ライフサイエンスコーパス: SDB

1 SDB is associated with an increased risk of atrial fibri

2 SDB is associated with systolic/diastolic hypertension i

3 SDB measures accounted for 4-6% of the variance in NP co

4 SDB of moderate level was significantly associated with

5 SDB severity during REM and non-REM sleep was quantified

6 SDB was assessed at baseline with full polysomnography.

7 SDB was assessed with home overnight multichannel monito

8 SDB was associated with an increased adjusted odds of im

9 SDB was categorized using the apnea-hypopnea index (AHI)

10 SDB was characterized by apnea-hypopnea index >/=15 even

11 SDB was characterized with the respiratory disturbance i

12 SDB was identified on the basis of either sleep apnea or

13 SDB was quantified with the apnea hypopnea index (AHI) a

14 inantly white children 6 to 10 years of age, SDB amplified the adverse cognitive and weight outcomes

15 AMI-SDB and AMI-only patients were matched by age, body mass

16 e formation were significantly higher in AMI-SDB compared with AMI-only patients.

17 n monocytes were significantly higher in AMI-SDB patients, whereas plasma stromal cell-derived factor

18 tive function, as well as the presence of an SDB cutoff, have not been fully explored.

19 etween l-DLPFC GABA levels, but not Glx, and SDB severity by AHI (r = -0.68, P < 0.0001), and a posit

20 Patients with HF and SDB have more severe muscle vasoconstriction during hypo

21 d be more pronounced in patients with HF and SDB than in patients with HF without SDB (NoSBD).

22 s varied with increasing body mass index and SDB.

23 h home overnight multichannel monitoring and SDB was defined based on an apneahypopnea index >/= 10 (

24 health-related problems, such as obesity and SDB.

25 B), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians.

26 ons increased the risk of adverse weight and SDB outcomes by 2.9- and 7.9-fold, respectively.

27 enrolled: NoSDB (n=13, 46 [39-53] years) and SDB (n=28, 57 [54-61] years).

28 ossibly owing to different methods to assess SDB or cognitive domains, making it difficult to draw co

29 Our study suggests that baseline SDB is associated with increased cancer mortality in a c

30 cted of the longitudinal association between SDB and change in weight.

31 017 that reported on the association between SDB and cognitive function.

32 inding of an independent association between SDB and frailty indicator variables among older women co

33 It is possible that the association between SDB and glucose metabolism is distinct for non-REM versu

34 types reveals a stronger association between SDB and hypertension for those aged <60 years than previ

35 y have underestimated an association between SDB and systolic/diastolic hypertension in the elderly b

36 However, potential associations between SDB severity and neurocognitive function, as well as the

37 No association was found between SDB and systolic/diastolic hypertension in those aged >

38 sults support a direct temporal link between SDB events and the development of these arrhythmias.

39 that interactions may be operational between SDB and obesity to adversely affect neurocognitive outco

40 sion in those aged > or =60 years or between SDB and ISH in either age category.

41 6, the authors explored the relation between SDB and components of frailty among 1,042 participants o

42 s to assess the independent relation between SDB and impaired glucose metabolism.

43 on-based studies on the relationship between SDB and risk of cognitive impairment.

44 ociation between sleep-disordered breathing (SDB) and cognitive decline in elderly persons.

45 olymorphism with sleep-disordered breathing (SDB) and hypertension in 1,100 subjects of the Wisconsin

46 reported between sleep-disordered breathing (SDB) and insulin resistance, but no prospective studies

47 g recognition of sleep-disordered breathing (SDB) and its morbidity have prompted reevaluation of tec

48 Sleep-disordered breathing (SDB) and sleep apnea have been linked to hypertension in

49 Sleep-disordered breathing (SDB) has been associated with neuropsychological (NP) de

50 Sleep-disordered breathing (SDB) has been noted commonly in hemodialysis (HD) patien

51 tophan can treat sleep-disordered breathing (SDB) in an animal model of OSAHS; the effectiveness of t

52 risk factors for sleep-disordered breathing (SDB) in children and adolescents; specifically, quantify

53 Sleep-disordered breathing (SDB) in children is associated with cognitive challenges

54 risk factors for sleep-disordered breathing (SDB) in children.

