ライフサイエンスコーパス: Ras GTPase

1 ied that encode a palmitoyltransferase for a Ras GTPase.

2 1 also activates the functionally distinct R-Ras GTPase.

3 have in common the ability to interact with ras GTPase.

4 imited the ability of ExoS to ADP-ribosylate Ras GTPases.

5 ls, or the ability of ExoS to ADP-ribosylate Ras GTPases.

6 ucleotide exchange factors that activate the Ras GTPases.

7 ntain Rab, Rho, Arf, and Ran GTPases, but no Ras GTPases.

8 -promoting phorbol esters with activation of Ras GTPases.

9 fficiently than the oncogenic Ha-, K-, and N-Ras GTPases.

10 fically on Rho and not on the Rac, Cdc42, or Ras GTPases.

11 rovided a wealth of mechanistic insight into Ras GTPases.

12 ble to elicit the activation of both Ral and Ras GTPases.

13 ction and intermediate G proteins, including Ras GTPases.

14 y region retained activation by both Rho and Ras GTPases.

15 ic MAP kinase activation by constitutive p21(ras) GTPases.

16 discovery of a new downstream target for the Ras GTPases - a Nore1-Mst1 protein complex - reveals a m

17 pathway by controlling the ubiquitination of Ras GTPase-accelerating protein Ira2.

18 analysis reveals that Ubp3 interacts with a Ras GTPase-accelerating protein, Ira2, and regulates its

19 Ras GTPases act as "molecular switches", alternating bet

20 sential for signaling and contains a R-Ras/M-Ras GTPase activating protein (GAP) domain that is divid

21 Moreover, the synaptic Ras GTPase activating protein (GAP) SynGAP is selectivel

22 la mutation on the interaction of H-Ras with Ras GTPase activating protein (GAP), neurofibromin 1 (NF

23 ells while the phosphorylation/activation of Ras GTPase activating protein (Ras GAP) and mitogen acti

24 Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is

25 effect found in our previous studies of the Ras GTPase activating protein (RasGAP) and the elongatio

26 ras GTPase activating protein (rasGAP) is highly conserv

27 n (G125V) in the scat Rasa3 gene, encoding a Ras GTPase activating protein (RasGAP), and elucidate th

28 One key regulator of this cascade is the Nf1 Ras GTPase activating protein (RasGAP), which attenuates

29 SYNGAP1, a synaptic Ras GTPase activating protein, and SHANK3, a synaptic sc

30 f the neurofibromatosis type 1 (NF1) gene, a Ras GTPase activating protein.

31 th high levels of RAS-GTP had loss of NF1, a RAS GTPase activating protein.

32 In addition to the two Ras GTPase activating proteins (GAPs; p120- and NF1-GAP)

33 n of the effect of Ca2+ on Ras activity, and Ras GTPase activating-like protein (RASAL), which functi

34 The Ras-GTPase activating activity of p135 SynGAP is inhibit

35 ere we report that sphingosine can stimulate Ras-GTPase activating protein (GAP) activity in vitro, a

36 coded protein, neurofibromin, functions as a Ras-GTPase activating protein (GAP), nothing is known ab

37 Here, we report a novel synaptic Ras-GTPase activating protein (p135 SynGAP) that is a ma

38 ongly reduced by silencing expression of the Ras-GTPase activating protein (Ras-GAP) neurofibromin, a

39 coded protein, neurofibromin, functions as a Ras-GTPase activating protein (RasGAP).

40 emonstrates that the loss of DAB2IP, a novel Ras-GTPase activating protein frequently found in many c

41 SynGAP is a Ras-GTPase activating protein highly enriched at excitat

42 completely rescued by expression of the GAP (RAS-GTPase activating protein) domain of neurofibromin.

43 992 receptors were associated with more SOS, Ras-GTPase activating protein, phosphatidylinositol 3-ki

44 Here, we describe the isolation of a novel Ras-GTPase activating protein, SynGAP, that interacts wi

45 that members of the Ras network of proteins, Ras-GTPase activating protein-SH3-domain-binding protein

46 nositol 3'-kinase, phospholipase Cgamma, and Ras-GTPase activating protein.

