ライフサイエンスコーパス: RPTPbeta

1 RPTPbeta expression is largely restricted to the central

2 RPTPbeta is known to facilitate tumor cell adhesion and

3 RPTPbeta-deficient mice are viable, are fertile, and sho

4 RPTPbeta/zeta knockdown initiates EMT, promotes pleiotro

5 RPTPbeta/zeta plays a suppressor-like role in prostate c

6 nd to interact with both alpha(v)beta(3) and RPTPbeta/zeta.

7 of RPTPbeta promotes galectin-1 binding and RPTPbeta levels of retention on the cell surface.

8 Finally, in vivo studies showed that an anti-RPTPbeta immunotoxin (7E4B11-SAP) could significantly de

9 Others, such as RPTPbeta, might exert feedback control of the channel it

10 To assess RPTPbeta as a potential target for treatment of glioblas

11 receptor protein tyrosine phosphatase beta (RPTPbeta) and its catalytically inactive, secreted isofo

12 Receptor protein tyrosine phosphatase beta (RPTPbeta) expressed on the surface of glial cells binds

13 receptor protein tyrosine phosphatase beta (RPTPbeta) in regulating IGF-I signaling and cellular pro

14 receptor protein tyrosine phosphatase beta (RPTPbeta) is a functional biomarker for several solid tu

15 Receptor protein tyrosine phosphatase beta (RPTPbeta) is expressed as soluble and receptor forms wit

16 receptor protein tyrosine phosphatase beta (RPTPbeta), a potential glial receptor for contactin, blo

17 receptor protein-tyrosine phosphatase beta (RPTPbeta).

18 receptor protein tyrosine phosphatase beta (RPTPbeta)/phosphacan.

19 receptor protein tyrosine phosphatase-beta (RPTPbeta)].

20 Boosting RPTPbeta/zeta or attenuating Syndecan-3 signaling pathwa

21 IGFBP-2 bound RPTPbeta, which led to its dimerization and inactivation

22 f RPTPbeta/zeta at sites dephosphorylated by RPTPbeta/zeta in cells not stimulated by PTN.

23 in ALK no longer can be dephosphorylated by RPTPbeta/zeta; thus, autoactivation and tyrosine phospho

24 sodium channel signaling complex containing RPTPbeta, which acts to regulate sodium channel modulati

25 he protein and Ptn the gene) is a ligand for RPTPbeta/zeta; PTN inactivates RPTPbeta/zeta, leaving un

26 These results suggest that binding of glial RPTPbeta to the contactin/Nr-CAM complex is important fo

27 ever, conduction velocity was not altered in RPTPbeta-deficient mice.

28 his PTP, we have generated mice deficient in RPTPbeta.

29 he normal development of neurons and glia in RPTPbeta-deficient mice demonstrates that RPTPbeta funct

30 e of nerves of the central nervous system in RPTPbeta-deficient mice suggests a fragility of myelin.

31 a ligand for RPTPbeta/zeta; PTN inactivates RPTPbeta/zeta, leaving unchecked the continued endogenou

32 nT-Vb promotes its dimerization and inhibits RPTPbeta intrinsic phosphatase activity, resulting in hi

33 tion of the tyrosine phosphatase activity of RPTPbeta/zeta, the PTN/RPTPbeta/zeta signaling pathway c

34 The binding of RPTPbeta to the contactin-Caspr complex could provide a

35 in and the intracellular catalytic domain of RPTPbeta interacted with sodium channels.

36 lated by the associated catalytic domains of RPTPbeta.

37 s, DU145 and PC3, in which the expression of RPTPbeta/zeta or syndecan-3 was down-regulated by the RN

38 GnT-Vb-mediated glycosylation of RPTPbeta promotes galectin-1 binding and RPTPbeta levels

39 h the Src and Fak pathway, the inhibition of RPTPbeta/zeta expression increased pleiotrophin-mediated

40 has been proposed that the three isoforms of RPTPbeta play a role in regulation of neuronal migration

41 for these processes in vivo or that loss of RPTPbeta can be compensated for by other PTPs expressed

42 Importantly, the loss of RPTPbeta/zeta expression increased metastasis in nude mi

43 The loss of RPTPbeta/zeta expression initiated epithelial-to-mesench

44 ther, these results suggest that the loss of RPTPbeta/zeta may contribute to the metastasis of prosta

45 These results place GnT-Vb as a regulator of RPTPbeta signaling that influences cell-cell and cell-ma

46 ncrease phosphorylation of the substrates of RPTPbeta/zeta at sites dephosphorylated by RPTPbeta/zeta

47 osphorylation of the different substrates of RPTPbeta/zeta in PTN-stimulated cells alone is sufficien

48 tors, receptor protein tyrosine phosphatase (RPTPbeta/zeta), and syndecan-3 during tumor development,

49 In cells not stimulated by PTN, RPTPbeta/zeta dephosphorylates ALK at the site(s) in ALK

50 osphatase activity of RPTPbeta/zeta, the PTN/RPTPbeta/zeta signaling pathway coordinately regulates t

51 The data indicate that the PTN/RPTPbeta/zeta signaling pathway is a critical regulator

52 stimulated cells is mediated through the PTN/RPTPbeta/zeta signaling pathway.

53 Receptor PTPbeta (RPTPbeta; also known as PTPzeta) is expressed predominan

54 hosphatase cell-surface proteoglycan PTPzeta/RPTPbeta and support the hypothesis that the diverse bio

55 The role of pleiotrophin and its receptors RPTPbeta/zeta and Syndecan-3 during tumor metastasis rem

56 clonal antibodies that selectively recognize RPTPbeta and bind to the antigen with low nanomolar affi

57 ombinant extracellular domain of human short RPTPbeta was used to immunize mice and generate monoclon

58 We also demonstrate that RPTPbeta/zeta counterbalanced the pleiotrophin-mediated

59 in RPTPbeta-deficient mice demonstrates that RPTPbeta function is not necessary for these processes i

60 tro experiments, our study demonstrates that RPTPbeta is not essential for neurite outgrowth and node

61 Here, we show that RPTPbeta is expressed in a variety of solid tumor types

62 ing and phosphatase-dead mutants showed that RPTPbeta bound specifically to PTEN and dephosphorylated

63 obtained from IGFBP-2(-/-) mice showed that RPTPbeta was activated, and this was associated with inh

64 urface localization of NCL downstream of the RPTPbeta/zeta/c-Src signaling cascade and can be used as

65 ma and other cancers, antibodies directed to RPTPbeta have been developed and profiled in vitro and i

66 In contrast, when RPTPbeta/zeta is inactivated in PTN-stimulated cells, th

67 gagement of the contactin-Caspr complex with RPTPbeta may thus regulate cell-cell interactions contri

68 cocultures of Schwann cells and neurons with RPTPbeta-Fc, a soluble construct containing the carbonic

69 ptor protein-tyrosine phosphatase beta/zeta (RPTPbeta/zeta) and c-Src activation.

70 ptor protein-tyrosine phosphatase beta/zeta (RPTPbeta/zeta), and Apc(Min/-) cells demonstrated an ass

71 ptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta).