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1 SLAM accomplishes these four features by using a time-re
2 SLAM binds near the stalk-head junction of the hemagglut
3 SLAM coengagement with CD3 under Th17 polarizing conditi
4 SLAM engagement amplified PKC-theta recruitment in wt bu
5 SLAM family markers enhanced the purification of fetal l
6 SLAM family members are now recognized as important immu
7 SLAM family receptor expression is conserved among HSCs
8 SLAM is a program that simultaneously aligns and annotat
9 SLAM recruited a complex containing the intracellular cl
10 SLAM regulated activity of the NADPH oxidase NOX2 comple
11 SLAM signaling was shown to inhibit production of IL-12
12 SLAM-expressing T cells are more readily infected by all
13 ls, T(FR) cell development depends on Bcl-6, SLAM-associated protein (SAP), CD28 and B cells; however
14 orylation of NK, T, and B cell Ag (NTB-A), a SLAM family homophilic receptor, in clone 2E2 compared w
17 l selection on hematopoietic cells through a SLAM-associated protein (SAP)-dependent mechanism simila
19 ther with their downstream signaling adaptor SLAM-associated protein (SAP), have emerged as key playe
20 nd the downstream recruitment of the adaptor SLAM-associated protein (SAP) and the Src kinase Fyn, wh
22 ural data also suggest that, like NTB-A, all SLAM family homophilic dimers adopt a highly kinked orga
27 located in these areas for SLAM-binding and SLAM-dependent membrane fusion, as measured by surface p
33 c strains demonstrated that the FcgammaR and SLAM intervals independently controlled the severity of
36 essive overgrowth of myeloid, Lin-, LSK, and SLAM cells, but not lymphocytes, from a low number of en
40 g lymphocyte activation molecule (SLAM), and SLAM activation further increased ERK phosphorylation.
43 h African American ancestry, higher baseline SLAM scores, reduced B cell depletion, and lower levels
44 enomes of other large DNA viruses might bear SLAM family homologs further underscores the importance
50 ptor-induced interleukin (IL)-4 secretion by SLAM(-/-) CD4(+) cells is down-regulated, whereas interf
52 mophilic adhesion molecules, CD84 and CD150 (SLAM [signaling lymphocyte activation molecule]), which
60 ata illustrate complexities of SAP-dependent SLAM family receptor signaling, revealing a prominent ro
62 verexpress C57BL/6 (B6) alleles of different SLAM family genes on an autoimmune-prone B6.Sle1b backgr
63 n provides an opportunity for all two-domain SLAM family receptors to colocalize within the immunolog
64 These findings prove formally that efficient SLAM recognition is necessary for MV virulence and patho
65 aused by mutations in SH2D1A/SAP that encode SLAM-associated protein (SAP), is characterized by an in
66 ) arises from mutations in the gene encoding SLAM-associated protein (SAP) and leads to abnormalities
68 5RA(+)CD62L(+)) T lymphocytes, which express SLAM very infrequently, with much higher efficiency than
70 omyelocytic leukemia zinc finger-expressing, SLAM family receptor adapter protein-dependent thymocyte
71 tion strategies that specifically facilitate SLAM signaling may improve vaccine potency when targetin
73 idual amino acids located in these areas for SLAM-binding and SLAM-dependent membrane fusion, as meas
75 eover, PKC-theta, like SAP, was required for SLAM-mediated increases in IL-4 production, and, convers
76 or signaling, revealing a prominent role for SLAM receptor ligation in IL-4 production by GC CD4 T ce
87 magglutinin (H) amino acids supporting human SLAM-dependent cell entry, we mutated canine distemper v
88 n of T cell:B cell interactions and identify SLAM family members as critical components of sustained
90 ude to the previously reported Th2 defect in SLAM-/- mice but is more subtle than that observed in SA
91 thought to contribute to HLH development in SLAM-Associated Protein deficiency were not observed in
95 plasma cell development, and Ab responses in SLAM(-/-) mice after a viral infection (lymphocytic chor
97 tified a critical role for the co-inhibitory SLAM family member 2B4 (CD244) in attenuating primary an
98 were identified by diminished intracellular SLAM-associated protein (SAP), X-linked inhibitor of apo
103 sed SHIP-1, SHP-1, SHP-2, and CSK but lacked SLAM-associated protein (SAP) and Ewing's sarcoma-activa
104 mediates its effects in NK cells by linking SLAM family receptors to phospholipase Cgamma, calcium f
106 Although HSPCs (Lin(-)Sca1(+)Kit(+) (LSK)/SLAM(+) and LSK) in Mll(PTD/WT) mice are reduced in abso
108 to lipopolysaccharide (LPS) by macrophages, SLAM does not regulate phagocytosis and responses to pep
109 hen generated an EpR-blind virus maintaining SLAM-dependent cell entry and inoculated rhesus monkeys
110 e validated Systemic Lupus Activity Measure (SLAM) and the Safety of Estrogens in Lupus Erythematosus
114 ity (by the Systemic Lupus Activity Measure [SLAM]) and damage (by the Systemic Lupus International C
115 Stochastic Lagrangian Apportionment Method (SLAM) carries out the following: (1) account for chemica
116 synthetic-lethality analysis by microarray (SLAM) methods have been used for synthetic-lethality scr
121 ment for the costimulation/adhesion molecule SLAM (signaling lymphocytic activation molecule) was fou
122 e signaling lymphocytic activation molecule (SLAM [CD150]) that is expressed in lymphocytes and other
