ライフサイエンスコーパス: SCF

1 SCF (Skp1-Cullin-F-box) ubiquitin ligases comprise sever

2 SCF complexes have a variable F-box protein subunit that

3 SCF E3 ligases are activated in many cancers and inhibit

4 SCF enzymes share a common catalytic core containing Cul

5 SCF ligases contribute to the timely destruction of nume

6 SCF prevented loss of clonogenic potential under differe

7 SCF(FBXW7) E3 ligase then promotes polyubiquitylation of

8 SCF(Skp2/Cks1) ubiquitinates Thr187-phosphorylated p27 f

9 SCF(Slmb) interacts with a phosphor degron embedded with

10 SCF-FBXO24 polyubiquitinates NDPK-A at K85, and two NH(2

11 SCF-type complexes can engage variant ubiquitination sub

12 anolysis reactions in the presence of Cu(O(3)SCF(3))(2) determined.

13 substrate of FBW7, a tumor suppressor, and a SCF (SKP1/CUL1/F-box)-type ubiquitin ligase.

14 iquitinated proteins, including TDP-43 and a SCF(Cyclin F) substrate.

15 Mck1 kinase, promotes Cdc6 degradation in a SCF(Cdc4)-dependent manner, therefore preventing rerepli

16 codes the substrate recognition subunit of a SCF ubiquitin ligase that targets proteins for degradati

17 Our results indicate that abnormal SCF activity with subsequent impairment of the autophagi

18 reduced degree of apoptosis 1 week after Ad.SCF injection.

19 creased by 12% relative to baseline after Ad.SCF therapy, whereas it decreased by 4.2% (P=0.004) in p

20 recombinant adenovirus encoding for SCF (Ad.SCF, n=9) or beta-gal (Ad.beta-gal, n=6) into the infarc

21 antly higher in pigs after SCF treatment (Ad.SCF, 55.5+/-11.6 mm Hg versus Ad.beta-gal, 31.6+/-12.6 m

22 work was significantly higher in pigs after SCF treatment (Ad.SCF, 55.5+/-11.6 mm Hg versus Ad.beta-

23 kp1 and Cul1 are invariant components of all SCF complexes, the 69 different human F-box proteins are

24 (ARI-1) coordinate with CDC34 (UBC-3) and an SCF E3 complex to ubiquitinate a common substrate, a SKP

25 (JASMONATE-ZIM DOMAIN [JAZ] proteins) by an SCF receptor complex (SCF(COI1)/JAZ).

26 l levels, ICR1 is rapidly destabilized by an SCF(TIR1/AFB) [SKP, Cullin, F-box (transport inhibitor r

27 owth and pigmentation, partly by creating an SCF-dependent niche for follicular melanocytes.

28 related FBP, reduces its ability to form an SCF, resulting in an increase in AFB1 levels.

29 racts with CUL1 and Skp1 proteins to form an SCF-type (Skp1, Cullin1, F-box) ubiquitin E3 ligase comp

30 abditis elegans DRE-1/FBXO11 functions in an SCF E3-ubiquitin ligase complex to regulate the transiti

31 T D816V converted ROSA(KIT WT) cells into an SCF-independent clone, ROSA(KIT D816V), which produced a

32 catalytic degradation when assembled into an SCF.

33 ed ubiquitination events and that EXO1 is an SCF-Cyclin F substrate in the response to UV radiation.

34 s to act as a ubiquitin ligase as part of an SCF (SKP1, CUL1 and F-box) complex.

35 lin F, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box protein) complex, as the G2 ubiquit

36 Each SLF is a component of an SCF (Skp1/Cullin/F-box) complex that is responsible for

37 W7 is the substrate-recruiting subunit of an SCF ubiquitin ligase and a major tumor-suppressor protei

38 ), which encodes the substrate adaptor of an SCF-class E3 ubiquitin ligase, cause dramatic loss of po

39 and the E3 ligase Hiw function as part of an SCF-like complex that attenuates Wnd/DLK signaling.

40 t complex with COI1, the F-box subunit of an SCF-type ubiquitin E3 ligase.

41 ly cell wall remodeling genes, mainly via an SCF(TIR/AFB)-dependent pathway.

42 art by the atypically fast rate of Cdc34 and SCF association.

43 n explain the rapid association of Cdc34 and SCF.

