ライフサイエンスコーパス: S. maltophilia

1 S. maltophilia has been isolated in association with nem

2 S. maltophilia is highly resistant to most antibiotics,

3 developed and tested against a panel of 112 S. maltophilia isolates collected from diverse geographi

4 patients with > or =10 positive cultures (12 S. maltophilia cultures, 15 A. xylosoxidans cultures) ha

5 Sixty-one of 69 CF centers screened had 183 S. maltophilia culture-positive patients, and 46 centers

6 Analysis of a collection of 766 S. maltophilia isolates indicated that approximately 20%

7 Although patients with CF who acquire S. maltophilia have more advanced disease than those who

8 We compared patients who acquired S. maltophilia with those who did not, using survival an

9 resulted in amplification of a band from all S. maltophilia isolates and was uniformly negative for a

10 aureus, A. xylosoxidans, D. acidovorans and S. maltophilia.

11 values for P. aeruginosa, A. baumannii, and S. maltophilia were 94.1%, 92.7%, and 95.5%, respectivel

12 values for P. aeruginosa, A. baumannii, and S. maltophilia were 99.5%, 99.2%, and 100%, respectively

13 -pathogen interaction between C. elegans and S. maltophilia and established a new animal model with w

14 gnificantly differentially expressed between S. maltophilia JCMS and avirulent bacteria (Escherichia

15 ell as the inflammatory response elicited by S. maltophilia infection.

16 genic bacteria also play a role in combating S. maltophilia JCMS.

17 % of CF patients with moderate lung disease, S. maltophilia can be cultured from respiratory tract se

18 nical microbiology laboratories were in fact S. maltophilia.

19 . aeruginosa, 14 for A. baumannii, and 2 for S. maltophilia Categorical agreement (CA) was assessed u

20 S. maltophilia, those patients positive for S. maltophilia had the following baseline characteristic

21 had at least one sputum sample positive for S. maltophilia.

22 am plus aztreonam as combination therapy for S. maltophilia infections and confirm that aztreonam-lik

23 A putative alginate lyase (Smlt1473) from S. maltophilia was heterologously expressed in Escherich

24 However, S. maltophilia JCMS is virulent to normally pathogen-res

25 tested their utility to accurately identify S. maltophilia directly from sputum.

26 col that can rapidly and accurately identify S. maltophilia isolates and which can be used for the di

27 e utility of the SS-PCR to directly identify S. maltophilia in sputum was examined.

28 inhibitors reverse ceftazidime resistance in S. maltophilia because, unlike clavulanic acid, they do

29 at Xps T2S likely plays an important role in S. maltophilia pathogenesis.

30 rates of the Xps type II secretion system in S. maltophilia strain K279a.

31 y represents the first examination of T2S in S. maltophilia, and the data obtained indicate that Xps

32 ve P. aeruginosa, live E. aerogenes, or live S. maltophilia gave good recovery of cysts.

33 We found that a local S. maltophilia isolate, JCMS, is more virulent than the

34 At the six centers with multiple S. maltophilia culture-positive patients and the seven c

35 Respiratory and nonrespiratory S. maltophilia isolates were highly immunostimulatory an

36 nt aminodeoxychorismate synthase activity of S. maltophilia PabB alone revealed that it is virtually

37 problem, the genetic and molecular basis of S. maltophilia virulence is quite minimally defined.

38 Foundation Registry, to assess the effect of S. maltophilia on survival.

39 To examine the molecular epidemiology of S. maltophilia and A. xylosoxidans in CF, isolates from

40 The extents of S. maltophilia contamination of environmental sites freq

41 o dedicated pabA is evident in the genome of S. maltophilia, suggesting that another cellular amidotr

42 Identification of S. maltophilia can be problematic, and analysis of isola

43 Despite the lack of invasiveness of S. maltophilia, the immunostimulatory properties of this

44 strain K279a, the first clinical isolate of S. maltophilia to be sequenced, encodes a functional typ

45 typing can distinguish unique CF isolates of S. maltophilia and A. xylosoxidans, person-to-person tra

46 nd overall virulence of clinical isolates of S. maltophilia using the well-characterized opportunisti

47 Eighty-two isolates of S. maltophilia were cultured from 67 different environme

48 evident among other respiratory isolates of S. maltophilia.

49 The source of the majority of S. maltophilia strains colonizing the respiratory tracts

50 pears to be important in the pathogenesis of S. maltophilia infection as less than 20% of TNFR1 null

51 The immunostimulatory properties of S. maltophilia were studied in vitro by stimulating airw

52 he SCV S. maltophilia isolates were the only S. maltophilia isolates in these cultures, and none were

53 ed with live P. aeruginosa, E. aerogenes, or S. maltophilia offer optimal recovery of Acanthamoeba.

54 olate, JCMS, is more virulent than the other S. maltophilia isolates (R551-3 and K279a) tested.

55 SXT-resistant S. maltophilia has been reported, but the mechanism of r

56 Recovery of SCV S. maltophilia from the sputum of CF patients has implic

57 Nutritional studies of SCV S. maltophilia have suggested auxotrophy in hemin, methi

58 The SCV S. maltophilia isolates were the only S. maltophilia iso

59 e to antibiotics may select for both the SCV S. maltophilia phenotype and SXT resistance by interfere

60 sis confirmed that once established, the SCV S. maltophilia strains persisted.

61 The phenotypic switch from wild-type to SCV S. maltophilia was reproducible in vitro by exposure to

62 ings of suspected small-colony-variant (SCV) S. maltophilia isolates from the sputa of five CF patien

63 c data from this study, we hypothesized that S. maltophilia strain ZL1 was able to convert E1 to amin

64 We recently reported that S. maltophilia strain K279a encodes the Xps type II secr

65 Taken together, these findings suggest that S. maltophilia JCMS evades the pathogen resistance confe

66 mass spectral analysis further suggest that S. maltophilia PabB, like Escherichia coli PabB, binds t

67 The S. maltophilia isolates were weakly invasive, and low-le

68 Thus, we purified StmPr1 from the S. maltophilia strain K279a culture supernatant and eval

69 II) ions in the dinuclear active site of the S. maltophilia Class B3 MbetaL move away from each other

70 insight into the virulence potential of the S. maltophilia Xps type II secretion system and its StmP

71 vities exhibited by StmPr1 may contribute to S. maltophilia pathogenesis in the lung by inducing tiss

72 ne sequencing for identification and, unlike S. maltophilia, demonstrated susceptibility to most anti

73 997 who were older than 6 years of age, were S. maltophilia negative in the first year of enrollment,

74 aeruginosa, the hazard ratio associated with S. maltophilia detection was 0.89 (95% confidence interv

75 Compared with patients without S. maltophilia, those patients positive for S. maltophil