47 in the cleavage of the SG-nucleating protein Ras-GTPase activating SH3 domain-binding protein (G3BP1)

48 in-dependent protein kinase II increases its Ras GTPase-activating activity by 70-95%.

49 GAP from the Rsu-1 transfectants showed less Ras GTPase-activating activity than GAP from control cel

50 However, a decrease in Ras GTPase-activating activity was detected in lysates o

51 Ras signalling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity.

52 The NF1-encoded protein neurofibromin is a Ras GTPase-activating protein (GAP) and can directly lim

53 t their effects via an intracellular R-Ras/M-Ras GTPase-activating protein (GAP) domain or by activat

54 ut not GAPex-5DeltaGAP, a mutant lacking the Ras GTPase-activating protein (GAP) domain.

55 One domain is homologous to Ras GTPase-activating protein (GAP) domains.

56 DAB2 interacting protein) is a member of the Ras GTPase-activating protein (GAP) family that has been

57 at Ras, through an effector-like function of Ras GTPase-activating protein (GAP) in neonatal cardiac

58 The Ras GTPase-activating protein (GAP) p120RasGAP inhibits

59 romoted Ras inactivator), a Ca(2+)-dependent Ras GTPase-activating protein (GAP) that switches off th

60 To distinguish between inhibition of Ras by Ras GTPase-activating protein (GAP) versus a potential e

61 kDa by SDS-PAGE and associates with the p120 ras GTPase-activating protein (GAP).

62 The mammalian Ras GTPase-activating protein (p120Ras-GAP) interacts wi

63 In the present study, we identified a novel Ras GTPase-activating protein (Ras-GAP) as an ASK1-inter

64 l abolished the association of PDGFalphar to Ras GTPase-activating protein (Ras-GAP), but it did not

65 The NF1-encoded protein is a Ras GTPase-activating protein (RasGAP) [2].

66 NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss driv

67 aptor Grb2-associated binder-1 (GAB1) on its RAS GTPase-activating protein (RASGAP) binding sites and

68 orylation of Dok-1, augmented recruitment of Ras GTPase-activating protein (RasGAP) by Dok-1, and inh

69 AP1 as a human protein related to a putative Ras GTPase-activating protein (RasGAP) from the fission

70 Specifically, we show that loss of the Ras GTPase-activating protein (RasGAP) gene DAB2IP induc

71 We have previously reported that Ras GTPase-activating protein (RasGAP) is involved in a

72 otifs in the C terminus and does not bind to Ras GTPase-activating protein (RasGAP) upon phosphorylat

73 p62(dok) associates with the Ras GTPase-activating protein (RasGAP), but only when p6

74 predicted, growth-related targets, including Ras GTPase-activating protein (RasGAP), cyclin-dependent

75 peptide derived from the N2 fragment of p120 Ras GTPase-activating protein (RasGAP), sensitizes tumor

76 Dok, a 62-kDa Ras GTPase-activating protein (rasGAP)-associated phosph

77 A 62-kDa Ras GTPase-activating protein (RasGAP)-associated protei

78 the process of Ras inactivation catalyzed by Ras GTPase-activating protein (RasGAP).

79 docking platform for the SH2 domains of the Ras GTPase-activating protein (RasGAP).

80 otein (CREB) phosphorylation via RASA1 (p120 Ras GTPase-activating protein 1) down-regulation, wherea

81 al known properties and functions, including Ras GTPase-activating protein activity, adenylyl cyclase

82 d Ras on the plasma membrane by means of the Ras GTPase-activating protein CAPRI.

83 Elimination of Ras GTPase-activating protein enhanced E-CD4 but decreas

84 (AIP1), a recently identified member of the Ras GTPase-activating protein family, is highly expresse

85 synGAP is a neuron-specific Ras GTPase-activating protein found in high concentratio

86 novel GTPase-activating protein containing a Ras GTPase-activating protein homology domain (N terminu

87 mutations in the NF1 gene, which encodes the RAS GTPase-activating protein neurofibromin.

