ライフサイエンスコーパス: SET domain

1 SET domain [Su(var)3-9, Enhancer-of-zeste, Trithorax] pr

2 SET domain containing (lysine methyltransferase) 7 (SETD

3 SET domain containing 6 (SETD6) monomethylates the RelA

4 SET domain enzymes represent a distinct family of protei

5 SET domain lysine methyltransferases (KMTs) are S-adenos

6 SET domain lysine methyltransferases (KMTs) methylate sp

7 SET domain lysine methyltransferases are known to cataly

8 SET domain protein lysine methyltransferases (PKMT) are

9 SET domain protein lysine methyltransferases (PKMTs) reg

10 SET domain proteins are histone lysine methyltransferase

11 SET domain-containing proteins of the SU(VAR)3-9 class a

12 SET domain-containing proteins play a vital role in regu

13 SET-domain (SET: Su(var)3-9, E(z) and Trithorax)-contain

14 thylation activity is conferred by the ALL-1 SET domain.

15 subset of ccRCC (these included polybromo-1, SET domain containing 2 and BRCA1-associated protein-1,

16 ation of this enzyme, it appears that the 12 SET domain family members in yeast can now be divided in

17 y be a target for methylation by subfamily 2 SET domain methyltransferases.

18 The relationships of 22 SET domain proteins from maize (Zea mays) and 32 SET dom

19 domain proteins from maize (Zea mays) and 32 SET domain proteins from Arabidopsis were evaluated by p

20 encodes the zebrafish homolog of Blimp-1, a SET domain-containing transcription factor that promotes

21 ecognition motif at its amino terminus and a SET domain at the carboxy terminus, abolishes H3 Lys-4 m

22 ontains a methyl-CpG binding, a preSET and a SET domain, suggesting that CLLD8 might be associated wi

23 box and hath region plus 4 PHD fingers and a SET domain.

24 E(Z) bears a SET domain that houses the enzyme active site.

25 fic histone methyltransferases all contain a SET domain, a conserved 130 amino acid motif originally

26 methyltransferases, Dot1 does not contain a SET domain, and it specifically methylates nucleosomal h

27 The protein contains a SET domain, a PHD finger, four AT hooks, and a region wi

28 Set9 contains a SET domain, but lacks the pre- and post-SET domains.

29 2/E(Z), mes-6/ESC, or mes-4, which encodes a SET domain protein.

30 The YDR198c gene encodes a SET domain similar to that of the Rkm1 enzyme responsibl

31 pSET, a transcriptional regulator encoding a SET domain-containing protein recruited to active and in

32 Here, we show that mice expressing a SET domain mutant of MLL3 share phenotypes with isogenic

33 Enhancer of zeste 2 (Ezh2), a SET domain-containing protein, is crucial for developmen

34 tified a protein, termed Metnase, that has a SET domain and a transposase/nuclease domain.

35 The mutant has a nonsense mutation in a SET domain of a gene related to histone methyltransferas

36 yielded seven loss-of-function alleles in a SET domain protein with histone H3 Lys9 methyltransferas

37 MLL5 includes a SET domain and a single PHD finger, but lacks A-T hooks

38 arge subunit methyltransferase (PsLSMT) is a SET domain protein responsible for the trimethylation of

39 Egg is a SET domain protein that is similar to the human protein

40 SMYD3 is a SET domain-containing protein with histone methyltransfe

41 a Rubisco large subunit methyltransferase, a SET domain protein lysine methyltransferase catalyzing t

42 presents the first structural analysis of a SET domain PKMT in complex with its intact polypeptide s

43 peatedly isolated the C-terminal region of a SET domain-containing protein subsequently identified as

44 Knockdown of Setdb2, a SET domain-containing protein possessing a potential his

45 that ESET (an ERG-associated protein with a SET domain, also called SETDB1) histone methyltransferas

46 Here, we report that MES-4, a SET-domain protein, binds to the autosomes but not to th

47 d the F644 gene and showed that it encodes a SET-domain polycomb protein.

48 bidopsis thaliana gene MEDEA (MEA) encodes a SET-domain protein of the Polycomb group that regulates

49 essed ASH1-RELATED3 (ASHR3) gene, encoding a SET-domain protein conferring histone H3 lysine-36 methy

50 MES-3 is a novel protein, and MES-4 is a SET-domain protein.

51 We report further that the 149-aa SET domain of ASH1 is sufficient for H3-K4 methylation i

52 ns are important for cofactor binding across SET domain enzymes.

