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1 S1P can bind to several G-protein-coupled receptors (GPC
2 S1P deficiency aggravated vasoplegia in this model, argu
3 S1P deficiency impaired aggregation and spreading of was
4 S1P did not increase production of this pro-inflammatory
5 S1P exerts its effects in S1P receptor-independent manne
6 S1P induced SynI relocation to extrasynaptic regions of
7 S1P is a ligand for five G-protein-coupled receptors, S1
8 S1P levels within the mammalian host are tightly regulat
9 S1P production was selectively impaired in mouse platele
10 S1P promotes cell growth, survival, and migration and is
11 S1P serum level in humans was correlated with endothelia
12 S1P signalling maintains the mitochondrial content of na
13 S1P-induced SynI relocation occurred in a Ca(2+)-indepen
14 S1P-R1 and Kruppel-like factor 2 expression were monitor
15 S1P-R1 was the prevalent S1P receptor on mature human th
18 Our study suggests that primordial SKI-1/S1P likely contained a simpler prodomain consisting of t
20 cover a modular structure of the human SKI-1/S1P prodomain and define its function in folding and act
22 eloped cell-based molecular sensor for SKI-1/S1P to characterize the processing of arenavirus GPC-der
23 ver, little is known about the role of the 2 S1P-specific phosphohydrolase isoforms, SGPP1 and SGPP2,
24 und that Th17 cells egress from the gut in a S1P-receptor-1-dependent fashion and subsequently migrat
25 were abolished following administration of a S1P receptor 2 (S1P2) antagonist or a PI3K inhibitor.
26 Knockdown of either MRTF-A or YAP abrogates S1P-stimulated CCN1 expression, demonstrating that both
27 ike factor 2 expression were monitored after S1P exposure by using flow cytometry and quantitative PC
32 ic process and suggest that p120 catenin and S1P/S1pr2 signaling enhance cancer progression by regula
35 transporter, spinster homolog 2 (Spns2), and S1P receptor, S1P1, in lamellipodia formation and perhap
36 We used a highly specific neutralizing anti-S1P antibody (mAb) and the sphingosine-1-phosphate recep
38 ical inhibitors of the Hippo pathway such as S1P recover the ER instability and necrosis in HD model
46 R knockout mice does not elevate circulating S1P levels, nor does it ameliorate post-MI dysfunction,
47 eta1AR-blockers display elevated circulating S1P levels, confirming that Meto promotes S1P secretion/
53 ypes, including a delay in epiboly, depleted S1P levels, elevated levels of sphingosine, and resistan
54 dered both platelet- and erythrocyte-derived S1P essential for survival, with a contribution from blo
55 urkholderia-infected macrophages with either S1P or a selective agonist of S1P receptor 1 enhanced ba
56 inase-2 deficient mice had higher endogenous S1P levels and the LPS/PepG-induced impaired systolic co
59 Here, we report that increased erythrocyte S1P binds to deoxygenated sickle Hb (deoxyHbS), facilita
60 abolomic profiling, we show that erythrocyte S1P levels rapidly increase in 21 healthy lowland volunt
61 source redundancy normally secures essential S1P signaling in developing and mature blood vessels, pr
62 ocyte population or populations that express S1P-Rs and respond to S1P by migrating across a concentr
64 egia in this model, arguing a vital role for S1P in maintaining vascular resistance during recovery f
70 ociated with reduced survival signaling from S1P receptor 2, resulting in selective downregulation of
72 liver tissue from mice and patients, hepatic S1P levels increased owing to increased hepatic sphingos
74 nhibitors of sphingolipid cascade identified S1P as the sphingolipid mediating SynI redistribution.
