substrates involved in HmLAR-i

37 llel to its ability to inactivate endogenous RPTP beta/zeta, PTN sharply increases tyrosine phosphory

38 more, shRNA-mediated knockdown of endogenous RPTP-beta increases basal and HGF-stimulated Met phospho

39 l+neo (beta-geo) insertion in the endogenous RPTP-kappa gene, the consequent loss of RPTP-kappa's enz

40 ene's expression is driven by the endogenous RPTP-kappa promoter, distribution of the truncated RPTP-

41 Five highly expressed RPTPs (RPTP-beta, delta, kappa, mu, and xi) were functio

42 sophila RPTP, and is the last of the six fly RPTPs to be genetically characterized.

43 ne, by acting as an intracellular anchor for RPTP signalling at synaptic junctions.

44 lts suggest that PTN is a natural ligand for RPTP beta/zeta.

45 the first evidence of an essential role for RPTPs in epithelial organ development.

46 stall at an aberrant, abrupt border of high RPTP(delta) expression.

47 of the tandem D1 and D2 domains of the human RPTP LAR revealed that the tertiary structures of the LA

48 ree of the six are also orthologous to human RPTP subfamilies.

49 el mechanism of EGFR regulation and identify RPTP-kappa as a key molecular target for antioxidant pro

50 l interfering RNA (siRNA) screen to identify RPTPs in the human genome that serve as RTK phosphatases

51 In the vertebrate, type IIa RPTPs [protein tyrosine phosphatase (PTP)-delta, PTP-sig

52 ar region of RPTPmu, a prototypical type IIB RPTP.

53 ed the expression of mouse PTPRO, a type III RPTP with an extracellular region containing eight fibro

54 iments in our lab have identified a type III RPTP, CRYP-2/cPTPRO, specifically expressed during the p

55 te common-antigen-related)] and the type III RPTP, PTP receptor type O (PTPRO), have been implicated

56 eletions in the fly have shown that type III RPTPs are important in axon pathfinding, but nothing is

57 at competition between type IIa and type III RPTPs can regulate motor axon outgrowth, consistent with

58 ssion of wild-type or catalytically inactive RPTP-kappa reduced or enhanced, respectively, basal and

59 RPTPs are expressed in the brain, including RPTP-kappa which participates in homophilic cell-cell in

60 shRNA-mediated reduction of TGF-beta-induced RPTP-kappa significantly attenuates the ability of TGF-b

61 receptor protein tyrosine phosphatase kappa (RPTP-kappa) and the laminin receptor 1 (ribosomal protei

62 tor-type protein tyrosine phosphatase kappa (RPTP-kappa), and the interaction of the two proteins in

63 tor-type protein-tyrosine phosphatase-kappa (RPTP-kappa) dephosphorylates EGFR and thereby regulates

64 tor type protein tyrosine phosphatase-kappa (RPTP-kappa) specifically dephosphorylates EGFR, thereby

65 ative inhibition of receptor type PTP-kappa (RPTP-kappa).

66 nsion to our understanding of liprin and LAR RPTP function during synapse formation.

67 In neurons, liprin-alpha and LAR-RPTP are enriched at synapses and coimmunoprecipitate wi

68 R-RPTP and tyrosine dephosphorylation by LAR-RPTP.

69 f cIAP1 reverts the apoptotic deficit of LAR-RPTP-deficient embryos.

70 receptor protein tyrosine phosphatases (LAR-RPTP) bind to liprin-alpha (SYD2) and are implicated in

71 We finally demonstrate that LAR-RPTP deficiency increases cIAP1 stability during apoptot

72 We report that LAR-RPTP is concentrated in mature synapses in cultured rat

73 that involves binding of liprin-alpha to LAR-RPTP and tyrosine dephosphorylation by LAR-RPTP.

74 lice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-dependent presynaptic different

75 receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presynaptic developmen

76 receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPdelta, and PTPsigma).

77 ynaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory

78 n of postsynaptic SALM5 with presynaptic LAR-RPTPs.

79 Here we show that LAR-RPTPs act through cellular inhibitor of apoptosis protei

80 ation inhibits the activity of a full-length RPTP in vivo.