44 Biologically, both CRL4(Cdt2) and SCF(beta-TRCP)-mediated pathways contribute to ultraviol

45 on, and the ubiquitin ligases CRL4(Cdt2) and SCF(Skp2) couple to degrade p21 prior to the G1/S transi

46 Both G-CSF and SCF had pronounced effects on frataxin levels (the prima

47 l-1 degradation through a GSK3-dependent and SCF-FBXW7-mediated mechanism.

48 icle delivery, next generation gammaPNAs and SCF treatment may offer a minimally invasive treatment f

49 tion of Hst3 by cyclin-dependent kinases and SCF(Cdc4).

50 Interweaving MALDI and SCF facilitates a comparison between the experimentally

51 cted a direct association between mTORC2 and SCF-FBXW7; this association could be inhibited by TORKin

52 arin, which binds ligands including PDGF and SCF, and imatininib which blocks downstream tyrosine kin

53 ticipants consuming fibers (polydextrose and SCF combined) in comparison with NFC.

54 erial gene abundances after polydextrose and SCF supplementation included genes associated with carbo

55 2 +/- 2% and 13 +/- 2% with polydextrose and SCF, respectively, compared with NFC.

56 h activities depend on the F-box protein and SCF (Skp, Cullin, F-box) complex component MORE AXILLARY

57 Here we describe an insulin-signaling and SCF(LIN-23)-regulated pathway that controls mitochondria

58 h synergistic interactions between SMAP1 and SCF(TIR)(1) ubiquitin proteasome components.

59 e were resistant to TRAIL-induced apoptosis, SCF-stimulated MCs underwent apoptosis in response to TR

60 e we show that the ubiquitin ligase known as SCF(Dia2) promotes ubiquitylation of CMG during the fina

61 s and deubiquitylates the same substrates as SCF(Fbw7).

62 fically with Cullin-RING E3 ligases, such as SCF (Skp1-Cullin-F-box).

63 mal degradation by FBXL20 and the associated SCF complex expression provides a novel checkpoint for p

64 We engineered a mechanism-based SCF partial agonist that impaired c-Kit dimerization, tr

65 argets YAP1 for degradation via the betaTrCP-SCF ubiquitin ligase complex.

66 nd a site flanking Myc Box I that also binds SCF(FbxW7) We determined the crystal structure of the co

67 In SHP2 KO BMMCs, SCF-induced phosphorylation of the inhibitory C-terminal

68 The Skp-Cul-F box (SCF) ubiquitin E3 ligase machinery recognizes predominan

69 Skp1-Cul1-F-box (SCF) E3 ligases play key roles in multiple cellular proc

70 a substrate adaptor for the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase complex.

71 sary for recognition by Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligases leading to subsequent proteaso

72 nated by a member of the Skp1-Cullin1-F-box (SCF) family of ubiquitin ligases in a phosphorylation-de

73 s analogous to the cellular Skp1-Cul1-F-box (SCF) ubiquitin ligase complex.

74 te recognition subunit of SKP1-CULLIN-F-box (SCF) ubiquitin ligases.

75 e Kinase-Associated Protein1, Cullin, F-box [SCF] with Transport Inhibitor Response1 [TIR1]/Auxin Sig

76 Cdt2 itself is attenuated by SCF(FbxO11)-mediated proteasomal degradation.

77 oteins stimulates robust EIN3 degradation by SCF(EBF1/EBF2) E3 ligases.

78 re cytosolic XLF is subsequently degraded by SCF(beta-TRCP) in a CKI-dependent manner.

79 by GSK3 kinase and consequently degraded by SCF(FBW)(7alpha) Failure to degrade SOX9 promotes migrat

80 the regulation of mitochondrial function by SCF/Kit signalling and lay a foundation for exploring SC

81 ic potential of which might be influenced by SCF and selective KIT splicing.

82 is necessary for Hst3 polyubiquitylation by SCF(Cdc4).

83 ontexts that depend on p27 ubiquitination by SCF(Skp2-Cks1) ubiquitin ligase and therefore help forec

84 as a context in which p27 ubiquitination by SCF(Skp2/Cks1) is required for p27 downregulation.

