ライフサイエンスコーパス: Ran GTPase

1 in (a guanine nucleotide-exchange factor for Ran-GTPase).

2 guanine nucleotide exchange factor (GEF) for Ran GTPase.

3 s the mechanism of substrate displacement by Ran GTPase.

4 hat it was a CRM-1-dependent event driven by Ran GTPase.

5 RanGAP1 is the activating protein for the Ran GTPase.

6 y-dependent process, but may not involve the RAN GTPase.

7 o the guanine nucleotide exchange factor for Ran GTPase.

8 nsitive to the nucleotide-bound state of the Ran GTPase.

9 nd by a dominant-negative mutant form of the Ran GTPase.

10 lly interact with both the NES motif and the Ran GTPase.

11 o leptomycin B and nucleotide-bound state of Ran-GTPase.

12 tinal cyclophilin-related protein that binds Ran-GTPase.

13 d but clearly involves L binding to cellular Ran GTPase, a critical factor of active NCT.

14 Without Ran GTPase, a critical regulator of transport directiona

15 us (EMCV) binds and inhibits the activity of Ran-GTPase, a key regulator of nucleocytoplasmic transpo

16 The Ran GTPase activating protein (RanGAP) is important to R

17 GTP.RBH complex stimulated GTP hydrolysis by Ran GTPase activating protein 1 both in vitro and in per

18 dissociation by RanBP1 and GTP hydrolysis by Ran GTPase activating protein 1.

19 The cytoplasmic Ran GTPase activating protein RanGAP is critical to esta

20 at resides on chromatin, and the cytoplasmic Ran GTPase activating protein RanGAP.

21 for distortion, encodes a truncated RanGAP (Ran GTPase activating protein), a key nuclear transport

22 r import were used together with cytoplasmic Ran GTPase-activating factors to demonstrate that import

23 DP, established by the spatial separation of Ran GTPase-activating protein (RanGAP) and the Ran guani

24 However, injection of Ran GTPase-activating protein (RanGAP) into RCC1-deplete

25 -purification strategy, we have identified a Ran GTPase-activating protein (RanGAP2) as an Rx-interac

26 (gsp1), and essential Ran regulatory factors Ran GTPase-activating protein (rna1), Ran guanine nucleo

27 Cdc25C (Chk1, Chk2, and H2AX), as well as on Ran GTPase-activating protein 1 conjugated to small ubiq

28 sentrin-2 could covalently modify RanGAP1, a Ran GTPase-activating protein critically involved in nuc

29 GDP enabled by the specific locations of the Ran GTPase-activating protein RanGAP and the nucleotide

30 sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide

31 We have found that the mammalian Ran GTPase-activating protein RanGAP1 is highly concentr

32 Covalent modification of the Ran GTPase-activating protein RanGAP1 with the ubiquitin

33 if at all, to a major SUMO-1 substrate, the Ran GTPase-activating protein RanGAP1.

34 s been characterized as a coactivator of the Ran GTPase-activating protein RanGAP1.

35 is not stimulated to hydrolyze bound GTP by Ran GTPase-activating protein, RanGAP1.

36 n vitro, this interaction can accelerate the Ran GTPase-activating protein-mediated hydrolysis of GTP

37 ulator of the Ran GTP/GDP cycle is the 70-kD Ran-GTPase-activating protein RanGAP1.

38 not identical to Fug1/RanGAP1, the mammalian Ran-GTPase-activating protein.

39 plasm where it is disassembled by RanBP1 and Ran GTPase--activating protein.

40 This trafficking was dependent on the high Ran GTPase activity resulting from oncogenic transformat

41 ng nuclear localization signals requires the Ran GTPase and a complex of proteins assembled at the nu

42 the nuclear/cytoplasmic concentration of the Ran GTPase and inhibits the nuclear localization of Ubc9

43 ast in part, through reduced function of the Ran GTPase and SUMOylation pathways.

44 been defined by their ability to bind to the Ran GTPase and the presence of a common region of approx

45 Importin-11 interacts with the Ran GTPase, and constitutively shuttles between the nucl

46 ntrosome independent, operates downstream of Ran GTPase, and depends upon BRCA1/BARD1 E3 ubiquitin li

47 plore the relationship between progerin, the Ran GTPase, and oxidative stress.

