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1 SAM binds to the unique iron atom of a site-differentiat
2 SAM develop endothelial dysfunction.
3 SAM domain and HD domain-containing protein 1 (SAMHD1),
4 SAM vaccines are based on engineered self-amplifying mRN
5 SAM-functionalised organic devices give rise to complete
6 SAM-WD showed increased endothelial inflammation (interc
8 tion and abrogated by the deletion of SLP-76 SAM domain (DeltaSAM) or mutation of Tyr-113, Tyr-128, a
10 il with the H3K9 methyltransferase Clr4 in a SAM (S-adenosyl-methionine)-dependent manner, and Clr4 i
12 ometallic center in which the 5' carbon of a SAM-derived deoxyadenosyl moiety forms a bond with the u
13 te architecture of viperin with bound SAH (a SAM analog) or 5'-dAdo and l-Met (SAM cleavage products)
15 y, cells that lack PE methylation accumulate SAM, which leads to hypermethylation of histones and the
18 erase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes
19 that the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 complex by binding direc
21 is an unusual radical S-adenosylmethionine (SAM) enzyme involved in the first step of diphthamide bi
26 determined two radical S-adenosylmethionine (SAM) enzymes, one each from an SNP gene and a differenti
28 ls of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological proces
30 dicted class C radical S-adenosylmethionine (SAM) methylase, catalyzes both the transfer of a C1 unit
33 gdom have ArsM As(III) S-adenosylmethionine (SAM) methyltransferases that methylates inorganic As(III
34 as well as with bound S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SAH) in the catalytic si
35 member of the radical S-adenosylmethionine (SAM) superfamily of enzymes, but it does not catalyze th
36 of the growing radical S-adenosylmethionine (SAM) superfamily of enzymes, which use a reduced [4Fe-4S
37 the methyl group from S-adenosylmethionine (SAM) to lysine residues in histone tails and core histon
38 eads to an increase in S-adenosylmethionine (SAM), which is the major cellular donor of methyl groups
41 effect transistor (ISFET) with the afforded SAM resulted in the production of a KI-sensitive sensor.
43 as ultra-sensitive label-free biosensors and SAM/organic transistors that can be used as robust exper
47 rd applications of our approach to FASTQ and SAM archives require a few lines of code, produce soluti
51 At 24 weeks, both SAM on WD (SAM-WD) and SAM on regular diet displayed endothelial dysfunction, a
52 Administration of an anti-PAR2 antibody, SAM-11, after the initial development of airway inflamma
53 We present a method for converting arbitrary SAM states into total angular momentum states characteri
54 s a rapid and user-friendly interface to BAM/SAM/CRAM files, global sequence alignment operations and
55 An interesting positive association between SAM/SAH ratio and high H19 methylation levels was detect
56 general material-mediated connection between SAM and OAM of light and may find applications in produc
59 ion by SAM, explains the requirement of both SAM and magnesium to form the fully collapsed metabolite
61 ostridium thermocellum ATCC 27405, with both SAM and an N-terminal fragment of its peptidyl-substrate
62 ium, in combination with P1 stabilization by SAM, explains the requirement of both SAM and magnesium
63 ervous system (SNS) upregulates NE uptake by SAMs and shifts the SAM profile to a more proinflammator
67 methyltransferase fold containing conserved SAM-binding and catalytic motifs, the isolated TlyA carb
68 1408 methyltransferases within its conserved SAM-binding fold but the region linking core beta strand
69 d, as human sympathetic ganglia also contain SAMs expressing the analogous molecular machinery for NE
71 tivity by interactions with the cosubstrate, SAM, which is bound to the catalytic iron-sulfur cluster
73 have generated a drug-free, all-in-one dCAS9-SAM vector that can activate endogenous gene expression