85 DFT and CAS-SCF calculations have been used to probe the ground and

86 However, the structural aspects of the Cdc34-SCF interaction and how they permit rapid complex format

87 implicating the same mechanism for the Cdc34-SCF interaction in other members of the cullin-RING ubiq

88 cross-linking to demonstrate that the Cdc34-SCF interaction occurs in multiple conformations, where

89 ng Skp1 and ANK proteins that mimic cellular SCF-associated proteins.

90 tein-mediated viral latency through cellular SCF E3 ligase targeting of viral replication proteins is

91 ociated protein1/Cullin1/F-box protein COI1 (SCF(COI1)) E3 ubiquitin ligase complex, and their degrad

92 bunit of E3 ubiquitin protein ligase complex SCF, and the latter was functionally involved in NICD1 u

93 of Skp1, Cullin 1, F-box containing complex (SCF)-type E3 ligase, is the E3 ligase mediating the degr

94 t of an E3 ubiquitin-protein ligase complex (SCF(Cyclin F)).

95 [JAZ] proteins) by an SCF receptor complex (SCF(COI1)/JAZ).

96 erfering RNAs (siRNAs) against the conserved SCF subunit Skp1 protected PKR from NSs-mediated degrada

97 tability is regulated by the SKP2-containing SCF (SKP1-cullin1-F-box protein) E3 ubiquitin ligase in

98 omponent of the Skp-Cullin-F-box-containing (SCF) E3 ubiquitin ligase complex, recognizes the NF-kapp

99 unit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex.

100 r Fbw7, betaTrCP, and Skp2 Skp-F-box-cullin (SCF) E3 ubiquitin ligases, which degrade and suppress st

101 7(+) cells expressed CXCL12 and the cytokine SCF, were mesenchymal progenitors capable of differentia

102 Daily SCF consumption significantly increased bone calcium ret

103 f Mrc1 and Ctf4 or else tethering SCF(Dia2) (SCF [Skp1/cullin/F-box protein]) to the replisome to inc

104 results show that the skin microbiome drives SCF production in keratinocytes, which triggers the diff

105 phosphorylates ERalphaS341, to prime ERalpha-SCF(SKP2) binding via SKP2-L248QTLL252 in late G1.

106 revealing a novel mechanism whereby ERalpha/SCF(SKP2) transactivation of E2F-1 feeds forward to driv

107 ignalling and lay a foundation for exploring SCF/Kit signalling as a therapeutic target for metabolic

108 We have created a stable stem cell factor (SCF) -dependent human MC line, ROSA(KIT WT), expressing

109 nerally assumed to require stem cell factor (SCF) and KIT signaling during differentiation for the fo

110 Surprisingly, stem cell factor (SCF) as the MC-supportive mediator par excellence potent

111 Expression of stem cell factor (SCF) by these cells is necessary for the maintenance of

112 nic protein 4 (BMP-4), and stem cell factor (SCF) constituted a common cytokine signature in the vitr

113 9I progenitors cultured in stem cell factor (SCF) demonstrated a 10-fold expansion compared with prog

114 ulating factor (G-CSF) and stem cell factor (SCF) in a humanized murine model of Friedreich's ataxia.

115 Stem cell factor (SCF) is a growth factor that acts through the c-Kit rece

116 ersed by neutralization of stem cell factor (SCF) or cell adhesion molecule 1 (CADM1).

117 Stem cell factor (SCF) was secreted by differentiated tumor cells and supp

118 elated with skin levels of stem cell factor (SCF), a critical MC differentiation factor, and lipoteic

119 Stem cell factor (SCF), a ligand of the c-kit receptor, is a critical cyto

120 kinase Kit and its ligand, stem cell factor (SCF), play a critical role in the growth and survival of

121 taxis of mast cells toward stem cell factor (SCF), the ligand for KIT receptor.

122 human MCs, which depend on stem cell factor (SCF)-induced or constitutive KIT activation.

123 on plus stimulation of the stem cell factor (SCF)/c-Kit pathway yielded high levels of gene editing i

124 7 and 8 as well as stem cell growth factor (SCF).

125 terleukin-7 [IL-7], Flt3L, stem cell factor [SCF], ThPO, and IL-6) from bone marrow mesenchymal strom

126 Shoot-soil concentration factors (SCFs) for all crops showed a decrease with increasing ch

127 sessed the sources of the key niche factors, SCF (also known as KITL) and CXCL12, in the mouse spleen

128 commonly referred to as the Skp1-Cul1-Fbox (SCF) ligase.

