ライフサイエンスコーパス: SH3 domain

1 that overlaps with PPII binding site in its SH3 domain.

2 conserved Nef PXXPXR motif engaging the Hck SH3 domain.

3 fibrils occur by a domain-swap mechanism in SH3 domain.

4 izing PEGylation site within the chicken Src SH3 domain.

5 binding proteins derived from the human Fyn SH3 domain.

6 of dAbp1, which are mediated largely by its SH3 domain.

7 a function-blocking mutation into the dAbp1 SH3 domain.

8 an inhibitory function exerted by plectin's SH3 domain.

9 the SKAP-Hom Y260 and Y297 residues and its SH3 domain.

10 by amino acid substitutions in the adjacent SH3 domain.

11 e Pro-rich motif with acidic clusters in the SH3 domain.

12 eting of Ptc1p to proteins recognized by the SH3 domain.

13 ly binds PRL-1 in vitro and in cells via its SH3 domain.

14 -630, consisting of four SRs and an inserted SH3 domain.

15 on, the C-lobe of the kinase domain, and the SH3 domain.

16 in the FA targeting function of the p130Cas SH3 domain.

17 a modified topology and failed to engage the SH3 domain.

18 up to nine spectrin repeats (SR1-SR9) and an SH3 domain.

19 a groove identified under the RT loop of the SH3 domain.

20 n the local environments upon binding to the SH3 domain.

21 c tail of the beta3 integrin subunit via its SH3 domain.

22 ft perturbations on the opposite face of the SH3 domain.

23 development does not require the C-terminal SH3 domain.

24 globular domains corresponding to the three SH3 domains.

25 ated by the kindlin-2 F0 and the Src SH2 and SH3 domains.

26 e that is up-regulated by N-terminal SH2 and SH3 domains.

27 ional changes in both the ankyrin repeat and SH3 domains.

28 he poly-proline region of WASp using its two SH3 domains.

29 ormation of larger protein complexes via the SH3 domains.

30 ptor protein consisting of one SH2 and three SH3 domains.

31 tion motif in a linker between the first two SH3 domains.

32 expressed with or without a src homology 3 (SH3) domain.

33 d occur with and without the Src homology 3 (SH3) domain.

34 omology 2 (SH2) domain and a Src homology 3 (SH3) domain.

35 through the function of its Src homology 3 (SH3) domain.

36 through their SRC homology 2 and 3 (SH2 and SH3) domains.

37 CD2AP SH3 domains 1 and 2 generally bound with similar charact

38 resistant Nck1(K178R) or Nck2 containing the SH3 domain 2 of Nck1 restores stress fibres in synaptopo

39 ntrol F-BAR-membrane interactions as well as SH3 domain activities, and suggest that these two functi

40 region (AIR) and the tandem Src homology 3 (SH3) domains, allowing the AIR to undergo phosphorylatio

41 ycete fungal genomes and that all possess an SH3 domain and a conserved novel Ptc1p binding motif.

42 More interestingly, beta1a SH3 domain and C terminus, when simultaneously engineere

43 directly to FAK PRR2 and PRR3 sites via its SH3 domain and cortactin expression is important in prom

44 tion and showed direct binding between dAmph-SH3 domain and dNedd4Lo N-terminus.

45 es kinase activity in a manner unique to the SH3 domain and linker topologies present in the intact H

46 Tp53BP2 encodes ASPP2 (ankyrin repeats, SH3 domain and protein rich region containing protein 2)

47 inimally, this interaction requires UNC-89's SH3 domain and residues 294-376 of paramyosin and has a

48 terozygous, causative alleles in SH3TC2 (the SH3 domain and tetratricopeptide repeats 2 gene), involv

49 A fragment comprising the SH3 domain and the guanylate kinase domain of synapse-as

50 synaptic proteins are known to bind to this SH3 domain and to thereby activate gephyrin clustering.

51 entral coiled-coil region, a WH2 domain, two SH3 domains and a C-terminal RhoGEF (DH)-PH domain.

