ライフサイエンスコーパス: SK

1 SK blockade partially suppressed the arrhythmic burst pa

2 SK channel blockade slows repolarization and subsequent

3 SK channel transcripts are expressed at early stages of

4 SK channels are a potential pharmacological target for m

5 SK channels are predominantly expressed in the atria as

6 SK channels show a distinct subcellular localization tha

7 SK channels were activated by intracellular Ca(2+) spark

8 SK channels were also activated by Ca(2+) influx through

9 SK current is important in the transmural repolarization

10 SK currents play a role in porcine atrial repolarization

11 SK-channel activation and the subsequent reduction in Ca

12 SKs frequently have acquired oncogenic mutations in the

13 TA-Fab-PEG24-EGF to tumor cells (MDA-MB-231, SK-OV-3, MDA-MB-231/H2N, or TrR1) coexpressing HER2 and

14 itro IC50 values were 11-48 ng/mL in HER2 3+ SK-BR-3 and KPL-4 (7 inactive) for the anti-HER2 ADCs (H

15 four cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3) and two noncancerous kidney cell lines (LLC-PK1

16 ) influx through TRPV4 channels can activate SK channels in PDGFRalpha(+) cells and prevent bladder o

17 These data suggest that purines activate SK currents via mainly P2Y1 receptors in PDGFRalpha(+) c

18 hrough the endoplasmic reticulum to activate SK channels.

19 antagonist, MRS2500, inhibited ATP-activated SK currents.

20 pe, and small-conductance calcium-activated (SK) potassium and HCN) and two receptors (AMPAR and NMDA

21 t under control conditions but present after SK channel block.

22 Against SK-OV-3 tumor xenografts, the rGel/4D5 construct with ex

23 of reversible competitive inhibitors against SK from Mycobacterium tuberculosis and Helicobacter pylo

24 GluN3A knock-out mice, cocaine did not alter SK channel function or VTA DA neuron firing.

25 An SK channel activator (SKA-31) decreased contractions dur

26 ly, although wild-type SypF functioned as an SK in vitro, this activity was dispensable for colonizat

27 urons were suppressed by preceding APs in an SK-dependent manner.

28 r cell lines (MDA-MB-231, BT-20, Zr-75-1 and SK-BR-3) covering a wide range of HER2 expression were i

29 p-C (140 +/- 7.95), ID (27.8 +/- 2.23), and SK (63.9 +/- 1.55)), demonstrating the feasibility of MO

30 high PD-L1-expressing tumors (MDA-MB-231 and SK-Br-3), whereas no specific uptake was observed in tum

31 Upon mensacarcin exposure, SK-Mel-28 and SK-Mel-5 melanoma cells, which have the BRAF(V600E) muta

32 neuroblastoma cell lines Kelly, IMR-32, and SK-N-SH.

33 , and HCT 116) and melanoma (MDA-MB-435S and SK-MEL-28) cell lines using short hairpin RNA (shRNA) le

34 Proliferation of MCF-7 and SK-BR-3 cells was evaluated by MTT assays.

35 ere we report that CaCCs coexist with BK and SK channels in inferior olivary (IO) neurons that send c

36 2+)-activated K(+) channels, known as BK and SK channels, the physiological importance of Ca(2+)-acti

37 cells and breast cancer cell lines BT474 and SK-BR3.

38 of strain CBA/J lacking T and NK cells), and SK(-/-) (an isogenic strain of strain C57BL6/J lacking S

39 ed by Ca(2+) -dependent activation of IK and SK channels.

40 re unaffected by inhibitors of TRPV4, IK and SK channels.

41 iate and small conductance potassium (IK and SK) channels, thereby causing hyperpolarization and endo

42 ermediate and small conductance K(+) (IK and SK, respectively) channels.

43 elanoma cells, specifically the LOX IMVI and SK-MEL-28 cell lines.

44 n, but persisted in the presence of KATP and SK antagonists.