129 Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adoles

130 lydextrose (21 g/d), and soluble corn fiber (SCF; 21 g/d) for 21 d each.

131 re combined with self-consistent mean-field (SCF) calculations to detect and predict ligand phase sep

132 well as serum concentrations of IL-7, Flt3L, SCF, and ThPO to the levels displayed by specific pathog

133 either a recombinant adenovirus encoding for SCF (Ad.SCF, n=9) or beta-gal (Ad.beta-gal, n=6) into th

134 , was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035).

135 compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d.

136 effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.

137 Paracrine signaling from SCF to KIT, between differentiated tumor cells and undif

138 XL2 (the receptor subunit of one of 69 human SCF (SKP1, CUL1, F-box protein) ubiquitin ligase complex

139 hether gene transfer of membrane-bound human SCF improves cardiac function in a large animal model of

140 3 ligase siRNA library screen and identified SCF-FBXO11 as an important E3 that targets SNAIL for ubi

141 library based on western blot and identified SCF-FBXO32 to be a new E3 ligase, which is responsible f

142 st cell (BMMC) model, we observed defects in SCF-induced cell spreading, polarization, and chemotaxis

143 cking of KIT also resulted in an increase in SCF-induced mast cell proliferation and migration, which

144 ac activation, and F-actin polymerization in SCF-treated BMMCs.

145 rotein linking cullin-1 to F-box proteins in SCF (Skp1/Cullin-1/F-box protein) E3 ubiquitin ligases,

146 This interaction seems to inactivate SCF-mediated protein degradation in general, since the u

147 ity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryot

148 Fs (SLF4 and SLF13) that were assembled into SCF(SLF) complexes.

149 tating their ubiquitination by the E3 ligase SCF(beta-TrCP).

150 its the ubiquitination of c-Jun by E3 ligase SCF(FBW) (7) (FBW7), increases c-Jun-dependent transcrip

151 onjugating enzyme Cdc34 and ubiquitin ligase SCF are capable of building polyubiquitin chains onto pr

152 argeted for turnover by the ubiquitin ligase SCF(Cdc4) after phosphorylation of a multisite degron.

153 vivo is dependent upon the ubiquitin ligase SCF(Cdc4) and that Hst3 is phosphorylated at two Cdk1 si

154 n that is recognized by the ubiquitin ligase SCF(Cdc4).

155 nd ubiquitination by the E3 ubiquitin ligase SCF(FbxW7) However, N-Myc protein (the product of the MY

156 as the degron that mediates ubiquitin ligase SCF(Grr1)-dependent destruction of Med13 following oxida

157 after ubiquitination by the ubiquitin ligase SCF(TIR1/AFB) (for S-Phase Kinase-Associated Protein1, C

158 at the cell surface: two ubiquitin ligases (SCF(betaTrCP2) and CHIP) determine the GH responsiveness

159 elf) and four families of ubiquitin ligases (SCF(EBF1/2), CUL3(LRB), CUL3(BOP), and CUL4(COP1-SPA)) t

160 Thus, SHP2 inhibitors may be useful to limit SCF/KIT-induced mast cell recruitment to inflamed tissue

161 broad-spectrum inhibitors that targeted many SCF ligases, or conversely, a highly specific inhibitor

162 ere, we identified components of the modular SCF (Skp1, Cul1, F-box protein)-type E3 ubiquitin ligase

163 ocultured, and was inhibited by neutralizing SCF or CADM1.

164 13, IL-17F, leptin, G-CSF, GM-CSF, LIF, NGF, SCF, and TGF-alpha.

165 Together, our work reveals a novel SCF(Cyclin F)-mediated mechanism required for precise on

166 is model is based on the NOD-scid IL2rg(null)SCF/GM-CSF/IL3 (NSG-SGM3) strain of mice engrafted with

167 Furthermore, the absence of SCF or imatinib treatment prevents progenitors from deve

168 K509I progenitors cultured in the absence of SCF survived but lacked expansion and developed into hyp

169 this topology may limit the accessibility of SCF(betaTrCP)/Cdc34 to the distal Ub Lys-48 and result i

170 p28 deficiency corrected the accumulation of SCF(Fbw7) substrate proteins, including NICD1, c-Jun, an

171 o stimulate the ubiquitin ligase activity of SCF(beta-TrCP) toward its target beta-catenin, resulting

172 4 binds to RBX1 and inhibits the activity of SCF(TIR)(1), an E3 ligase responsible for degradation of

173 at GF mice express abnormally low amounts of SCF, a critical MC differentiation factor, and contain M

174 ods that preserve the in vivo assemblages of SCF complexes and apply quantitative mass spectrometry t

175 aimed to determine the skeletal benefits of SCF in postmenopausal women.

