ライフサイエンスコーパス: Rho-associated kinase

1 ling pathways, myosin light chain kinase and Rho-associated kinase.

2 n of matrix metalloproteinase 15 (MMP15) and Rho-associated kinase 1 (ROCK1).

3 ets pretreated with a P2Y(1) antagonist or a Rho-associated kinase 1 inhibitor, confirming the crucia

4 Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase

5 Rho-associated kinase 2 (ROCK2) recently was shown to be

6 Rho-associated kinase 2 (ROCK2) regulates the secretion

7 but also on well-known players such as PAR1, Rho-associated kinase 2, phospholipase C, and proteins r

8 Inhibition of either beta(2) integrins or Rho-associated kinase, a kinase downstream from RhoA, gr

9 Furthermore, inhibition of the Rho-associated kinase, a regulator of cytokinesis, impro

10 ROCK or Rho-associated kinase, a serine/threonine kinase, is an

11 treated with FGF-2 and Y27632 (inhibitor of Rho-associated kinase) achieved an 84% recovery of the w

12 Both myosin light chain kinase and Rho-associated kinase acted as mediators of ERK1/2-depen

13 t extension that could be rescued by RhoA or Rho-associated kinase activation.

14 kinase, p140, which appears to be the major Rho-associated kinase activity in most tissues.

15 FLCN positively regulates RhoA activity and Rho-associated kinase activity, consistent with the only

16 distal cell edge, and the correct levels of Rho-associated kinase activity.

17 Inhibitors of Rho-associated kinase and PKC prevented the decline in G

18 ncreased actin polymerization in response to Rho-associated kinase and PKC signaling contributes sign

19 evering is partially slowed by inhibition of Rho-associated kinase and virtually abolished by direct

20 ivity was dependent on actin, Cav1, Src, and Rho-associated kinase as well as downstream protein kina

21 tide-based proteomic screen identified ROCK (Rho-associated kinase) as a putative substrate for SNRK,

22 Inhibition of PI-3K, PKCs, or Rho-associated kinase by pharmacologic inhibitors abroga

23 Selective inhibition of rho-associated kinase decelerated migration in response

24 and higher plateau retraction distances than Rho-associated kinase-dependent SFs located in the cell

25 neuropeptides and bioactive lipids (Rho- and Rho-associated kinase-dependent), tyrosine kinase recept

26 Here, we show that Drosophila Rho-associated kinase (Drok) works downstream of Fz/Dsh

27 r beta (TGF-beta) and the migratory proteins rho-associated kinase, focal adhesion kinase, and matrix

28 Inhibition of Rho-associated kinase had no effect.

29 dependently of its known associates, p53 and Rho-associated kinase I (ROCK I).

30 We found that RhoE inhibits ROCK I (Rho-associated kinase I) activity during genotoxic stres

31 phosphorylation at Thr(697) and Thr(855) by Rho-associated kinase inhibited phosphatase activity and

32 is localized at the mitotic cell cortex, and Rho-associated kinase inhibition increases the degree of

33 No Rho-associated kinase inhibitor (ROCK-i), or centrifugat

34 ll as single-cell survival in the absence of Rho-associated kinase inhibitor (ROCKi).

35 Administration of the Rho-associated kinase inhibitor fasudil prevented renal

36 GTPase inhibitor C. difficile toxin B or the Rho-associated kinase inhibitor Y-27632 also blocked TGF

37 FAK to focal contacts and treatment with the Rho-associated kinase inhibitor Y-27632 did not prevent

38 phosphorylation, which was inhibited by the Rho-associated kinase inhibitor Y-27632.

39 istered ML-7 (a MLCK inhibitor) or Y27632 (a Rho-associated kinase inhibitor).

40 n, and pretreatment of HUVECs with Y27632, a Rho-associated kinase inhibitor, rescued TP-impaired ins

41 Recent studies using known Rho-associated kinase isoform 1 (ROCK1) inhibitors along

42 lial cells by selectively activating the Rho/Rho-associated kinase/LKB1/PTEN pathway.

43 o-effector protein kinase that is related to Rho-associated kinases of ROCK/ROK/Rho-kinase family.

44 sphorylation of MLC phosphatase (SMPP-1M) by Rho-associated kinase or endogenous SMPP-1M-associated k

45 n of cell contractility through RhoA GTPase, Rho-associated kinase, or myosin light chain kinase rest

46 ere, we describe the purification of a novel Rho-associated kinase, p140, which appears to be the maj

47 Y-27632, an inhibitor of the Rho-associated kinase p160ROCK, diminished polyglutamine

48 The inhibition of a Rho-associated kinase, p160ROCK, decreased the traction

49 ltered the Ras homolog gene family, member A/Rho-associated kinase pathway with increased stress acti

50 arget the transforming growth factor-beta or Rho-associated kinase pathways converts embryonic fibrob

51 We found that Rho and its effector, Rho-associated kinase, preferentially regulated the amou

52 Rho-associated kinases (Rho kinases), which are downstre

53 Y-27632, an inhibitor of the Rho-associated kinase ROCK, is a therapeutic lead for Hu

54 The previously reported Rho-associated kinases ROCK I and II are ubiquitously ex

55 cyclin E acquires a high binding affinity to Rho-associated kinase (ROCK II), and physically associat

56 Ras-MAPK leads to loss of apically localized Rho-associated kinase (Rock) 2a, which results in failed

57 These events were dependent on Rho and Rho-Associated Kinase (ROCK) activation.

58 Although Rho-associated kinase (ROCK) activity has been implicate

59 least partially depends on the activation of Rho-associated kinase (ROCK) and LIMK-1.