53 o subunits to confer an unusual split active SET domain for catalysis.

54 thologs Drosophila E(Z) and human EZH2 among SET domain proteins known to function as HMTs (reviewed

55 somatic cells, and Polycomb group (PcG) and SET domain-related proteins promote this ectopic express

56 ing that the molecular partnership of WD and SET domain polycomb proteins has been conserved during t

57 RM (FIE) and MEDEA (MEA) genes encode WD and SET domain polycomb proteins, respectively.

58 Both the conserved chromo- and SET domains of Clr4 are required for H3 Lys9 methylation

59 of N320 directly interacts with the FYRC and SET domains of C180.

60 Bop encodes a protein containing MYND and SET domains, which have been shown to regulate transcrip

61 in interactions that are mediated by PHD and SET domains, and by binding to DNA via A-T hooks and met

62 he evolutionarily conserved SACI, SACII, and SET domains of Set2 are necessary for this repression.

63 ough the domains present in plant and animal SET domain proteins often differ, the domains found in t

64 MEDEA (MEA) encodes an Arabidopsis SET domain Polycomb protein.

65 mbined analysis of the maize and Arabidopsis SET domain proteins reveals that duplication of SET doma

66 MEA and a related protein, SWINGER (SWN), as SET-domain partners of FIS2.

67 The histone methylating activity of the ATX1-SET domain argues that the molecular basis of these effe

68 small family of HMTs that contain bifurcated SET domains.

69 A single FSXXLXXL motif in the NR-binding SET domain protein NSD1 facilitates its interactions wit

70 Nuclear receptor-binding SET domain protein 2 (NSD2) is a histone H3 lysine 36 (H

71 The NSD (nuclear receptor-binding SET domain protein) family encodes methyltransferases th

72 The nuclear receptor-binding SET domain-containing protein (NSD1) belongs to an emerg

73 sine methylase, the nuclear receptor-binding SET domain-containing protein 1 (NSD1), and a lysine dem

74 gh sequestration and inhibition of SAM-bound SET domain methyltransferases.

75 chromatin states and is mostly catalyzed by SET domain-containing proteins.

76 Protein lysine methylation by SET domain enzymes regulates chromatin structure, gene s

77 in modulating lysine multiple methylation by SET domain KMTs and provide the first molecular snapshot

78 le versus multiple methyl group transfers by SET domain protein lysine methyltransferases.

79 ism is less likely for lysine methylation by SET domains; and that the only invariant active site res

80 s indicate that Set8 employs its i-SET and c-SET domains to engage nucleosomal DNA 1 to 1.5 turns fro

81 strains with deletion mutations in candidate SET domain-containing genes were in vivo labeled with S-

82 20h2 active site diverges from the canonical SET domain configuration and generates a high degree of

83 containing protein 2 (SMYD2) is a catalytic SET domain containing methyltransferase reported to mono

84 ilial relatives, Set1A possesses a catalytic SET domain responsible for histone H3K4 methylation.

85 The fly complex contains a catalytic SET domain subunit, E(Z), plus three noncatalytic subuni

86 despite the presence of an intact catalytic SET domain.

87 ation at lysine residue 266 in its catalytic SET domain.

88 7 of histone H3 (H3K27me3) via its catalytic SET domain.

89 he EZH2 CXC region adjacent to the catalytic SET domain and associates with EZH2 on the CDH1 and BRCA

90 nomethylation, and mutation of the catalytic SET domain is sufficient to cause the re-replication def

91 Y641 and A677 residues within the catalytic SET domain of EZH2 occur in diffuse large B-cell lymphom

92 ne 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other s

93 SET-II, the isoform containing the catalytic SET domain, inhibits CSR without affecting either IgH ge

94 Similarly, loss of the catalytic SET domains of MLL3 and MLL4 in mouse embryonic stem cel

95 hyltransferase that possesses characteristic SET domain and ANK repeats.

96 PKMTs contain a conserved SET domain in almost all of the cases and may transfer o

97 ursaria chlorella viruses encode a conserved SET domain methyltransferase, termed vSET, that function

98 is elegans gene, set-1, encoding a conserved SET-domain protein.