52 protein family that contains an SH2 and two SH3 domains and is involved in signal transduction from

53 rstand the interaction between the N-BAR and SH3 domains and its effect on biological function.

54 erent CaV isoforms as a binding site for the SH3 domains and report a crystal structure of the comple

55 distinct from others observed previously in SH3 domains and, to our knowledge, this is the first exa

56 ng F-BAR domain as well as a Src homology 3 (SH3) domain and a G protein-binding homology region 1 (H

57 vealed a pivotal role of the src homology 3 (SH3) domain and C terminus of beta1a in charge movement

58 DHHC6, contains a predicted Src-homology 3 (SH3) domain and DHHC6 is localized to the ER membrane.

59 IP1-R405C mutation is in the SRC homology 3 (SH3) domain and impairs Wiskott-Aldrich syndrome protein

60 of-function mutations in the Src homology 3 (SH3) domain and tetratricopeptide repeats 2 (SH3TC2) gen

61 o a number of different proteins through its SH3 domain, and a region N-terminal to the SH3 domain bi

62 ly through weak interactions with the second SH3 domain, and this effect appears to promote phase sep

63 that include a PDZ domain, a Src homology 3 (SH3) domain, and a region of homology to guanylate kinas

64 with signature sequences of ankyrin repeat-, SH3 domain-, and proline-rich region-containing protein

65 GTPase-activating protein (GAP), ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) in th

66 studies indicate that ACK1 and the cortactin SH3 domain are essential for ligand-mediated EGFR intern

67 SLP-76 PR region that interacts with the ITK SH3 domain as a competitive inhibitor to disrupt the ass

68 n the transition-state ensemble (TSE) in src SH3 domain as f is increased.

69 t containing distinct classes of ligands for SH3 domains, as well as on a new, an order of magnitude

70 iously studied tight complexes, we find that SH3 domain association rates are enhanced by long range

71 Experimental aggregation of Nck SH3 domains at the membrane induces actin comet tails--d

72 o better understand the connectivity of this SH3 domain-based protein network at the CR and its funct

73 We show in atomic detail that RBP C-terminal SH3 domains bind a proline-rich (PxxP) motif of Aplip1/J

74 tion and angiogenesis via directly targeting SH3 domain binding glutamate-rich protein (SH3BGR).

75 interactions are inhibited in the absence of SH3 domain binding ligands such as dynamin's prolin rich

76 -1), TIA1-related protein (TIAR), and RasGAP-SH3 domain binding protein 1 (G3BP1) are required for ef

77 ression of a noncleavable form of the RasGAP-SH3 domain binding protein in PV-infected cells enables

78 n of Hck activity by HIV-1 Nef and other Hck SH3 domain binding proteins and implicate the existence

79 lutamic acid did not alter BCAR3-induced Src SH3 domain binding to p130(cas).

80 these two proteins block augmentation of Src SH3 domain binding.

81 infected cells despite lacking intact RasGAP SH3-domain binding protein 1 (G3BP) and eukaryotic initi

82 entified in this screen is a RhoGAP protein, SH3-domain binding protein 1 (SH3BP1).

83 at is associated with point mutations in the SH3-domain binding protein 2 (SH3BP2) gene, which encode

84 mes of infection, GTPase-activating protein (SH3 domain) binding protein 1 (G3BP1) and G3BP2 were als

85 localisation with GTPase Activating Protein (SH3 domain) Binding Proteins (G3BPs).

86 In addition, cyclophilin A increased Crk SH3 domain-binding guanine-nucleotide releasing factor (

87 ective interactions that conform to class II SH3 domain-binding peptides.

88 TYMP contains an N-terminal SH3 domain-binding proline-rich motif and forms a comple

89 line with reduced expression of the Ras-GAP SH3 domain-binding protein (G3BP) that displayed an inhi

90 SG-nucleating protein Ras-GTPase activating SH3 domain-binding protein (G3BP1), which is mediated by

91 Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) was identified as a

92 Here, we identify SH3 domain-binding protein 4 (SH3BP4) as a binding prote

93 associates with Btk), also known as Sh3bp5 (SH3 domain-binding protein 5).

