ライフサイエンスコーパス: S. sonnei

1 table candidate for vaccine construction, 16 S. sonnei strains were screened for stability of the vir

2 with Ty21a-AR-Ss produced antibodies against S. sonnei and S.

3 ectrum Shigella vaccine must protect against S. sonnei and 15 S. flexneri serotypes/subserotypes.

4 p a bivalent oral vaccine to protect against S. sonnei shigellosis and typhoid fever.

5 iveness of Ty21a-AR-Ss in protecting against S. sonnei shigellosis and typhoid fever, as compared wit

6 cide vector pCVD442, was used to generate an S. sonnei virG deletion strain, WRSS1, which was invasiv

7 se isolates; S. flexneri comprised 65.9% and S. sonnei 23.7%.

8 on a pathogenicity island in S. flexneri and S. sonnei and in a different chromosomal location in S.

9 o protect mice against Shigella flexneri and S. sonnei in the lethal pulmonary challenge.

10 tion in induction of inflammatory cytokines (S. sonnei DeltahtrB, 800-fold; DeltamsbB mutants, 300-fo

11 e to create Ty21a-Ss, which stably expresses S. sonnei form I O antigen.

12 h of the four Shigella species: S. flexneri, S. sonnei, S. boydii, and S. dysenteriae.

13 A quadrivalent vaccine with O antigens from S. sonnei, S. flexneri 2a, S. flexneri 3a, and S. flexne

14 esent in pINV from S. flexneri but absent in S. sonnei pINV.

15 cholate negatively regulates IcsA and MAM in S. sonnei resulting in reduction in attachment and invas

16 Typhi, and survived lethal intranasal S. sonnei challenge.

17 a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defi

18 Here, we describe a novel S. sonnei adhesin, SSO1327 which is a multivalent adhesi

19 is and PFGE allow better characterization of S. sonnei transmission patterns of "endemic" strains and

20 Outbreak-related and control isolates of S. sonnei from each city were subtyped by pulsed-field g

21 Our analysis was limited by the number of S. sonnei sequences available from diverse geographical

22 Hence, a single subtype of S. sonnei caused an international outbreak involving 8 t

23 r sociodemographic variables and preexisting S. sonnei serum IgA antibodies (adjusted OR, 0.37; 95% C

24 n-antitoxin system, CcdAB, from pINV reduces S. sonnei plasmid stability outside the host, reflecting

25 rvoir populations of antimicrobial-resistant S. sonnei.

26 continental surge of ciprofloxacin-resistant S. sonnei and is capable of establishing endemic transmi

27 However, ciprofloxacin-resistant S. sonnei are being increasingly isolated in Asia and sp

28 y, we found that all ciprofloxacin-resistant S. sonnei formed a single clade within a Central Asian e

29 f 60 contemporaneous ciprofloxacin-resistant S. sonnei isolated in four countries within Asia (Vietna

30 ernational spread of ciprofloxacin-resistant S. sonnei.

31 upied by the O-antigen in the case of smooth S. sonnei phase I.

32 A stable strain, S. sonnei Mosely, was selected for further work.

33 This study has demonstrated that S. sonnei phylogeny can be accurately defined with limit

34 Our data show that S. sonnei was introduced into Vietnam in the 1980s and h

35 The S. sonnei MAM mediates intimate attachment to host cells

36 levels induced in young outbred mice by the S. sonnei O-SPC conjugates were significantly higher the

37 600-fold reduced ability, and GMMA from the S. sonnei DeltahtrB mutant showed a 60,000-fold reduced

38 lsed-field gel electrophoresis (PFGE) of the S. sonnei isolates identified 11 and 4 patterns, respect

39 nal Kdo residues at the reducing ends of the S. sonnei saccharides and aminooxy linkers bound to BSA

40 We recombineered the S. sonnei form I O-antigen gene cluster into the Ty21a c

41 Attempts to synthesize the S. sonnei O-SP based oligosaccharides were not successfu

42 ce-encoding region of pINV, we show that the S. sonnei plasmid is less stable than that of S. flexner

43 , we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y.

44 d immune protection in mice against virulent S. sonnei challenge, thereby supporting the promise of l

45 ngestion of contaminated food and/or water), S. sonnei predominates in wealthy countries and is mainl

46 amate decarboxylase systems coexpressed with S. sonnei form I O-antigen gene.

47 r of antimicrobial-resistant pathogens, with S. sonnei acting as a tractable model for studying how a

48 i-infected subjects among case patients with S. sonnei shigellosis was also significantly lower than

49 show that resistance to ciprofloxacin within S. sonnei may be globally attributed to a single clonal