ライフサイエンスコーパス: SLC

1 SLC also induced calcium mobilization specifically in ma

2 SLC and Epstein-Barr virus-induced molecule 1 ligand che

3 SLC elicited a substantial infiltration of DCs and T cel

4 SLC had a greater effect on naive CD4+ T cells than on m

5 SLC injection led to significant increases in CD4 and CD

6 SLC is a highly efficacious chemoattractant for lymphocy

7 SLC is likely to play an important role in regulating th

8 SLC is the first chemokine demonstrated to have the char

9 SLC was a potent in vitro chemoattractant for cultured,

10 SLC-mediated antitumor responses were lymphocyte depende

11 SLCs interact with several important drugs, and a quarte

12 CC chemokine CCL21, also known as Exodus-2, SLC, 6Ckine, and TCA4 induces both the adhesion and migr

13 emokines, Exodus-1/LARC/MIP-3alpha, Exodus-2/SLC/6Ckine/TCA4, and Exodus-3/CKbeta11/MIP-3beta, were f

14 Its ligands, CCL-19 (MIP-3beta) and CCL-21 (SLC), play an important role in the migration of these c

15 nt drugs, and a quarter of the more than 400 SLC genes are associated with human diseases.

16 SDF-1 (stromal cell-derived factor); and 6CK/SLC competes for MIP-3beta binding to resting mouse lymp

17 TCA4, or Exodus-2 (herein referred to as 6CK/SLC) can trigger rapid integrin-dependent arrest of lymp

18 Moreover, 6CK/SLC and MIP-3beta attract the same major populations of

19 We show that 6CK/SLC is an agonist for the lymphocyte chemoattractant rec

20 ty of circulating lymphocytes respond to 6CK/SLC and MIP-3beta in large part through their common rec

21 -3beta inhibits lymphocyte chemotaxis to 6CK/SLC but not to the alpha chemokine SDF-1 (stromal cell-d

22 The CC chemokine known as 6Ckine (SLC, Exodus-2, or TCA4) has been identified as a ligand

23 isolated by us and others as Exodus-2/6Ckine/SLC/TCA4) is highly potent and highly specific for stimu

24 olar concentrations of MCH strongly activate SLC-1-related pathways through G(alpha)i and/or G(alpha)

25 hese cells are likely to be the sought-after SLCs.

26 sity increased the probability of evoking an SLC and decreased mean SLC latencies while increasing th

27 single functional ELC gene, leaving only an SLC gene that is expressed in lymphatic endothelium and

28 ph node addressins) together with ICAM-1 and SLC.

29 es confirmed increased IL-7, SDF-1alpha, and SLC gene expression in MHC class II+ CD45- epithelial ce

30 polymorphisms in genes encoding for ABC and SLC transporters may have a significant impact on the ph

31 ivity, as excretion of BR depends on ABC and SLC transporters.

32 A large number of ABC and SLC transpoters exist; however, only a small number have

33 This study implicates BLC and SLC in chronic inflammation and presents further evidenc

34 a was not necessary for induction of BLC and SLC in inflamed tissues, whereas, in contrast, tumor nec

35 ross-kissing interactions (SL-C to SL-D' and SLC' to SL-D) and stack in an end-to-end manner (SL-C to

36 We propose that ELC- and SLC-expressing T zone stromal cells play a central role

37 y livers demonstrate impaired hepatocyte and SLC function, after even a very brief preservation.

38 Hepatocyte and SLC trypan blue uptake were minimal and similar in both

39 sed a significant decrease in hepatocyte and SLC trypan blue uptake.

40 art from their latencies, SLC kinematics and SLC field potential parameters were intensity independen

41 Importantly, SL1 and SLC are functionally interchangeable, and separate excha

42 Therefore, SL1 and SLC are likely essential comoviral RNA structures that p

43 While the stems of SL1 and SLC share little sequence similarity, their end loops ar

44 The levels of IL-7, SDF-1alpha, TECK, and SLC mRNA inversely correlated with the kinetics of regen

45 at expression of IL-7, SDF-1alpha, TECK, and SLC mRNA is induced in the thymic stroma during T cell d

46 Anti-SLC Abs, but not control or anti-eotaxin Abs, blocked th

47 In addition, anti-SLC Ab did not inhibit CHS responses when given at the t

48 se to hapten challenge was inhibited by anti-SLC Ab treatment in a dose-dependent manner.