99 h sequence similarity to proteins containing SET domain methyltransferase, although experiments using

100 These results identify critical SET domain residues needed for PRC2 enzyme function, and

101 ctures are reported for three very different SET domain-containing proteins.

102 Proteins bearing the widely distributed SET domain have been shown to methylate lysine residues

103 H3-K27 methylation in vivo, shows that each SET domain mutation disrupts PRC2 histone methyltransfer

104 Ybr030w and SET7 genes both encode SET domain containing proteins homologous to known prote

105 77A/Y5523A/Y5563A mutations in the enzymatic SET domain of the MLL4 protein.

106 d covalently bound to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH ter

107 tSWP1, and a plant-specific C2H2 zinc finger-SET domain protein, AtCZS, interact with each other in p

108 A model is proposed for SET domain protein lysine methyltransferases in which in

109 letion of the histone methyltransferase gene SET-domain containing 2 (SETD2) and the ensuing loss of

110 rs, including histone deacetylase 1 (HDAC1), SET domain, bifurcated 1 (SETDB1), DNA methyltransferase

111 We purified and cloned a novel human SET domain-containing protein, named SET8, which specifi

112 Recent studies have identified SET domain-containing proteins such as SUV39H1 and Clr4

113 plex assembled with a catalytically inactive SET domain variant preferentially catalyzes H3K4 dimethy

114 protein lysine methyltransferases, including SET domain-containing protein 8 (SETD8), are highly desi

115 yses indicated that RNA interaction inhibits SET domain-containing proteins, such as PRC2, nonspecifi

116 H2-mediated cell invasion required an intact SET domain and histone deacetylase activity.

117 T activity of PRC2 is dependent on an intact SET domain in the E(z) protein.

118 aucity of E(z) mutant alleles that alter its SET domain.

119 tion, and this property was conferred by its SET domain, required for the HKMT activity.

120 SET1B, but not its SET domain, is critical for maintaining cell viability,

121 function in replication restart and that its SET domain is essential for recovery from hydroxyurea-in

122 zymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase

123 Through its SET domain, WHSC1 regulates the methylation status of th

124 to DNA in hotspots and subsequently uses its SET domain to locally trimethylate histone H3 at lysine

125 ethylation in H3, we show that Set2, via its SET domain, is responsible for methylation at this site

126 Based on known SET domain structures, the mutations likely affect eithe

127 ansferase (RLSMT) is a chloroplast-localized SET domain PKMT responsible for the formation of trimeth

128 Mammalian SET domain-containing proteins define a distinctive clas

129 deed, deletion of the H3K9 methyltransferase SET domain bifurcated 1 (Setdb1) results in reduced H3K9

130 n to its canonical histone methyltransferase SET domain, the MLL protein contains three plant homeodo

131 bules and that the histone methyltransferase SET-domain-containing 2 (SETD2), which is responsible fo

132 We further show that the MLL SET domain is a histone H3 lysine 4-specific methyltrans

133 kemogenic MLL fusion proteins delete the MLL SET domain Lys(4) methyltransferase activity and fuse ML

134 We demonstrate that the isolated MLL1 SET domain is a slow monomethyltransferase and that tyro

135 We introduced these mutations into the MLL1 SET domain and observed that all are defective for H3K4

136 iate does not significantly bind to the MLL1 SET domain during the dimethylation reaction.

137 determined the crystal structure of the MLL1 SET domain in complex with cofactor product AdoHcy and a

138 the SET-I subdomain indicates that the MLL1 SET domain possesses significantly more conformational p

139 In contrast, a complex containing the MLL1 SET domain, WDR5, RbBP5, Ash2L, and DPY-30, displays a m

140 nknown non-active-site surface from the MLL1 SET domain.

141 We found that unlike MLL1, the MLL3 SET domain assembles with the RbBP5/Ash2L heterodimer in

142 n-protein interactions, indicating that most SET domain proteins operate in complexes.

143 one methyltransferase (HMT) multiple myeloma SET domain (MMSET) in mouse B cells and the CH12F3 cell

144 The multiple myeloma SET domain (MMSET) protein is overexpressed in multiple

145 n occurred in myelomas with multiple myeloma SET domain (MMSET) translocation.

146 ctor receptor 3 (FGFR3) and multiple myeloma SET domain (MMSET).