45 anoma cell lines (A375, Hs294t, SK-Mel28 and SK-Mel119) with cryptolepine (1.0, 2.5, 5.0 and 7.5 muM)

46 p4A is a potent native agonist for P2Y1R and SK-channel activation in human and mouse colon.

47 Because the interaction of SK peptide and SK receptors (SKR) initiates the SK signaling, we have s

48 ssing melanoma cell lines SK-MEL-2 (SK2) and SK-MEL-5 (SK5), we show that glutamate is both necessary

49 lting from WA exposure in MCF-7, SUM159, and SK-BR-3 cells was associated with a marked decrease in p

50 urface regulation in the related SH-SY5Y and SK-N-SH human neuroblastoma cell lines.

51 TRPV4 and SK channel blockers also increased contractions of intac

52 els supporting faster synaptic waveforms and SK channels supporting slower synaptic waveforms.

53 t exploits the enzymatic activity of another SK, an adaptation that demonstrates the elegant plastici

54 mages and classified each dermoscopically as SK or not SK.

55 n 3 human neuroblastoma cell lines (SK-N-AS, SK-N-BE2, and SH-SY5Y), soluble HBEGF is sufficient to p

56 eal a causal link for the first time between SK channel dysregulation and 5-HT neuron activity in a l

57 ramidal cell excitability and highlights BLA SK channels as promising targets for the treatment of an

58 Blocking SK channels disrupted the one-to-one signal transmission

59 Blocking SK channels with apamin depolarized the resting membrane

60 pacemaker firing through modulation of both SK and the hyperpolarization-activated cation currents (

61 ingle 4 plays a role in recognition of Pg by SK.

62 [Lys]Pg complexes were weakened similarly by SK Lys(414) deletion and blocking of lysine-binding site

63 In CA1 pyramidal cells, SK channels in dendritic spines were shown to regulate s

64 The small conductance K channel (SK) activity showed no difference of channel properties

65 conductance Ca(2+) -activated K(+) channels (SK) play an important role in regulating the activity of

66 onductance, Ca(2+) -activated K(+) channels (SK, KCa 2) are expressed in human atrial myocytes and ar

67 onductance, Ca(2+) -activated K(+) channels (SK, KCa 2) are unique subclasses of K(+) channels that a

68 ly regulated by Ca2+ -activated K+ channels (SK-channels) which are in turn inhibited by neuromodulat

69 ctance calcium-activated potassium channels (SK channels) are present in spines and can be activated

70 e calcium-dependent potassium (SK) channels; SK channels regulate firing of VTA DA neurons, but this

71 ly examine these subjects, isogenic chimeric SK- and M-protein-containing GAS strains were generated,

72 We report that fidelity of cholinergic SK responses requires the continued presence of extracel

73 hen K(V)7/M channel activity is compromised, SK channel activation significantly and uniquely reduces

74 d a calcium-activated potassium conductance (SK), respectively.

75 ht to involve exclusively small conductance (SK potassium channels), recent findings have shown that

76 and represents a promising target to control SK severity.

77 A key to controlling SK lesion severity is to identify cellular and molecular

78 calcium-activated potassium channel current (SK), as well as elevates dopaminergic neuron pacemaker f

79 ctance calcium-dependent potassium currents (SK).

80 independent risk markers of dermoscopically SK-like melanomas.

81 st score of 4.4 (2.3), while dermoscopically SK-like melanomas achieved a total dermoscopy score of o

82 patterns of (clinically and dermoscopically) SK-like melanomas, patient demographics, and interobserv

83 ost helpful criteria in correctly diagnosing SK-like melanomas were the presence of blue-white veil,

84 plex virus 1-infected mice led to diminished SK lesions and corneal vascularization.

