ライフサイエンスコーパス: Ranvier

1 Moreover, internode length decreased and Ranvier node diameter increased progressively along the

2 nlagen - a region encompassing the groove of Ranvier - caused ectopic cartilage formation.

3 the perichondrial structures (ie, groove of Ranvier and bone bark), metaphyseal undulation, and cort

4 he fetal period, the perichondrial groove of Ranvier and the bone bark were easily identifiable at MR

5 ressing cells in the perichondrial groove of Ranvier that display markers and functional properties c

6 in progenitor cells including the groove of Ranvier.

7 ts are in the vicinity of ankyrin 3, node of Ranvier (ANK3) and polybromo-1 (PBRM1).

8 ium channels (Nav) at the developing node of Ranvier and can restore electrophysiological function in

9 On axonal surfaces that flank the node of Ranvier and in overlying glial paranodal loops, proteins

10 icate that the ultrastructure of the node of Ranvier and paranode is intact in Mtmr13-deficient nerve

11 Detailed structures of the node of Ranvier and Schmidt-Lanterman incisure are resolved.

12 voltage-gated sodium channels at the node of Ranvier and Shaker-type potassium channel (Kv1.2) at the

13 nderstanding of the structure of the node of Ranvier and surrounding apparatus.

14 tiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane

15 hat OMgp does not participate in CNS node of Ranvier assembly or maintenance.

16 the paranodes on either side of the node of Ranvier at a rate consistent with diffusion through an e

17 The node of Ranvier complex is an elaborate organization of membrane

18 gliomedin and enhances clustering of node of Ranvier components.

19 zed elevation in axonal calcium at a node of Ranvier during action potentials, and showed that this c

20 is study support the hypotheses that node of Ranvier formation begins with the onset of myelination a

21 We chose to study myelination and node of Ranvier formation in the hypomyelinating mouse mutant cl

22 Sodium channel clustering and node of Ranvier frequency were studied in whole-mount sciatic ne

23 ssium ion channel dysfunction at the node of Ranvier has been implicated.

24 ved in Na+ channel clustering at the node of Ranvier have been investigated during early development.

25 ponsible for formation of the mature node of Ranvier in the CNS.

26 highly polarized localization at the node of Ranvier in the developing rat sciatic nerve.

27 can, is a molecular component of the node of Ranvier in the peripheral nervous system.

28 The node of Ranvier is a complex macromolecular assembly of ion chan

29 The node of Ranvier is a distinct domain of myelinated axons that is

30 The node of Ranvier is a functionally important site on the myelinat

31 The node of Ranvier is a tiny segment of a myelinated fiber with var

32 This suggests that the node of Ranvier is relatively resistant to acute antiganglioside

33 zed in the axon, and assembly of the node of Ranvier is significantly delayed.

34 Recently, we demonstrated that the node of Ranvier is the primary site of the immune attack in pati

35 n, paranodal defects, and changes in node of Ranvier number and structure).

36 ubtype to be localized either at the node of Ranvier or to a dendrite.

37 The mechanisms that govern node of Ranvier organization, stability, and long-term maintenan

38 nction: the morphology and length of node of Ranvier segments and adjacent paranodal segments.

39 s of Ca(2+) channels decorate future node of Ranvier sites.

40 +) homeostasis, axonal growth, (para)node of Ranvier stability and synaptic transmission.

41 manner, to recruit mitochondria to a node of Ranvier to match metabolic needs.

42 s to non-compact myelin flanking the node of Ranvier where it is required for paranodal axo-glial adh

43 s underlying the degeneration of the node of Ranvier, a characteristic aberration of type 1 diabetic

44 ie the slow potassium current at the node of Ranvier, I(Ks).

45 ated by a computer model of a single node of Ranvier, in which the variability arose because of the s

46 ane domains in myelinated nerve, the node of Ranvier, the paranode, and the myelinated internodal reg

47 lidated and applied to a generalized node of Ranvier, where numerical results for computed action pot

48 ined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch

49 juxtaparanodal regions flanking the node of Ranvier.

50 y of a critical neuronal domain, the node of Ranvier.

51 can orchestrate the formation of the node of Ranvier.

52 ential for proper development of the node of Ranvier.

