ライフサイエンスコーパス: Ras-GRF

コーパス検索結果 (left1)

通し番号をクリックするとPubMedの該当ページを表示します

1 A Ras-GRF mutant containing the PH domain from Ras-GTPase-

2 escues defective LTP induction in adolescent Ras-GRF knockout mice, consists of NMDA glutamate recept

3 activation is reduced in the brains of adult Ras-GRF knockout mice and neuronal damage is enhanced.

4 fraction of cells is not sufficient to allow Ras-GRF activation by calcium.

5 d IQ domains function cooperatively to allow Ras-GRF activation.

6 dent calcium channels, an event that is also Ras-GRF-independent.

7 Sos and Ras-GRF are two families of guanine nucleotide exchange

8 e nucleotide exchange factors (GEFs) such as Ras-GRF; however, there is no Ca(2+)-dependent mechanism

9 tive activation of a single Ras homologue by Ras-GRF/Cdc25Mm or other Ras guanine nucleotide exchange

10 ains of Ras-GRF function together to connect Ras-GRF to multiple components in the particulate fracti

11 In contrast, Ras-GRF proteins are expressed primarily in central nerv

12 and the phosphorylation state of endogenous Ras-GRF.

13 Consistent with this function for Ras-GRFs and the known neuroprotective effect of CREB ac

14 against specific domains of hSOS1 and human Ras-GRF gene products.

15 Similar phenotypes are seen with mutant Ras-GRFs containing point mutations in either the PH or

16 In contrast, neither Ras-GRF protein influences synaptic plasticity in prepub

17 Moreover, the postnatal appearance of Ras-GRF-dependent LTP and LTD coincides with the emergen

18 is necessary for particulate association of Ras-GRF, it is not sufficient for targeting the core cat

19 -terminal PH, coiled-coil, and IQ domains of Ras-GRF function together to connect Ras-GRF to multiple

20 Remarkably, this form of Ras-GRF is constitutively activated.

21 H domain redistributes a large percentage of Ras-GRF from the particulate to the cytosolic fraction o

22 Here, using a set of Ras-GRF knock-out mice, we show that Ras-GRF2 contribute

23 ictate, at least in part, the specificity of Ras-GRF/CDC25Mm for Ha-Ras protein.

24 nding to an IQ domain near the N terminus of Ras-GRF.

25 chanism for Ras activation, mediated by p140 Ras-GRF.

26 shown that the neuronal exchange factor p140 Ras-GRF becomes activated in vivo in response to elevate

27 t mice; however, at this developmental stage Ras-GRF (guanine nucleotide-releasing factor) proteins a

28 and phosphorylation state of epitope-tagged Ras-GRF.

29 nimals NMDARs signal through Sos rather than Ras-GRF exchange factors, implying that Ras-GRFs endow N

30 We found that Ras-GRF/Cdc25Mm activates Ha-Ras, but does not activate

31 ippocampal-dependent behavior, implying that Ras-GRF proteins contribute to forms of synaptic plastic

32 than Ras-GRF exchange factors, implying that Ras-GRFs endow NMDARs with functions unique to mature ne

33 cotransfection of hm1 or hm2 receptors with Ras-GRF conferred carbachol-dependent increases in excha

WebLSDに未収録の専門用語（用法）は "新規対訳" から投稿できます。