85 f Methacholine Chloride (name of study drug: SK-1211) in order to get approved for the airway hyperre

86 ns lead to the adult expression map for each SK channel subunit and how their coexpression in the sam

87 Smith GS, Van Den Eeden SK, Garcia C, Shan J, Baxter R, Herring AH, Richardson D

88 quency OHCs is altered by blockade of either SK or BK channels, with BK channels supporting faster sy

89 Moreover, enhanced SK activity contributes to the adaptive responses of MNC

90 al application of fingolimod, an established SK/sphingosine-1-phosphate antagonist already in clinica

91 Upon mensacarcin exposure, SK-Mel-28 and SK-Mel-5 melanoma cells, which have the BR

92 e onset of expression and regions expressing SK channel subunits in the embryonic and postnatal devel

93 The encounter and final SK .[5F]FFR-[Lys]Pg complexes were weakened similarly by

94 he substantially lower affinity of the final SK . Pg complex compared with SK . Pm is characterized b

95 stamine with reduced extravasation of fluid, SK-1 activity, proinflammatory cytokine and chemokine pr

96 pe) Ca(2+) channels as the Ca(2+) source for SK channel activation.

97 te and average volume of tumors derived from SK-Hep1 cell (mesenchymal-typed).

98 ts the first in vivo example of a functional SK that exploits the enzymatic activity of another SK, a

99 However, the presence of functional SK channels in the somata and their role in controlling

100 lockers, we provide evidence that functional SK channels are expressed in the somata and proximal den

101 The photodynamic treatment of 3T3, HeLa, SK-MEL-28, and HCT 116 cancer cells revealed that the ma

102 ivity on a number of tumor cell lines (HeLa, SK-MEL-28, A549, MCF-7) with effective concentrations (E

103 knockout mice were more resistant to herpes SK with marked suppression of T helper cells type 1 and

104 ls isolated from the NCX KO exhibited higher SK current than wildtype (WT) and apamin prolonged their

105 of human melanoma cell lines (A375, Hs294t, SK-Mel28 and SK-Mel119) with cryptolepine (1.0, 2.5, 5.0

106 aborate TCS phosphorelay containing a hybrid SK, RscS, and two RRs, SypE and SypG, to control biofilm

107 Here, we found that another hybrid SK, SypF, was essential for biofilms by functioning down

108 through its regulation of cAMP, modulates I-SK and I-TRPC channel-mediated ionic currents that we ha

109 n also increased intracellular Ca2+ waves, I-SK and decreased I-TRPC.

110 n response to increases in EC calcium and IK/SK channel activation and suggest that EC Kir channels c

111 ceptor potential vanilloid 4) channel and IK/SK channel agonists were highly attenuated by Kir channe

112 f muscarinic receptors, TRPV4 channels or IK/SK channels were reduced, but not eliminated, by Kir cha

113 We imaged SK channels labeled with fluorophore-tagged apamin and m

114 eveal that chronic adolescent stress impairs SK channel function, which contributes to an increase in

115 rifosine on proteome and lysine acetylome in SK-N-AS cells and expands our understanding of the mecha

116 onses, it remains unknown whether changes in SK channel function/expression contribute to exacerbated

117 Nevertheless, whether changes in SK function/expression contribute to exacerbated MNC act

118 indicate that a dorsal-ventral difference in SK channel regulation of NMDAR activation has a profound

119 lysine acetylation sites were quantified in SK-N-AS cells and 216 differentially expressed proteins

120 Our studies suggest that a reduction in SK channel expression, but not changes in Ca(2+) -mediat

121 utput function, and also that a reduction in SK channel-mediated, apamin-sensitive AHP is a critical

122 and acetylome after perifosine treatment in SK-N-AS neuroblastoma cells using SILAC labeling, affini

123 cell carcinoma, have not been identified in SKs.

124 Although an increased SK channel function contributes to adaptive physiologica

125 High K intake increased SK channel number per patch and increased the ROMK chann

126 pens up a new avenue in treating HSV-induced SK lesions by increasing the stability and function of r

127 t-PA induces SK-N-SH cell proliferation via binding to GRP78 on the c

128 In vivo, we demonstrate that inhibiting SK channels normalizes chronic social isolation-induced

129 re-operated calcium entry channel inhibitor (SK&F96365) also reduced MSU crystal-induced NET release.