88 Yeast 2-hybrid analyses identified the Ras GTPase-activating protein Rasa1, a known regulator o

89 tors (HERs), induced expression of G3BP, the Ras GTPase-activating protein SH3 domain-binding protein

90 to citron, p135 SynGAP, an abundant synaptic Ras GTPase-activating protein that can bind to all three

91 RASA1 (also known as p120 RasGAP) is a Ras GTPase-activating protein that functions as a regula

92 SynGAP is a brain-specific ras GTPase-activating protein that is an abundant compon

93 e we report the characterisation of RASAL, a Ras GTPase-activating protein that senses the frequency

94 Ras GTPase-activating protein was found to be a caspase

95 RasGAP (Ras GTPase-activating protein) is a negative regulator a

96 ating protein (SynGAP) is a neuronal RasGAP (Ras GTPase-activating protein) that is selectively expre

97 gene product, neurofibromin, functions as a Ras GTPase-activating protein, and has been proposed to

98 F receptors including phospholipase C gamma, Ras GTPase-activating protein, and phosphotyrosine phosp

99 The NF1 gene encodes for neurofibromin, a RAS GTPase-activating protein, and thus negatively regul

100 calcium-promoted Ras inactivator (CAPRI), a Ras GTPase-activating protein, functions as an adaptor f

101 ity of, Bruton's tyrosine kinase (Btk) and a Ras GTPase-activating protein, Gap1m, in vitro and in vi

102 ith PLCgamma, phosphatidylinositol 3-kinase, Ras GTPase-activating protein, or protein tyrosine phosp

103 -back' mutants in which association with the Ras GTPase-activating protein, phosphatidylinositol 3-ki

104 as, suggesting that it may also compete with Ras GTPase-activating protein, thus contributing to the

105 hoprotein reported to bind the SH3 domain of Ras GTPase-activating protein.

106 that binds to the pleckstrin domain of p120 Ras GTPase-activating protein.

107 ppressor postulated to function in part as a Ras GTPase-activating protein.

108 directed against either pp60(src), RhoA, or Ras GTPase-activating protein.

109 the NF1 gene, which encodes neurofibromin, a RAS GTPase-activating protein.

110 One insertion was in the gene encoding Ras GTPase-activating protein; its overexpression phenot

111 GAP1(m) is a member of the GAP1 family of Ras GTPase-activating proteins (GAPs) [1].

112 he tyrosine phosphorylation of two important Ras GTPase-activating proteins (GAPs), p120 Ras-GAP and

113 ced wild-type TC21 activity in vivo and that Ras GTPase-activating proteins (GAPs; p120-GAP and NF1-G

114 However, it is unknown which Ras GTPase-activating proteins (RasGAPs) inactivate Ras

115 Ras GTPase-activating proteins (RasGAPs) inhibit signal

116 Rasal, belonging to the GAP1 subfamily of Ras GTPase-activating proteins (RasGAPs) with dual RasGA

117 an include functional alteration of GTPases, Ras GTPase-activating proteins, Ras guanine exchange fac

118 ed CAPRI and RASAL as related Ca2+-triggered Ras GTPase-activating proteins.

119 The Ras GTPase-activating-like protein IQGAP1 is a multimodu

120 we have isolated a novel human gene, RASAL (Ras GTPase-activating-like) and its murine ortholog, MRA

121 s that contains a 216-amino acid domain with Ras-GTPase-activating protein (Ras-GAP) activity.

122 we demonstrate that RASAL2, which encodes a RAS-GTPase-activating protein (RAS-GAP), is a functional

123 Finally, we showed that Carabin Ras-GTPase-activating protein domain and calcineurin-int

124 DAB2 interactive protein) is a member of the RAS-GTPase-activating protein family.

125 Ras-GRF mutant containing the PH domain from Ras-GTPase-activating protein in place of its own N-term

126 resis and identified by mass spectrometry as Ras-GTPase-activating protein SH3 domain-binding protein

127 teins (p85 (phosphoinositide 3-kinase), Vav, Ras-GTPase-activating protein SH3 domain-binding protein