53 functions in the assembly of the CNS node of Ranvier.

54 may be important in formation of the node of Ranvier.

55 the axonal membrane to demarcate the node of Ranvier.

56 the axonal initial segment (AIS) and node of Ranvier.

57 he soma/initial segment or the first node of Ranvier.

58 acrophages to invade the axon at the node of Ranvier.

59 bserved in the perinodal glia of the Node of Ranvier.

60 in distribution in the region of the node of Ranvier.

61 cts and abnormal organization of the node of Ranvier.

62 imely coalescence to form the mature node of Ranvier.

63 chlear nerve fibers, near the first nodes of Ranvier (D2) and in the inner spiral bundle region (D1 a

64 conduction and abnormalities at the nodes of Ranvier (NOR) interface where myelin and axons interact.

65 at axon initial segments (AISs) and nodes of Ranvier (NR).

66 the AIS and normal morphogenesis of nodes of Ranvier all require a heretofore uncharacterized alterna

67 a(v)1.6 is heavily expressed at the nodes of Ranvier along adult CNS and PNS axons and along unmyelin

68 that betaIV spectrin recruitment to nodes of Ranvier also depends on binding to ankG.

69 axon diameter and distances between Nodes of Ranvier also influence signal propagation times along an

70 membranous localization of Ank-G at nodes of Ranvier and AIS.

71 These domains include nodes of Ranvier and axon initial segments.

72 nctional domains of axons (e.g. the nodes of Ranvier and axon terminals) whose development depends on

73 elin around host axons and restored nodes of Ranvier and conduction velocity as efficiently as CNS-de

74 resent within the axolemma at early nodes of Ranvier and deleterious mutations of the alpha(1A) subun

75 se into a desheathed nerve, bind to nodes of Ranvier and fix complement in vitro without resulting in

76 th SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-t

77 rucial role in the formation of the nodes of Ranvier and in the rapid propagation of the nerve impuls

78 and K(+) channels are clustered at nodes of Ranvier and mediate the transmembrane currents necessary

79 vo, and progressive accumulation at nodes of Ranvier and paranodes during postnatal mouse development

80 odes and incisures of control mice, nodes of Ranvier and paranodes were unaffected in Pals1-deficient

81 with betaIV and betaII spectrin at nodes of Ranvier and paranodes, respectively, but that loss of al

82 ral organization of proteins at the nodes of Ranvier and pave the way for deeper investigations of th

83 osed between sodium channels at the nodes of Ranvier and potassium channels in the juxtaparanodal reg

84 he initial segment, and near/within nodes of Ranvier and presynaptic terminals, dendritic KChs found

85 atrix (ECM) protein surrounding CNS nodes of Ranvier and proposed to function as (1) an inhibitor of

86 ural and biochemical alterations at nodes of Ranvier and reduced somatosensory-evoked potentials.

87 These patterns highlight nodes of Ranvier and Schmidt-Lanterman incisures and can be used

88 their processes are in contact with nodes of Ranvier and synapses, suggesting a regulatory role at th

89 he clustering of sodium channels at nodes of Ranvier and the AIS.

90 At the nodes of Ranvier and the axon hillocks of central neurons, VGSCs

91 7.3, which are instead localized to nodes of Ranvier and the cell bodies of large sensory neurons.

92 These domains include the nodes of Ranvier and the flanking paranodal regions where glial c

93 s the development and maturation of nodes of Ranvier and the restoration of impulse conduction in cen

94 tectural rearrangements such as the nodes of Ranvier and their associated molecular domains.

95 , we show that AOE elongates the AN nodes of Ranvier and triggers notable perinodal morphological cha

96 equired for assembly of the AIS and nodes of Ranvier and was a transformative innovation in evolution

97 gated ion channel clustering at the nodes of Ranvier are essential for the rapid saltatory conduction

98 The nodes of Ranvier are essential regions for action potential condu

99 Nodes of Ranvier are excitable regions of axonal membranes highly

100 natal day 5, during the period that nodes of Ranvier are forming.

