ライフサイエンスコーパス: SHBG

1 SHBG and TE are independent risk factors for the develop

2 SHBG concentrations were 23% lower in women with a high

3 SHBG increased 22.4% (P < .001) with diet and 25.8% (P <

4 SHBG increased total androgen and estrogen concentration

5 SHBG levels were positively associated with isoflavones

6 SHBG may be an important diagnostic measure of risk for

7 SHBG produced in the brain may be released endogenously

8 SHBG was inversely associated with the risk of T2D, wher

9 SHBG was negatively associated only with bone density in

10 SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxyt

11 east cancer risk (odds ratio doubling, 0.82 [SHBG] to 1.37 [estrone sulfate]).

12 [2.69] vs 5.66 [1.93] mIU/mL; P < .001) and SHBG (35.07 [11.11] vs 46.41 [14.03] nmol/L; P < .001).

13 ound between plasma TNF-alpha receptor 1 and SHBG levels in obese patients.

14 y higher concentrations of insulin (16%) and SHBG (19%) and lower concentrations of leptin (18%) (all

15 plore the relationship between TNF-alpha and SHBG in obese patients and an interventional study to ex

16 l 1.02-1.24); other endogenous androgens and SHBG were not associated with overall risk.

17 SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxytocin all significantly increased female

18 ssing the prospective association of ESH and SHBG with T2D in women.

19 s produced stronger effects on estrogens and SHBG.

20 ed on the Pritikin Program, insulin fell and SHBG rose and it was suggested that prostate cancer migh

21 e was no relation between D327N genotype and SHBG levels.

22 COS and suggests including BMI, glucose, and SHBG-circulating levels in the risk stratification.

23 s (kd) for testosterone with soluble HSA and SHBG.

24 homocysteine levels and elevate Apo A-I and SHBG concentrations.

25 e presence of SHBG (immunocytochemistry) and SHBG mRNA (in situ hybridization).

26 testosterone or between any of the PFAAs and SHBG.

27 strone sulfate, testosterone, prolactin, and SHBG; change in AUC, 8.8 [P < .001] for Gail score and 5

28 the relation between breast cancer risk and SHBG rs6259 was found to vary by body mass index (weight

29 rs1003623, ESR1 rs2234693, GSTP1 rs1695, and SHBG rs6259) showed generally consistent results in SBCS

30 Total testosterone and SHBG concentrations were measured in serum obtained from

31 authors found higher total testosterone and SHBG to be inversely related to carotid atherosclerosis,

32 er levels of total and free testosterone and SHBG were significantly associated with increased develo

33 associated with lower serum testosterone and SHBG, and greater E2.

34 n men, even after adjustments for weight and SHBG.

35 directions corresponding to their associated SHBG.

36 explain heterogeneity in studies associating SHBG gene variants and soy consumption with breast cance

37 G levels versus type 2 diabetes association (SHBG levels are 0.23 standard deviations lower in type 2

38 the SHBG-SNP versus SHBG levels association (SHBG levels are 0.2 standard deviations higher per copy

39 monstrated a significant association between SHBG and insulin, testosterone, triacylglycerols, body m

40 ificant gene-environment interaction between SHBG D356N polymorphism and dietary isoflavone exposure

41 The clinical usefulness of both SHBG genotypes and plasma levels in stratification and i

42 AI), the amount of testosterone not bound by SHBG.

43 prostate tissue, whose RSHBG was occupied by SHBG, reproduced the results seen with dihydrotestostero

44 s associated with differences in circulating SHBG and sex steroid hormones.

45 ecially since mice and rats lack circulating SHBG post-natally.

46 n why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mec

47 he in vivo physiological role of circulating SHBG remains unclear, especially since mice and rats lac

48 ect of insulin administration on circulating SHBG in type 2 diabetic patients were performed.

49 d dietary isoflavone exposure on circulating SHBG levels in 1,988 postmenopausal women.

50 D327N) have been associated with circulating SHBG concentrations in women.

51 uivalent AR binding affinity-but contrasting SHBG binding-and therefore can be used as agents for eva

52 alpha plays an important role downregulating SHBG in chronic low-grade inflammatory diseases such as

53 SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxytocin all significantly incr

54 of protein kinase A prevented the estradiol.SHBG-induced increase in prostate-specific antigen but n

55 The estradiol.SHBG-induced increase in prostate-specific antigen was n

56 re aged 20-34 years at the time of the first SHBG measurement.