94 outer membrane of mitochondria, namely Sab (SH3 domain-binding protein that preferentially associate

95 irst report the discovery of Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3

96 rotein 3 (nsP3) forms a complex with Ras-GAP SH3-domain-binding protein (G3BP) and sequesters it into

97 We find that the Arg SH3 domain binds directly to N-WASp.

98 s SH3 domain, and a region N-terminal to the SH3 domain binds to the protein phosphatase, Ptc1p.

99 RBP, via its C-terminal Src-homology 3 (SH3) domains, binds Aplip1/JIP1, a transport adaptor inv

100 ced form of Brk (Alt Brk) which contains its SH3 domain blocks pY88 and acts as an endogenous cdk4 in

101 he mutation does not cause misfolding of the SH3 domains, but abolishes the interaction.

102 CD2AP binding sites, recognized by all three SH3 domains, but SH3-3 appeared non-functional in precip

103 rn blot-type experiment to show that the Abl SH3 domain can be detected in one step by observing the

104 CB2 harboring the N-terminal Src homology 3 (SH3) domain (CB2SH3+) adopts a closed and autoinhibited

105 old protein in TLR4 signaling called SAM and SH3 domain containing protein 1 (SASH1).

106 of Src homology-2 (SH2) and Src homology-3 (SH3) domain containing proteins that controls the coordi

107 phorylation and nuclear translocation of the SH3-domain containing protein GRB2 and an SH3-domain lig

108 Multiple SH3 domain-containing adapter proteins can bind and poss

109 Here we show that ubiquitin-associated and SH3 domain-containing B (UBASH3B), a protein tyrosine ph

110 ences of the Itch PRR toward its most common SH3 domain-containing partners and demonstrate that the

111 Two SH3 domain-containing PCH family members, Cdc15 and Imp2

112 Proteome profiling identified sorbin and SH3 domain-containing protein 2 (SORBS2) and PDZ and LIM

113 p at the 4q35 locus involving the sorbin and SH3 domain-containing protein 2 gene, SORBS2, a skeletal

114 nd characterized sorb-1, the only sorbin and SH3 domain-containing protein family member in Caenorhab

115 iated endocytosis, is a approximately 40 kDa SH3 domain-containing protein that binds to the proline/

116 Rho family GTPases, phosphoinositide lipids, SH3 domain-containing proteins, kinases, and phosphatase

117 ted that the TRD3 binds WD40, WWI, WWII, and SH3 domain-containing proteins.

118 iverging into A and B subgroups, are BAR and SH3 domain-containing proteins.

119 th beta-PIX and a 1:1 complex with the other SH3 domain-containing proteins.

120 csins but can also target a variety of other SH3 domain-containing proteins.

121 own to interact with several Src homology 3 (SH3) domain-containing proteins.

122 Nbp2p is an Src homology 3 (SH3) domain-containing yeast protein that is involved in

123 Vamana, an SH3-domain-containing protein, physically associates wit

124 idues and is generally considered to bind to SH3-domain-containing proteins.

125 These data indicate that the Lck SH3 domain controls T lymphocyte activation by regulatin

126 This process is associated with the SH3 domain-dependent translocation of Dok-3/Grb2 complex

127 R constriction most likely by inhibiting the SH3-domain-dependent interactions of Hof1.

128 vity to allow covalent decoration of natural SH3 domains, depending on choice of catalyst but indepen

129 udies, focused on ketosteroid isomerase, the SH3 domain, dihydrofolate reductase, and cytochrome c, w

130 uncated protein lacking WD40-repeats and the SH3 domain; disease was hitherto attributed to loss of t

131 pecificity for certain domain types, such as SH3 domains distributed across different proteins.

132 On membrane binding, Nwk SH3 domains do not completely dissociate from the F-BAR

133 n single-molecule pulling experiments on src SH3 domain, exhibits upward curvature on a [Formula: see

134 solution, the isolated MLV IN CTD adopts an SH3 domain fold flanked by a C-terminal unstructured tai

135 in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3.

