ライフサイエンスコーパス: Ras guanine nucleotide exchange factor

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1 , with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor.

2 g from PKC to Ras in a manner independent of Ras-guanine nucleotide exchange factor.

3 28-838 in Sos1 and 1057-1067 in Ras-GRF1) of Ras guanine nucleotide exchange factors.

4 via phosphotyrosine-dependent recruitment of Ras guanine nucleotide exchange factors.

5 We describe the identification of Ras guanine nucleotide exchange factor 1, Ras-GRF1, by m

6 c*Grb2 complex formation, and recruitment of Ras guanine nucleotide exchange factor activity.

7 naling cascades, we assessed whether a given Ras guanine nucleotide exchange factor could selectively

8 le Ras homologue by Ras-GRF/Cdc25Mm or other Ras guanine nucleotide exchange factors could potentiall

9 RasGRP1, a Ras guanine-nucleotide exchange factor, critically media

10 leotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors, designating it

11 SHEP1 also contains a domain similar to Ras guanine nucleotide exchange factor domains and binds

12 We observed that Ras guanine nucleotide exchange factors failed to activa

13 is thought to be regulated by signaling from Ras guanine nucleotide exchange factors (GEFs), through

14 vation of Ras appears to be independent of a Ras-guanine nucleotide exchange factors (GEFs).

15 rast, DN Ras17N, which functions by blocking Ras guanine nucleotide exchange factors, has been well c

16 Furthermore, Grap is associated with a Ras guanine nucleotide exchange factor mSos1, primarily

17 der): leucine-rich repeats, Ras, MEK kinase, Ras guanine nucleotide exchange factor N-terminal (RasGE

18 utations in SOS1, which encodes an essential RAS guanine nucleotide-exchange factor (RAS-GEF), in app

19 tains two Ras-associating (RA) domains and a Ras guanine nucleotide exchange factor (RasGEF) motif.

20 Two families of Ras guanine nucleotide exchange factors (RasGEFs), SOS a

21 periments showed that down-regulation of the Ras guanine nucleotide exchange factor RasGRP1 diminishe

22 ent activation of phospholipase Cgamma1, the Ras guanine nucleotide exchange factor RasGRP1 transloca

23 sociated with defective translocation of the Ras guanine nucleotide-exchange factor RasGRP1 to the pl

24 structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son

25 ignal-regulated protein kinase (ERK) and the Ras guanine nucleotide exchange factor, Son of sevenless

26 te MAPK cascades via an interaction with the Ras guanine nucleotide exchange factor SOS and with othe

27 ated serine/threonine phosphorylation of the Ras guanine nucleotide exchange factor Sos correlates wi

28 phosphorylated proteins associated with the Ras guanine nucleotide exchange factor Sos in FGF-stimul

29 with another adapter protein, Grb2, and the Ras guanine nucleotide exchange factor SOS.

30 now demonstrate that ITSN complexes with the Ras guanine nucleotide exchange factor Sos1 leading to i

31 First, we determined that Ras guanine nucleotide exchange factors (SOS1 and RasGRF

32 folds for the plasma membrane recruitment of Ras guanine nucleotide exchange factors, such as the Grb

33 RasGRP4 is a member of the RasGRP family of Ras guanine nucleotide exchange factors that may play a

34 kinase cascade by stimulating recruitment of Ras guanine nucleotide exchange factors to the plasma me

35 nits of Fc epsilon RI, Lyn, or Syk or of the Ras-guanine nucleotide exchange factor, Vav, was not sup

36 associates via its SH3 domains with Sos, the Ras guanine nucleotide exchange factor; with dynamin, a

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