176 haracterization of SkpA, a core component of SCF E3 ubiquitin ligases.

177 e capacity is dependent upon the coupling of SCF(betaTrCP) and miR-21 to suppression of SKP2 protein

178 Here we report that the expression of SCF and Kit in adipose tissues is responsive to food ava

179 Despite the broad cellular impact of SCF enzymes, important questions remain about the archit

180 The importance of SCF function is highlighted by cancer-specific alteratio

181 Mouse models of SCF-mediated anaphylaxis, radioprotection, and hematopoi

182 Local overexpression of SCF post-MI induces the recruitment of c-kit(+) cells at

183 Here we show purification of SCF(Fbxo4) complexes results in the identification of fr

184 s the antiviral kinase PKR by recruitment of SCF-type E3 ubiquitin ligases containing FBXW11 and beta

185 ce the Src tyrosine kinase as a regulator of SCF(beta-TrCP).

186 er, these factors enable rapid remodeling of SCF complexes to promote biased assembly of SR modules b

187 hanism of the former is through restraint of SCF(betaTrCP)-dependent destruction of the repressor ele

188 When the role of SCF(Skp2/Cks1)-mediated p27 ubiquitination in cancer was

189 3 months and suggests an angiogenic role of SCF.

190 ecific because IkappaB, another substrate of SCF(beta-TrCP), is not sensitive to NORE1A-promoted degr

191 es reveal that Fxr1 is a direct substrate of SCF(Fbxo4).

192 s well as the DELLA repressors, substrate of SCF(SLY)(1) We propose that the alf4 phenotype is partly

193 unctions as the substrate-binding subunit of SCF(cyclin F) E3 ubiquitin ligase.

194 a-TrCP, the substrate recognition subunit of SCF-type ubiquitin ligases, is ubiquitously expressed fr

195 Suppression of SCF or KIT signaling greatly reduced the expression of g

196 Instead, the tethering of SCF(Dia2) to the replisome progression complex increases

197 ein, we discuss the current understanding of SCF function and contribution to cell biology.

198 ic C-terminal tail of Cdc34 and a feature on SCF called the basic canyon.

199 ; this was prevented by inhibition of KIT or SCF.

200 nly activated by pro-inflammatory stimuli or SCF but also plays an important role in maintaining mTOR

201 Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes subs

202 sion and thermogenesis, while overexpressing SCF systemically or specifically in brown adipose tissue

203 We found previously that the PALL-SCF E3-ubiquitin ligase complex promotes apoptotic cell

204 iling of migrating cells revealed a possible SCF/c-Kit paracrine mechanism contributing to migration

205 depends exclusively on keratinocyte-produced SCF.

206 d chemotaxis, consistent with SHP2 promoting SCF-induced chemotaxis of mast cells via a phosphatase-d

207 by the Skp1-cullin 1-betaTrCP F-box protein (SCF(betaTrCP)) E3 ubiquitin (Ub) ligase complex.

208 F3-EBFs to the core SKP1-CUL1-F box protein (SCF) scaffold is facilitated by light signals or PIF3 ph

209 Skp1-Cul1-F-box protein (SCF) ubiquitin ligases direct cell survival decisions by

210 proteins in E3 Skp1/Cullin-1/F-box protein (SCF) ubiquitin ligases is well characterized.

211 subunit of the Skp1/Cullin-1/F-box protein (SCF)-class of E3-ubiquitin ligases, is a natural substra

212 beta-transducin repeats-containing protein) (SCF(Slimb/beta-TrCP)) as the E3 ubiquitin ligase complex

213 ase traps of eight different F box proteins (SCF specificity factors) coupled with mass spectrometry,

214 ial amoeba Dictyostelium, where it regulates SCF assembly and O2-dependent development.