101 Axonal initial segments (IS) and nodes of Ranvier are functionally important membrane subdomains i

102 Nodes of Ranvier are regularly placed, nonmyelinated axon segment

103 at axon initial segments (AISs) and nodes of Ranvier are required for initiation, propagation, and mo

104 Axon initial segments (AISs) and nodes of Ranvier are sites of action potential generation and pro

105 Axon initial segments (AISs) and nodes of Ranvier are sites of clustering of voltage-gated sodium

106 Nodes of Ranvier are specialized, highly polarized axonal domains

107 ndent manner.SIGNIFICANCE STATEMENT Nodes of Ranvier are the myelin-free gaps along myelinated axons

108 The axon initial segment (AIS) and nodes of Ranvier are the sites of action potential initiation and

109 tic tree-like arbors with excitable nodes of Ranvier at peripheral and branching nodes and exhibit no

110 ct sodium channel clustering at the nodes of Ranvier but alters the location of the Shaker-type Kv1.1

111 rom WAVE1-/- mice, there were fewer nodes of Ranvier but nodal morphology was normal, implicating a d

112 ated with the presence of malformed nodes of Ranvier characterized by an accumulation of axoplasmic v

113 elpful for high-frequency firing at nodes of Ranvier compared to Nav1.2.

114 , Nav1.6, and the Kv7.3 channels in nodes of Ranvier either dissolved or extended into the paranodal

115 dal junctional components, immature nodes of Ranvier form normally, but rapidly destabilize in their

116 contactin and Na(+) channels at new nodes of Ranvier forming during remyelination.

117 gM (immunoglobulin M) deposition at nodes of Ranvier from 5.3+/-3.1% to 28.7+/-8.4% (mean+/-SEM) of d

118 disrupts the targeting of beta2 to nodes of Ranvier in a myelinating co-culture system and to the ax

119 tage-gated sodium channels (Nav) at nodes of Ranvier in a nodal complex.

120 stal axon initial segment (AIS) and nodes of Ranvier in a ratio of approximately 40 to 1.

121 and may include dysfunctions at the nodes of Ranvier in a subgroup of patients.

122 Nav 1.6 is selectively expressed at nodes of Ranvier in both the CNS and the PNS.

123 xons in MS, with Nav1.6 confined to nodes of Ranvier in controls but with diffuse distribution of Nav

124 a pumps, mitochondrial motility) at nodes of Ranvier in frog during normal nerve activity.

125 show both in vivo and ex vivo, that nodes of Ranvier in intramuscular motor nerve bundles are also ta

126 channels are highly concentrated at nodes of Ranvier in myelinated axons and play a key role in promo

127 the major sodium channel isoform at nodes of Ranvier in myelinated axons and, additionally, is distri

128 e sensitive to the distance between nodes of Ranvier in myelinated axons have implications for nervou

129 ensity in axon initial segments and nodes of Ranvier in myelinated axons.

130 ons, but are highly concentrated at nodes of Ranvier in myelinated axons.

131 Axoglial junctions flank the nodes of Ranvier in myelinated nerves.

132 rs voltage-gated sodium channels at nodes of Ranvier in myelinated nerves: here, we investigate its r

133 colocalizes with Na(v)1.6 at mature nodes of Ranvier in myelinated sensory fibers in the dorsal root

134 oteins to axon initial segments and nodes of Ranvier in neurons, and betaIV-spectrin dysfunction unde

135 d more myelinated axons with intact nodes of Ranvier in oestrogen receptor beta ligand-treated mice.

136 is study, developmental analysis of nodes of Ranvier in optic nerve axons reveals that early node int

137 Nr-CAM are localized at developing nodes of Ranvier in peripheral myelinated axons prior to clusteri

138 Nodes of Ranvier in peripheral nerve and in the spinal cord were

139 assium (Kv1.1, 1.5) channels at the nodes of Ranvier in peripheral nerves from human, rat and dystrop

140 d/or maintenance of myelination and nodes of Ranvier in sciatic nerve.

141 ents that have been reported at the nodes of Ranvier in sensory versus motor axons.

142 Nodes of Ranvier in the axons of myelinated neurons are exemplars

143 The absence of FHFs from Navs at nodes of Ranvier in the central nervous system suggests a similar

144 chanisms of channel localization at nodes of Ranvier in the CNS during development in both normal and

145 Here, we show that the assembly of nodes of Ranvier in the CNS involves three mechanisms: a glia-der

146 that Kv3.1b subunits are present at nodes of Ranvier in the CNS of both rats and mice.