74 ategy to express the components of the dCas9-SAM system to create an artificial transcriptional compl
75 ase, CDP-Glc 4,6-dehydratase, NADH-dependent SAM:C-methyltransferase, and NADPH-dependent CDP-3-C-met
76 reased H3K4me3 caused by knockdown of either SAM synthetase (Sam-S) or the histone methyltransferase
78 ing embryogenesis to establish the embryonic SAM and to specify cotyledon boundaries, and STM control
79 mildly spiral growth, and flat and enlarged SAM, including those related to plant hormones and those
80 horylation levels upon deletion of the EphA2 SAM domain (EphA2DeltaS) in DU145 and PC3 prostate cance
81 on these results, we conclude that the EphA2 SAM domain inhibits kinase activity by reducing receptor
83 gs thus reveal a novel motif requirement for SAM binding by TlyA and set the stage for future mechani
84 for this unexpectedly low value of beta for SAMs of S(EG)nCH3 rests on the possibility of disorder i
85 .01 A(-1)) indistinguishable from values for SAMs of oligophenyls (beta(Ph)n = 0.28 +/- 0.03 A(-1)),
86 es indicate that greenhouse gases will force SAM into its positive phase even if stratospheric ozone
87 atalyzes both the transfer of a C1 unit from SAM to 3-methylindolic acid linked to Cys8 of a syntheti
95 on of methionine metabolic genes to increase SAM, which in turn leads to an increase in global H3K4me
98 investigated different approaches involving SAMs of aromatic thiols, namely p-mercaptobenzoic acid (
99 usly upregulated in vegetative stages of ltm SAMs, among them, the antiflorigen gene SELF PRUNING (SP
100 y sympathetic neuron-associated macrophages (SAMs) as a population of cells that mediate clearance of
101 sed management of severe acute malnutrition (SAM) has been shown to be safe and cost-effective, but p
103 esponding value obtained with length-matched SAMs of oligophenyls (HS(Ph)nH) and n-alkanethiols (HS(C
105 /Cas9-based synergistic activation mediator (SAM) system to identify potential lncRNAs capable of reg
106 at the flanks of the shoot apical meristem (SAM) following auxin maxima signals; however, little is
107 ent and doming of the shoot apical meristem (SAM) is a hallmark of the transition from vegetative gro
108 contained within the shoot apical meristem (SAM) is maintained in Arabidopsis by the homeodomain pro
112 und SAH (a SAM analog) or 5'-dAdo and l-Met (SAM cleavage products) is consistent with the canonical
115 ogenous) methyl donor S-adenosyl methionine (SAM) did not affect CpG methylation and IEG gene express
116 es two equivalents of S-adenosyl methionine (SAM) to insert a carbide atom and fuse two substrate [Fe
118 erase (CCoAOMT) is an S-adenosyl methionine (SAM)-dependent O-methyltransferase responsible for methy
119 ures of RlmH bound to S-adenosyl-methionine (SAM) and the methyltransferase inhibitor sinefungin.
120 ates the methyl donor S-adenosyl-methionine (SAM), which is converted via methylation to S-adenosyl-h
122 (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the formation of 3-methyl-2-i
123 FL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically essential glyc
125 )-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have been identified through seq
126 a putative radical S-adenosyl-l-methionine (SAM) protein, are unable to synthesize BChl e but accumu
127 report a versatile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that can catalyse stereosel
131 combined with the standard addition method (SAM), allows for the absolute quantification of uric aci
132 ENDOR studies of the PFL-AE/[(13)C-methyl]-SAM complex show that the target sulfonium positioning v
133 METHODS AND Senescence-accelerated mice (SAM, n=18) and control mice with normal senescence (n=15
135 o the family of synaptic adhesion molecules (SAMs) due to its impact on synapse formation and synapti
136 ents that convert the spin angular momentum (SAM) of light into vortex beams have found applications
138 ide mimotope mixed self-assembled monolayer (SAM) biointerface and dilution of the analysis buffer.