136 ry expressing the entire complement of human SH3 domains for novel NS5A-host cell interactions.

137 nomer cross-interaction between H0 helix and SH3 domain from different subunits within a homodimer.

138 In the current study, we tested whether SH3 domains from the F-BAR (FCH-Bin-Amphiphysin-Rvs) sub

139 e the binding pathway of the Src homology 3 (SH3) domain from the Fyn tyrosine kinase, which forms co

140 Our results demonstrate that Lck SH3 domain function regulates activation of T lymphocyte

141 ise analysis identified SNX25, PDLIM3, and 3 SH3 domain genes (SORBS2, SH3RF3, and NPHP1) to be signi

142 rising a metastable triple mutant of the Fyn SH3 domain, have been investigated using pressure-depend

143 s the first example of peptide-binding of an SH3 domain in a bacterial system.

144 embranes, highlighting the importance of the SH3 domain in regulating the function of endophilin.

145 that the proline-rich region in AIP4 and the SH3 domain in STAM-1 are essential for the interaction.

146 We also show that the SH3 domain in the C-terminus plays an important role in

147 l regions of dense bodies via its C-terminal SH3 domains in an ATN-1(alpha-actinin)- and ALP-1(ALP/En

148 eals a requirement for the PACSIN1 F-BAR and SH3 domains in controlling these NMDAR-dependent process

149 mposed of the central SH2 and the C-terminal SH3 domains in Grb2(-/-) thymocytes fully restores thymo

150 nization exposes the binding sites of all 12 SH3 domains in the tetramer, allowing simultaneous bindi

151 res and relative orientations of the SH2 and SH3 domains in this shorter protein were very similar to

152 the endophilin N-BAR domain (which lacks the SH3 domain including a linker region of the full length

153 F4alpha F domain that interacts with the Src SH3 domain, increase phosphorylation by Src and decrease

154 cal shift perturbations in the (15)N-labeled SH3 domain induced by the C-terminal beta3 tail peptide

155 e the first evidence for the function of the SH3 domain interaction in synaptic vesicle (SV) organiza

156 the negative regulatory effects mediated by SH3 domain interactions.

157 BCR-ABL1 SH3 domain interacts with RAD51 proline-rich regions, re

158 e studies have highlighted a role for EH and SH3 domain Intersectin (Itsn) proteins in synaptic vesic

159 the Wiskott-Aldrich syndrome protein via its SH3 domain is critical for integrin activation and neutr

160 Thus, the SH3 domain is far less reliant on electrostatic enhancem

161 Although the N-terminal SH3 domain is important for p130Cas localization, it has

162 When the SH3 domain is overexpressed, paramyosin is mislocalized.

163 The SH3 domain is present in a loop between two helices of a

164 tation analysis indicates that the cortactin SH3 domain is responsible for binding to ACK1.

165 on between GK and the nearby Src homology 3 (SH3) domain, leading to a closed conformation, whereas a

166 a (SPRR2a), which acts as an src homology 3 (SH3) domain ligand, induces biliary epithelial cell (BEC

167 he SH3-domain containing protein GRB2 and an SH3-domain ligand in ZEB1 is required for SPRR2a-induced

168 d with (15)N CEST experiments recorded on an SH3 domain-ligand exchanging system and subsequently use

169 These syndapin I functions reflected direct, SH3 domain-mediated associations and functional interact

170 n of the cell wall integrity pathway through SH3 domain-mediated interaction with Bck1p, a component

171 ne mutants (Y260F, Y260F/Y297F), or SKAP-Hom SH3 domain mutant (W335K).

172 Interestingly, the SH3 domain mutant-rescued MEFs showed an enhanced cell m

173 hobic residues on both domains and keeps the SH3 domain near the end of the N-BAR domain, in agreemen

174 y way of miR-200c/141-associated EMT through SH3-domain networks and contributes to benign and malign

175 ng point mutation of either the c-Src SH2 or SH3 domain obviates the RANK/alphavbeta3 association.

176 PxxP ligand-binding site of the p115 RhoGAP SH3 domain occupies a folded groove within PRL-1.

177 10 and ABI-1 and showed that it requires the SH3 domain of ABI-1.