123 or signaling lymphocyte activation molecule (SLAM or CD150), we asked whether and how its tropism is
127 Signaling lymphocytic activation molecule (SLAM) family (SLAMF) receptors are involved in the regul
129 he signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic recept
130 e signaling lymphocytic activation molecule (SLAM) family includes homophilic and heterophilic recept
131 signalling lymphocytic activation molecule (SLAM) family member 7 (SLAMF7), selectively kills SLAMF7
133 signalling lymphocytic activation molecule (SLAM) family of homotypic haematopoietic cell-specific r
134 e signaling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors, is mutated i
135 he signaling lymphocyte activation molecule (SLAM) family of receptors and their associated signaling
136 he signaling lymphocyte activation molecule (SLAM) family of receptors has been reported in the mouse
137 e signaling lymphocytic activation molecule (SLAM) family of receptors plays an important role in sev
138 he signaling lymphocyte activation molecule (SLAM) family of receptors that signals through SLAM-asso
139 r signaling lymphocytic activation molecule (SLAM) family receptor CD244 (2B4/SLAMf4) has been shown
141 Signaling lymphocytic activation molecule (SLAM) family receptors (SFRs) can mediate either activat
142 Signaling lymphocyte activation molecule (SLAM) family receptors are critically involved in modula
143 he signaling lymphocyte activation molecule (SLAM) family receptors CD319 and CD229 on pDCs and CD319
145 e signaling lymphocytic activation molecule (SLAM) receptor-binding site and has been implicated in t
146 Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes
147 ed signaling lymphocyte activation molecule (SLAM), and SLAM activation further increased ERK phospho
149 r signaling lymphocytic activation molecule (SLAM), it replicates briskly in SLAM-expressing cells in
151 Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP [SH2D1A]) expression in CD
152 Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) can mediate the function
153 in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impai
154 al signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) in T, invariant natural k
155 Signaling lymphocyte activation molecule (SLAM)-associated protein (SAP)) interactions with SLAM f
156 o signaling lymphocytic activation molecule (SLAM)-associated protein (SAP), the X-linked lymphoproli
157 a signaling lymphocytic activation molecule (SLAM)-associated protein (SAP)-deficient mouse model.
158 he signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as t
161 e signaling lymphocytic activation molecule (SLAM)/CD150 family includes a family of chromosome 1-enc
162 Signaling lymphocytic activation molecule (SLAM, CD150) is the universal morbillivirus receptor.
164 e signaling lymphocytic activation molecule (SLAM; CD150) and the adherens junction protein nectin-4
165 e signaling lymphocytic activation molecule (SLAM; CD150) is the immune cell receptor for measles vir
168 d homing and maintenance of long-term murine SLAM(+) hematopoietic stem cells (HSCs), as well as huma
169 We isolated SLAM (CD150(+)CD48(-)) and non-SLAM (not CD150(+)CD48(-)) cells from human umbilical co
172 cross-linking in the presence or absence of SLAM cross-linking revealed that SLAM coengagement block
174 onstraints relevant to the colocalization of SLAM-family proteins with other signaling molecules in t
176 purify HSCs based on a simple combination of SLAM receptors allowed us to identify HSCs in tissue sec
177 ce that PKC-theta is a critical component of SLAM/SAP-mediated pathways that influence TCR-driven IL-
178 ates cytokine production in DC downstream of SLAM engagement and that a genetic polymorphism that dis
183 type strains correlate with the frequency of SLAM expression and are highest in B cells, which are 40
184 ed protein (SAP) can mediate the function of SLAM molecules, which have been proposed to be involved
185 mportantly, we find that stringent gating of SLAM markers is essential to achieving purity in HSC iso
186 rophage function resulted in an inability of SLAM(-/-) C57Bl/6 mice to remove the parasite Leishmania
187 MV) immunosuppression is due to infection of SLAM-positive immune cells, whereas respiratory shedding
188 interactions that permits the intermixing of SLAM receptors with major histocompatibility complex-spe
190 Mutations in SH2D1A resulting in lack of SLAM-associated protein (SAP) expression cause the human
193 the interaction between a phosphopeptide of SLAM (signaling lymphocytic activation molecule) and its
197 ew, we cover recent findings on the roles of SLAM family receptors and the SAP family of adaptors, wi
198 that interacts with the cytoplasmic tail of SLAM and related receptors, including 2B4, Ly108, CD84,
205 f B cell-intrinsic expression of polymorphic SLAM receptors that affect B cell tolerance at the GC ch
206 at the self ligand and cell surface receptor SLAM functioned not only as a costimulatory molecule but
208 ugh mice that lack the adaptor molecule SAP (SLAM-associated protein) resemble ICOS(-/-) mice (and ca
209 ylation of NTB-A and the association of SAP (SLAM-associated protein), the protein absent in X-linked
210 a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development.