57 rgely attenuated after further adjusting for SHBG (OR 0.71 [95% CI 0.31-1.61]; P for trend = 0.47).

58 r, 7alpha-18F-FM-DHT has a high affinity for SHBG, whereas 7alpha-18F-FM-norT has a relatively low af

59 t 7alpha-FM-norT has much lower affinity for SHBG.

60 boon may be related to its high affinity for SHBG.

61 The corresponding constants for SHBG were 0.053-0.058 s(-1) and 0.7-1.2 x 10(9) M(-1).

62 clinico-endocrinological profiles (LH, FSH, SHBG, DHEAS, and testosterone levels) of men with early

63 otein (9%) and sex-hormone binding globulin (SHBG) (21%), and lower concentrations of leptin (28%), t

64 adiol bound to sex hormone-binding globulin (SHBG) and total estradiol in the statistical model, the

65 umin (HSA) and sex hormone binding globulin (SHBG) as models.

66 androgens and sex hormone-binding globulin (SHBG) as potential mediators of increasing cardiovascula

67 hat unliganded sex hormone-binding globulin (SHBG) binds to a receptor (RSHBG) on prostate membranes.

68 inding protein sex hormone binding globulin (SHBG) by attempting to block E-BSA-stimulated release of

69 tenedione, and sex hormone-binding globulin (SHBG) concentrations (secondary).

70 stosterone and sex hormone-binding globulin (SHBG) concentrations at age 15 years with prenatal expos

71 estradiol, and sex hormone binding globulin (SHBG) concentrations were not related to baseline period

72 estradiol, and sex hormone-binding globulin (SHBG) for 3,043 cases and 3,478 controls in the Breast a

73 In the sex hormone binding globulin (SHBG) gene, a pentanucleotide-repeat polymorphism [(TAAA

74 prolactin, and sex hormone-binding globulin (SHBG) improved risk prediction for postmenopausal invasi

75 androgens, and sex hormone-binding globulin (SHBG) in a population-based sample of postmenopausal wom

76 Sex hormone-binding globulin (SHBG) is a plasma protein synthesized and secreted by th

77 Sex hormone-binding globulin (SHBG) is an important regulator of plasma sex steroids a

78 Sex hormone-binding globulin (SHBG) is believed to play a key role in steroidal radiop

79 Sex hormone binding globulin (SHBG) is found in the brain and acts directly on plasma

80 Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens

81 estradiol, and sex hormone binding globulin (SHBG) levels and calculated free androgen index (FAI), f

82 Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the

83 at circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than

84 y decreased as sex hormone-binding globulin (SHBG) levels at follow-up increased.

85 mone (FSH) and sex hormone-binding globulin (SHBG) levels were measured in the three matrices.

86 ng circulating sex hormone-binding globulin (SHBG) levels.

87 x hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between co

88 hat binding to sex hormone binding globulin (SHBG) might enhance tumor uptake.

89 androgens, and sex hormone-binding globulin (SHBG) was investigated in 2172 postmenopausal control wo

90 hether ESH and sex hormone-binding globulin (SHBG) were associated with the risk of incident T2D.

91 s needed since sex hormone binding globulin (SHBG), a glycoprotein which binds androgens with high af

92 fate (DHEAS)], sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i.e., hist

93 testosterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), luteinizi

94 association of sex hormone-binding globulin (SHBG), testosterone, and the risk of developing diabetes

95 st quartile of sex hormone-binding globulin (SHBG), those in the highest quartile had a significantly

96 tosterone, and sex hormone-binding globulin (SHBG), were performed in 682 women (ages 35 to 49 years)

97 ther the whole sex hormone-binding globulin (SHBG)-like domain (Val243-Ser635; chimera III) or the SH

98 um insulin and sex hormone-binding globulin (SHBG).

99 d moieties and sex hormone binding globulin (SHBG).

100 ex steroids or sex hormone binding globulin (SHBG).

101 one (BAT), and sex hormone binding globulin (SHBG).

102 d hormones and sex hormone-binding globulin (SHBG).