178 The SH3 domain of Boi2, which is dispensable for bud growth

179 ring under the control of the release of the SH3 domain of CB is essential for regulating gephyrin cl

180 n PakB-1-180 that directly interact with the SH3 domain of Dictyostelium actin-binding protein 1 (dAb

181 ne NMR data on the 7-kDa globular N-terminal SH3 domain of Drosophila signal transduction protein drk

182 LSP1 interacts with the SH3 domain of myosin1e, and the localization and dynamic

183 novel ligand (PDN1) that targets the unique SH3 domain of N1-Src and inhibits N1-Src in cells.

184 nd to N-WASP, by interacting with the second SH3 domain of Nck.

185 Nck1 partners, chimaerins bind to the third SH3 domain of Nck1.

186 We found that the SH3 domain of NOSTRIN is involved in the NOSTRIN-TRAF6 i

187 events the canonical interaction between the SH3 domain of p115 RhoGAP and MEKK1 and results in activ

188 We demonstrate that only the SH3 domain of p120 selectively inhibits the RhoGAP activ

189 t not in alpha-spectrin, suggesting that the SH3 domain of plakins contributes to the stability and r

190 Direct binding of the SH3 domain of PLC-gamma1 to Pak1 dissociates inactive Pa

191 ociation of PTK6 with AKT occurs through the SH3 domain of PTK6 and is enhanced through SH2 domain-me

192 porter Fps1p, which was shown to require the SH3 domain of Sho1p for binding via its N-terminal solub

193 The SH3 domain of Sho1p was found to be important for bindin

194 Associated molecule with the SH3 domain of signal transduction adaptor molecule (STAM

195 Furthermore, inhibition of the SH3 domain of Son of Sevenless, which is an upstream ada

196 Here, we report that Bag3 interacts with the SH3 domain of Src, thereby mediating the effects of Hsp7

197 exon leads to a 5 or 6 aa insertion into the SH3 domain of Src.

198 h contains a Rac-specific GAP domain; 2) the SH3 domain of srGAP2 binds the formin homology 1 domain

199 tinating enzyme associated molecule with the SH3 domain of STAM (AMSH) is crucial for the removal of

200 The DUB AMSH (associated molecule with the SH3 domain of STAM) has been shown to be involved in reg

201 , a proline-rich peptide in HD-PTP binds the SH3 domain of STAM2.

202 dopsis thaliana associated molecule with the SH3 domain of STAM3 (AMSH3) is a deubiquitinating enzyme

203 n Aim21, which interacts physically with the SH3 domain of the Arp2/3 complex regulator Bbc1.

204 The N-terminal SH3 domain of the Drosophila signal transduction protein

205 mma1 interaction enhances the binding of the SH3 domain of the phospholipase with Pak1.

206 The SH3 domain of the PI3 kinase (PI3-SH3 or PI3K-SH3) readi

207 cture-function studies showed that the fifth SH3 domain of Tks5 binds to the N-terminus of XB130, whi

208 ogether, these results suggest that only the SH3 domains of CD2AP were necessary to enhance the E3 li

209 The SH3 domains of CD2AP were sufficient to drive the Cbl-3/

210 Despite these distinct roles, the SH3 domains of Cdc15 and Imp2 cooperate in the essential

211 These effects depend on the F-BAR and SH3 domains of CIP4 and on its ability to multimerize.

212 The SH2 and SH3 domains of Crk are required for transformation, but

213 Here, we report crystal structures of tandem-SH3 domains of different STAC isoforms up to 1.2-A resol

214 SHP1 and THEMIS engage with the N-SH3 and C-SH3 domains of GRB2, respectively, a configuration that

215 f a Src family kinase inhibitor and when the SH3 domains of Nck are mutated.