81 Mechanistically, we found that Meto-induced S1P secretion is beta3AR-dependent because Meto infusion
82 show that elevated erythrocyte Sphk1-induced S1P protects against tissue hypoxia by inducing O2 relea
85 1 phosphorylation and enhanced intracellular S1P levels in HLMVECs, which was blocked by inhibition o
86 activation of SphK1, increased intracellular S1P, and up-regulated expression of SphK1, Col alpha1(I)
87 e, we investigated the role of intracellular S1P in insulin-secreting INS1E cells by genetically mani
88 Mechanistically, we show that intracellular S1P promotes deoxygenated Hb anchoring to the membrane,
91 lbumin-sized particles in ApoM deficiency is S1P- and S1P1-dependent and this dependency exacerbates
94 he use of a reporter for the signaling lipid S1P (sphingosine 1-phosphate), we found that cells sense
97 cantly reduces expression of genes mediating S1P/S1pr2 signaling in vivo and in vitro, and this effec
99 of fingolimod was found to be a nonselective S1P receptor agonist, agonism specifically of S1P1 is re
102 y regulated, in part through the activity of S1P lyase (S1PL) which catalyses its irreversible degrad
103 es with either S1P or a selective agonist of S1P receptor 1 enhanced bacterial colocalisation with LA
104 Fourteen fluorine-containing analogues of S1P ligands were synthesized and their in vitro binding
105 tor mediated most of the survival benefit of S1P, whereas the endothelial S1P1 receptor was dispensab
107 d that cells sensed higher concentrations of S1P in the medullary cords than in the T cell zone and t
109 -013 to study the signaling contributions of S1P and S1PR2 to MC- and IgE-dependent airway allergic r
110 ases in ceramide and consequent decreases of S1P reduce proliferation of various cancers, AC might of
115 is dependent on intracellular generation of S1P via activation and localization of SphK1 to cell per
128 In this work, we dissect the mechanism of S1P generation downstream of epidermal growth factor (EG
129 ro-survival actions seen after modulation of S1P-metabolizing enzymes allows this axis to emerge as a
132 lso challenge previous models of the role of S1P in lymphocyte recirculation and suggest that S1P pro
133 s, neither platelets nor any other source of S1P was essential for vascular development, vascular int
134 As the key mediators in the synthesis of S1P, sphingosine kinase (SphK) isoforms 1 and 2 have att
140 BH3 mimetics with either SPHK1 inhibition or S1P receptor 2 antagonism triggered synergistic AML cell
141 equired for transcriptional control of other S1P-regulated genes in various cell types and for S1P-st
142 vity on S1P1 while sparing activity on other S1P receptors could offer equivalent efficacy with reduc
145 ing evidence indicates that sphingosine-1-P (S1P) upregulates glutamate secretion in hippocampal neur
146 1P egress signal, whereas thymic parenchymal S1P levels are kept low through S1P lyase (SPL)-mediated
147 at deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased imm
150 the bioactive lipid sphingosine 1-phosphate (S1P) and has established roles in tumor initiation, prog
151 active sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it have been implicate
152 the lipid mediator sphingosine-1-phosphate (S1P) are reduced in septic patients and are inversely as
153 ctivation and local sphingosine-1-phosphate (S1P) are significantly augmented after OVA treatment in
154 duced intracellular sphingosine-1-phosphate (S1P) generation catalyzed by sphingosine kinase 1 (SphK1
156 The chemoattractant sphingosine 1-phosphate (S1P) guides T cell circulation among secondary lymphoid
158 M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have
163 The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are
170 Here, we show that sphingosine 1-phosphate (S1P) levels are not only increased in palmitate-stimulat
175 rray data indicated sphingosine 1-phosphate (S1P) metabolism and signalling was deregulated in OSCC.
176 Rs for thrombin and sphingosine-1-phosphate (S1P) on human glioblastoma cells robustly couple to RhoA
180 ed the potential of sphingosine 1-phosphate (S1P) receptor (S1PR) agonism in the treatment of infecti
181 ng mutations in the sphingosine-1-phosphate (S1P) receptor 2 (S1PR2) promoter have been associated wi
183 role of endothelial sphingosine 1-phosphate (S1P) receptor-1, a G protein-coupled receptor known to p
187 drug FTY720 affects sphingosine-1-phosphate (S1P) signaling on targeted cells that bear the S1P recep
188 velopment, required sphingosine 1-phosphate (S1P) signaling via the G protein-coupled S1P receptor 1
190 The sphingolipid sphingosine-1-phosphate (S1P) signals through five G-protein-coupled receptors (S
192 sis was observed in sphingosine-1-phosphate (S1P) transporter spinster homologue 2 (Spns2)-deficient
193 However, levels of sphingosine-1-phosphate (S1P) were significantly increased in Ormdl3(Delta2-3/Del
