ライフサイエンスコーパス: Rho GTPase

1 lial and alveolar epithelial cells via small Rho GTPase.

2 ivision plane, bypassing the requirement for Rho GTPase.

3 eviously unknown mode of activation for this Rho GTPase.

4 a in vitro through possible interaction with Rho GTPases.

5 e formation of the active GTP-bound state of Rho GTPases.

6 ly involve spatially localized activation of Rho GTPases.

7 by monitoring the activation state of small Rho GTPases.

8 s that serve as key downstream effectors for Rho GTPases.

9 or of ECT2, a GEF required for activation of Rho GTPases.

10 aspects of cell morphogenesis by turning on Rho-GTPases.

11 -Cbl, phosphoinositide 3-kinase (PI-3K), and Rho-GTPases.

12 n and cytoskeletal dynamics are regulated by Rho-GTPases.

13 mitochondrial membrane protein mitochondrial Rho GTPase 1 (Miro1) is a master regulator of mitochondr

14 e used cells deficient for the mitochondrial Rho-GTPase 1 (Miro1), an essential mediator of microtubu

15 The mitochondrial Rho-GTPase 1 protein (Miro1) regulates mitochondrial tra

16 Through studying Borg5 (Binder of the Rho GTPase 5), which belongs to a family of poorly under

17 RAC1 is a widely studied Rho GTPase, a class of molecules that modulate numerous

18 ad perturbations in four signaling pathways, Rho GTPases, actin, microtubule, and kinases-related pat

19 in cytoskeletal remodeling via regulation of Rho GTPases, acting as a negative regulator of ECT2, a G

20 Rho GTPases, activated by guanine nucleotide exchange fa

21 Rho GTPases, activated by Rho guanine nucleotide exchang

22 anism involves p120 catenin interaction with Rho GTPase activating protein (p190RhoGAP), leading to p

23 3D spheroids of human cells, we identify the Rho GTPase activating protein ARHGAP18 as an effector of

24 ends on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and it

25 interacts with the PDZ binding motif of the Rho GTPase-activating protein (GAP) Myosin-9A.

26 Deleted in Liver Cancer 1 (DLC1) is a RHO GTPase-activating protein (GAP) that negatively regu

27 9, and S567) in the DLC1 tumor suppressor, a Rho GTPase-activating protein (RhoGAP) associated with f

28 BPGAP1 is a Rho GTPase-activating protein (RhoGAP) that regulates ce

29 ssociation of intronic variants in ARHGAP15 (Rho GTPase-activating protein 15; rs4662344-T: P=1.9 x 1

30 on control protein 42) and Srgap2 (SLIT-ROBO Rho GTPase-activating protein 2).

31 e 12 (MMP12)/MMP13, catenin alpha3 (CTNNA3), rho GTPase-activating protein 24 (ARHGAP24), angiopoieti

32 ll spreading through its interaction partner Rho GTPase-activating protein 29 (ArhGAP29), a GTPase ac

33 comprising the Cdc42-interactor IQGAP1, the Rho GTPase-activating protein ARHGAP10, and the integrin

34 emonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle

35 ty defect of macrophages lacking the RhoGAP (Rho GTPase-activating protein) myosin IXb (Myo9b).

36 Here we show that ArhGAP30, a Rho GTPase-activating protein, is a pivotal regulator fo

37 with exception of the Crossveinless-c (Cv-c) Rho GTPase-activating protein, most effectors exert litt

38 1, a kinesin-6 motor, and CYK-4/MgcRacGAP, a Rho GTPase-activating protein.

39 AP3, a member of the Slit-Robo sub-family of Rho GTPase-activating proteins (Rho GAPs), controls acti

40 RHO GTPase-activating proteins (RHOGAPs) are one of the

41 neurons require Crossveinless-c, a specific Rho-GTPase-activating protein (Rho-Gap), to alter their

42 cell, which might install platforms allowing Rho-GTPase-activating protein (RhoGAP) activity to be fo

43 Here, we demonstrate that the Rho-GTPase-activating protein alpha2-chimaerin is specif

44 Homeostatic sleep control requires the Rho-GTPase-activating protein encoded by the crossveinle

45 hat through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitator

46 subsequent LFA-1 engagement leads to altered Rho GTPase activation signaling by downregulating RhoA a

47 on and motility function by restoring normal Rho GTPase activation signaling.