216 The first and third SH3 domains of Nck are not required to recruit the WIP:N

217 the 50-residue linker between the first two SH3 domains of Nck enhances phase separation of Nck/N-WA

218 We identify the SH3 domains of nebulin and nebulette as novel ligands of

219 -Rak binding is direct, requires the SH2 and SH3 domains of Rak/Frk for efficient complex formation a

220 The SH3 domains of syndapin and endophilin bind the PXXP mot

221 report here that TbetaRI interacts with the SH3 domains of the adaptor protein CIN85 in response to

222 l as its complex with the ankyrin repeat and SH3 domains of the pro-apoptotic factor ASPP2.

223 The RXXK motif of AMSH interacts with the SH3 domains of the STAM and Grb2 families of adaptor pro

224 ity, can be inhibited by the Src homology 3 (SH3) domain of a Ras-specific GAP (p120RasGAP).

225 s to the target protein, the Src homology 3 (SH3) domain of human Abelson tyrosine kinase (Abl), was

226 ith a conserved motif in the Src homology 3 (SH3) domain of p115 Rho GTPase-activating protein (GAP).

227 molecular recognition of the Src homology 3 (SH3) domain of the yeast protein Sho1 with its cognate p

228 e-rich protein, binds to the Src homology 3 (SH3) domains of GRB2 resulting in PI3K activation.

229 ne-rich region 1 of THEMIS to the C-terminal SH3-domain of GRB2.

230 catalytic domain or Src homology 2 (SH2) or SH3 domains or of the cysteine residue that undergoes LP

231 ion of either the N-terminal Src homology 3 (SH3) domain or the Cas-family C-terminal homology (CCH)

232 s crucial in the recognition between PRM and SH3 domain, our results suggest that attaching multiple

233 ovide additional specificity to the syndapin SH3 domain outside of the well described polyproline-bin

234 nc-89 loss-of-function mutants that lack the SH3 domain, paramyosin is found in accumulations.

235 ECM secretion phenotypes, whereas binding of SH3-domain partners is not required.

236 ole of BAR sequence-mediated dimerization on SH3 domain partnership.

237 activities as well as a dramatic decrease of SH3 domain partnership.

238 ncated Hck protein consisting of the SH2 and SH3 domains plus the linker.

239 , but not by an N-WASp binding-deficient Arg SH3 domain point mutant.

240 its Dyn2-binding C-terminal Src homology 3 (SH3) domain prevents Hsc70 binding, resulting in a stabi

241 les in establishment of a robust multivalent SH3 domain-PRM network in vivo, giving actin assembly on

242 rcoma) to a multivalent poly-Src homology 3 (SH3) domain protein that phase-separates when mixed with

243 suggesting that the spatial presentation of SH3 domains, rather than affinity, governs the recruitme

244 Thus, the data suggest that the SH3 domain recognizes its cognate peptide with a compone

245 scaffolding model proposes that endophilin's SH3 domain recruits essential endocytic proteins, wherea

246 o induce curvature; however, the role of the SH3 domain remains controversial.

247 ain responsible for membrane bending, and an SH3 domain responsible for the recruitment of dynamin an

248 d found that the peptide interacted with the SH3 domain RT-loop and surrounding residues.

249 fy direct low affinity interactions with the SH3 domain(s) of ESCRT-0 proteins, STAM1/2.

250 e in the linker between the first and second SH3 domain (SH3.1/SH3.2) and the second SH3 domain (SH3.

251 cond SH3 domain (SH3.1/SH3.2) and the second SH3 domain (SH3.2).

252 t, iteratively with Y221, the Crk C-terminal SH3 domain (SH3C) is routinely phosphorylated on Y239 an

253 pY221 auto-clamp to interrupt SH2-N-terminal SH3 domain (SH3N) signaling.

254 nd that mutants that lack either H0 helix or SH3 domain show significantly faster dissociation kineti

255 conserved SAM and RA domains, as well as two SH3 domains specific to basidiomycetous Ste50 proteins.