194 2 (SK2) synthesize sphingosine-1-phosphate (S1P), a bioactive lipid messenger critically involved in
196 ve bioactive lipid, sphingosine-1-phosphate (S1P), could ameliorate the microvascular leakage followi
198 d the metabolism of Sphingosine-1-phosphate (S1P), one of the most important bioactive lipids, in bot
199 h cl-CD95L produced sphingosine-1-phosphate (S1P), which promoted endothelial transmigration by activ
203 de (-50 +/- 3%) and sphingosine 1-phosphate (S1P, -40 +/- 4%), which ended up to reduction in cell mo
204 bioactive sphingosine-1-phosphatephosphate (S1P) is present in plasma, bound to carrier proteins, an
206 Yet rapid and profound depletion of plasma S1P during systemic anaphylaxis rendered both platelet-
207 blood vessels, profound depletion of plasma S1P renders both erythrocyte and platelet S1P pools nece
209 ma S1P renders both erythrocyte and platelet S1P pools necessary for recovery and high basal plasma S
210 spirin in mice with but not without platelet S1P, suggesting that platelet activation and stimulus-re
214 report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RAL
215 sin kexin isozyme-1 (SKI-1)/site-1 protease (S1P) is implicated in lipid homeostasis, the unfolded pr
218 We aimed to determine whether S1P receptors (S1P-Rs) play a role in mature human thymocyte egress and
219 ssion of the two major enzymes that regulate S1P levels were altered in OSCC: SPHK1 was significantly
222 support the survival of T cells by secreting S1P via the transporter SPNS2, that this S1P signals thr
223 he safety and efficacy of the oral selective S1P receptor modulator ozanimod in patients with relapsi
224 gical or genetic approaches that alter serum S1P may attenuate cardiac dysfunction and whether S1P si
225 e that activation of S1P2 by increased serum S1P and the subsequent activation of the PI3K-Akt surviv
226 f the immunomodulator FTY720 increased serum S1P, improved impaired systolic contractility and activa
232 n catalyzed by sphingosine kinase 1 (SphK1), S1P transporter, spinster homolog 2 (Spns2), and S1P rec
236 tructure at 1.9 A resolution deciphered that S1P binds to the surface of 2,3-BPG-deoxyHbA and causes
238 of the CCN1 gene promoter demonstrated that S1P increases coactivator binding at the canonical trans
240 he context of murine work demonstrating that S1P is required for thymocyte egress to the periphery, o
241 data represent the first demonstration that S1P induces SynI mobilization from synapses, thereby ind
249 lysis of rat hippocampal neurons showed that S1P applied at nanomolar concentration alters the distri
250 , vascular transcriptome analysis shows that S1P pathway is critical in the regulation of vascular fu
253 in lymphocyte recirculation and suggest that S1P promotes retention of memory T cell subsets in secon
255 eficiency in sphingosine kinase (SphK)1, the S1P-producing enzyme, or in MC, remarkably mitigates all
262 sses the cellular and molecular basis of the S1P gradients and aims to interpret its physiological si
265 that expression of SPNS2, expression of the S1P receptor S1PR5 on NK cells, and expression of the ch
266 In an attempt to investigate the role of the S1P/S1P2 axis in vivo, the New Zealand obese (NZO) diabe
267 at the corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels
268 y cords than in the T cell zone and that the S1P transporter SPNS2 on lymphatic endothelial cells gen
270 cells from C57BL6 mice, with or without the S1P antagonist FTY720; we then studied HSC mobilization
272 ing S1P via the transporter SPNS2, that this S1P signals through S1P1R on T cells, and that the requi
275 herapies for humans with hearing loss due to S1P signalling defects need to target strial function.
282 o flow cytometry to evaluate the response to S1P of thymocytes at different stages of maturation.
283 but not blood leukocytes were responsive to S1P gradients, suggesting that T cell responsiveness is
285 ) expression and diminished migration toward S1P in the Pparg(C/-) splenocytes, which impeded lymphoc
286 e functional and structural bases underlying S1P-mediated pathogenic metabolic reprogramming in SCD a
288 0 and FTY720-P with S1P, we show that unlike S1P, the sphingosine analogs do not induce cytokine prod
290 FTY720 triggers MDSCs to release GM-CSF via S1P receptor 3 (S1pr3) through Rho kinase and extracellu
292 ay attenuate cardiac dysfunction and whether S1P signaling might serve as a novel theragnostic tool i
295 complexes, the molecular mechanism by which S1P promotes neurotransmission remained largely undefine
296 rain-specific knockout mouse models in which S1P-lyase (SPL), the enzyme responsible for irreversible
298 ever, the molecular mechanisms through which S1P enhances excitatory activity remain largely undefine
299 ultiple cytoskeletal changes associated with S1P-mediated endothelial barrier enhancement and suggest
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