48 Y16 works synergistically with Rhosin/G04, a Rho GTPase activation site inhibitor, in inhibiting LARG

49 also linked to cell survival, by increasing Rho GTPase activation.

50 says the Sestd1-Dact1 interaction can induce Rho GTPase activation.

51 leukemia-associated RhoGEF (LARG)-dependent Rho GTPase activation.

52 TM and SC cells ( approximately 60%), while Rho GTPase activator thrombin caused cell impedance to i

53 either the endocytic regulator TRIP10 or the Rho GTPase activator VAV2 reduces E-cadherin levels at j

54 rin, actin reorganization, localized Rac and Rho GTPase activities, and the development of strong cel

55 conds, we detect the spatial localization of Rho GTPase activity (biosensor FRET signal) as well as t

56 demonstrate that NG2 is a core organizer of Rho GTPase activity and localization in the cell, which

57 These results indicate that Rho GTPase activity is required to establish a planar po

58 Rho GTPase activity needs to be precisely tuned at disti

59 promote wound closure by local inhibition of Rho GTPase activity via a redox-sensitive motif.

60 gnals through Abl family kinases to restrain Rho GTPase activity, support Hippo pathway suppressor fu

61 how that SLAIN2 inactivation does not affect Rho GTPase activity, trafficking, and focal adhesion for

62 ply our approach to the control of the Cdc42 Rho GTPase activity.

63 severe inhibition of phagocytosis than ExoS Rho GTPase activity.

64 n remodeling through the control of ECT2 and Rho GTPase activity.

65 Differences in PtdIns3K and Rho-GTPase activity were attributable to the activity of

66 pEM to experimental protein trajectories of Rho GTPases, an integral regulator of cytoskeletal dynam

67 on of Y256 of N-WASP via activation of small Rho GTPase and focal adhesion kinase mediates TGF-beta1-

68 s fibroblast migration through PDGFRbeta and Rho GTPase and JNK activation.

69 osyltransferase domain for inactivating host Rho GTPases and a cysteine protease domain for the deliv

70 oblasts, PDGF-D activated the Rac1 and Cdc42 Rho GTPases and c-Jun N-terminal kinase (JNK).

71 viduals with SRNS abrogated interaction with RHO GTPases and increased active GTP-bound RAC1 and CDC4

72 monstrated that ARHGDIA is in a complex with RHO GTPases and is prominently expressed in podocytes of

73 esses regulated by Rasip1 through downstream Rho GTPases and NMII.

74 Although the role of typical Rho GTPases and other Rho-linked proteins in synaptic pl

75 The role of Rho GTPases and related signaling pathways previously se

76 By regulating actin cytoskeleton dynamics, Rho GTPases and their activators RhoGEFs are implicated

77 is intrinsically linked to the activation of Rho GTPases and their cytoskeletal-remodeling effectors.

78 SLC11A1 reduced TcdB glucosylation of small Rho GTPases and, consequently, toxin lethality.

79 on of the actomyosin cytoskeleton, through a Rho-GTPase and Rho-associated kinase (ROCK).

80 o metastasize and engages actin dynamics via Rho-GTPases and cofilin in this process.

81 of paxillin and activated p42/44-MAP kinase, Rho GTPase, and paxillin/GEF-H1/p42/44-MAPK association.

82 patiotemporal dynamics of F-actin and active Rho GTPase, and that Cdh6 is required for accumulation o

83 , likely secondary to elevated activation of RHO GTPases, and 2) increased salivary cell proliferatio

84 signaling molecules, including MAP kinases, Rho GTPases, and components of the Wnt signaling pathway

85 Rho GTPases are activated by guanine nucleotide exchange

86 Rho GTPases are activated by Rho guanine exchange factor

87 found in cancer and developmental disorders, Rho GTPases are activated most commonly in disease by in

88 Several Rho GTPases are also regulated by RhoGDI binding and seq

89 e nucleotide exchange factors (Rho GEFs) and Rho GTPases are among the key regulators of cytokinesis.

