ライフサイエンスコーパス: SCAM

1 ow been analyzed by scanning mutagenesis and SCAM.

2 to the accessibility patterns determined by SCAM studies of TMH6 in the opioid and dopamine D2 recep

3 y other GPCR in which TM6 has been mapped by SCAM.

4 sidues to thiol blockers (a technique called SCAM), we have identified the pore-lining residues of a

5 l substituted cysteine accessibility method (SCAM) and a new fluorescence binding assay.

6 e substituted cysteine accessibility method (SCAM) in transmembrane domains 6 (TM6) and 7 (TM7) and e

7 e substituted-cysteine accessibility method (SCAM) to map the residues in the sixth membrane-spanning

8 e substituted cysteine accessibility method (SCAM) to map the residues of the transmembrane helices (

9 d substituted cysteine accessibility method (SCAM) to provide new evidence for a centrally located ga

10 e substituted-cysteine-accessibility method (SCAM) to the M2 segment and the M1-M2 loop of the acetyl

11 e substituted cysteine accessibility method (SCAM) was applied to the first membrane-spanning segment

12 e substituted-cysteine accessibility method (SCAM) was applied to transmembrane span seven of the hum

13 e substituted-cysteine-accessibility method (SCAM), we are mapping the residues that contribute to th

14 e substituted-cysteine-accessibility method (SCAM), we are mapping the residues that contribute to th

15 e substituted cysteine accessibility method (SCAM), we defined the VirB2 IM topology and then identif

16 e substituted cysteine accessibility method (SCAM), we evaluated the role of possible pore-lining res

17 e substituted cysteine accessibility method (SCAM), we previously mapped the residues in the third, f

18 e substituted cysteine accessibility method (SCAM).

19 e substituted cysteine accessibility method (SCAM).

20 e substituted cysteine accessibility method (SCAM).

21 e substituted cysteine accessibility method (SCAM).

22 ituted cysteine (Cys) accessibility methods (SCAM) with sodium (2-sulfonatoethyl)methanethiosulfonate

23 e CB2 binding pocket, further confirming our SCAM results.

24 S-SCAM (synaptic cell adhesion molecule) and PSD-93 (posts

25 S-SCAM transgenic mice showed an increased number of later

26 x proteins from glomerular lysates, MAGI-2/S-SCAM (membrane-associated guanylate kinase inverted 2/sy

27 he earliest identifiable podocytes, MAGI-2/S-SCAM is first detected in junctional complexes in podocy

28 PSD-93 and S-SCAM bind to APC and its binding partner beta-catenin, r

29 ved in spine/synapse maturation, Shank and S-SCAM.

30 inase inverted-2), a protein also known as S-SCAM (synaptic scaffolding molecule).

31 MAGI-2 [also known as S-SCAM (synaptic scaffolding molecule)] is a multi-PDZ dom

32 Conversely, decreasing S-SCAM levels by RNA interference-mediated knockdown cause

33 Finally, S-SCAM overexpression hampered NMDA-induced internalizatio

34 Further, S-SCAM increased surface AMPAR levels in the absence of PS

35 We identify S-SCAM as a novel component of neuronal nicotinic synapses

36 Importantly, S-SCAM regulated synaptic AMPAR levels in a manner, depend

37 Increasing S-SCAM levels in rat hippocampal neurons led to specific i

38 lication of Synaptic Scaffolding Molecule (S-SCAM, also called MAGI-2), which encodes a postsynaptic

39 rt that the synaptic scaffolding molecule (S-SCAM; also called membrane-associated guanylate kinase i

40 g the duplication conditions, elevation of S-SCAM levels in excitatory neurons of the forebrain was s

41 to decreased postsynaptic accumulation of S-SCAM, but not PSD-93.

42 e of PSD-95, while PSD-95 was dependent on S-SCAM to increase surface AMPAR levels.

43 validate a causal relationship of the rare S-SCAM CNV and provide supporting evidence for the rare CN

44 Together, these results suggest that S-SCAM is an essential AMPAR scaffolding molecule for the

45 We show that S-SCAM, PSD-93, neuroligin and neurexin are enriched at al

46 Furthermore, the S-SCAM transgenic mice provide a valuable new animal model

47 Notably, the S-SCAM transgenic mice showed a unique sex difference in s

48 e induction of long term-depression, while S-SCAM knockdown did not.

49 Seven SCAM-sensitive residues (S3107.33, F3147.37, and I3167.3

50 The SCAM approach involved a systematic probe of receptor st

51 The SCAM data were consistent with a C-terminus at 4.58, but

52 the Xenopus oocyte expression system and the SCAM (substituted cysteine accessibility method), we fou

53 Combining the SCAM data with rhodopsin-based molecular models of the r

54 study, using a method coined as the "in vivo SCAM", identified several residues in the channel pore t

55 in vivo functional characterization, in vivo SCAM, electrophysiological studies, and disulfide-trappi