ライフサイエンスコーパス: SCF complex

1 FBXW7 and disables its recruitment into the SCF complex.

2 e F-box protein may regulate activity of the SCF complex.

3 is indirect via binding to Skp1 in the host SCF complex.

4 tain optimal composition and function of the SCF complex.

5 sm may involve regulation of assembly of the SCF complex.

6 n of Grr1 that should not associate with the SCF complex.

7 WD-1, the substrate-recruiting subunit of an SCF complex.

8 uclear localization and assimilation into an SCF complex.

9 odes CULLIN1, an invariable component of the SCF complex.

10 conjugating enzyme of the Skp1/cullin/F-box (SCF) complex.

11 by the Cdc4 E3 ligase of the Skp1/Cul1/Rbx1 (SCF) complex.

12 3 ligase activity, but not activity of other SCF complexes.

13 e best-characterized families of E3s are the SCF complexes.

14 profoundly alters the cellular landscape of SCF complexes.

15 to-ubiquitination in the context of Cdc53 or SCF complexes.

16 ) appeared to be internalized along with Kit-SCF complexes.

17 orate to regulate the cellular repertoire of SCF complexes.

18 nhibitors to modulate function of individual SCF complexes.

19 controlling the localization of the cognate SCF complexes.

20 e aspects of flower development as a part of SCF complexes.

21 e to the selection of substrates by metazoan SCF complexes.

22 s suggests an extensive set of combinatorial SCF complexes.

23 An activated SCF complex, a heterotetramer (Skp1, Cul-1, beta-TrCP [F

24 vity or its capacity to interact with the E3-SCF complex abrogate its abd1 suppressor function.

25 e substrate specificity to Skp Cullin F box (SCF) complexes, acting as E3 ligases that target phospho

26 r TRIM9-mediated regulation of the beta-TrCP SCF complex activity but also identifies TRIM9 as a brai

27 This SCF complex also recognizes a conserved destruction moti

28 ain ubiquitin protein ligases, including the SCF complex and APC, have been suggested to govern termi

29 ts interaction with active components of the SCF complex and that HOS stability is regulated by a bou

30 ata shows that Arabidopsis has exploited the SCF complex and the ubiquitin/26S proteasome pathway as

31 ods that preserve the in vivo assemblages of SCF complexes and apply quantitative mass spectrometry t

32 e subunits and substrates of CUL1-associated SCF complexes and CUL2 ubiquitin ligases are well establ

33 Hrt1 assembles into recombinant SCF complexes and individually binds Cdc4, Cdc53 and Cdc

34 CULLIN1 (CUL1) is a core component of SCF complexes and is involved in multiple signaling path

35 ition of p18-Cyclin E by the Skp1-Cul1-Fbw7 (SCF) complex and its interaction with the Fbw7 protein i

36 st that CAND1 regulates the formation of the SCF complex, and its dissociation from CUL1 is coupled w

37 E interacted with the CULLIN1 subunit of the SCF complex, and this interaction required the F-box dom

38 e that the cellular responses mediated by an SCF complex are directly regulated by environmental cond

39 Because the constituents of the SCF complex are members of protein families, SCFCdc4 is

40 SCF complexes are a conserved family of ubiquitin ligase

41 To illuminate how SCF complexes are regulated, we sought proteins that int

42 SCF complexes are the largest and best studied family of

43 SCF complexes are the largest family of E3 ubiquitin-pro

44 Skp1, Cullin, F-box (SCF) complexes are one influential E3 class that use F-b

45 y and a component of the Skp1.Cullin1.F-box (SCF) complex, as a new p53-interacting protein.

46 ZTL with the three known core components of SCF complexes (ASK1, AtCUL1 and AtRBX1) demonstrates tha

47 nterferes with Skp1 binding, thus preventing SCF complex assembly.

48 anism for maintaining activities of specific SCF complexes based on availability of a particular subs

49 umor suppressor and Skp1-Cul1-F-box protein (SCF) complexes belong to families of structurally relate

50 the incorporation of F box proteins into the SCF complex, causing their destabilization.

51 an E3 ubiquitin ligase, a Skp1-cullin-F-box (SCF) complex composed of SKR-1 and the F-box protein SEL

52 SCF complexes consist of three invariable components, Sk

53 Ectopic expression of SCF complex containing beta-TrCP1 is sufficient to induc

54 In Saccharomyces cerevisiae, an SCF complex contains a common set of components, namely,

55 SCF complexes couple protein kinase signaling pathways t

56 th these results, cells that overexpress the SCF complex display an inhibited TGF-beta-dependent tran

57 ggesting that a hierarchical organization of SCF complexes exists defined by distinct Skp/F-box prote

58 mal degradation by FBXL20 and the associated SCF complex expression provides a novel checkpoint for p

59 ught to artificially target a protein to the SCF complex for ubiquitination and degradation.

60 recognition component of SKP1/Cullin/F-box (SCF) complexes for targeted protein polyubiquitination.

61 These differences in substrate recognition, SCF complex formation, and tissue distribution suggest t

62 ved in cul1-6 plants are caused by defective SCF complex formation.

63 family of ubiquitin ligase complexes, called SCF complexes, found throughout eukaryotes, is involved

64 SCF complexes have a variable F-box protein subunit that

65 In yeasts, three SCF complexes have been demonstrated to associate with t

66 In plants, SCF complexes have been found to regulate auxin response

67 ) demonstrates that ZTL can assemble into an SCF complex in vivo.