139 the first time, a self-assembled monolayer (SAM) derived from calixtubes was formed on a SiO2 surfac
140 biofunctionalized self assembled monolayer (SAM) functionalized on gold nanoparticles (GNPs) in poly
142 issociation of the self-assembled monolayer (SAM) was detected by the naked eye and analysed using an
144 sfer (ET) across a self-assembled monolayer (SAM) was the developed for highly sensitive detection of
146 Functionalized self-assembled monolayers (SAMs) are the focus of ongoing investigations because th
149 ly based on mixed self-assembled monolayers (SAMs) of thiol-modified oligonucleotides and alkanethiol
150 tunneling across self-assembled monolayers (SAMs) of thiol-terminated derivatives of oligo(ethylene
151 transport across self-assembled monolayers (SAMs) of two donor-acceptor systems consisting of a poly
153 philic terminated self-assembled monolayers (SAMs) sensor surfaces are compared to a hydrophobic term
154 ers such as thiol self-assembled monolayers (SAMs) to physisorbed monolayers as well as for complex s
156 graphene sheets, self-assembled monolayers (SAMs) with chemical patterns, and mutants of the protein
160 us of Shank3 contains a sterile alpha motif (SAM) domain that is essential for its postsynaptic local
162 re based on engineered self-amplifying mRNA (SAM) replicons encoding an Ag, and formulated with a syn
163 otein G was covalently immobilized on 11-MUA SAM via amine coupling and bioaffinity-based oriented im
165 osensor with self-assembly gold nanoislands (SAM-AuNIs) can be used to detect and distinguish exosome
168 lkanethiolate self-assembled monolayers (OEG-SAMs) are studied using the polarization modulation infr
169 ontrast to free carboxy-group-terminated OEG-SAMs, only a partial deactivation of EDC/NHS-activated z
171 ect reductive cleavage of the 5' C-S bond of SAM to form a 5'-deoxyadenosyl 5'-radical (5'-dA(*)) int
173 that would promote the reductive cleavage of SAM, 6-CP is turned over to 6-deoxyadenosylpterin (6-dAP
175 dithionite, BciD catalyzed the conversion of SAM into 5'-deoxyadenosine and BChlide c or d into BChli
177 h America (SAS), to quantify the coupling of SAM and regional wildfire variability using recently cre
178 stic simulations, we calculate the effect of SAM and magnesium ions on the folding free energy landsc
182 hanistically, Runx2 bound to the promoter of SAM-pointed domain-containing Ets-like factor (SPDEF), a
185 and RUTF use in the outpatient treatment of SAM was maintained over 4 wk of follow-up with a monthly
187 ethylation of PE facilitates the turnover of SAM for the synthesis of cysteine and glutathione throug
188 stablish that APLPs show typical features of SAMs and indicate that increased surface expression, as
191 ics, discuss the mechanism of interaction of SAMs in a microscopic device, and highlight the applicat
193 (-1)), and significantly lower than those of SAMs of n-alkanethiolates (beta(CH2)n = 0.94 +/- 0.02 na
194 teins, HemW contains three cysteines and one SAM coordinating an [4Fe-4S] cluster, and we observed on
195 es are required for methylation and that one SAM (SAM1) is converted to 5'-deoxyadenosine and the sec
197 that the N-terminal sterile alpha motif (or SAM) domain of SMSr drives self-assembly of the protein
200 ave shown that ERI significantly outperforms SAM and Localfdr in detecting early responding molecules
201 uce medium chain fatty acids and overproduce SAM, we obtain medium chain FAMEs at titers of 0.56 g/L,
204 ivation of a floral antagonist that promotes SAM growth in concert with floral transition protects it
206 Aminofutalosine synthase (MqnE) is a radical SAM enzyme involved in the menaquinone biosynthetic path
207 )-OH-BChlide c and d Thus, BciD is a radical SAM enzyme that converts the methyl group of BChlide c o
210 ovel rRNA methylation mechanism by a radical SAM superfamily enzyme, indicating that two resistance m
213 onstitution of a cobalamin-dependent radical SAM enzyme catalyzing the conversion of a methyl group t
214 mechanistic links among SPASM domain radical SAM enzymes and supports the involvement of non-cysteiny
215 the emerging family of SPASM domain radical SAM enzymes, likely contains three [4Fe-4S] clusters.