147 ctor receptor 3 [FGFR3] and multiple myeloma SET domain [MMSET]), 16q23 (c-maf), and 20q11 (mafB).

148 ociated antigens (including multiple myeloma SET domain containing protein) which are characterized b

149 eceptor 3) from der(14) and multiple myeloma SET domain protein/Wolf-Hirschhorn syndrome candidate ge

150 hyltransferase MMSET/WHSC1 (Multiple Myeloma SET domain) is overexpressed in a number of metastatic t

151 domains, our studies draw attention to the n-SET domain as a predictor of an H2B ubiquitylation-sensi

152 , and such cross-talk is attributed to the n-SET domain of Set1 and its interaction with the Cps40/Sp

153 hes to demonstrate that Cps40/Spp1 and the n-SET domain of Set1 are required for the stability of Set

154 genetic analyses, we demonstrate that the n-SET domain within Set1, but not Swd2, is essential for H

155 the H3K4 methyltransferase family contain n-SET domains, our studies draw attention to the n-SET dom

156 contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichi

157 Dot1 is a non-SET domain protein that methylates histone H3 at lysine

158 In this paper, we identify a class I, non-SET domain protein methyltransferase, calmodulin-lysine

159 We have also discovered that the non-SET domain components of the MLL1 core complex possess a

160 Here we report that DOT1L, the non-SET domain containing methyltransferase that modifies Ly

161 riptional silencers binds to SETDB1, a novel SET domain protein with histone H3-K9-specific methyltra

162 Recent studies suggest that SmyD1, a novo SET domain-containing protein, may play a critical role

163 Our analysis reveals five classes of SET domain proteins in plants that can be further divide

164 Comparison of SET domain methyltransferase substrates in yeast reveal

165 They are composed of SET domain methyltransferases and structurally unrelated

166 domain proteins reveals that duplication of SET domain proteins in plants is extensive and has occur

167 l repression signal, mediated by a family of SET domain containing AdoMet-dependent enzymes.

168 one of the founding members of the family of SET domain-containing proteins.

169 Ectopic overexpression of SET domain mutant (F681Y) almost completely rescued WIF1

170 olded conformation observed in structures of SET domain histone lysine methyltransferases.

171 Members of the SU(VAR)3-9 family of SET-domain proteins methylate K9 of histone H3.

172 duction in methylation through inhibition of SET-domain enzymes.

173 und that in the absence of WRAD, all but one SET domain catalyzes at least weak H3K4 monomethylation.

174 domain (CTD) distinguishes SmyD1 from other SET domain containing methyltransferases.

175 tumor suppressor (VHL), polybromo 1 (PBRM1), SET domain containing 2 (SETD2), phosphatase and tensin

176 However, a majority of plant SET domain proteins do not have an animal homolog with s

177 have determined the structures of the plant SET domain enzyme, pea ribulose-1,5 bisphosphate carboxy

178 ding the MYND domain, the cysteine-rich post-SET domain, and the C-terminal domain (CTD), were also i

179 n allele that lacks the entire pre- and post-SET domains and that expresses lacZ under the endogenous

180 ide substrate binds between the SET and post-SET domains, with the epsilon-ammonium of K9 positioned

181 ns a SET domain, but lacks the pre- and post-SET domains.

182 t H3 lysine 9 methylation activities of a PR/SET domain have tumor suppression functions and may unde

183 y homologous, especially in the catalytic PR/SET domain, where they differ by only three amino acid r

184 ly conserved member of the Prdm family of PR/SET domain zinc finger proteins.

185 downstream signaling through the protein PR/SET domain 1 (PRDM1).

186 erved in cells expressing either the Riz1 PR/SET domain or PR-Set7 binding domain indicating that Riz

187 essor and demonstrate that the N-terminal PR/SET domain of Riz1 preferentially monomethylates H3K9.

188 The PR/SET domain 9 (PRDM9) protein is a major determinant of m

189 lhe22) forms a repressor complex with the PR/SET domain protein, Prdm8.

190 Here, we have established that the PR/SET domain-containing transcription factor Prdm1a is co-

191 ariegation, enhancer of zeste, trithorax (PR/SET) domain-containing zinc finger protein family, and i

192 hetic binding proteins, targeting the Prdm14 SET domain and demonstrate their utility, respectively,

193 ession or by EZH2 mutated at the region (pre-SET domain) of TRIM28 interaction.

