1                                              SLAMF1 deficiency associated with increased expression o

2                                              SLAMF1 ligation with an agonistic monoclonal antibody in

3                                              SLAMF1 silencing in CLL-like Mec-1 cells, which constitu

4                                 Accordingly, SLAMF1-silenced cells or SLAMF1(lo) primary CLL cells we

5 oteins found on the surface of the virus and SLAMF1, the immune cell receptor.

6  unfavorable clinical outcome experienced by SLAMF1(lo) patients.

7 f the autophagy macrocomplex, which contains SLAMF1, beclin1, and the enzyme VPS34.

8 ke Mec-1 cells, which constitutively express SLAMF1, modulated pathways related to cell migration, cy

9 signaling lymphocyte activation molecule F1 (SLAMF1) is both a microbial sensor and entry receptor fo

10           Herein, we describe a new role for SLAMF1 to mediate MeV endocytosis that is in contrast wi

11 ibit Slamf1 reduce colitis in mice, so human SLAMF1 might be a therapeutic target for inflammatory bo

12  steps governing entry of measles virus into SLAMF1-positive cells and identified endocytic uptake of

13       We demonstrated that MeV engagement of SLAMF1 induces dramatic but transient morphological chan

14  the half-life of DP cells and expression of SLAMF1, SLAMF6 and SAP.

15 ogether, these results indicate that loss of SLAMF1 expression in CLL modulates genetic pathways that

16        Accordingly, SLAMF1-silenced cells or SLAMF1(lo) primary CLL cells were resistant to autophagy

17  costimulatory molecule and microbial sensor SLAMF1 (also known as CD150) is lost in a subset of pati

18 Beclin1 dissociated from BCL2 in response to SLAMF1 ligation, resulting in formation of the autophagy

19           This uptake pathway is specific to SLAMF1-positive cells and occurs within 60 min of viral