215 not mean that mast cell progenitors require SCF and KIT signaling throughout differentiation.

216 ease of important bone marrow niche signals (SCF, IL-1beta, G-CSF, TGFbeta and CXCL4) and activation

217 thodology that involves engineering a single SCF(betaTrCP)-based ubiquitin ligase that is capable of

218 showed that mH2A1 is a new substrate of Skp2 SCF complex whose degradation by Skp2 promotes CDK8 gene

219 e LKB1 polyubiquitination by activating Skp2-SCF ubiquitin ligase.

220 t K63-linked LKB1 polyubiquitination by Skp2-SCF ubiquitin ligase is critical for LKB1 activation by

221 In the chronic stages, SCF gene transfer was associated with improved cardiac f

222 ed13 itself is modified by Slt2 to stimulate SCF(Grr1)-mediated destruction.

223 ation in its inhibitory sites and subsequent SCF-dependent degradation of the PHLPP phosphatase respo

224 Targeting SCF and CADM1 may enhance beta2-AR efficacy, particularl

225 gradation of Mrc1 and Ctf4 or else tethering SCF(Dia2) (SCF [Skp1/cullin/F-box protein]) to the repli

226 We conclude that SCF can have selective MC-dampening functions.

227 ical and functional studies demonstrate that SCF(FBXO31) is capable of recruiting and ubiquitinating

228 In focused studies, we found that SCF(FBXW11) bound, polyubiquitylated, and destabilized R

229 Rapidly accumulating data indicate that SCF(Fbw7) regulates a network of crucial oncoproteins.

230 Here, we report that SCF(beta-TRCP) earmarks Set8 for ubiquitination and degr

231 Competition experiments revealed that SCF(betaTrCP) formed a complex with IkappaBalpha and tha

232 prevailing consensus, our results show that SCF and KIT signaling are dispensable for early mast cel

233 Here, we show that SCF(Dia2) does not mediate replisome-specific degradatio

234 It has been shown that SCF expression increases after myocardial infarction (MI

235 These results suggest that SCF(SLF) complexes have evolved specifically to function

236 Both genetic and molecular data support that SCF(EBF1/2) function as photomorphogenic E3s during seed

237 The SCF(FBXO31) (Skp1-Cul1-Rbx1-FBXO31) ubiquitin ligase com

238 pha via the interactions between p97 and the SCF(beta-TRCP) ubiquitin ligase and between the polyubiq

239 Instead, we found that Src attenuates the SCF(beta-TrCP) E3-ligase activity in blunting Taz protea

240 for proteasome-dependent degradation by the SCF(betaTrCP) ubiquitin ligase.

241 n the absence of JA, but de-repressed by the SCF(COI)(1) complex on perception of JA.

242 ion of JA signal, degradation of JAZ3 by the SCF(COI1) complex releases YABs to activate a subset of

243 player in HR, RAD51, is ubiquitylated by the SCF(FBH1) complex.

244 quitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase.

245 ersity of pathways and is exemplified by the SCF(Fbw7) ubiquitin ligase.

246 ion-dependent cyclin E ubiquitylation by the SCF(Fbw7) ubiquitin ligase.

247 otecting it from degradation mediated by the SCF(Fbxw7) ubiquitin ligase.

248 ion factor Met4, which is carried out by the SCF(Met30) E3 ubiquitin ligase.

249 em and label-free proteomics to identify the SCF(Slmb) ubiquitin E3 ligase complex as a novel SMN bin

250 es encode several components involved in the SCF ubiquitin ligase complex including a viral Skp1 homo

251 kpoint kinase Chk1 at the MBT results in the SCF(beta-TRCP)-dependent degradation of a limiting repli

252 may directly associate with and inhibit the SCF-FBXW7 complex, resulting in delayed Mcl-1 degradatio

253 FBXW7 and disables its recruitment into the SCF complex.

254 equires E3 ubiquitin ligase complexes of the SCF (Skp1, Cul1, F-box protein) type to destroy PKR.

255 Skp1 is a subunit of the SCF (Skp1/Cullin 1/F-box protein) class of E3 ubiquitin

256 capable of contacting a broad region of the SCF basic canyon.

257 sm may involve regulation of assembly of the SCF complex.

258 2 is a novel interactor and substrate of the SCF E3 ubiquitin ligase beta-TrCP (FBXW1).