194 a triangular Zn3Cys9 zinc cluster in the pre-SET domain and a AdoMet binding site in the SET domain e

195 Plasmodium falciparum encodes ten predicted SET domain-containing protein methyltransferases, six of

196 deletion of SET1, but not of other putative SET domain-containing genes, in S. cerevisiae, results i

197 Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the met

198 The NSD (nuclear receptor SET domain-containing) family of histone lysine methyltr

199 We propose that other closely related SET domain proteins may function similarly in gametogene

200 en K-to-M mutant histones and the respective SET domain methyltransferases are currently unknown.

201 or Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic target

202 The removal of the Set1A SET domain does not diminish bulk H3K4 methylation in ES

203 A (Set1A(DeltaSET)); surprisingly, the Set1A SET domain is dispensable for ESC proliferation and self

204 23-amino acid fragment upstream of the Set1A SET domain is necessary for interaction with CFP1, Ash2,

205 re we report the crystal structures of SETD2 SET domain in complex with an H3K36M peptide and SAM or

206 We further identified SETDB1 (SET domain, bifurcated 1), an H3K9-specific histone meth

207 s 92% identical to the human protein SETDB1 (SET domain, bifurcated 1).

208 ese studies suggest that the remaining seven SET domain proteins may also be lysine methyltransferase

209 Several SET-domain proteins possess intrinsic histone methyltran

210 enerally encode three types of H3K9-specific SET domain methyltransferases that contribute to chromat

211 Especially histone-specific SET domain PKMTs have received widespread attention beca

212 the GxG motif in the S-sequence of the split SET domain, as a G18A/G20A double mutant and a sequence

213 domain structure characterized by a "split" SET domain, a conserved MYND zinc finger, and a novel C-

214 In Drosophila, the C-terminal SET domain is encoded by trithorax-related (trr), which

215 its include the methyltransferase C-terminal SET domain of Set1/MLL, Cps60/Ash2L, Cps50/RbBP5, Cps30/

216 tain conserved motifs including a C-terminal SET domain, central PHD fingers, an N-terminal DNA-bindi

217 ransferase activity of the carboxyl-terminal SET domain.

218 These results show that SET domain methyltransferases can be involved in transla

219 Here we show that SET domain-containing 5 (Setd5) is divergently transcrib

220 We have demonstrated that SET domains mediate highly conserved interactions with a

221 The SET domain is a highly conserved domain shared between p

222 The SET domain is responsible for histone lysine methyltrans

223 The SET domain of Ash1 binds all three TRE transcripts, with

224 The SET domain of Set1 is located at the juncture of Cps50,

225 The SET domain proteins PR-Set7 and Suv4-20 have been implic

226 Accordingly, the SET domain of ASH1L methylates H3K4 in vitro, and knockd

227 tients with missense mutations affecting the SET domain and its adjacent domains.

228 ntified one enhancer, called set-2 after the SET domain encoded by the gene.

229 V39H1 utilizes both the chromodomain and the SET domain for catalysis.

230 trated that the SNAG domain of Snail and the SET domain of Suv39H1 were required for their mutual int

231 characterization of the HKMT family and the SET domain.

232 e structure of a ternary complex between the SET domain histone methyltransferase DIM-5, its cofactor

233 Lysine 142 of DNMT1 is methylated by the SET domain containing lysine methyltransferase 7 (SET7),

234 ly dimethylated at two distinct sites by the SET domain-containing enzyme Rkm1 in the yeast Saccharom

235 alpha is a new AR coregulator containing the SET domain with an exceptionally large molecular mass th

236 males bearing an egg allele that deletes the SET domain, oogenesis arrests at early stages.

237 horax-related gene of Drosophila encodes the SET domain protein TRR.

238 ion reveals an all-beta architecture for the SET domain embedded within a larger alpha-helical enzyme

239 mammalian su(var) protein and implicate the SET domain as a gatekeeper motif that integrates upstrea

240 e of CH ... O hydrogen bond formation in the SET domain active site and suggest a role for these inte

241 -SET domain and a AdoMet binding site in the SET domain essential for methyl transfer.

242 methylation), has a nonsense mutation in the SET domain of an H3-specific histone methyltransferase a

243 terozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice we

244 d within chromatin regulators, including the SET domain.