90 remains unknown how activities of different Rho GTPases are coordinated by Rasip1 to direct tubuloge

91 Rho GTPases are critical signal transducers of multiple

92 The monomeric Rho GTPases are essential for cellular regulation includ

93 Rho GTPases are frequent targets of virulence factors as

94 Rac-family Rho GTPases are implicated in leukocyte function; howeve

95 Rho GTPases are known to be involved in formin activatio

96 Rho GTPases are master regulators of the eukaryotic cyto

97 Rho GTPases are molecular "switches" that cycle between

98 Rho GTPases are molecular switches that modulate a varie

99 Recent studies suggest that Rho GTPases are necessary for LTP.

100 Our results reveal that the three Rho GTPases are necessary to control and coordinate acti

101 The GTP hydrolysis activities of Rho GTPases are stimulated by GTPase-activating proteins

102 Rho GTPases are the major players that guide cells throu

103 cular pathways downstream of Cdc42, Rac, and Rho GTPases are well documented, but we know surprisingl

104 Rho GTPases are well known to regulate cell adhesion and

105 sophila melanogaster cell wound repair model Rho GTPase arrays form in response to prepatterning by R

106 Our data identify the activation of small Rho GTPases as a pathogen-induced process sensed through

107 guanine nucleotide exchange factor (GEF) for Rho GTPases, as an interacting partner of mTOR.

108 F7, a guanine nucleotide exchange factor for Rho GTPases, as one novel TIP-1-interacting protein in h

109 Rho GTPase-based signaling networks control cellular dyn

110 Our results provide evidence for a RHO GTPase-based signalling mechanism to mediate sperm r

111 cell imaging including the use of FRET-based Rho GTPase biosensors.

112 a system to mimic the membrane anchoring of Rho GTPases by creating liposomes containing both PIP2 a

113 ease-like catalytic triad, which inactivates Rho GTPases by deamidating a conserved asparagine in the

114 CNF1 constitutively activates small Rho GTPases by deamidation of a conserved glutamine resi

115 that medium folate regulates the function of Rho GTPases by enabling their carboxyl methylation and t

116 Excessive activation of small Rho GTPases by virulence factors of enteric pathogens al

117 Herein, we demonstrate that AMPylation of Rho GTPases by VopS is a multifaceted virulence mechanis

118 nalysis of Rho GTPase signaling and that the Rho GTPases can be fruitfully considered as components o

119 tream signaling molecules of TLR4, including Rho GTPase Cdc 42 and TRAF6.

120 forts that investigate how PARs regulate the Rho GTPase CDC-42, which in turn regulates the actin-myo

121 nick accelerates migration by activating the Rho GTPase Cdc42 and inducing fascin expression.

122 in part mediated by down-regulation of small Rho GTPase CdC42 and the protein target PAK1, but not by

123 Here, we show that the Rho GTPase Cdc42 controls synapse formation in monosynap

124 The Rho GTPase Cdc42 coordinates regulation of the actin and

125 The small Rho GTPase Cdc42 regulates key signaling pathways requir

126 The small Rho GTPase Cdc42, known to interact with Wiskott-Aldrich

127 a adenosine A1 receptor (A1R) induction of a Rho GTPase CDC42-dependent conformational change of the

128 with EXC-5/FGD, a predicted activator of the Rho GTPase Cdc42.

129 terminus of INF2 does not directly bind the Rho GTPase Cdc42.

130 (PAK1) is activated by binding to GTP-bound Rho GTPases Cdc42 and Rac via its CRIB domain.