55 Sleep-disordered breathing (SDB) is a common disorder in aging that is associated wi

56 Whether sleep-disordered breathing (SDB) is a risk factor for left ventricular (LV) hypertro

57 ng evidence that sleep-disordered breathing (SDB) is an independent risk factor for cardiovascular di

58 Sleep-disordered breathing (SDB) is associated with daytime sleepiness and impaired

59 ies suggest that sleep-disordered breathing (SDB) is associated with glucose intolerance and insulin

60 Sleep-disordered breathing (SDB) is associated with hypertension in the middle-aged.

61 Sleep-disordered breathing (SDB) is associated with pathophysiology that may influen

62 Sleep-disordered breathing (SDB) is both prevalent and associated with serious chron

63 Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), and

64 in children with sleep-disordered breathing (SDB) is different from healthy children and, if so, whet

65 Yet, sleep-disordered breathing (SDB) is highly prevalent in patients with AMI.

66 in patients with sleep-disordered breathing (SDB) is not well defined.

67 Prevalence of sleep-disordered breathing (SDB) is reported to increase in menopausal women.

68 erformed because sleep-disordered breathing (SDB) is suspected, but periodic leg movements during sle

69 extent to which sleep-disordered breathing (SDB) may explain associations between obesity and wheezi

70 The effect of sleep-disordered breathing (SDB) on right heart structure and function is controvers

71 sing to familial sleep-disordered breathing (SDB) was assessed in 31 subjects 28 +/- 10 yr of age (me

72 determinants of sleep-disordered breathing (SDB), a common set of disorders that contribute to signi

73 associated with sleep-disordered breathing (SDB), a prevalent condition in the US general population

74 in children with sleep-disordered breathing (SDB), but during wakefulness, active neural processes pr

75 H), as occurs in sleep disordered breathing (SDB), induces spatial learning deficits associated with

76 family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk

77 eepiness to mild sleep-disordered breathing (SDB), which affects as much as half the adult population

78 ildren with mild sleep-disordered breathing (SDB), who may not be recommended for adenotonsillectomy,

79 y presented with sleep-disordered breathing (SDB).

80 the severity of sleep-disordered breathing (SDB).

81 bjects with mild sleep-disordered breathing (SDB).

82 associated with sleep-disordered breathing (SDB).

83 in patients with sleep-disordered breathing (SDB).

84 ull polysomnography was used to characterize SDB.

85 s to the episodic hypoxia that characterizes SDB, thereby enhancing neurocognitive susceptibility in

86 In a community-based cohort, SDB is associated with echocardiographic evidence of inc

87 4 adult patients with suspected or confirmed SDB, we tested for an association between the rate of pe

88 studies used surrogate information to define SDB (eg, snoring) and were based on small clinic populat

89 rial diameter was not associated with either SDB measure.

90 nimum CSA is a useful measure for evaluating SDB risk factors in preadolescent children.

91 These data suggest that familial SDB may be based partly on a familial abnormality in ven

92 Further adjustment for SDB attenuated the association between obesity and wheez

93 ory problems and obesity as risk factors for SDB in children and adolescents.

94 amplified the risk by 0.39- to 0.40-fold for SDB and cognitive outcomes, respectively.

95 These findings have implications for SDB screening and treatment.

96 were evaluated twice at 4-year intervals for SDB.

97 els were 0.50, 0.43, 0.97, and 1.66 mg/L for SDB severity levels of AHI <1, 1 to 4.9, 5 to 14.9, and

98 They were offered surgical treatment for SDB.

99 ercent were overweight or obese, and 12% had SDB (AHI > or =5).