128 Here, the Ras-GTPase-activating protein SH3 domain-binding protein

129 alyzed GTP hydrolysis in water, Ras, and Ras.Ras-GTPase-activating protein using quantum mechanics/mo

130 n as DAB2IP), a novel member of the Ras-GAP (Ras-GTPase-activating protein) protein family, opens its

131 Nf1, a tumor suppressor gene that encodes a Ras-GTPase-activating protein, results in hyperactivity

132 We discovered that DAB2IP, a novel Ras-GTPase-activating protein, was frequently epigenetic

133 xtracellular chemical gradients and position Ras GTPase activation and phosphatidylinositol (3,4,5)-t

134 NA maturation, and reveal a link between Rab/Ras GTPase activation and the process of pre-mRNA splici

135 stically, miR-132 regulated the mRNA for the Ras GTPase activator Rasa1, a novel target in neuronal f

136 ino acid substitutions that reduce intrinsic Ras GTPase activity and confer resistance to GTPase-acti

137 t keystone regulatory residue that modulates Ras GTPase activity and ensures unidirectionality to the

138 -GAP (RRFFLDIA) block NF1-GAP stimulation of Ras GTPase activity and Ras-mediated activation of mitog

139 romin is a tumor suppressor protein that has Ras GTPase activity, thus attenuating the MAPK (mitogen-

140 pe I transmembrane receptor with intrinsic R-Ras GTPase activity, which regulates cytoskeletal remode

141 This is because Ras-GTPase activity sets the intrinsic response threshol

142 Raf-1 is a direct effector of the Ras GTPase and is the initiating kinase in this signalli

143 We show that the Ras GTPase and Raf1 serine/threonine kinase are required

144 Mutations in Ras GTPase and various other components of the Ras signa

145 t frequently display activating mutations in Ras GTPases and activation of signal transducer and acti

146 e Raf protein kinases are major effectors of Ras GTPases and key components of the transcriptional re

147 While oncogenic Ras GTPases and R-Ras share extensive sequence homology,

148 exchange factor-like domain that binds both Ras GTPases and the scaffolding protein Cas.

149 e ability to stimulate Src tyrosine kinases, Ras-GTPases and transcriptional activation.

150 Ras GTPases are activated by RasGEFs and inactivated by

151 ng nontransformed fibroblasts, we found that Ras GTPases are dispensable for growth-factor-stimulated

152 Ras GTPases are frequently mutated in cancer and so far

153 Ras GTPases are on/off switches regulating numerous cell

154 Ras GTPases are signaling switches that control critical

155 Using this system, we activated Ras GTPase at distinct intracellular locations and induc

156 Ras GTPases become functionally active when anchored to

157 upts Cas binding to SHEP1 without inhibiting Ras GTPase binding.

158 al homology to p120(GAP).H-Ras suggests that Ras GTPases can bind to the plexin GAP region.

159 Signaling through Ras GTPases controls the activity of many transcription

160 The Ras-GTPase controls cell fate decisions through the bind

161 ctivity and ensures unidirectionality to the Ras GTPase cycle.

162 Ras GTPases cycle between inactive GDP-bound and active

163 Ras GTPases cycle between inactive GDP-bound and active

164 Ras GTPase cycles between its active GTP-bound form prom

165 Although members of the Ras GTPase family control cell growth, differentiation,

166 fferentiation, and transformation, including Ras GTPase family members, require the covalent attachme

167 ARL13B belongs to the Ras GTPase family, and in other species is required for

168 Lipid-anchored Ras GTPases form transient, spatially segregated nanoclu

169 Ras GTPases function as binary switches in signaling pat

170 Ras GTPases function as binary switches in the signaling

171 The Ras GTPases function as molecular switches, regulating a

172 e shown that homozygous deletion of Nf1, the Ras GTPase gene underlying human neurofibromatosis type

173 A subset of Ras GTPase genes linked to membrane remodeling were upre

174 Self-assembly of plasma membrane-associated Ras GTPases has major implications to the regulation of

175 Proteins of the rho subfamily of ras GTPases have been shown to be crucial components of

176 ctivity on RalA, Rap1A, and R-Ras but not Ha-Ras GTPases in cells.