60 he interaction with its downstream effectors Rho-associated kinase (ROCK) and mDia.

61 Compaction, via activation of Rho-associated kinase (ROCK) and the stress kinase p38,

62 ation with inhibition of EMT by inclusion of Rho-associated kinase (ROCK) and transforming growth fac

63 n was only partially dependent on Rho kinase/Rho-associated kinase (ROCK) and was independent of RhoA

64 I3-kinase or phospholipase-C, but inhibiting Rho-associated kinase (ROCK) blocked only E13K-induced i

65 d endocytosis of TJ proteins was mediated by Rho-associated kinase (ROCK) but not myosin light chain

66 PKC and Rho-associated kinase (ROCK) Ca(2+)-sensitizing pathways

67 Rho-associated kinase (ROCK) has an essential role in go

68 ibition analysis revealed a critical role of Rho-associated kinase (ROCK) in AJC disassembly in calci

69 In contrast, Rho-associated kinase (ROCK) inhibition blocked MLC phos

70 cells could be rescued by treatment with the Rho-associated kinase (ROCK) inhibitor Y-27632 or introd

71 The Rho-associated kinase (ROCK) inhibitor Y-27632 permits h

72 ays, impedance-based assays with a selective Rho-associated kinase (ROCK) inhibitor, Galpha12/13 knoc

73 Activation of RhoA/Rho-associated kinase (ROCK) pathway and the associated

74 -I fiber orientation, inhibition of the RhoA/Rho-associated kinase (ROCK) pathway did not.

75 We investigated the involvement of the RhoA/Rho-associated kinase (ROCK) pathway in regulating ICAM-

76 s the thromboxane A2 receptor (TXAR) and the Rho-associated kinase (ROCK) pathway.

77 Inhibition of Rho-associated kinase (ROCK) prevented cytoskeletal defe

78 Rho-associated kinase (ROCK) regulates neural cell migra

79 ive phenotype was due, in part, to increased Rho-associated kinase (ROCK) signaling concomitant with

80 4c channel through its downstream Rap1A-RhoA-Rho-associated kinase (ROCK) signaling pathway for susta

81 eviously demonstrated that activation of the Rho-associated kinase (ROCK) signaling pathway promotes

82 Rho-associated kinase (ROCK) signaling plays a fundament

83 he nocodazole-induced activation of RhoA and Rho-associated kinase (ROCK) that mediates phosphorylati

84 Sustained blockade of Rho-associated kinase (ROCK) with Y-27632 down-regulates

85 MLC phosphorylation in MKs is regulated by Rho-associated kinase (ROCK), and consistent with our mo

86 Claudins, E-cadherin, F-actin, myosin II, Rho-associated kinase (ROCK), and myosin light chain kin

87 Na,K-ATPase exocytosis was regulated by the Rho-associated kinase (ROCK), as preincubation with the

88 Rho GTPase and its downstream target, Rho-associated kinase (ROCK), have been implicated in di

89 inhibition of RhoA, its downstream effector, Rho-associated kinase (ROCK), or a microtubule-associate

90 ments show that Vangl2, as well as Daam1 and Rho-associated kinase (Rock), regulate apical constricti

91 in to direct the subcellular localization of Rho-associated kinase (Rock), which in turn drives chang

92 Its binding to Htt is regulated by the rho-associated kinase (ROCK), which phosphorylates profi

93 yosin cytoskeleton, through a Rho-GTPase and Rho-associated kinase (ROCK).

94 iven by myosin light chain kinase (MLCK) and Rho-associated kinase (ROCK).

95 nd actin cytoskeletal remodeling through the Rho-associated kinase (ROCK).

96 hibition of RhoA or its downstream effector, Rho-associated kinase (ROCK).

97 Targeted inhibition of Rho-associated kinase (ROCK)2 downregulates the proinfla

98 lastoma patients, and elevated expression of Rho-associated kinase (ROCK)2 is associated with poor pa

99 cognized that an increased expression of the Rho-associated kinase (ROCK-I), a downstream target of R

100 In contrast, inhibiting Rho-associated kinase ROCK1/2 increased migration and sc

101 The Rho-associated kinases ROCK1 and ROCK2 are critical for

102 appears necessary for downregulation of the Rho-associated kinase (ROCK1) that occurs during myogeni

103 f inhibiting Rho or its downstream effector, Rho-associated kinase (ROCKII).

104 Rho-associated kinases (ROCKs) are critical molecules in

105 -induced STAT3 activation partly depended on Rho-associated kinase (ROK) and involved multiple effect

106 This synergy requires signaling via Rho-associated kinase (ROK) and p21-activated kinase (PA

107 muscle myosin II (Myo-II) by kinases such as Rho-associated kinase (Rok) is important to generate con

108 e myosin targeting subunit (MYPT1) by either Rho-associated kinase (ROK) or an unknown SMPP-1M-associ

109 hosphorylation of the targeting subunit at a Rho-associated kinase (ROK) phosphorylation site.

110 eously decreases RhoA affinity to its target Rho-associated kinase (ROK), a key mediator of neurite o

111 the activities of protein kinases, including Rho-associated kinase, that phosphorylate the myosin pho

112 ation and extracellular signal-regulated and Rho-associated kinases to regulate gene expression.

113 Moreover, inhibition of rho-associated kinase was distinguished by abrogation of

114 over, dominant-negative RhoA or inhibitor of Rho-associated kinase (Y27632) substantially negated the