81 on of vab-1 and ptp-3 suggests that LAR-like RPTPs and Eph receptors have related and partly redundan

82 experiments indicate a key role for LAR-like RPTPs in maintaining the integrity of the growth cone.

83 HmLAR2, one of two closely related LAR-like RPTPs in the embryonic leech, is expressed in a few cent

84 Here we report that two LAR-like RPTPs in the medicinal leech, HmLAR1 and HmLAR2, play ro

85 whether they normally express these LAR-like RPTPs.

86 which can be subdivided into receptor-like (RPTPs) and nonreceptor (NRPTPs).

87 Most RPTPs are expressed at very low levels, whereas nonrecep

88 alytic domain (D1) of a typical RPTP, murine RPTP alpha.

89 isolation of mutations in the fourth neural RPTP, DPTP10D.

90 The neural RPTP DPTP99A can also induce gp150 dephosphorylation but

91 equires a specific subset of the five neural RPTPs.

92 lso show that elimination of all four neural RPTPs converts most noncrossing longitudinal pathways in

93 Syndecan (Sdc) as a ligand for the neuronal RPTP LAR.

94 n) as a candidate substrate for the neuronal RPTP Ptp52F by using a modified two-hybrid screen with a

95 onally inactivates the catalytic activity of RPTP beta/zeta.

96 Because cleavage of RPTP occurs at a target motif (RXK/RR) recognized by a f

97 The brain distribution of RPTP-kappa-expressing cells has not been determined, how

98 und that an active site-containing domain of RPTP beta/zeta both binds beta-catenin and functionally

99 educed and the normally graded expression of RPTP(delta) in that domain is no longer apparent.

100 Expression of RPTP-beta in human primary keratinocytes reduces HGF ind

101 Expression of RPTP-beta in primary human keratinocytes reduces both ba

102 Expression of RPTP-beta, but not other RPTP family members or catalyti

103 Co-expression of RPTP-kappa, but not other RPTPs, specifically reduced ba

104 y members or catalytically inactive forms of RPTP-beta, reduces hepatocyte growth factor (HGF)-stimul

105 The homology of RPTP-kappa's ectodomain to neural cell adhesion molecule

106 gh ligand-dependent receptor inactivation of RPTP beta/zeta to increase levels of tyrosine phosphoryl

107 Reversible, oxidative inactivation of RPTP-kappa activity by UV irradiation shifts the kinase-

108 "ligand-dependent receptor inactivation" of RPTP beta/zeta and disrupts its normal roles in the regu

109 Induction of RPTP-kappa by TGF-beta significantly decreases basal and

110 ptor kinase completely prevents induction of RPTP-kappa.

111 possibility that homophilic interactions of RPTP-kappa contribute to establishment of connections be

112 Furthermore, siRNA-mediated knockdown of RPTP-kappa increased basal and EGF-stimulated EGFR tyros

113 nous RPTP-kappa gene, the consequent loss of RPTP-kappa's enzymatic activity does not produce any obv

114 ast, an (inactivating) active-site mutant of RPTP beta/zeta also binds beta-catenin but fails to redu

115 n addition, the substrate-trapping mutant of RPTP-beta specifically interacts with Met in intact cell

116 ls reached confluency, and overexpression of RPTP-kappa in subconfluent keratinocytes reduced keratin

117 ns may provide a basis for future studies of RPTP-kappa function.

118 tracellular ligands regulate the activity of RPTPs.

119 logists because the extracellular domains of RPTPs are similar to those of cell adhesion molecules (C

120 was clearly affected by dsRNA knock-down of RPTPs.

121 ported a general model for the regulation of RPTPs, derived from the crystal structure of the RPTPalp

122 This review focuses on the role of RPTPs in development of the nervous system in processes

123 To examine potential roles of RPTPs in axon growth and guidance in vivo, we used doubl

124 The LAR subfamily of RPTPs has been implicated in axon guidance and neural de

125 ith RTK signaling, the downstream targets of RPTPs.

126 Expression of RPTP-beta, but not other RPTP family members or catalytically inactive forms of R

127 he catalytic activity of RPTPalpha and other RPTPs.