49 A single injection of anti-SLC Ab given at the time of sensitization with FITC inhi

50 tudies, we examined the consequences of anti-SLC Ab treatment during Ag priming on T cell function in

51 Animals treated with anti-SLC Ab during hapten sensitization were not tolerant to

52 aining lymph nodes of mice treated with anti-SLC Ab during hapten sensitization.

53 As SLC transporters have high similarity in their membrane

54 he suppressor of long chain base auxotrophy (SLC, strain 7R4) showed a heat-sensitive phenotype that

55 beta2 integrin affinity modulation, because SLC does not elicit a beta2 integrin activation epitope

56 the potential to sequester latent TGF-beta (SLC) to the cell surface where TGF-beta activation could

57 Fny-CMV plays a role similar to that of BMV SLC in interacting with the CMV replicase.

58 s indicates that the requirements in the BMV SLC are highly specific.

59 n of the Cucumber mosaic virus (CMV) and BMV SLCs indicates that the requirements in the BMV SLC are

60 at the plt defect is due to the loss of both SLC and EBI-1 ligand chemokine (ELC) expression in secon

61 Neutrophils roll, but are not arrested by SLC, whereas they respond to immobilized IL-8 with rapid

62 itro requires a structure named stem-loop C (SLC) that contains a clamped adenine motif.

63 virus (BMV), a stem-loop structure named C (SLC) is present within the tRNA-like region and is requi

64 n this region, a stem-loop structure, called SLC, is necessary and sufficient for the binding of the

65 nd are encoded by two solute-linked carrier (SLC) gene families: ZnT (SLC30) and Zip (SLC39).

66 porter Bor1, a member of the solute carrier (SLC) 4 transporter family with homology to the human bic

67 ansport studies suggest that solute carrier (SLC) and ATP binding cassette (ABC) multispecific "drug"

68 s a member of a gene family, solute carrier (SLC) family 26, that encodes anion transporters and rela

69 variants in the proximity of solute carrier (SLC) genes.

70 Solute carrier (SLC) membrane transport proteins control essential physi

71 A number of solute carrier (SLC) proteins are subject to changes in expression and a

72 2 (SLC22A7), a member of the solute carrier (SLC) superfamily, was a facilitative transporter for cGM

73 ette (ABC) transporters and solute carriers (SLCs), have been identified in platelets.

74 lls is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but n

75 /MCP-1, CXCL12/SDF-1, CCL5/RANTES, and CCL21/SLC.

76 e hypothesized that sinusoidal lining cells (SLCs) in fatty livers of obese Zucker rats are more susc

77 ignaling complex with the surrogate L chain (SLC) components lambda5 and Vpre-B.

78 chain paired with two surrogate light chain (SLC) components.

79 posed of Ig heavy and surrogate light chain (SLC), signals pre-BII-cell proliferative expansion.

80 ed with a two-subunit surrogate light chain (SLC).

81 We previously characterized SLC, a stem-loop structure in the 5' untranslated region

82 s secondary lymphoid tissue chemoattractant (SLC) and macrophage inflammatory protein (MIP)-3beta, im

83 in response to the lymphoid homing chemokine SLC/CCL21: CD4(-) Valpha14i-negative NKT cells that were

84 al venules, stromal cells, and the chemokine SLC.

85 amma (Mig) and secondary lymphoid chemokine (SLC) gene expression within allografts and spleens respe

86 votal role for secondary lymphoid chemokine (SLC) in directing dendritic cell trafficking from periph

87 and 21 (CCL21)/secondary lymphoid chemokine (SLC), a ligand for CC chemokine receptor 7 (CCR7), has b

88 loss of secondary lymphoid-organ chemokine (SLC) expression in lymphoid tissues.