256 ning two ADAP-binding SKAP55 Src homology 3 (SH3) domains stabilized SLP-76 microclusters and promote

257 rogen bonds (13.0 +/- 0.6 kcal/mol), and the SH3 domain stabilizes the structure of the N-terminal he

258 The Arg SH3 domain stimulates N-WASp-dependent actin polymerizat

259 Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadl

260 resents a suboptimal ligand for the isolated SH3 domain, suggesting that it may form the polyproline

261 ology 2 (SH2) domain and alphavbeta3 via its SH3 domain, suggesting the kinase links the two receptor

262 me cases causes dimerization of endophilin's SH3 domains, suggesting that the spatial presentation of

263 We find that different SH3 domains target distinct proline-rich sequences overl

264 The process involves a SH3 domain that binds to a region of the RecB subunit in

265 s applied to the folding reaction of the Fyn SH3 domain that exchanges between a highly populated, NM

266 Purified Bzz1p has two SH3 domains that interact with Wsp1p and stimulate actin

267 domain downstream of the N-terminal SH2 and SH3 domains that regulate catalytic function and membran

268 daptor protein Nck has three SRC-homology 3 (SH3) domains that bind multiple proline-rich segments in

269 CD2AP contains three Src homology 3 (SH3) domains that mediate multiple protein-protein inter

270 We show, using simulations of src SH3 domain, that mechanical force enhances the populatio

271 a remarkable allosteric network linking the SH3 domain, the myristic acid binding pocket, and the ac

272 theless, an amino acid stretch preceding the SH3 domain, the so-called N-cap, reshapes the free-energ

273 ent surface uniformity and conserved fold of SH3 domains, they display different binding mechanisms a

274 nts the ability of p130(cas) to bind the Src SH3 domain through an RPLPSPP motif in the p130(cas) SBD

275 We predict that the helix binds to the SH3 domain through hydrophobic and salt-bridge interacti

276 t fashion by altering the ability of the Src SH3 domain to bind the p130(cas) SBD.

277 s, we studied the binding properties of each SH3 domain to the known interactor Casitas B-lineage lym

278 this interaction involves binding of the ITK SH3 domain to the polyproline-rich (PR) region of SLP-76

279 es splicing to insert short sequences in the SH3 domain to yield N1- and N2-Src.

280 We applied the strategy to SH3 domains to determine the properties of their binding

281 inases, acts in conjunction with the SH2 and SH3 domains to stabilize the inactive conformation.

282 induced aggregation of membrane-targeted Nck SH3 domains to test these predictions and to determine h

283 g GTPase complex through its Src homology 3 (SH3) domain under conditions of amino acid starvation an

284 SH3 domains usually interact with a proline-rich consens

285 N-terminal deleted mutant and/or Tks5 fifth SH3 domain W1108A mutant.

286 hesis that it targets Src homology domain 3 (SH3) domains was tested, but mutation of the putative SH

287 Conformational states of the metastable drkN SH3 domain were characterized using single-molecule fluo

288 logy 2 domain, followed by a Src homology 3 (SH3) domain, whereas CrkII possesses in addition a C-ter

289 ized with aPKC, Dlg is phosphorylated in its SH3 domain which disrupts autoinhibition and allows GukH

290 TOCA1 was recruited to pedestals by its SH3 domain, which bound directly to proline-rich sequenc

291 n addition a C-terminal linker region plus a SH3 domain, which operate as regulatory moieties.

292 d to include modification of the natural Fyn SH3 domain with metallopeptides based on a known proline

293 into a putative interaction mode of the p120 SH3 domain with the DLC1 RhoGAP domain that is atypical

294 Cocrystallization of the nebulette SH3 domain with the interacting XIRP2 peptide PPPTLPKPKL

295 e intimate intramolecular association of the SH3 domain with the preceding SR is also observed in ple

296 ing motifs are mapped and shown to bind both SH3 domains with micromolar affinity.

297 tion, and whether it affects interactions of SH3 domains with other cellular ligands, remain unclear.

298 nds the amphiphysin-2 (BIN1) Src homology-3 (SH3) domain with an unusually high affinity (Kd 24 nm).

299 the specific binding of the Src homology 3 (SH3) domain with short proline-rich peptides.

300 in metazoans as identified by an N-terminal SH3 domain, YxxP motifs, and a C-terminal FAT-like domai