131 s and stage-specific functions for the small Rho GTPases Cdc42 and Rac1 in the course of adult hippoc

132 sion yeast Schizosaccharomyces pombe has six Rho GTPases (Cdc42 and Rho1-Rho5) and seven Rho GEFs (Sc

133 The highly conserved Rho-GTPase Cdc42p promotes yeast fusion through interact

134 in neurons through increased turnover of the Rho GTPase Cell Division Cycle 42 (Cdc42) protein.

135 Rho GTPases control various signaling pathways downstrea

136 ases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fet

137 es revealed a smoke-induced up-regulation of Rho-GTPase-dependent actin cytoskeletal signaling that c

138 e Salmonella effector SopE, we recapitulated Rho GTPase-driven actin polymerization at model phosphol

139 rlying this process, we examined the role of Rho GTPases during cardiac migration using inhibitory an

140 The downstream Rho GTPase effectors mediating actin polymerization thro

141 Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key aspects of the act

142 tion clearance, as well as for regulation of Rho GTPase (enzyme that hydrolyzes GTP) activity.

143 spensable roles of individual members of the Rho GTPase family and the putative upstream and downstre

144 membrane dynamics; however, the roles of the Rho GTPase family are not limited to cell adhesion and m

145 In this study we examined the role of the Rho GTPase family member RhoE in trophoblast differentia

146 Inhibition of RhoA, a Rho GTPase family member, is proposed to curb Abeta prod

147 molecular targets in PCa cells including the Rho GTPase family members (for example, CDC42, CDC42EP3,

148 ct diffusive states conserved across various Rho GTPase family members.

149 imeric G protein subunits and members of the Rho GTPase family of small G proteins.

150 The Rho GTPase family plays critical roles in actin and memb

151 tic-specific, GTPase-deficient member of the Rho GTPase family that was first identified as a hypermu

152 ase (GTPase) 3 (Rnd3), a member of the small Rho GTPase family, is involved in the regulation of cell

153 are linked to cell migration such as p38 and rho GTPase-family activation, F-actin polymerization, ad

154 ng experimental data of mechanically-induced Rho GTPase FilGAP release from actin-filamin crosslinks.

155 ight the importance of CirA in coopting host Rho GTPases for establishment of Coxiella burnetii infec

156 Collectively, these findings identify a Rho GTPase-formin network that is critically involved in

157 l-cell adhesion factors and cytoskeletal and rho-GTPase genes.

158 Cdc42, a member of Rho GTPases (guanosine triphosphatases), participates in

159 Rho GTPases have previously been implicated in promoting

160 Expression of a constitutively active Rho GTPase, however, restored inflammatory signalling.

161 interactions blocks GBM cell invasion due to Rho GTPase hyperactivation.

162 ructural plasticity, we examined the role of Rho GTPase in dendritic spine remodeling.

163 es our current understanding of the roles of Rho GTPases in early erythropoiesis, downstream of cytok

164 erful tool for research of Cdc42 subclass of Rho GTPases in human pathogenesis, such as those of canc

165 o suggest that the targeting action of other Rho GTPases in other organ cells, such as RhoA in vascul

166 nteracted with ARHGDIA, a known regulator of RHO GTPases in podocytes that is dysfunctional in some t

167 Our findings reveal a critical role for Rho GTPases in positioning Ras activation and thereby es

168 We have analysed the expression levels of Rho GTPases in primary T-ALL samples compared with norma

169 Further elucidation of the role of Rho GTPases in the erythroid lineage development may rev

170 acellular signaling effector that sequesters Rho GTPases in their inactive GDP-bound states.

171 e levels of RhoGDIalpha, a stabilizer of the Rho GTPases including Cdc42.

172 d is dependent upon the activity of multiple Rho GTPases, including Rac1.

173 f actin filaments and myosin-2 controlled by Rho GTPases, including Rho and Cdc42.

174 This original mechanism of regulation of a Rho-GTPase-independent formin, recruited by Spire at Rab

175 During angiogenesis, Rho-GTPases influence endothelial cell migration and cel

176 o observed in embryos that were treated with RHO GTPases inhibitor.

