1 been shown to be effector targets for active
Ral GTPases.
2 lular actions of activated EGF receptors and
Ral-GTPases.
3 o Ras effector pathways cooperate to promote
Ral-GTPase activation.
4 t transduces growth factor signaling to both
Ral GTPase and Akt-mediated signaling cascades.
5 Here we investigated the roles of
Ral GTPases and their common effector exocyst complex in
6 interacts with the Ral signaling components,
Ral GTPase,
and the RalGDS family member Rlf.
7 Ral GTPases are critical effectors of Ras, yet the molec
8 Ral GTPases are important mediators of transformation, t
9 atodes and mammary tumor cells, we show that
Ral GTPases are involved in exosome biogenesis.
10 of the activities of Ras members identified
Ral GTPase as a key regulator during PMN activation and
11 irectly binds to exocyst component Sec5 in a
Ral GTPase-
dependent manner.
12 )-adrenergic receptors, activated c-Src by a
Ral-GTPase-
dependent mechanism.
13 ld-type geranylgeranylated proteins and that
Ral GTPases do not undergo alternative prenylation in re
14 alGDS, a Ras effector protein that activates
Ral GTPases,
has a second function that promotes Akt pho
15 Ral GTPases have been implicated as mediators of Ras-ind
16 Ral GTPases have been implicated in the regulation of a
17 To investigate
RAL GTPases in vivo, we generated null and conditional k
18 These results identify a role for
Ral-GTPases in the activation of c-Src by EGF receptors
19 redistribution of the GEFs to their target,
Ral-GTPases,
in the plasma membrane.
20 nt or expression of constitutively activated
Ral-GTPase led to tyrosine phosphorylation of Stat3 and
21 own a new post-translational modification of
Ral GTPases:
nondegradative ubiquitination.
22 Ral GTPases regulate exocyst-dependent vesicle trafficki
23 on vesicles and the plasma membrane and that
Ral GTPases regulate the assembly interface of a full oc
24 Therefore,
Ral GTPases represent new regulators of MVB formation an
25 These findings demonstrate a role for
Ral-GTPase signaling in the modulation of the readily re
26 Activities of both
Ral GTPases were mediated through the exocyst.
27 specifically catalyze the GTP loading of the
Ral GTPase when overexpressed in 293T cells.
28 n of 11 amino-terminal amino acids unique to
Ral GTPases,
which abolished the ability of RalA to prec
29 primary sequence to the Ras, Rap, R-Ras, and
Ral GTPases,
which regulate cell growth and differentiat