130 fying hypothesis' that rundown of inhibitory SK responses at resting membrane potentials (RMPs) refle

131 Interestingly, SK channels are transiently activated by calcium sparks

132 soma, was dendritic in origin, and involved SK-dependent suppression of NMDA receptor activation.

133 Small-conductance Ca(2+)-activated K(+) (SK or K(Ca)2) channels are widely expressed in the CNS.

134 ess small conductance Ca(2+)-activated K(+) (SK) and TRPV4 channels.

135 of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2

136 Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape

137 hat small-conductance Ca(2+)-activated K(+) (SK) channels constitute a new target for treatment of at

138 of small conductance Ca(2+)-activated K(+) (SK) channels in these cells is far higher ( approximatel

139 S: Small conductance Ca(2+) -activated K(+) (SK) channels play an important role in regulating the ex

140 Small-conductance Ca(2+)-activated K(+) (SK) channels play essential roles in the regulation of c

141 ive small conductance Ca(2+)-activated K(+) (SK) current (IKAS) in failing human ventricles remains u

142 ABSTRACT: Small conductance K(+) (SK) channels have been implicated as modulators of spont

143 of Ca(2+) -activated small conductance K(+) (SK) channels in the murine SAN.

144 of Ca(2+)-activated small-conductance K(+) (SK) channels.

145 bited a small conductance Ca2+-activated K+ (SK) current; blockade of the SK current prevented PPT-in

146 calcium (Ca2+) waves, small-conductance K+ (SK)-mediated hyperpolarization and a decrease of transie

147 reduced expression of small-conductance Kca (SK) channel protein in the BLA of socially isolated (SI)

148 can be effective to limit stromal keratitis (SK) lesion severity.

149 hronic immunoinflammatory stromal keratitis (SK) lesion that is a significant cause of human blindnes

150 Seborrheic keratoses (SKs) are common benign skin tumors that share many morph

151 that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment.

152 an environmental sensor [the sensor kinase (SK)] and a cognate, intracellular effector [the response

153 inding (SB) domains of the shikimate kinase (SK) enzyme have been exploited in the development of rev

154 The sphingosine kinase (SK) inhibitor, SKI-II, has been employed extensively in

155 The sphingosine kinase (SK) pathway is an important regulator of vascular beds,

156 nflammation involves the sphingosine kinase (SK)/sphingosine-1-phosphate axis.

157 hes, we demonstrate that sphingosine kinase (SK)2, and not SK1, is essential and sufficient in EGF-me

158 assembly for the K. marmoratus South Korea (SK) strain highlighting the diversity and distribution o

159 ning 24 cases (17.9%) were considered likely SKs, even by dermoscopy.

160 ein kinase A (PKA) levels, strongly limiting SK channel expression at the pyramidal neuron soma.

161 ersican expression in a LMS human cell line, SK-LMS-1.

162 Glu1 receptor-expressing melanoma cell lines SK-MEL-2 (SK2) and SK-MEL-5 (SK5), we show that glutamat

163 xic activity against four cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3) and two noncancerous kidney

164 In 3 human neuroblastoma cell lines (SK-N-AS, SK-N-BE2, and SH-SY5Y), soluble HBEGF is suffic

165 By use of human and rat neuronal cell lines (SK-N-SH and PC12), we show that overexpression of one of

166 examined purinergic receptor (P2Y) mediated SK channel activation as a mechanism for purinergic rela

167 -ctpfc)] toward prostate (DU-145), melanoma (SK-MEL-28), breast (MDA-MB-231), and ovarian (OVCAR-3) c

168 Rac1 in synaptic compartments and modulating SK channels.

169 with fluorophore-tagged apamin and monitored SK channel nanoclustering at the single molecule level b