177 Rhophilin-1 is a Rho GTPase-interacting protein, the biologic function of

178 ystematic RNA interference perturbation of a Rho GTPase interactome consisting of 219 proteins reveal

179 n, Bin3 forms a complex with Rac1 and Cdc42, Rho GTPases involved in actin polymerization, which are

180 Localized activation of Rho GTPases is essential for multiple cellular functions

181 Membrane localization of Rho GTPases is essential for their biological functions

182 The activation of Rho GTPases is governed by Rho guanine nucleotide exchan

183 Rnd3, a small Rho GTPase, is involved in the regulation of cell actin

184 is" that consists of Wnt-FZD/ROR-Galpha12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TE

185 nucleotide exchange factors (GEFs) activates Rho GTPases, leading to important roles for PREX protein

186 partitioning of charged polarity-regulating Rho GTPases like Rho1 or Cdc42 in a protein charge-depen

187 homodimer formation, increased activation of Rho GTPase, loss of cell polarity and decreased invasion

188 n certain instances inhibition of individual Rho GTPases may paradoxically result in pro-neoplastic e

189 t cell migrations require cell polarization, Rho GTPase-mediated cytoskeletal rearrangements, and myo

190 has been suggested to code signals to induce Rho GTPase-mediated fibrosis, but it is obscure how the

191 o PARKIN itself, its substrate mitochondrial Rho GTPase (MIRO), and UB.

192 interfere with the function of mitochondrial Rho GTPases Miro1 and Miro2.

193 GLOSS2 (PAN2) and PAN1, and the small GTPase RHO GTPASE OF PLANTS (ROP) promote mother cell polarity

194 Selective inhibition of Rho GTPases (particularly Rac1) and of JNK strongly redu

195 ARHGAP21 is a negative regulator of Rho-GTPases, particularly Cdc42.

196 Activation of the Rho GTPase pathway determines endothelial cell (EC) hype

197 rmeability driven by rapid activation of the Rho GTPase pathway was followed by Src kinase-dependent

198 ar mechanotransduction and regulation of the Rho GTPase pathway.

199 both GAPs regulate different spatiotemporal Rho GTPase pools, with distinct functions.

200 pression of RhoGDIalpha that in turn affects Rho GTPase protein levels, and thereby, controls cellula

201 Finally, we examined the role of the Rho GTPase proteins by injecting a selective inhibitor i

202 The Rho GTPase proteins Rac1, RhoA and Cdc42 have a central

203 in regulatory genes, including Snai2 and the Rho GTPase proteins Rhophilin and Rho guanine nucleotide

204 The Rho GTPase Rac is crucially involved in controlling mult

205 Instead, our results suggest that the small Rho GTPases Rac and Cdc42 serve as downstream effectors

206 ansmitted by SRC involving regulation of the Rho GTPases Rac and RhoA.

207 Here, we show that the Rho-GTPase Rac contains A-kinase anchoring protein prope

208 The Rho-GTPase, Rac-1, was also significantly activated by c

209 The Rho GTPase Rac1 activates the WAVE regulatory complex (W

210 The Rho GTPase Rac1 controls membrane spreading and stabiliz

211 r data provide a mechanism through which the Rho GTPase Rac1 cross-talks with PKD1 signaling pathways

212 Increased tension directly altered the small Rho GTPase Rac1, 3'-phosphoinositide, and cytoskeletal o

213 Since VAV2 serves as a GEF for the small Rho GTPase Rac1, a key player in cell motility and adhes

214 TKs), Src family PTK, focal adhesion kinase, Rho GTPase Rac1, and neural Wiskott-Aldrich syndrome pro

215 ivated in vitro by the plasma membrane-bound Rho GTPases Rac1 and Cdc42 as well as by the lipid phosp

216 cell invasion due to hyperactivation of the Rho GTPases Rac1 and Cdc42.

217 gnaling pathway and involves the PAR-1/c-Src/Rho GTPases Rac1 and Cdc42/c-Jun N-terminal kinase axis

218 ter was dependent on activation of the small Rho GTPases Rac1 and Rac2.