89 Secondary lymphoid organ chemokine (SLC) is expressed in high endothelial venules and in T c

90 iency of secondary lymphoid organ chemokine (SLC), a CC chemokine that chemoattracts both dendritic c

91 acks the secondary lymphoid organ chemokine (SLC)-ser gene and has disrupted trafficking of T cells a

92 luminal secondary lymphoid tissue chemokine (SLC) (6Ckine, Exodus-2, thymus-derived chemotactic agent

93 rt that secondary lymphoid-tissue chemokine (SLC) (also known as 6Ckine, Exodus-2, and thymus-derived

94 Secondary lymphoid tissue chemokine (SLC) and B lymphocyte chemoattractant (BLC) are homing c

95 okines (secondary lymphoid tissue chemokine (SLC) and EBV-induced molecule 1 ligand chemokine (ELC))

96 K), and secondary lymphoid tissue chemokine (SLC) but not of other chemokines.

97 express secondary lymphoid tissue chemokine (SLC) into growing B16 melanoma could result in a substan

98 Secondary lymphoid tissue chemokine (SLC) is a CC chemokine that is selective in its recruitm

99 Secondary lymphoid-tissue chemokine (SLC), a CC chemokine, is expressed in secondary lymphoid

100 Secondary lymphoid-tissue chemokine (SLC), a high endothelial venule (HEV)-associated chemoki

101 Secondary lymphoid tissue chemokine (SLC), a recently discovered chemokine for naive T cells,

102 actant, secondary lymphoid tissue chemokine (SLC), by T zone stromal cells is found to be markedly de

103 ngkine, secondary lymphoid-tissue chemokine (SLC), EBI1-ligand chemokine (ELC), fractalkine, macropha

104 tabase, secondary lymphoid-tissue chemokine (SLC), is expressed in the high endothelial venules of ly

105 C-kine, secondary lymphoid-tissue chemokine (SLC), TCA4, or Exodus-2 (herein referred to as 6CK/SLC)

106 ncludes secondary lymphoid tissue chemokine (SLC), which promotes the colocalization of naive, nonpol

107 LC) and secondary lymphoid tissue chemokine (SLC).

108 DCs to secondary lymphoid tissue chemokine (SLC)/CC chemokine ligand 21 (CCL21) were significantly l

109 s CCR7 (secondary lymphoid-tissue chemokine (SLC)/CC ligand (CCL)21), CXCR4 (stromal cell-derived fac

110 Secondary lymphoid tissue chemokine (SLC, also referred to as Exodus 2 or 6Ckine) is a recent

111 vement, secondary lymphoid tissue chemokine (SLC, CCL21) and Epstein-Barr virus-induced molecule 1 li

112 such as secondary lymphoid tissue chemokine (SLC; CCL21) to its counterreceptor, CCR7.

113 The chemokines SLC (CCL 21) and BLC (CXCL13) were present, as were B220

114 - that are known as sex-limited chromosomes (SLCs).

115 The second case is for the Salt Lake City (SLC) region for August 2012.

116 Salt Lake City (SLC), Utah, and the surrounding intermountain region exp

117 xt of the entire tRNA-like element, both CMV SLC-like motifs are recognized by the BMV replicase.

118 h their SLCs replaced with two different CMV SLCs were defective for replication.

119 Ps) composed of sequences of low complexity (SLC) have been shown to serve a variety of important cel

120 eplicated associations of the amine compound SLC (solute-carrier) transporters gene set with the lear

121 iseases using a "sneaking ligand construct" (SLC) selectively inhibiting NF-kappaB in the activated e

122 is paper, a sampling-based learning control (SLC) method is used to guide the design of control field

123 e Guyot (SG), single spur pruned low cordon (SLC) and single spur pruned high wire cordon (HSLC) as t

124 n sequencing (NGS) techniques to deciphering SLC sequences.

125 that increasing stimulus intensity decreased SLC latencies while increasing their precision, which wa

126 Surrogate light-chain-deficient (SLC-/-) mice harbored elevated levels of antinuclear ant

127 ne-linked cautery and ultrasonic dissection (SLC+UD) from December 2002 to January 2004.