100 Nineteen had SDB (oxygen desaturation index > 5 events/h).

101 e information on medical and family history, SDB symptoms; measurement of height, weight, blood press

102 dependent determinants of hypersomnolence in SDB.

103 information on quality of life impairment in SDB.

104 and bed partner-assessed quality of life in SDB.

105 Diabetes is more prevalent in SDB and this relationship is independent of other risk f

106 and glutamate, respectively, play a role in SDB.

107 y enhancing neurocognitive susceptibility in SDB patients.

108 sion increased significantly with increasing SDB measures, although some of this association was expl

109 Interestingly, SDB and the insertion/deletion polymorphism interacted s

110 nized under the leadership of Judith Kimble (SDB President, U. Wisconsin-Madison), the meeting attrac

111 ntrol are likely to be effective in managing SDB and reducing new occurrence of SDB.

112 nitive measures in a severity-graded manner, SDB could adversely impact children's capacity to attain

113 confidence interval [CI], 0.5-2.7) for mild SDB (AHI, 5-14.9), 2.0 (95% CI, 0.7-5.5) for moderate SD

114 assessing the clinical significance of mild SDB, we estimate that an AHI of 15 is equivalent to the

115 (the reference category), subjects with mild SDB (5.0-14.9 events/hour) and moderate to severe SDB (>

116 ls had an age-adjusted prevalence of minimal SDB (AHI >/= 5), moderate SDB (AHI >/= 15), and severe S

117 Moderate SDB was associated with being male (adjusted odds ratio,

118 valence of minimal SDB (AHI >/= 5), moderate SDB (AHI >/= 15), and severe SDB (AHI >/= 30) of 25.8, 9

119 5-14.9), 2.0 (95% CI, 0.7-5.5) for moderate SDB (AHI, 15-29.9), and 4.8 (95% CI, 1.7-13.2) for sever

120 +/- 8.5 kg/m2) and had evidence of moderate SDB (AHI: 47.6 +/- 29.3 events/h).

121 40 children with primarily mild to moderate SDB before and after adenotonsillectomy and in 40 matche

122 Coexistent mild to moderate SDB in patients with AMI increased the mobilization, pro

123 We hypothesize that in the absence of SDB the effect of the deletion allele alone may not be s

124 ndependent and dose-response associations of SDB with CRP were addressed through linear mixed-effects

125 is study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better un

126 support the need for increased awareness of SDB, with particular emphasis on children with more seve

127 study of the cardiovascular consequences of SDB.

128 facial morphology in midlife development of SDB in women.

129 Diagnosis of SDB was based on the results of overnight polysomnograph

130 hing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucas

131 lation-based study of the natural history of SDB.

132 elded conflicting results, and the impact of SDB on the right heart has not been investigated in the

133 lights the significant deleterious impact of SDB, particularly in children with moderate to severe ob

134 groups, indicating a dose-response impact of SDB.

135 The incidence of SDB and the effect of risk factors on this incidence are

136 Incidence of SDB is influenced independently by age, sex, BMI, waist-

137 ly relevant and easily measured indicator of SDB severity but its genetic contribution has never been

138 sex, ethnicity, prematurity, and indices of SDB.

139 e-aged snorers with relatively low levels of SDB (RDI < 30) may benefit more from nasal CPAP than fro

140 hazards of cancer mortality across levels of SDB severity were compared using crude and multivariate

141 ESS score was seen across all four levels of SDB, from 7.2 (4.3) in subjects with RDI < 5 to 9.3 (4.9

142 At severe levels of SDB, the effect of sleep apnea on blood pressure overwhe

143 abetes in subjects with increasing levels of SDB.

144 tial mechanisms for the higher likelihood of SDB in the HD population must be identified to provide s

145 tions of hypertension with either measure of SDB were seen in both sexes, older and younger ages, all

146 ypercapnia to a greater extent in members of SDB families than in controls (0.169 +/- 0.054 cm H2O/L/

147 o evaluate the utility of various metrics of SDB and to identify the optimal respiratory metric that

148 ed in terms of a pathophysiological model of SDB in which hypoxia-mediated inhibitory neurotransmissi

149 fluence body mass index or the occurrence of SDB, but was dose-dependently associated with blood pres

150 managing SDB and reducing new occurrence of SDB.