219 tes cell migration through modulation of the Rho GTPases Rac1, Cdc42, and RhoA.

220 Here, we show that a Dictyostelium Rho GTPase, RacE, and a guanine nucleotide exchange fact

221 indirectly, through activation of the small Rho GTPase Ras-related C3 botulinum toxin substrate 1 (R

222 toma-associated protein and increases in the Rho GTPases Ras-related C3 botulinum toxin substrate 1 (

223 We show that Rho GTPase recruits Rho-kinase to adherens junctions and

224 multitude of RhoGEFs that activate a single Rho GTPase reflects the very specific role of each RhoGE

225 nd some overall quantitative features of PKC-Rho GTPase regulation.

226 vertebrate species, TRIO is a well-conserved Rho GTPase regulator that is highly expressed in the dev

227 profiling of the nucleus accumbens (NAc) for Rho GTPase-related genes, which are known regulators of

228 croscopy and RT-PCR expression of Rac1/CdC42 Rho GTPases, responsible for actin remodeling, we show t

229 Moreover, investigating the role of Rho GTPases revealed that Cdc42 attenuates MMP-1 express

230 The Rho GTPases-Rho, Rac, and Cdc42-control an enormous vari

231 anization of actin filaments mediated by two Rho GTPases, Rho1p and Cdc42p.

232 The Rho GTPases RhoA and Rac1 function as master regulators

233 statin caused the translocation of the small Rho GTPases RhoA, Cdc42, and Rac1/2/3 from cell membrane

234 ugh a wealth of data exists on the canonical Rho GTPases RhoA, Rac1, and Cdc42, several other family

235 orphological switch that signals through the Rho-GTPase RhoA.

236 e spatiotemporally coordinated activation of Rho GTPases (RhoA, Cdc42 and Rac1) in migrating glioblas

237 y of actin cytoskeleton regulators, that is, Rho GTPases (RhoA, Rac1, and Cdc42).

238 In the current study, we identified Rho GTPases, RhoA, Rac1, and Cdc42, as potential upstrea

239 c Ca(2+) pools, which leads to a decrease in Rho-GTPases, RhoA and Rac1, and Ca(2+)-dependent Calpain

240 thy and have elucidated the role of atypical Rho GTPase RhoBTB in Drosophila neurological function an

241 hange factor (PIX; Arhgef6), an activator of Rho GTPases, showed greatly increased motility and alter

242 To test the hypothesis that dysregulated Rho GTPase signaling and a resulting fibrotic activity w

243 , p190RhoGAP-A and -B, are key regulators of Rho GTPase signaling and are essential for actin cytoske

244 ession of the ADFH domain of mAbp1 increased Rho GTPase signaling and breast cancer cell invasion.

245 y integrating guidance signals with the ROP1 Rho GTPase signaling and coordinating intracellular sign

246 inding partners that differentially regulate Rho GTPase signaling and MTLn3 breast cancer cell invasi

247 t the model is a useful tool for analysis of Rho GTPase signaling and that the Rho GTPases can be fru

248 Rho guanine nucleotide exchange factor (GEF)-Rho GTPase signaling axis has been implicated in human p

249 hat LLG1 is a component of the FER-regulated RHO GTPase signaling complex and that fer and llg1 mutan

250 IPs in mutant HTT toxicity, we show that the Rho GTPase signaling components, BAIAP2, EZR, PIK3R1, PA

251 evasion mechanism whereby tumor cells induce Rho GTPase signaling defects in T cells that prevent app

252 fy a single-gene cause of NS and reveal that RHO GTPase signaling is a pathogenic mediator of SRNS.

253 Agonist-induced activation of Rho GTPase signaling leads to endothelial cell (EC) perm

254 e a starting point to dissect spatiotemporal Rho GTPase signaling networks that regulate neurite outg

255 Apical constriction depends on a Rho GTPase signaling pathway (T48/Fog) that is deployed

256 Surprisingly, RNA-Seq analysis of the Rho GTPase signaling transcriptome revealed high express

257 HD, including mammalian target of rapamycin, Rho GTPase signaling, and oxidative stress response.

258 podocyte function, likely through regulating RHO GTPase signaling.