128 he regulation of CD45, and by homology other RPTPs, in which dimerization inhibits phosphatase activi

129 cytoplasmic region of CD45, like many other RPTPs, contains two homologous protein tyrosine phosphat

130 Co-expression of RPTP-kappa, but not other RPTPs, specifically reduced basal EGFR tyrosine phosphor

131 The known effects of other RPTPs in axon guidance could result from modulation of g

132 identify which neurons express a particular RPTP.

133 r), a receptor protein tyrosine phosphatase (RPTP) and the only known Drosophila HSPG receptor, for p

134 h the receptor protein tyrosine phosphatase (RPTP) beta/zeta in U373-MG cells.

135 that receptor protein tyrosine phosphatase (RPTP) beta/zeta is a physiological PTN receptor.

136 receptor-type protein tyrosine phosphatase (RPTP) CD148 is thought to have an inhibitory function in

137 find that the receptor tyrosine phosphatase (RPTP) Dlar and integrins are involved in organizing basa

138 brane receptor protein tyrosine phosphatase (RPTP) that functions in AVM to inhibit signaling through

139 f the receptor protein tyrosine phosphatase (RPTP), Dlar, and an associated intracellular protein, Dl

140 The receptor protein tyrosine phosphatase (RPTP)beta/zeta is a transmembrane tyrosine phosphatase w

141 e PTN/receptor protein tyrosine phosphatase (RPTP)beta/zeta signaling pathway.

142 s of receptor protein tyrosine phosphatases (RPTP) occur at high cell density and may have an importa

143 receptor-like protein tyrosine phosphatases (RPTPs) and has essential roles in immune functions.

144 IIB receptor protein tyrosine phosphatases (RPTPs) are bi-functional cell surface molecules.

145 Receptor tyrosine phosphatases (RPTPs) are essential for axon guidance and synaptogenesi

146 ceptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and syn

147 Receptor protein tyrosine phosphatases (RPTPs) are implicated as regulators of axon growth and g

148 Receptor protein tyrosine phosphatases (RPTPs) are important for growth-cone migration [1-5], bu

149 transmembrane protein tyrosine phosphatases (RPTPs) are not well understood.

150 Receptor protein tyrosine phosphatases (RPTPs) are of particular interest to developmental biolo

151 ays and receptor-like tyrosine phosphatases (RPTPs) are rarely considered in chemoattractant-mediated

152 Receptor-type protein tyrosine phosphatases (RPTPs) are required for appropriate growth of axons duri

153 ceptor-linked protein tyrosine phosphatases (RPTPs) are required for guidance of motoneuron and photo

154 onal receptor protein tyrosine phosphatases (RPTPs) as key determinants of axon pathfinding behavior.

155 Receptor protein tyrosine phosphatases (RPTPs) can play essential roles in the dephosphorylation

156 Receptor protein tyrosine phosphatases (RPTPs) comprise a family of proteins that feature intrac

157 receptor-like protein tyrosine phosphatases (RPTPs) contain two conserved phosphatase domains (D1 and

158 Receptor-like protein tyrosine phosphatases (RPTPs) continue to emerge as important signalling molecu

159 Receptor protein tyrosine phosphatases (RPTPs) control many aspects of nervous system developmen

160 Receptor-like protein-tyrosine phosphatases (RPTPs) form a diverse family of cell surface molecules w

161 receptor-type protein tyrosine phosphatases (RPTPs) have adhesion molecule-like extracellular segment

162 Receptor protein tyrosine phosphatases (RPTPs) have been shown to play key roles in regulating a

163 receptor-like protein tyrosine phosphatases (RPTPs) is not well understood.

164 h as receptor protein tyrosine phosphatases (RPTPs) mediate this process, but how they regulate the c

165 III receptor protein tyrosine phosphatases (RPTPs) regulate axon extension and pathfinding in Drosop

166 ceptor-linked protein tyrosine phosphatases (RPTPs) regulate axon guidance and synaptogenesis in Dros

167 s of receptor protein tyrosine phosphatases (RPTPs) that control axon guidance decisions in the Droso

168 Receptor-like protein-tyrosine phosphatases (RPTPs), like their non-receptor counterparts, regulate t

169 ila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D.