170 Moreover, SK channels were activated by action potentials and affe

171 Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, Cecil KM, Dietrich KN, Pug

172 mplementary approaches, we found that native SK channel distribution in pyramidal neurons, across the

173 ab-IRDye800CW was noted in the CAIX-negative SK-RC-59 tumor (4.1 +/- 1.5 %ID/g), and no uptake of (12

174 Y79 retinoblastoma cells and CD44-negative SK-N-DZ neuroblastoma cells transduced with adenoviral v

175 peptide 42 (Abeta42) by human neuroblastoma SK-N-SH cells as well as by primary mouse neuronal cells

176 is expressed on the surface of neuroblastoma SK-N-SH cells where it is co-localized with the voltage-

177 drial trafficking in cultured human neuronal SK-N-SH cells and on axonal transport in mouse sciatic n

178 onstant in the picomolar range (Kd 0.044 nM, SK-N-MC cells) and very high Y1R selectivity.

179 ptides were more potent than the nonsulfated SK, suggesting the importance of the sulfate moiety.

180 classified each dermoscopically as SK or not SK.

181 There is abundant subtype 2 of SK protein in the intercalated discs of myocytes.

182 Immunohistochemical staining of subtype 2 of SK protein showed increased expression in intercalated d

183 (V)7/M channels are operative, activation of SK channels during repetitive firing does not notably af

184 These findings indicate that activation of SK channels in spines by backpropagating APs plays a key

185 is associated with an enhanced activation of SK channels that strongly suppresses NMDAR activation at

186 c signal integration, via over-activation of SK channels, and synapse plasticity, phenotypes rescued

187 ot changes in Ca(2+) -mediated activation of SK channels, contributes to exacerbated MNC activity in

188 actions were also inhibited by activation of SK channels.

189 on conductance that coupled to activation of SK channels.

190 unction are due to an enhanced activation of SK-type K(+) channels that suppresses NMDAR-dependent EP

191 and a decrease in the functional activity of SK channels.

192 e rescued by pharmacological augmentation of SK channel activity.

193 This indicated that binding of SK Lys(414) to Pg kringle 4 plays a role in recognition

194 gCRND8 cortex by pharmacological blockade of SK channels, suggesting a novel target for the treatment

195 (+) cells that were inhibited by blockers of SK channels.

196 To allow studies on the contribution of SK channels to different phases of development of single

197 To describe the dermoscopic features of SK-like melanomas to understand their clinical morpholog

198 thereby maintaining the ongoing fidelity of SK-mediated inhibition in response to phasic release of

199 renergic agonist, normalized the function of SK and TRPC channels.

200 ity produces intermittent hyperactivation of SK channels, leading to arrhythmic pauses alternating wi

201 Further, we found that the impact of SK channels on the SMT critically depended on the voltag

202 usive and SNX increases EPSPs independent of SK channel activity.

203 some adverse reactions during inhalation of SK-1211, all of which were mild in severity and resolved

204 Furthermore, LTP requires inhibition of SK channels by mGluR1, which removes a negative feedback

205 ur model further predicts that inhibition of SK channels results in a depolarisation of action potent

206 Inhibition of SK channels with the specific blocker apamin prolonged a

207 Because the interaction of SK peptide and SK receptors (SKR) initiates the SK signa

208 yonic development suggests an involvement of SK channels in the regulation of developmental processes

209 Real-time PCR measurements of SK channel subunits mRNA in supraoptic nucleus punches r

210 Understanding the mechanisms of SK channel trafficking may provide new insights into the

211 the past two decades, positive modulators of SK channels such as NS309 and 1-EBIO have been developed

212 ated whether the Ca(2+) -sensitive nature of SK channels could explain arrhythmic SAN pacemaker activ

213 t miR-155 contributes to the pathogenesis of SK and represents a promising target to control SK sever

214 r study reveals a new level of regulation of SK channels by cAMP-PKA and suggests that ion channel to