68 The RBX1 protein is a component of SCF complexes in Arabidopsis.

69 RING-H2 finger protein RBX1 is a subunit of SCF complexes in fungi and animals.

70 SN inhibits the ubiquitin ligase activity of SCF complexes in vitro.

71 results, also provide evidence for distinct SCF complexes in vivo and support the idea that their F-

72 CSN plays a central role in the assembly of SCF complexes in vivo, regulation of Jab1/CSN5 by MIF is

73 st to substrates of the SKP1-Cullin 1-F box (SCF) complexes, in vitro ubiquitination of E2F1 by CUL1-

74 ), an accessory protein that associates with SCF-complex, in plant transformation.

75 rf)-p53 response is impaired, whereas a Skp2-SCF complex inhibitor can trigger cellular senescence in

76 apable of binding Skp1p and entering into an SCF complex interfered with proteolysis of SCF targets a

77 nents Skp1, Cul1, and Rbx1 serve in multiple SCF complexes involving different substrate-specific F-b

78 Another component of SCF complexes is provided by members of the Roc1/Rbx1/Hr

79 However, how the repertoire of SCF complexes is sustained remains unclear.

80 , we show that Skp2, a component of the Skp2 SCF complex, is an important regulator for HSC quiescenc

81 Only in fully assembled SCF complexes, it is believed, can substrates bound to F

82 s suggest that the cullin specificity of the SCF complex may reflect its ability to associate with Rb

83 mal F-box proteins, suggesting that distinct SCF complexes may direct proteolysis of factors mediatin

84 h Skp1, Cullin-1, and Rbx1, could compose an SCF complex mediating the degradation of nonself S-RNase

85 ntrast to IGF-1 induced activation, the Skp2 SCF complex, not TRAF6, is a critical E3 ligase for ErbB

86 ), the substrate recognition component of an SCF (complex of SKP1, CUL1 and F-box protein)-type E3 ub

87 rticular, SKP1, cullin/CDC53, F-box protein (SCF) complexes play important roles in selecting substra

88 Each SCF complex recognizes different substrates according to

89 In contrast, the SCF complex recruits substrates through a substrate adap

90 These results suggest that SCF complexes regulate several aspects of floral develop

91 These findings define a new SCF complex required for caspase activation during sperm

92 ility of mutant CUL1 to assemble into stable SCF complexes resulting in reduced degradation of the SC

93 -TrCP-containing Skp-Cullin 1-F-box protein (SCF) complex (SCF(beta-TrCP)) E3 ubiquitin ligase in a p

94 biochemical dissection of a novel mammalian SCF complex, SCFbeta-TRCP, that specifically recognizes

95 co-precipitated components of the canonical SCF complex (Skp1, Cullin1, and Rbx1), yet FBXO2 bound v

96 Polyubiquitination of proteins by Cdc34/SCF complexes targets them for degradation by the 26S pr

97 of Skp2, the rate-limiting component of the SCF complex that degrades p27(kip1), was reduced.

98 Both are components of the SCF complex that ubiquitinates proteins during the G1-S

99 teract with SKP1 and cullin proteins to form SCF complexes that selectively recruit regulatory protei

100 sually forms part of an Skp1, cullin, F-box (SCF) complex that targets specific protein substrates fo

101 integrated into functional Skp-Cullin-F-box (SCF) complexes that confer E3 ubiquitin ligase activity.

102 kp1 and Cul1 are invariant components of all SCF complexes, the 69 different human F-box proteins are

103 ligases is defined by the recently described SCF complexes, the archetype of which was first describe

104 bound to SKR-1 and inhibited assembly of the SCF complex, thereby protecting nearby synapses.

105 In the SCF complex, this module is composed of Skp1, which bind

106 n the substrate in an optimal way within the SCF complex to enable efficient ubiquitin transfer.

107 ts that Slimb and Roc1a function in the same SCF complex to target Ci but that a different RING-H2 pr

108 er, these factors enable rapid remodeling of SCF complexes to promote biased assembly of SR modules b

109 eins, EBF1 and -2, that work coordinately in SCF complexes to repress ethylene action.

110 o assess the contribution of CUL1-containing SCF complexes to signaling within the plant oscillator,

111 he ability of the Skp1-Cullin-F-box protein (SCF) complex to ubiquitylate p27, such a mutation has no

112 dentify regulators/components of hCUL1-based SCF complexes, to determine whether the hCUL2-hCUL5 prot

113 C/C with another multiprotein E3 ligase, the SCF complex, uncovers remarkable structural similarities

114 o report that M-T5 can bind Akt and the host SCF complex (via Skp1) simultaneously in MYXV-infected c

115 Grr1p, another F box component of SCF complexes, was also ubiquitinated.

116 determine whether COI1 also functions in an SCF complex, we have characterized Arabidopsis proteins

117 omponents and substrates of a putative human SCF complex, we isolated hSKP1 in a two-hybrid screen wi

118 uring G(2) and M phase is dependent upon the SCF complex, whereas the APC/C is responsible for Cig2 d

119 -beta negatively regulates components of the SCF complex, which degrades the p27Kip1 during the G1 to

120 he anaphase-promoting complex (APC/C) or the SCF complex, which mediate the major cell cycle regulate

121 al structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF complex, which shows that Cul1 is an elongated prote

122 ass of ubiquitin ligases (E3 enzymes) called SCF complexes, which regulate the abundance of proteins

123 showed that mH2A1 is a new substrate of Skp2 SCF complex whose degradation by Skp2 promotes CDK8 gene

124 F-box proteins also act in non-SCF complexes whose functions are not well understood.

125 quitin ligases is formed by the multisubunit SCF complex, whose core complex (Rbx1/Cul1-Cdc53/Skp1) b

126 Being a part of SCF complex with Skp1 and Cullin1, HOS specifically inte

127 BF1 or -2, suggesting that the corresponding SCF complexes work together in EIN3 breakdown.