151 ifty-seven participants with a wide range of SDB contributed 62 arrhythmias (76% NSVT).

152 on biases, or are manifest across a range of SDB is unclear.

153 36% black; 50% female) with a wide range of SDB severity underwent polysomnography and measurement o

154 We assessed the relation of SDB to LV morphology and systolic function in a communit

155 The relationship of SDB with a broad range of NP functions was examined in 1

156 ly lower among the first-degree relatives of SDB families than among controls (-0.76 +/- 0.47 L/min/%

157 adolescents to better understand the role of SDB in CVD risk.

158 rtality was less with increasing severity of SDB (P value for interaction between AHI and FEV1, 0.004

159 tronger in those with increasing severity of SDB in a community-based cohort of middle-aged and older

160 ality diminishes with increasing severity of SDB.

161 xamined in 100 volunteers with a spectrum of SDB and without underlying comorbidity.

162 o be associated with SDB, but few studies of SDB and hypertension distinguish systolic/diastolic hype

163 icipants in a genetic-epidemiologic study of SDB and included 399 children and adolescents 2 to 18 yr

164 nclude that in this community-based study of SDB and right heart echocardiographic features, RV wall

165 e common conditions and whether treatment of SDB might reduce risk of cognitive impairment.

166 Successful treatment of SDB, which is frequently associated with chronic sleepwa

167 An understanding of SDB among these populations is needed given evidence tha

168 related to degree of baseline sleepiness or SDB.

169 ing levels of CRP, suggesting that pediatric SDB may confer additional CVD risk beyond that of obesit

170 each independently (of the other) predicted SDB.

171 obin saturation < 90%) were used to quantify SDB severity.

172 /= 5), moderate SDB (AHI >/= 15), and severe SDB (AHI >/= 30) of 25.8, 9.8, and 3.9%, respectively.

173 lts of overnight polysomnography, and severe SDB was defined as an apnea-hypopnea index of >30 per ho

174 e was independent association between severe SDB and 1 or more frailty indicator variables (adjusted

175 29.9), and 4.8 (95% CI, 1.7-13.2) for severe SDB (AHI >/= 30) (P-trend = 0.0052).

176 HD patients were more likely to have severe SDB (>30 respiratory events per hour) compared with the

177 ncidence is about 7.5% for moderately severe SDB and 16% (or less) for mild to moderately severe SDB.

178 16% (or less) for mild to moderately severe SDB.

179 5.0-14.9 events/hour) and moderate to severe SDB (> or =15 events/hour) had adjusted odds ratios of 1

180 66.1 +/- 1.9 years) with moderate to severe SDB, defined as having an Apnea-Hypopnea Index (AHI) gre

181 in the odds of developing moderate-to-severe SDB.

182 e was a strong association of HD with severe SDB and nocturnal hypoxemia independent of age, BMI, and

183 for age, sex, body mass index, and smoking, SDB was associated with total and cancer mortality in a

184 a homolog binned within the 'Smithella' sp. SDB genome scaffold, were detected via RT-PCR, implying

185 hildren referred for evaluation of suspected SDB and control subjects, before and after application o

186 However, it is not clear that SDB is causal in the development of diabetes.

187 We conclude that SDB and obesity each are associated with asthma and whee

188 We conclude that SDB is associated with excess sleepiness in community-dw

189 se populations is needed given evidence that SDB increases cardiovascular risk.

190 cross-sectional study to date indicate that SDB is associated with systemic hypertension in middle-a

191 The results of this study suggest that SDB is independently associated with glucose intolerance

192 conductance) were significantly lower in the SDB group compared with the NoSDB group (P<0.001 to all

193 conductance) were significantly lower in the SDB group compared with the NoSDB group (P<0.01 to all c

194 MSNA was higher in the SDB group.

195 to be higher to hypercapnia (P=0.066) in the SDB group.