170 ila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D.

171 like receptor protein tyrosine phosphatases (RPTPs), which are reported to be highly expressed in the

172 the receptor protein tyrosine phosphatases (RPTPs): LAR and RPTPsigma.

173 The regulation of receptor-like PTP (RPTP) activity remains poorly understood, but based on t

174 Nine of 25 receptor PTPs (RPTPs) corresponded to human, nematode, or fly homologue

175 Purified RPTP-beta intracellular domain preferentially dephosphor

176 Purified RPTP-kappa preferentially dephosphorylated EGFR tyrosine

177 TGF-beta up-regulates RPTP-kappa mRNA and protein, in a dose and time dependen

178 tem, but also suggest a model for regulating RPTP dimerization and function.

179 ectopic expression of HmLAR1 and the related RPTP, HmLAR2 in the P and other neurons, including those

180 Five highly expressed RPTPs (RPTP-beta, delta, kappa, mu, and xi) were functionally a

181 Several RPTPs are expressed in the brain, including RPTP-kappa w

182 We describe DPTP52F, the sixth RPTP to be discovered in Drosophila.

183 structure revealed that sea urchin-specific RPTPs including two, PTPRLec and PTPRscav, may act in im

184 e first demonstration that an Ig superfamily RPTP regulates the lamination of any neural tissue.

185 We report here that RPTP-kappa mediates functional integration of EGFR and T

186 Taken together, the above data indicate that RPTP-beta is a key regulator of Met function.

187 Taken together, the above data indicate that RPTP-kappa is a key regulator of EGFR tyrosine phosphory

188 The results also suggest that RPTP beta/zeta is a functional receptor for PTN; PTN sig

189 Our results indicate that RPTPs, and especially PTPRO, are required for axon growt

190 This suggests that RPTPs may have functions in development similar to CAMs.

191 The RPTP-kappa transmembrane P subunit interacts with and se

192 A small proportion of TCAs extend around the RPTP(delta) domain and reach the ventral thalamic-hypoth

193 tion of synapse growth and maturation by the RPTP LAR depends on catalytic phosphatase activity and o

194 ctly to and is an in vitro substrate for the RPTP DPTP10D.

195 The role of the RPTP CD45 in immune cell signaling is well known, but th

196 choice point pathway as an antagonist of the RPTP Dlar.

197 rst natural ligand identified for any of the RPTP family; its identification provides a unique tool t

198 It is a member of the RPTP R2B subfamily, which includes PTPkappa, PTPmu and P

199 lete understanding of the involvement of the RPTP subfamily in RTK tyrosyl dephosphorylation has not

200 Downregulation of Egfr signaling by the RPTPs is required for the construction of tubular lumens

201 Remarkably, deficiency in either of these RPTPs influenced neutrophil GPCR responses in unique way

202 retinal lamination, we examined whether this RPTP could be regulating cell adhesion and migration wit

203 Three RPTPs, known as DLAR, DPTP69D, and DPTP99A, have been ge

204 PTP-delta together with PTPRO, or all three RPTPs combined, had less severe phenotypes than embryos

205 F-beta stimulates Smad3 and Smad4 binding to RPTP-kappa gene promoter.

206 del to map the distribution of the truncated RPTP-kappa/beta-geo fusion protein in the adult mouse br

207 appa promoter, distribution of the truncated RPTP-kappa/beta-geo fusion protein should reflect the re

208 Here, we report that two RPTPs, CD45 and CD148, previously shown to share redunda

209 egional and cellular expression of wild-type RPTP-kappa, and thus may identify sites where RPTP-kappa

210 -proximal catalytic domain (D1) of a typical RPTP, murine RPTP alpha.

211 Vertebrate RPTPs are now implicated in controlling axon outgrowth,

212 PTP-kappa, and thus may identify sites where RPTP-kappa is important.

213 The first step to investigate whether RPTPs influence axon growth in the more complex vertebra

214 between EGFR and TGF-beta pathways, in which RPTP-kappa functions to integrate growth-promoting and g

215 hedgehog-responsive gene MIM cooperates with RPTP to induce cytoskeletal changes.