128 ILC when compared with historic rates during SLC.

129 ELC, SLC, and TECK comprised high affinity ligands (IC50 <15

130 as abolished in the presence of soluble ELC, SLC (CCR7 ligands), and TECK (a CCR9 ligand).

131 Administration of amplicons encoding SLC (HSV-SLC) into s.c. tumors established previously re

132 tal structures of prokaryotic and eukaryotic SLC transporters indicating the location of both (or one

133 c. injection of lysate-pulsed DCs expressing SLC promoted the migration of T cells to the immunizatio

134 rters and the organic solute carrier family (SLC) proteins.

135 diverse heavy chains are paired with a fixed SLC were expressed in mammalian, Escherichia coli, and p

136 A CP was found to have higher affinities for SLC and the B box compared with those of wild-type CP an

137 hemokine receptor 7 (CCR7), the receptor for SLC and for macrophage inflammatory protein (MIP)-3beta

138 there are several specific requirements for SLC recognition.

139 These results indicate an important role for SLC during sensitization for CHS and suggest a strategy

140 the hypothalamus, consistent with a role for SLC-1 in mediating the effects of MCH on feeding.

141 for both CD4 and CD8 lymphocyte subsets for SLC-mediated tumor regression.

142 four of eight BALB/c mice and three of four SLC:ddY mice expressed one or more opacity (Opa) protein

143 r, splenic and lymph node-derived cells from SLC-treated tumor-bearing mice secreted significantly mo

144 ubtraction of field potential latencies from SLC latencies revealed a fixed time delay between the tw

145 s tumor, lymph node-derived lymphocytes from SLC-treated tumor-bearing mice demonstrated enhanced cyt

146 rradiated autologous tumor, splenocytes from SLC-treated mice secreted significantly more IFN-gamma a

147 natural ligand of a particular orphan GPCR (SLC-1) that is sequentially homologous to the somatostat

148 While the majority of CMV isolates have SLC-like elements similar to that of Fny-CMV, a second g

149 dministration of amplicons encoding SLC (HSV-SLC) into s.c. tumors established previously resulted in

150 mbined transduction of either tumor with HSV-SLC and HSV-CD40L resulted in a more enhanced antitumor

151 Immobilized SLC increased the adhesion of HUT-78 T cells and human P

152 We now show that immobilized SLC strongly induces beta2 integrin-mediated binding of

153 In SLC, the incidence of ARF coresurged with the occurrence

154 P-3beta signaling, and occurs efficiently in SLC(low/-) HEV segments in wild-type mice, and in the SL

155 BMV RNA3s with mutations in SLC were transfected into barley protoplasts, and the re

156 response to albuterol in Latinos, notably in SLC genes that include membrane transport proteins invol

157 or loss of cyclin A activity was observed in SLC-1 cells.

158 d nonmucoid pharyngeal isolates recovered in SLC from 1984 to 1999 were studied by sequencing the emm

159 nvolved in lymphoid organogenesis, including SLC, BLC, ELC, SDF1, and BAFF.

160 the fact that a sulfonamide CA IX inhibitor (SLC-0111) is presently in phase I clinical trials.

161 In immunocompetent mice, intratumoral SLC injection led to a significant increase in CD4 and C

162 Apart from their latencies, SLC kinematics and SLC field potential parameters were i

163 ately derive from undifferentiated stem LCs (SLCs), which are postulated to be present in testes befo

164 ee stem loops (SLB-SLD), and that stem loops SLC and SLD play prominent roles in packaging.

165 essed by T zone stromal cells that also make SLC.