217 human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD
219 gagement of the homophilic receptors Slamf1 (SLAM) and Slamf6 (Ly108) and the downstream recruitment
226 absence of SLAM cross-linking revealed that SLAM coengagement blocked activation of p38 MAPK and JNK
227 e cytoplasmic tail of SLAM, and we show that SLAM is expressed on resting and activated CD4 T cells,
229 Collectively, these results suggest that SLAM-SAP signaling drives the differentiation and functi
230 y recognizing self-antigens, suggesting that SLAM/SAP regulate B-cell receptor-mediated central toler
235 the observed genetic association between the SLAM locus and SLE, suggest a role for CD319 and CD229 i
237 into the multiplicity of roles played by the SLAM/CD2 family and its potential importance in human au
238 promoter region of the NZB gene encoding the SLAM signaling pathway adapter molecule EWS-activated tr
240 findings demonstrate a specific role for the SLAM-SH2D1A system in the regulation of T-dependent humo
241 D4 T cell differentiation, separate from the SLAM-SAP-Fyn signaling pathway regulating Th1/Th2 differ
242 ucture-based stage for understanding how the SLAM-elicited conformational changes travel through the
245 ally occurring polymorphic variations in the SLAM family show a direct role in initiating the break i
246 t signaling of the adhesion molecules in the SLAM family, activated by proximity during aggregation,
248 be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly10
249 dy, we hypothesized that coexpression of the SLAM adapter EWS-FLI1-activated transcript 2 (EAT-2) alo
251 , regulation, and mechanism of action of the SLAM family in NK cells by analyzing a mouse lacking the
254 2B4 is the only heterophilic receptor of the SLAM family, whose other members, e.g., NK-T-B-antigen (
255 his study reveals that the expression of the SLAM receptors CD319 and CD229 is regulated on pDCs and
257 We have now examined the role(s) of the SLAM-SAP-Fyn signaling axis in in vivo CD4 T cell functi
258 ure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mic
261 portance in human autoimmunity positions the SLAM/CD2 family as an excellent target for immunotherapy
262 with previous reports, demonstrate that the SLAM family homophilic affinities span at least three or
264 In the absence of SAP, signaling through the SLAM family members Ly108 and 2B4 resulted in increased
266 new isolation method was reported, using the SLAM family of cell-surface markers, including CD150 (Sl
268 We examined the possibility of using the SLAM markers to facilitate the isolation of highly enric
274 ulatta) was inoculated intranasally with the SLAM-blind virus, no clinical symptoms were documented.
275 sponsible for binding specificity within the SLAM family and imposes physical constraints relevant to
277 tein hemagglutinin and infects cells through SLAM about 40 times less efficiently than the isogenic w
280 t activation of p38 and ERK, in part through SLAM, mediates T-cell IFN-gamma production in response t
281 s both positive and negative signals through SLAM receptors to stabilize intercellular contacts.
282 AM) family of receptors that signals through SLAM-associated protein (SAP), an SH2 domain protein tha
286 creased levels of Th1 markers, such as Tim3, SLAM, T-bet, and Ly6C, had smaller amounts of cytotoxic
291 +) T cells produce more IL-17 in response to SLAM costimulation as compared with CD28 costimulation.
292 ude soluble forms and the absence of typical SLAM signaling motifs in their cytoplasmic domains, like
293 ly defined spike-in pool to resemble typical SLAM experiments and performed TAG microarray hybridizat
299 ese data emphasize the robustness with which SLAM family markers distinguish progenitors at different
300 -associated protein (SAP)) interactions with SLAM family proteins play important roles in immune func
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