48 Red/green opsin, Ran-GTPase, and the 19 S regulatory complex of the prote

49 uclear protein import pathway, including the Ran-GTPase, and the dimeric import receptor, importin-al

50 Our previous work identified the Ran GTPase as an essential component in this process.

51 Ribosome export is dependent on the Ran-GTPase as mutations in Ran or its regulators caused

52 Maintaining the Ran GTPase at a proper concentration in the nucleus is i

53 to the nucleus of 10-20% of the cytoplasmic Ran GTPase-binding protein (RanBP1) indicating that RanB

54 We identified a region in the human Ran GTPase-binding protein RanBP1 that shares similariti

55 shows that plants contain Rab, Rho, Arf, and Ran GTPases, but no Ras GTPases.

56 We posit that the control of Ran GTPase by Ranbp2 emerges as a novel therapeutic targ

57 the C9-isoforms with both Importin beta1 and Ran-GTPase, components of the nuclear pore complex.

58 The Ran GTPase controls multiple cellular processes includin

59 rt through the NPC can be uncoupled from the Ran GTPase cycle and can occur without GTP hydrolysis.

60 karyopherin-alpha, karyopherin-beta1 and the Ran GTPase cycle are required for INM targeting, undersc

61 we suggest that Yrb2p may play a role in the Ran GTPase cycle distinct from nuclear transport.

62 Here, we report the first evidence that the Ran GTPase cycle is required for nuclear pore complex (N

63 TPase Ran, and it has been proposed that the Ran GTPase cycle mediates translocation.

64 otein-1 (RanBP1), a known coregulator of the Ran GTPase cycle.

65 import is dependent on the integrity of the Ran GTPase cycle.

66 control of the Ras-related nuclear protein (Ran) GTPase cycle depends on the regulated activity of r

67 The Ran GTPase drives nucleocytoplasmic transport, stabilize

68 Overexpression of Ran or RanGEF (Ran GTPase exchange factor) in the male germline fully s

69 Ran GTPase has been shown to be involved in host innate

70 al. (2014) describe how microtubules and the RAN GTPase/importin-beta system collaborate to control t

71 s been identified as an important target for Ran GTPase in spindle formation in fission yeast.

72 L segment that makes subsequent contact with Ran GTPase in the nucleus, and Ran can displace 2A from

73 ttles between the cytoplasm and nucleus in a Ran GTPase-independent manner.

74 We also found that the Ran GTPase is not required for GR export.

75 The Ran GTPase is required for nuclear assembly, nuclear tra

76 Ran GTPase is required for nucleocytoplasmic transport o

77 n guanine-nucleotide exchange factor for the Ran GTPase, is an approximately 45-kD nuclear protein th

78 In a proteomics screen, we identified RAN GTPase, MST1 and 2 kinases, and alpha- and gamma-tub

79 d microtubule formation system that uses the Ran-GTPase nuclear transport machinery, but no targets o

80 Similarly, the Ran GTPase pathway is also involved in the nuclear trans

81 Analysis of the Ran-GTPase pathway in Xenopus extracts allows the examin

82 The Ran GTPase plays a central role in nucleocytoplasmic tra

83 The Ran GTPase plays a critical role in this process, becaus

84 Ran GTPase plays essential roles in multiple cellular pr

85 ith an expression vector for OPN to identify RAN GTPase (RAN) as the most overexpressed gene, in addi

86 ween docking and translocation mediated by a Ran GTPase-Ran binding protein complex.

87 se (DDR) and the cell cycle depends on their Ran GTPase-regulated nuclear-cytoplasmic transport (NCT)

88 nbp2(-/-) share proteostatic deregulation of Ran GTPase, serotransferrin, and gamma-tubulin and suppr

89 uclear pore complex and interaction with the Ran-GTPase support also its role in nucleocytoplasmic tr

90 ific changes in the nuclear pore complex and Ran GTPase system in lower eukaryotes.

91 lation of RanBP3, an accessory factor in the Ran GTPase system.

92 in order to unravel the complexities of the Ran GTPase system.

93 ic compartmentalization of components of the Ran GTPase system.

94 protein and RNA in eukaryotes depends on the Ran-GTPase system to regulate cargo-receptor interaction

95 rm1, a nuclear export receptor that binds to Ran GTPase, thereby inducing nuclear localization of NF-

96 s that interact with the GTP-charged form of Ran GTPase through a conserved Ran-binding domain (RBD).

97 se, Nek6, and also binds specifically to the Ran GTPase through both its catalytic and its RCC1-like

98 oplasmic trafficking, a process regulated by Ran GTPase through its nucleotide cycle.

99 , we show that importin beta cooperates with Ran GTPase to promote ubiquitination and proteasomal deg

100 e mechanisms of Ran function, mutants of the Ran GTPase were characterized, several of which are capa

101 The recently solved structures of the Ran GTPase with a Ran-binding domain and with karyopheri

102 We illustrate this here for Ran GTPases, within which two highly conserved histidine