103 s of total and sex-hormone-binding-globulin (SHBG)-bound testosterone were 13% and 15% higher, respec

104 gene encoding sex hormone-binding globulin, SHBG, that were robustly associated with the protein lev

105 s in 511 Black men and 698 White men who had SHBG measured in multiple serum samples collected over a

106 ; 2) the aMED was associated with 19% higher SHBG and 16% lower triglycerides (P-trend = 0.02 and 0.0

107 In contrast, higher SHBG was associated with higher BNP and NT-proBNP, while

108 95% CI, 0.12 to 0.30), while men with higher SHBG levels (>28.3 vs < or =28.3 nmol/L) had a 52% lower

109 ve studies indicating that women with higher SHBG levels (>60 vs < or =60 nmol/L) had an 80% lower ri

110 on target organs in mice expressing a human SHBG transgene.

111 vo studies using human HepG2 cells and human SHBG transgenic mice.

112 infused into the medial basal hypothalamus, SHBG-E plus oxytocin resulted in significantly increased

113 According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiti

114 tional studies to estimate the difference in SHBG levels between type 2 diabetes patients and control

115 -I), and free testosterone with increases in SHBG and IGF binding protein-1.

116 rs1799941 in SHBG is highly significantly associated with circulating

117 known loci with serum T levels (rs727428 in SHBG: P = 1.26 x 10(-12); rs5934505 in FAM9B: P = 1.61 x

118 Moreover, two additional variants in SHBG [rs72829446, in strong linkage equilibrium with the

119 Infusing SHBG into the medial preoptic area or medial basal hypot

120 These three loci (JMJD1C, SHBG and FAM9B) were estimated to account for ~5.3 and 4

121 terminus sex hormone-binding globulin-like (SHBG) domain of PS is critical for neuronal protection i

122 iation study (GWAS) has identified two loci, SHBG at 17p13 and FAM9B at Xp22, for serum testosterone

123 Low SHBG and high FAI are strongly associated with CV risk f

124 Low SHBG and high FAI were strongly and consistently related

125 Low SHBG and testosterone may constitute part of the prediab

126 could be the main factor accounting for low SHBG levels in obesity.

127 drogen profiles (higher median FAI and lower SHBG levels) than controls.

128 Among HT nonusers, lower SHBG and higher FAI levels were noted among postmenopaus

129 nd physical activity, nonusers in the lowest SHBG quartile had an OR of 2.25 (95% CI, 1.03 to 4.91) f

130 tatistically significant differences in mean SHBG concentrations for White men with genotypes of (TAA

131 Neither estradiol alone nor SHBG alone duplicated these effects.

132 To better understand the action of SHBG, we have synthesized and tested in vivo 2 novel 18F

133 Addition of SHBG or any measure of free testosterone to the multivar

134 le and noncarriers of rs6257 minor allele of SHBG gene consuming >/=2 cups/day of caffeinated coffee

135 release of oxytocin with two antagonists of SHBG receptor actions: the 5alpha-reduced androgens dihy

136 ower risk in men; the inverse association of SHBG with risk was stronger in women than in men.

137 The association of SHBG with T2D did not change by menopause status, wherea

138 Study, the authors assessed associations of SHBG polymorphisms with serum SHBG levels in 511 Black m

139 riables and diet to plasma concentrations of SHBG.

140 These two disparate functions of SHBG, regulation of the concentration of free steroids i

141 xamined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-andros

142 cantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous stud

143 than 1,912 incident T2D cases, low levels of SHBG and high levels of TE were associated with increase

144 vels of FAI, and Chinese had lower levels of SHBG and higher levels of FAI.

145 red with whites, blacks had higher levels of SHBG and lower levels of FAI, and Chinese had lower leve

146 tivariable-adjusted geometric mean levels of SHBG were 26.6 nmol/l among women consuming >/=4 cups/da

147 ained a significant independent predictor of SHBG.

148 ter adjustments, the strongest predictors of SHBG concentrations were the dietary intake of rice (bet

149 man prostate, we demonstrate the presence of SHBG (immunocytochemistry) and SHBG mRNA (in situ hybrid

150 TNF-alpha-induced reduction of SHBG expression was mediated by downregulating HNF4A.

151 be used as agents for evaluating the role of SHBG binding in the target tissue uptake of AR PET imagi

152 To probe the role of SHBG in prostate tumor uptake of PET imaging agents, we

153 ls to evaluate more definitively the role of SHBG in radiotracer delivery of steroidal systems to tar

154 T, no significant differences in hormones or SHBG were observed among women who developed CVD and con

155 free estradiol to release oxytocin, perhaps SHBG receptors.