216 chanisms of how viperin acquires its radical SAM Fe/S cluster to gain antiviral activity are poorly u
218 conditions highlights the ability of radical SAM enzymes to carry out both polar and radical transfor
219 arrel fold that is characteristic of radical SAM enzymes, as well as a C-terminal SPASM domain that c
220 ynthesis requires a unique family of radical SAM enzymes, which contain multiple [4Fe-4S] clusters, t
222 viperin is similar to several other radical SAM enzymes, including the molybdenum cofactor biosynthe
225 -bearing carbon is prevented and the radical SAM machinery sits adjacent rather than opposite to the
226 sion, our findings indicate that the radical SAM protein family HemW/RSAD1 is a heme chaperone cataly
228 In cells, methionine starvation reduces SAM levels below this dissociation constant and promotes
230 e the role of the early type I IFN response, SAM vaccines were evaluated in IFN receptor knockout mic
231 onverted to 5'-deoxyadenosine and the second SAM (SAM2) is converted to S-adenosyl-l-homocysteine (SA
232 the dissociation process of the EphA2-SHIP2 SAM-SAM domain heterodimer complex using unrestrained al
233 ethyl donor in the reaction, in our studies, SAM itself plays this role, giving rise to S-adenosylhom
235 StrB, in various forms, including apo SuiB, SAM-bound SuiB, and a complex of SuiB with SAM and its p
237 duce the hydrophobicity of methyl-terminated SAMs most effectively not when they are clustered togeth
238 , and deposited on an electrode as a ternary SAM configuration, is a suitable platform to develop cli
239 nalysis by methods such as student's t-test, SAM, and Empirical Bayes often searches for statisticall
242 n-alkanethiols (HS(CH2)nH) demonstrates that SAMs of oligo(ethylene glycol) have values of beta (beta
247 rests on the possibility of disorder in the SAM and a systematic discrepancy between different estim
248 Substitution of conserved residues in the SAM binding pocket reveals a functional dichotomy in the
270 he desired biosynthetic end product via the (SAM-dependent) retro-Claisen rearrangement catalysed by
271 he simplified Simmons equation) across these SAMs with the corresponding value obtained with length-m
272 glycol) (HS(CH2CH2O)nCH3; HS(EG)nCH3); these SAMs are positioned between gold bottom electrodes and G
276 ecular surface coverage, the tip radius, tip-SAM adhesion force (F), and sample elastic modulus (E),
277 le elastic modulus (E), we find that the tip-SAM contact area is approximately 25 nm(2), correspondin
278 (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-gl
279 In this context, dNTP triphosphohydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) h
281 ood (RUTF) in the treatment of uncomplicated SAM, in terms of clinical response to treatment and hous
284 na users (MAR), smoking-and-marijuana users (SAM), marijuana-and-drinking users (MAD), and users of a
286 M functions to suppress SP in the vegetative SAM In agreement, SP-overexpressing wild-type plants exh
287 ring and precocious doming of the vegetative SAM LTM encodes a kelch domain-containing protein, with
288 ts exhibited precocious doming of vegetative SAMs combined with late flowering, as found in ltm plant
289 n in SP restored the structure of vegetative SAMs in ltm sp double mutants, and late flowering was pa
290 nscriptional activation systems, namely VPR, SAM and SunTag, have been developed for animal cells (2-
293 in = 2.0 A) as well as binary complexes with SAM (dmin = 2.3 A) or the reaction product S-adenosylhom
295 ection-site tissues from mice immunized with SAM-based vaccine revealed an early and robust induction
296 3-ketopentanoyl-ACP (9) were incubated with SAM and BonMT2 from module 2 of the bongkrekic acid poly
300 performing surface chemistry tailoring with SAMs constitutes a versatile approach towards the tuning
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