259 mb, the substrate specificity subunit of the SCF E3 ubiquitin ligase that targets proteins for degrad

260 utation destabilizes the CUL1 subunit of the SCF Reduced CUL1 levels are associated with increased le

261 about the architecture and regulation of the SCF repertoire, including whether SRs compete for Cul1 a

262 iates with the CULLIN1 (CUL1) subunit of the SCF through the N-terminal H1 helix of the F-box domain.

263 1 interacts with beta-TrCP, a subunit of the SCF ubiquitin ligase complex that mediates the degradati

264 , the substrate recognition component of the SCF(beta-TrCP) ubiquitin ligase complex.

265 showed that Vif is a novel substrate of the SCF(cyclin F) E3 ligase, where cyclin F mediates the ubi

266 cription factor BLMP-1 as a substrate of the SCF(DRE-1/FBXO11) complex.

267 To elucidate the molecular basis of the SCF(Fbp1) E3 ligase function, we analyzed potential Fbp1

268 1 (a conventional Rbx1) as components of the SCF(S) (2-) (SLF) (1) complex.

269 gulatory subunit 1 (Cks1), a cofactor of the SCF(Skp2) ubiquitin ligase complex and a downstream targ

270 As part of the SCF(Skp2) ubiquitin ligase, Skp2 drives the cell cycle b

271 Skp2, a substrate-recruiting subunit of the SCF(Skp2) ubiquitin ligase.

272 Here, we show that inactivation of the SCF-type E3 ubiquitin ligase substrate recognition compo

273 me to "trap" ubiquitylated substrates on the SCF(FBXW11) E3 complex.

274 While it is very clear that the SCF(beta-TRCP) ubiquitin ligase ubiquitinates IkappaBalp

275 We propose that the SCF(betaTrCP)-mediated degradation of Tiam1 controls the

276 Here we report that the SCF(Cyclin F) ubiquitin ligase complex prevents DNA re-r

277 Thus, the SCF(FBXO17) E3 ubiquitin ligase complex negatively regul

278 Inherent to the SCF calculation is the enumeration of local interactions

279 , interacts with TCP14 and targets it to the SCF(COI1) degradation complex by connecting it to the JA

280 late CREB-H stability by targeting it to the SCF(Fbw1a) E3 ubiquitin ligase.

281 te stability by targeting the protein to the SCF(Fbw1a) E3 ubiquitin ligase.

282 d by the ubiquitin-proteasome system via the SCF(betaTrCP) ubiquitin ligase.

283 This SCF variant elicited biased activation of hematopoietic

284 d hematopoietic expansion revealed that this SCF partial agonist retained therapeutic efficacy while

285 In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE,

286 maturation of MCs within the dermis through SCF production by LTA-stimulated keratinocytes.

287 autophagy and receptor endocytosis, through SCF (Skp1-Cul1-F-box)-mediated ubiquitination and degrad

288 environment, such as nutrient loss, through SCF E3 ligase activities, and responds by initiating act

289 d is predicted to severely impair binding to SCF proteins.

290 of Thr-187-phosphorylated p27 (p27T187p) to SCF(Skp2/Cks1) ubiquitin ligase.

291 r TRIM9-mediated regulation of the beta-TrCP SCF complex activity but also identifies TRIM9 as a brai

292 (MIG, IL22, TRAIL, APRIL, VEGF, IL3, TWEAK, SCF, IL21), identified patients who developed de novo HC

293 rypt-derived epithelial cells have uncoupled SCF(betaTrCP) from SKP2 and respond to RASSF1A inactivat

294 ubiquitylation alone or in combination with SCF(Skp2)-mediated ubiquitylation.

295 urification, we found JAZ12 to interact with SCF(COI1) components, matching with observed in vivo ubi

296 to Aurora-A alters how N-Myc interacts with SCF(FbxW7) to disfavor the generation of Lys48-linked po

297 f a conserved serine (S270A) interferes with SCF(Slmb) binding and stabilizes SMNDelta7.

298 Injection of thalassemic mice with SCF plus nanoparticles containing gammaPNAs and donor DN

299 cultured in serum-free medium together with SCF, TPO, FGF, with or without Igfbp2 and Angptl5 (STF/S

300 ood survive, mature, and proliferate without SCF and KIT signaling in vitro.