156 Plasma SHBG was significantly increased rather than decreased a

157 affinity to a specific membrane receptor (R(SHBG)) in prostate stromal and epithelial cells, wherein

158 mal and epithelial cells, wherein the SHBG.R(SHBG) complex forms.

159 and the N variant is associated with reduced SHBG clearance compared with the D variant.

160 The RSHBG.SHBG complex is rapidly activated by estradiol to stimul

161 The importance of the protein S SHBG-like domain (and its laminin G-type 1 subunit) for

162 e show that binding of TFPI to the protein S SHBG-like domain enables TFPI to interact optimally with

163 to the interindividual variability in serum SHBG levels.

164 ssociations of SHBG polymorphisms with serum SHBG levels in 511 Black men and 698 White men who had S

165 SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxytocin a

166 model including the covariates testosterone, SHBG, age, etiology, and MELD, total testosterone remain

167 rations of estrone, estradiol, testosterone, SHBG, dehydroepiandrosterone sulfate, free estradiol, an

168 Pretransplantation serum testosterone, SHBG, and other variables were collected on 190 consecut

169 In this paper we demonstrate that SHBG is produced in human prostate cancer cell lines (LN

170 cent genetic study, strengthen evidence that SHBG and sex hormones are involved in the aetiology of t

171 onal and prospective studies both found that SHBG was more protective in women than in men (P< or =.0

172 ions are consistent with the hypothesis that SHBG, destined to participate in signaling at the cell m

173 Our findings suggest that SHBG may account for the inverse association between cof

174 The SHBG gene contains a D356N polymorphism and the N varian

175 The SHBG SNP rs1799941 was associated with type 2 diabetes [

176 ons higher per copy of the A allele) and the SHBG levels versus type 2 diabetes association (SHBG lev

177 fat, high-fiber diet was significant for the SHBG-bound fraction (P = 0.04).

178 ted (OR 0.92, 95% CI: 0.88, 0.96), given the SHBG-SNP versus SHBG levels association (SHBG levels are

179 s/liter with placebo) and an increase in the SHBG concentration (4.3 versus -1.3 mmoles/liter with pl

180 est that the (TAAAA)(n) repeat length in the SHBG gene, but not the D327N variant, might contribute t

181 ingle nucleotide polymorphism (SNP) near the SHBG gene, rs1799941, that is strongly associated with S

182 allele, carriers of a variant allele of the SHBG single-nucleotide polymorphism (SNP) rs6259 had 10%

183 e domain (Val243-Ser635; chimera III) or the SHBG laminin G-type 1 subunit (Ser283-Val459; chimera I)

184 We also observed that the SHBG locus was associated with serum DHT levels (rs72742

185 te stromal and epithelial cells, wherein the SHBG.R(SHBG) complex forms.

186 5% CI: 0.91, 0.97; P = 2 x 10(-5)], with the SHBG raising allele associated with reduced risk of type

187 atively associated with % estradiol bound to SHBG (OR for the highest quartile = 0.05, 95% CI 0.01-0.

188 l) that prevents the binding of estradiol to SHBG.

189 % CI: 0.88, 0.96), given the SHBG-SNP versus SHBG levels association (SHBG levels are 0.2 standard de

190 but not insulin, is the main factor by which SHBG is reduced in obesity.

191 and estradiol (E2) were evaluated along with SHBG and the free androgen index (FAI), the amount of te

192 inated coffee was positively associated with SHBG but not with sex hormones.

193 rs1799941, that is strongly associated with SHBG levels.

194 ffeinated coffee nor tea was associated with SHBG or sex hormones.

195 strongest reduction in risk associated with SHBG rs6259 was found for lean (body mass index <23) pos

196 ted cholesterol eliminated associations with SHBG and FAI.

197 bles was modestly positively correlated with SHBG and negatively with insulin values.

198 s of (TAAAA)(n) and D327N polymorphisms with SHBG concentrations.

199 cted P = 0.006); and 11q13.2-rs10896449 with SHBG (uncorrected P = 0.005)).

200 In women, SHBG is also implicated in diverse pathologies such as c