147 express myelin proteins and reform nodes of Ranvier in the context of chronic demyelination in the a

148 Na(+) channel clustering at nodes of Ranvier in the developing rat optic nerve was analyzed t

149 uences Na(+) channel distributions, nodes of Ranvier in the hypomyelinating mouse Shiverer were exami

150 Nerve impulses are propagated at nodes of Ranvier in the myelinated nerves of vertebrates.

151 f NG2 cells and astrocytes with the nodes of Ranvier in the optic nerve, corpus callosum, and spinal

152 ed the development of heminodes and nodes of Ranvier in the peripheral axons of type I ANFs in the ra

153 These results demonstrate that nodes of Ranvier in the peripheral nervous system form in contact

154 ed by high-frequency firing, and at nodes of Ranvier in the PNS and some nodes in the CNS.

155 aIV spectrin is concentrated at the nodes of Ranvier in the rat sciatic nerve.

156 and that the number and location of nodes of Ranvier in the sciatic nerve are determined by myelinati

157 cle fusion, in the formation of the nodes of Ranvier in the vertebrate nervous system.

158 Sixty-two percent of all nodes of Ranvier in this region were flanked by at least one para

159 r the low level of Na(v)1.6-S21P at nodes of Ranvier in vivo and at the surface of transfected cells.

160 NG2(+) cells form associations with nodes of Ranvier in white matter, measurements of conduction velo

161 Clustering of Na(+) channels at the nodes of Ranvier is coordinated by myelinating glia.

162 the axon initial segment (AIS) and nodes of Ranvier is essential for the initiation and propagation

163 rrier important for assembly of the nodes of Ranvier is found at the paranodal junction.

164 A high density of Na(+) channels at nodes of Ranvier is necessary for rapid and efficient action pote

165 ge-gated sodium (Na(v)) channels at nodes of Ranvier is paramount for action potential propagation al

166 are slowed and the number of mature nodes of Ranvier is reduced, but Na(v)1.6, contactin, caspr 1, an

167 her continued axon-glial contact at nodes of Ranvier is required to maintain these channels at the no

168 their association with pathology of nodes of Ranvier is unclear.

169 mote the reestablishment of AIS and nodes of Ranvier is unknown.

170 emble the axon initial segments and nodes of Ranvier necessary for rapid and efficient action potenti

171 Na(v)1.6 is highly concentrated at nodes of Ranvier of both sensory and motor axons in the periphera

172 ponent of axon initial segments and nodes of Ranvier of mature axons in peripheral and central nervou

173 d against axon initial segments and nodes of Ranvier of myelinated axons, including the axons of moto

174 density at juxtaparanodes flanking nodes of Ranvier of myelinated axons.

175 the predominant isoform present at nodes of Ranvier of myelinated fibres.

176 tex or cerebellum or at optic nerve nodes of Ranvier of Scn1b(W/W) mice.

177 12 glial and axonal proteins at the nodes of Ranvier of teased sciatic nerve fibers.

178 d peripheral nerve fibers, and that nodes of Ranvier of these axons display proper sodium channel org

179 nn cells can establish and maintain nodes of Ranvier on central axons for over one year, and that the

180 then persists almost exclusively at nodes of Ranvier on myelinated axons.

181 ensity at axon initial segments and nodes of Ranvier or in regulating the activity of immobilized sod

182 to discrete axonal subdomains (i.e. nodes of Ranvier or presynaptic terminals) are poorly understood,

183 igh densities of sodium channels at nodes of Ranvier permit action potential conduction and depend on

184 uronal neurofascin; however, Nav at nodes of Ranvier persist, albeit with approximately 40% reduction

185 sensitive sodium channels at axonal nodes of Ranvier play a significant role in the secondary injury

186 CK2 at the axon initial segment and nodes of Ranvier provides a mechanism to regulate the specific ac

187 tics between human, rat, and bovine nodes of Ranvier suggests an essential role for this defined chan

188 s also important for organizing the nodes of Ranvier that occupy the gaps in the insulation.