196 l these patients were treated only for their SDB, using nasal continuous positive airway pressure (CP

197 en of disease may be attributed to untreated SDB, supporting the development and evaluation of cultur

198 ies have been performed to determine whether SDB is causal in the development of diabetes.

199 ctive of this study was to determine whether SDB was associated with glucose intolerance and insulin

200 of the present study was to examine whether SDB is associated with cancer mortality in a community-b

201 Of 1,001 polysomnography subjects, 90 with SDB defined as a respiratory disturbance index (RDI) sco

202 African-Americans with SDB were younger than Caucasians with SDB (37.2 +/- 19.5

203 for covariates, ISH was not associated with SDB in either age category.

204 pertension is expected to be associated with SDB, but few studies of SDB and hypertension distinguish

205 e partly mediated by factors associated with SDB.

206 s with SDB were younger than Caucasians with SDB (37.2 +/- 19.5 versus 45.6 +/- 18.7 yr, p < 0.01).

207 Twenty-four children with SDB completed an open-label intervention study for 16 we

208 Children with SDB displayed reduced HEP amplitude during sleep, which

209 EP were significantly lower in children with SDB during non-REM sleep (stage 2: P = 0.03; slow-wave s

210 hildren, habitual snorers, and children with SDB relative to unaffected children.

211 as therapeutic alternatives in children with SDB too mild to justify referral for adenotonsillectomy.

212 ances, which were absent in 16 children with SDB who did not receive treatment.

213 curate identification of those children with SDB.

214 ecruited from families having no member with SDB.

215 13 families having two or more members with SDB.

216 increased by only 6.0% in participants with SDB (hazard ratio, 1.06; 95% confidence interval, 1.04-1

217 assess quality of life in 122 patients with SDB (apnea-hypopnea index > or = 5 events/hour), this st

218 gree of hypersomnolence in 741 patients with SDB (apnea-hypopnea index [AHI] >/= 10 events/h).

219 t in both control subjects and patients with SDB (p < 0.005).

220 s/hour), this study found that patients with SDB generally rate their quality of life higher than the

221 the RV hypertrophy observed in persons with SDB is associated with increased morbidity and mortality

222 CRP levels demonstrated a dose response with SDB above a threshold AHI of 5.

223 icantly greater (p = 0.005) in subjects with SDB (0.78 +/- 0.02 cm) than in the low-RDI subjects (0.6

224 ignificantly different between subjects with SDB and the low-RDI subjects.

225 cidence of type II diabetes in subjects with SDB and whether an independent relationship exists betwe

226 echocardiographic features of subjects with SDB at the Framingham Heart Study site of the Sleep Hear

227 In subjects with SDB, levels of l-DLPFC GABA, but not Glx, were significa

228 all thickness was increased in subjects with SDB.

229 as 26.9 per 1,000 person-years in those with SDB (AHI >/=5 events/h) and 18.2 per 1,000 person-years

230 -sectional studies suggested that those with SDB had slightly worse executive function (standard mean

231 rospective studies indicated that those with SDB were 26% (risk ratio, 1.26; 95% CI, 1.05-1.50) more

232 of life in normal subjects (n = 15) without SDB (apnea-hypopnea index < 5 events/hour) recruited fro

233 ytes compared with patients with AMI without SDB.

234 Subjects with (n = 10) and without SDB (n = 12) were recruited from 13 families having two

235 HF and SDB than in patients with HF without SDB (NoSBD).

236 xia and hypercapnia than HF patients without SDB, which seems to be associated with endothelial dysfu

237 ortality increased by 11.0% in those without SDB (hazard ratio, 1.11; 95% confidence interval, 1.08-1

238 lts (age +/- SD: 62.3 +/- 1.3 years) without SDB (AHI < 5).