215 Consistent with this prediction, rescue of SK responses by subthreshold depolarization required the

216 ith this, mRNA levels for the SK3 subunit of SK channels are significantly higher in ventral CA1 pyra

217 increased mRNA levels for the SK3 subunit of SK-type K(+) channels in ventral pyramidal cells is asso

218 Intact explants of SKs were also sensitive to Akt inhibition.

219 e eating behavior and suggest ERalpha and/or SK current in DRN 5-HT neurons as potential targets for

220 onspecific uptake of (111)In-RGD2 in FaDu or SK-RC-52 xenografts was not affected after antiangiogeni

221 did not affect currents through TRPV4, IK or SK channels.

222 Blockers of TRPV4 or SK channels inhibited currents activated by GSK and incr

223 ue-white veil, despite the presence of other SK features, allows the correct diagnosis of most of the

224 Up4A induced P2Y1R-SK-channel-mediated hyperpolarization in isolated PDGFRa

225 Bath application of a positive SK channel modulator (1-EBIO) normalized firing in ex vi

226 (control mAb) was noted in the CAIX-positive SK-RC-52 tumor (1.2 +/- 0.1 %ID/g).

227 mall conductance Ca(2+)-activated potassium (SK) channel activity in Purkinje cells from p75(-/-) mic

228 all-conductance calcium-activated potassium (SK) channel and CB1 cannabinoid receptor activation.

229 l conductance Ca(2)(+) -activated potassium (SK) channel was developed and incorporated into a physio

230 all conductance calcium-activated potassium (SK) channels are required for the slow inhibitory compon

231 all-conductance calcium-activated potassium (SK) channels in rat MNTB principal neurons.

232 all-conductance calcium-activated potassium (SK) channels in the MNTB neurons from rats of either sex

233 l inhibition of calcium-activated potassium (SK) channels increases the variability in their firing p

234 all-conductance calcium-activated potassium (SK) channels mediate a potassium conductance in the brai

235 all-conductance calcium-activated potassium (SK) channels regulate action potential firing and shape

236 all-conductance calcium-activated potassium (SK) channels.

237 all conductance Ca(2+) -activated potassium (SK) current (ISK ).

238 lcium-activated small conductance potassium (SK) channel member SK3 and mitochondrial ROS.

239 all-conductance calcium-dependent potassium (SK) channels; SK channels regulate firing of VTA DA neur

240 cium-dependent small conductance potassium ('SK') channels, and longer-lasting and voltage-dependent

241 cium-dependent small conductance potassium ('SK') channels, and longer-lasting and voltage-dependent

242 We propose SK channels as a potential target for modulating SAN rat

243 Therefore, proximal SK channels provide a "second line of defense" against i

244 d 0.30 for R:SN , 0.36 for R:SP , 0.32 for R:SK , 0.27 for R:SCa , and 0.35 for R:SMg , respectively.

245 eactive oxygen species formation and reduced SK-N-SH cell viability.

246 The reduced SK lesion severity was reflected by increased phosphatid

247 The mechanism by which p75 regulates SK channel activity appears to involve its ability to ac

248 differentiated SH-SY5Y cells and the related SK-N-SH cell line.

249 Further, rescued SK responses were time-locked to ACh application, rather

250 As a result SK channel activation by backpropagating APs gated STDP

251 applications of irreversible and reversible SK channel blockers, we provide evidence that functional

252 ne-mill operations in northern Saskatchewan (SK) and data from 1995-2010 for a third SK mine-mill ope

253 hese findings suggest that Ca(2+) -sensitive SK channels can translate changes in cellular Ca(2+) int

254 ), p-cresol (p-C), indole (ID), and skatole (SK)).