259 cancer-associated fibroblasts and linked to Rho GTPase signaling.

260 esion associated signalosome, which triggers Rho GTPase signaling.

261 Activation of c-Jun downstream of oncogenic Rho GTPase signalling leads to elevated GLS gene express

262 rin receptors sense these changes triggering Rho GTPase signals that modulate RPE tight junctions and

263 Rho GTPases such as Rac, RhoA, and Cdc42 are vital for n

264 cells contain more activated Rac1 than other Rho GTPases such as RhoA and Cdc42.

265 is widely acknowledged, the role of atypical Rho GTPases (such as RHOBTB2) in neurodevelopment has ba

266 Small Rho GTPases, such as Cdc42 and Rac1, have been implicate

267 Because other Rho GTPases, such as RhoA and Cdc42, also possess the GX

268 Rho GTPases, such as RhoA, Rac1, and Cdc42, are importan

269 mplications in the design and application of Rho GTPase targeting strategies in future cancer therapi

270 deficient mice, we define the poorly studied Rho GTPase TC10 as an immunomodulatory molecule playing

271 Cdc42 is a Rho GTPase that regulates diverse cellular functions, in

272 Wounding triggers the formation of arrays of Rho GTPases that act as signaling centers that modulate

273 known about signaling factors downstream of Rho GTPases that contribute to epidermal differentiation

274 pathway involving SWIP-13/ERK8 activation of Rho GTPases that dictates DAT surface expression and fun

275 guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at

276 rhotekin, as well as abnormal activation of Rho GTPases that was accompanied with impaired motility

277 dent on the levels of Miro1, a mitochondrial Rho-GTPase that regulates intercellular mitochondrial mo

278 immune cells in vitro the activity of small Rho GTPases, the key regulators of intracellular actin d

279 In turn, coordinated crosstalk among the Rho GTPases themselves, as well as with the cytoskeleton

280 a12 and Galpha13, regulate the activation of Rho GTPases, thereby contributing to many key biological

281 ors that alter the activation state of small Rho GTPases, thereby manipulating the host cell cytoskel

282 tracellular redistribution and activation of Rho GTPases, this study suggests that TIP-1 holds potent

283 In vivo, GBM invasion is mediated by Rho GTPases through unidentified downstream effectors.

284 dispensable for uptake and instead recruits Rho GTPase to promote biogenesis of the bacterial vacuol

285 ia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organ

286 Unlike other effector proteins that subvert Rho GTPases to modulate uptake, CirA is the first effect

287 ors, acts through protein kinase A (PKA) and Rho GTPases to stimulate Lats kinases and YAP phosphoryl

288 ormed by oncogenic Dbl, which hyperactivates Rho GTPases, together with (13)C-labeled glutamine and s

289 f plasma membrane cholesterol and disrupting Rho GTPase trafficking-a process required for cell adhes

290 K, MAPK, and PI3K); and (c) association with Rho GTPases, tyrosine kinase receptors, Toll-like recept

291 ciencies to glucosylate low-molecular-weight Rho GTPases, underlie the microbe's pathogenicity.

292 Conformation antibodies against active RHO GTPase were also obtained.

293 protein 42) and its effector Borg (binder of Rho GTPases), which act as up-stream regulators of septi

294 iated actin polymerization and activation of Rho GTPase, which appear to be essential for EMyT induct

295 Rho GAPs are important regulators of Rho GTPases, which are involved in various steps of cyto

296 tochondrial ROS (mtROS) levels and activates Rho GTPases, which then induces F-actin formation.

297 TCL/RhoJ is a Cdc42-related Rho GTPase with reported activities in endothelial cell

298 ive binding motif (CRIB) of coronin binds to Rho GTPases with a preference for GDP-loaded Rac.

299 Complex spatiotemporal interaction of Rho GTPases with microtubules (MTs) and MT-associated pr

300 ot apoptosis induced by global inhibition of Rho GTPases with ToxB.