189 ial for Na(+) channel clustering at nodes of Ranvier to facilitate fast and efficient action potentia

190 NF in clustering of Na+ channels at nodes of Ranvier via interactions with receptors on Schwann cells

191 paranodal loops, and the density of nodes of Ranvier was reduced, relative to control mice.

192 inated by the transplanted OECs and nodes of Ranvier were formed.

193 ization of Na(v)1.6 channels in the nodes of Ranvier were unchanged.

194 ity of Na(v)1.6 at the newly formed nodes of Ranvier which were flanked by paranodal Caspr staining.

195 beta1 subunits localize to nodes of Ranvier with neurofascin in sciatic nerve axons, and bet

196 P depolarizing wave invades initial nodes of Ranvier within a fraction of a millisecond and propagate

197 that NG2-positive processes contact nodes of Ranvier within the nodal gap at the location of nodal Na

198 ee and ten myelinated segments (2-9 nodes of Ranvier).

199 olved in axo-glial communication at nodes of Ranvier, and are required for normal action potential co

200 oncentrated in myelinated fibers at nodes of Ranvier, and NF155, the oligodendrocyte-specific isoform

201 ankyrinG at axon initial segments, nodes of Ranvier, and postsynaptic folds of the mammalian neuromu

202 ls are clustered at high density at nodes of Ranvier, and Shaker-type K+ channels are sequestered in

203 we observed minimal AGAb uptake at nodes of Ranvier, and this structure thus remained vulnerable to

204 ized to the paranodal region of the nodes of Ranvier, between axons and Schwann cells.

205 t and becomes clustered at immature nodes of Ranvier, but as myelination proceeds, Na(v)1.6 replaces

206 e population do not accumulate near Nodes of Ranvier, but continue to travel anterogradely.

207 onents of axon initial segments and nodes of Ranvier, colocalizing with ankyrin-G and voltage-depende

208 are associated closely with nascent nodes of Ranvier, identified by clusters of ankyrin G.

209 types are sequentially expressed at nodes of Ranvier, indicating an unexpected regulation in the comp

210 of axon initial segments (AISs) and nodes of Ranvier, it is difficult to uncouple their roles in main

211 While staining was observed at the nodes of Ranvier, it was not restricted to these locations.

212 ated but show structural defects at nodes of Ranvier, leading to delayed propagation of action potent

213 At nodes of Ranvier, Na+ channel clustering occurred very early (pos

214 These include nodes of Ranvier, paranodal axoglial junctions and juxtaparanodes

215 of voltage-gated sodium channels at nodes of Ranvier, possibly by mediating trans interactions betwee

216 to neurofascin selectively targeted nodes of Ranvier, resulting in deposition of complement, axonal i

217 Of particular importance are the nodes of Ranvier, sites of voltage-gated sodium channel clusterin

218 resulting in delayed maturation of nodes of Ranvier, slowed nerve conduction velocity, reduced muscl

219 r2 also resulted in widening of the nodes of Ranvier, suggesting that Caspr2 (which is present at par

220 chondrial function is high, such as nodes of Ranvier, synapses, and active growth cones.

221 At the axon initial segment and nodes of Ranvier, where nerve impulses are generated and propagat

222 hannels within the axon membrane at nodes of Ranvier, where their presence supports saltatory conduct

223 at axon initial segments (AISs) and nodes of Ranvier, where they are necessary for generation and pro

224 ricted to axon initial segments and nodes of Ranvier, where they are responsible for initiating and p

225 are clustered in high densities at nodes of Ranvier, while K(+) channels are found in juxtaparanodal

226 of glial cell insertions at central nodes of Ranvier.

227 esenting IgG reactivity against the nodes of Ranvier.

228 son to the extensive injury seen at nodes of Ranvier.

229 " on this property and clustered at nodes of Ranvier.

230 a crucial role in the formation of nodes of Ranvier.

231 sufficient for protein targeting to nodes of Ranvier.

232 ates are differentially targeted to nodes of Ranvier.

233 myelination and organization of the nodes of Ranvier.

234 Nfasc186 from the AIS but not from nodes of Ranvier.

235 ltered distribution of ezrin in the nodes of Ranvier.