177 l strain via substrate deformation activates Ras-GTPase, in particular the H-Ras isoform.

178 (Rabs are a family of Ras GTPases involved in membrane trafficking.) Both APPL

179 Regulated activation of the highly conserved Ras GTPase is a central event in the stimulation of cell

180 Ras GTPase is a molecular switch controlling a number of

181 RAS GTPase is a prototype for nucleotide-binding protein

182 Oncogenic mutations in the small Ras GTPases KRas, HRas, and NRas render the proteins con

183 The Ras GTPase links extracellular mitogens to intracellular

184 The Ras GTPase links extracellular signals to intracellular

185 Ras GTPase mediates several cellular signal transduction

186 endothelial cell apoptosis by attenuation of Ras GTPase methylation and activation and its downstream

187 Apart from the classic (H-, K-, and N-) Ras GTPases, only the R-Ras subfamily (R-Ras, R-Ras2/TC2

188 The Ras GTPase plays an essential role in many cellular sign

189 Rat sarcoma (Ras) GTPases regulate cell proliferation and survival th

190 These studies reveal that the Ras-GTPase regulator gefE is required for normal lineage

191 tantly activated by both RhoA and individual Ras GTPases resulting in diverse upstream control of sig

192 Ras GTPases signal by orchestrating a balance among seve

193 Activated RAS GTPase signalling is a critical driver of oncogenic

194 Members of the superfamily of Ras GTPase signalling proteins (monomeric G proteins) re

195 The proto-oncogene Ras GTPase stimulates transcription of p21Waf1/Cip1 (p21

196 n fusion and analyzed for protein stability, Ras GTPase stimulating activity, affinity for Ras-GTP, a

197 over, p120 N-terminal sequences enhanced the Ras GTPase-stimulating activity of the neurofibromin GAP

198 This identifies a second member of the Ras GTPase subfamily that can be ADP ribosylated by ExoS

199 it is one of the original members of a novel Ras GTPase subfamily that uses distinct effector pathway

200 rd Ras homologue enriched in brain (Rheb), a Ras GTPase superfamily member.

201 erence at Snowmass Village, Colorado, on the Ras GTPase superfamily provided testimony to the broad i

202 roteins constitute the largest branch of the Ras GTPase superfamily.

203 or synaptic plasticity, most notably in the Ras/GTPase superfamily, and in pathways that regulate cy

204 rminal hypervariable region (HVR) of Rho and Ras GTPases target these proteins to specific membrane c

205 y involved in the control of Ral, Rap, and R-Ras GTPases that may participate in the progression of b

206 colon cancers have a mutation in K-RAS or N-RAS, GTPases that operate as central hubs for multiple k

207 -state mechanisms, such as activation of the Ras GTPase, the diffusion-limited activation rate consta

208 by MRL proteins interact with both talin and Ras GTPases to activate integrins.

209 connect the membrane targeting sequences in Ras GTPases to talin, thereby recruiting talin to the pl

210 protein containing leucine-rich repeats and Ras/GTPase, tyrosine kinase-like, and WD40 domains.

211 ne nucleotide exchange factors that activate Ras GTPases, ultimately leading to MAPK activation and m

212 ism for regulating the activation of Rac and Ras GTPases via the actin cytoskeleton.

213 n the major signaling cascade, activation of Ras GTPase, we constructed fusions of Grb2, Shc, H-Ras,

214 nto the regulation of integrin activation by Ras GTPases, we created a series of H-Ras/R-Ras chimeras

215 e discovery that activating mutations of the Ras GTPase were associated with 30% or more of human can

216 Ras GTPases were long thought to function exclusively fr

217 e activation; activation of Rac1, cdc42, and Ras GTPases were not affected.

218 K-Ras4B belongs to the family of p21 Ras GTPases, which play an important role in cell prolif

219 The DIRAS2 gene is coding for a small Ras GTPase with so far unknown function.

220 M/lamellipodin (MRL) proteins link activated Ras-GTPases with actin regulatory Ena/VASP proteins to i