255 Injections of the specific SK channel antagonist apamin into PLC increased Fos expr

256 aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and the associated spine hea

257 Streptokinase (SK), secreted by Group A Streptococcus (GAS), is a singl

258 trate a three-step pathway of streptokinase (SK) binding to plasminogen (Pg), the zymogen of plasmin

259 developed a reliable culture system to study SKs in vitro and screened these cells using a library of

260 Subsequently, SK is secreted by GAS and activates hPg to plasmin (hPm)

261 These results suggest SK channel blockers as potentially interesting anti-AF d

262 us work demonstrated that insect sulfakinin (SK) signaling is involved in inhibiting feeding in an im

263 Third, the sulfated SK (sSK) and sSK-related peptides were more potent than

264 mmatory response, and examined ear swelling, SK activity, vascular permeability, leukocyte recruitmen

265 We conclude that SK channels have demonstrable effects on SAN pacemaking

266 We found that SK channels are tonically activated and contribute to th

267 r of spikes fired in bursts, indicating that SK channels play an important role in maintaining dopami

268 These data reveal that SK channels play crucial roles in regulating the resting

269 We show that SK and M-protein alterations influenced the virulence of

270 lly-plausible, dendritic spine, we show that SK-channels regulate calmodulin activation specifically

271 nces from different GAS strains suggest that SKs can be arranged into two clusters, SK1 and SK2, with

272 Moreover, although the SK blocker apamin (200 nm) strengthened the input-output

273 ctor (7.2 g CO2e/kWh) is substituted for the SK grid-average electricity GHG emission factor (768 g C

274 on the structural factors that influence the SK-SKR interaction.

275 at estrogens act upon ERalpha to inhibit the SK current in DRN 5-HT neurons, thereby activating these

276 peptide and SK receptors (SKR) initiates the SK signaling, we have special interest on the structural

277 Moreover, the SK channel blocker apamin enhanced the input-output func

278 be responsible for the lower affinity of the SK . Pg complex and the expression of a weaker "pro"-exo

279 Furthermore, local inhibition of the SK current in the DRN markedly suppressed binge-like eat

280 +-activated K+ (SK) current; blockade of the SK current prevented PPT-induced activation of DRN 5-HT

281 When the SK channel inhibitor AP14145 was tested in these animals

282 wan (SK) and data from 1995-2010 for a third SK mine-mill operation.

283 current and voltage, we identified all three SK isoforms (SK1, SK2 and SK3) in mouse SAN.

284 rehensive distribution profiles of all three SK subunits (SK1, SK2, and SK3) in the rat CNS during em

285 The three SK channel subunits display different developmental expr

286 e receptors are Ca(2+)-impermeable, and thus SK channels are not efficiently activated by synaptic ac

287 The addition of recombinant versican G1 to SK-N-DZ cells results in a similar activation of transge

288 tor defects, all of which are insensitive to SK pharmacological targeting and not found in the TRN-re

289 es that link Ca(2+) influx through NMDARs to SK channels and Ca(2+) influx through R-type Ca(2+) chan

290 tumor (SK-RC-52) and a CAIX-negative tumor (SK-RC-59) received (125)I-girentuximab-IRDye800CW or (12

291 roups of mice bearing a CAIX-positive tumor (SK-RC-52) and a CAIX-negative tumor (SK-RC-59) received

292 In untransfected SK-N-SH or PC12 cells, the introduction of siRNA(GAPDH)

293 Using SK-N-SH cells which are naturally deficient in beta-arre

294 receptor-mediated intracellular Ca2+ waves, SK and TRPC channel activity.

295 onic cAMP-PKA levels also controlled whether SK channels were expressed in nanodomains as single enti

296 However, the precise mechanisms by which SK-channels control the induction of synaptic plasticity

297 y of the final SK . Pg complex compared with SK . Pm is characterized by a approximately 25-fold weak

298 econd Pg in the substrate mode compared with SK . Pm.

299 The airway hyperresponsiveness test with SK-1211 was conducted in accordance with Japanese Societ

300 The airway hyperresponsiveness test with SK-1211 was no specific concern with safety and useful i

301 RDye800CW in CAIX-positive ccRCC xenografts (SK-RC-52, 31.5 +/- 9.6 percentage injected dose per gram