245 onto the three-dimensional structure of the SET domain and noticed that a subset of MLL2 (KMT2D, ALR

246 hancement of the catalytic efficiency of the SET domain and thus the propagation of this repressive h

247 Conserved regions of the SET domain bind S-adenosylmethionine and substrate lysin

248 yeast YPL208w gene product, a member of the SET domain family of methyltransferases, catalyzes the r

249 three-dimensional solution structure of the SET domain histone lysine methyltransferase (vSET) from

250 ghly variable but essential component of the SET domain must be repositioned.

251 generated ESCs harboring the deletion of the SET domain of Set1A (Set1A(DeltaSET)); surprisingly, the

252 Based on structural modeling of the SET domain of Set9 with RelA, we propose that the positi

253 The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltra

254 nges in the substrate binding regions of the SET domain, and the K36M residue interacts with the cata

255 g catalytic activity, due to deletion of the SET domain, fails to inhibit the Fgf21 promoter activity

256 K27M peptide bound to the active site of the SET domain, with the methionine residue located in the p

257 milar organization of domains outside of the SET domain.

258 e understanding of the molecular role of the SET domain.

259 is mediated through the HMT activity of the SET domain.

260 e MES complex appears to be dependent on the SET domain of MES-2.

261 ATX1 locus as an isoform containing only the SET domain (soloSET).

262 emphasize functional inputs from outside the SET domain.

263 somal dyad and in doing so, it positions the SET domain for catalysis with H4 Lys20.

264 in a cysteine-rich region that precedes the SET domain.

265 Gene silencing mediated by EZH2 requires the SET domain and is attenuated by inhibiting histone deace

266 ontain a conserved catalytic core termed the SET domain, which shares sequence homology with an indep

267 rved 130- to 140-amino acid motif termed the SET domain.

268 uence tag (EST) clone with similarity to the SET domain of Drosophila ASH1, and used it to clone the

269 ind that a basic N-terminal extension to the SET domain plays an even more prominent role in nucleoso

270 on, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trith

271 ositioning of the SRA domain relative to the SET domain.

272 that when hyperexpressed interacts with the SET domain and stabilizes the phosphorylated form of SUV

273 Along with the SET domain and the PHD fingers, this new element is a si

274 rough the conserved repeat 2 region with the SET domain of the homeotic regulator Trithorax (TRX), an

275 groups of AdoMet and methyllysine within the SET domain active site.

276 to a negatively charged "exosite" within the SET domain of Set9.

277 We report that the SET domains of TRX and TRX-related (TRR) have robust his

278 ated missense mutations that localize to the SET domains of several MLL family members.

279 in arginine methyltransferase family and the SET-domain-containing methyltransferase family.

280 Strikingly, the SET-domain protein MES-4 is concentrated on autosomes an

281 The level of homology of the SET-domains defined the distribution of the proteins int

282 gnment, compilation, and comparison of their SET-domains.

283 This SET domain protein bears no structural similarity to pre

284 u(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain, two LXXLL motifs, three nuclear translocati

285 ic Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain methyltransferases.

286 f variegation, enhancer of zeste, trithorax (SET) domain.

287 f variegation, enhancer of zeste, trithorax (SET) domains from human MLL1 and Drosophila Trithorax un

288 QM/MM) molecular dynamics simulations on two SET-domain PKMTs: SET7/9 and Rubisco large subunit methy

289 shares 39% identity with an uncharacterized SET domain protein, KIAA1076, hereafter denoted Set1B.

290 emonstrate that a previously uncharacterized SET domain protein, Set9, is responsible for H4-K20 meth

291 upported the distribution pattern built upon SET-domain similarity.

292 vSET (a viral SET domain protein) is an attractive polycomb repressive

293 However, the mechanism by which SET domain methyltransferases catalyze the transfer of t

294 MBD1 then interacts with SET domain bifurcated 1 methyltransferase to promote bim

295 the induction of ERG-associated protein with SET domain (ESET) and increases trimethylation of histon

296 ERG-associated protein with SET domain (ESET), a histone H3 (K9) methyltransferase,

297 was termed ESET (ERG-associated protein with SET domain).

298 Thus, the E(Z) SET domain requires multiple partner inputs to produce a

299 Four missense alleles identify key E(Z) SET domain residues, and a fifth is located in the adjac

300 hyltransferase (HMTase) activity of the E(Z) SET domain.