236 at axon initial segments (AIS) and nodes of Ranvier.

237 ndogenous and exogenous NG2 at some nodes of Ranvier.

238 he clustering of neurofascin at the nodes of Ranvier.

239 ricting its activity to the AIS and nodes of Ranvier.

240 its usual site of concentration at nodes of Ranvier.

241 of voltage-gated sodium channels at nodes of Ranvier.

242 ent to paranodal loops of myelin in nodes of Ranvier.

243 at axon initial segments (AIS) and nodes of Ranvier.

244 tability and disorganization of the nodes of Ranvier.

245 protein diffusion barriers flanking nodes of Ranvier.

246 ut the mechanisms that organize the nodes of Ranvier.

247 potassium channels (K(v)1.1) at the nodes of Ranvier.

248 ialized regions of the axon, termed nodes of Ranvier.

249 ate signaling for the maturation of nodes of Ranvier.

250 ation of sodium channel proteins at nodes of Ranvier.

251 bipolar cell body and at subsequent nodes of Ranvier.

252 s, ganglionic initial segments, and nodes of Ranvier.

253 at have internodes and well-defined nodes of Ranvier.

254 ifferentiation and formation of the nodes of Ranvier.

255 occur only at initial segments and nodes of Ranvier.

256 olarized domains that center around nodes of Ranvier.

257 ntials are thought to arise, and at nodes of Ranvier.

258 bute to sodium channel placement at nodes of Ranvier.

259 tion of sodium channel complexes at nodes of Ranvier.

260 ain sodium channel isoform at adult nodes of Ranvier.

261 t not all basal laminae, and (3) at nodes of Ranvier.

262 which subsequently associates with nodes of Ranvier.

263 role in sodium channel placement at nodes of Ranvier.

264 subcellular locations, such as the nodes of Ranvier.

265 plays a key role in the assembly of nodes of Ranvier.

266 d with Caspr, is present in central nodes of Ranvier.

267 n molecules at initial segments and nodes of Ranvier.

268 ted in the axon initial segment and nodes of Ranvier.

269 270-kD at axon initial segments and nodes of Ranvier.

270 elinated and reassemble new AIS and nodes of Ranvier.

271 s directed against the axolemma and nodes of Ranvier.

272 of disease-associated IgM positive nodes of Ranvier.

273 ctivity was absent at newly forming nodes of Ranvier.

274 axon proximal segments and possibly nodes of Ranvier.

275 at axon initial segments (AIS) and nodes of Ranvier.

276 elevates axoplasmic [C(2+)] around nodes of Ranvier.

277 of voltage-gated sodium channels at nodes of Ranvier.

278 resent in axon initial segments and nodes of Ranvier.

279 at axon initial segments (AIS) and nodes of Ranvier.

280 s accumulation of Na(+) channels at nodes of Ranvier.

281 ation of those channels at AISs and nodes of Ranvier.

282 the axon initial segment (AIS) and nodes of Ranvier.

283 important for the formation of the nodes of Ranvier.

284 ies but different molecules to form nodes of Ranvier.

285 kness, and molecular disruptions at nodes of Ranvier.

286 wrap axons tightly and had expanded nodes of Ranvier.

287 by influencing the spacing between nodes of Ranvier.

288 rm maintenance of Na(+) channels at nodes of Ranvier.

289 efore anchoring them to the AIS and nodes of Ranvier.

290 s in the axonal initial segment and nodes of Ranvier.

291 axons to cluster Na(+) channels at nodes of Ranvier.

292 substantial fraction of APs in its nodes of Ranvier.

293 equires Na(+) channel clustering at nodes of Ranvier.

294 lls with high concentrations at the nodes of Ranvier.

295 eath from Na(+) channels located at nodes of Ranvier.

296 splayed severe abnormalities at the nodes of Ranvier.

297 and targeting of components to PNS nodes of Ranvier.

298 s are also required for assembly of nodes of Ranvier.SIGNIFICANCE STATEMENT A periodic axonal cytoske

299 nating Schwann cells project to the nodes of Ranvier; their composition and physiologic function have

300 unexpected structural specializations in the Ranvier nodes and internodes of auditory brainstem axons