166 ability of evoking an SLC and decreased mean SLC latencies while increasing their precision; subtract

167 une strategy, we show that amplicon-mediated SLC and CD40L delivery may mimic lymph node conditions n

168 Moreover, SLC induces firm adhesion of naive T lymphocytes via bet

169 preferentially bind to an RNA element named SLC that contains the core promoter for genomic minus-st

170 In the lymph node, SLC is believed to play an important role in the initiat

171 The ability of SLC to chemoattract both Th1 lymphocytes and dendritic c

172 To this end, the antitumor activity of SLC and CD40L expressed singly or in combination using t

173 cells, suggesting that the dysregulation of SLC/ELC- expression alone in Ltbr-/- thymi can be suffic

174 This effect of SLC was seen in both static and flow chamber adhesion as

175 We show that the effects of SLC perturbation are mimicked by manipulation of either

176 trong rationale for additional evaluation of SLC in regulation of tumor immunity and its use in lung

177 a strong rationale for further evaluation of SLC in tumor immunity and its use in cancer immunotherap

178 phoid organs, is important for expression of SLC and BLC in secondary lymphoid organs during developm

179 duces inflammation and ectopic expression of SLC and BLC in the adult animal.

180 due to a genetic defect in the expression of SLC and that SLC mediates the entry of naive T cells and

181 In addition, the expression of SLC in lymphatic endothelium suggests that the migration

182 Here we demonstrate that expression of SLC is undetectable in plt mice.

183 Expression of SLC was also observed in the pancreas of prediabetic NOD

184 Intratumoral injections of SLC inhibited tumor growth in a CD8+, T cell-dependent m

185 Intratumoral injections of SLC-expressing DCs resulted in tumor growth inhibition t

186 tions strongly point to the participation of SLC in homing of lymphocytes to secondary lymphoid organ

187 Quantification of SLC kinematics and field potential parameters revealed t

188 behavior of mRNA levels for a wide range of SLC and ABC transporters in the rodent kidney throughout

189 s to the SLC locus; however, the sequence of SLC introns and exons in plt mice is normal.

190 , bile) via "matching" or homologous sets of SLC (e.g., SLC21, SLC22, SLC47) and ABC transporters.

191 ermined the high-resolution NMR structure of SLC, which demonstrated that a 5'-AUA-3' triloop region

192 r) determine the onset time and precision of SLCs.

193 OSS and dispersed South Louisiana crude oil (SLC) in laboratory microcosms.

194 The time is right for a systematic attack on SLC structure, specificity, and function, taking into ac

195 Each was enriched on SLC, the former at 25 degrees C, the latter at 5 degrees

196 Furthermore, RIP-mOVA transgenic mice on SLC/ELC deficient background (plt) demonstrated signific

197 lymphatic markers such as VEGFR-3, LYVE-1 or SLC.

198 nificantly better than either control DCs or SLC alone.

199 Along with OCT2, other SLC-family drug transporters are potentially part of an

200 5 was also evident with Dmu, but the overall SLC- and L chain-dependent requirements for Dmu maturati

201 In addition, chemokines, particularly SLC (CCL21), were also required for IS-CD8(+) cells' adh

202 We present design rules for IDPs possessing SLCs that phase separate into diverse assemblies within

203 d allowed for discrimination between primary SLCs and less frequent, long-latency startle responses (

204 teresting family of solute carrier proteins (SLCs), some of which have been suggested as being involv

205 growth factor I, and LH, 40% of the putative SLCs came to express 3betaHSD and to synthesize testoste

206 which LCs had been eliminated, the putative SLCs colonized the interstitium and subsequently express

207 The putative SLCs expanded over the course of 6 months while remainin

208 acid human orphan G-protein-coupled receptor SLC-1 expressed in HEK293 cells binds MCH with sub-nanom

209 cently the orphan G protein-coupled receptor SLC-1 was identified as the MCH receptor (MCHR).

210 dition, we demonstrate that the MCH receptor SLC-1 is expressed in adipocytes, suggesting that fat ce

211 An orphan G protein-coupled receptor (SLC-1/GPR24) has recently been identified as a receptor

212 Recently an orphan receptor, SLC-1, has been identified as an MCH receptor (MCH-R1).

213 Intratumoral injection of recombinant SLC evidenced potent antitumor responses and led to comp

214 Injection of recombinant SLC in the axillary lymph node region led to a marked re

215 Exploring the basis for the reduced SLC expression led to identification of further disrupti

216 n-sensitive B cell sticking does not require SLC or MIP-3beta signaling, and occurs efficiently in SL

217 we examined short-latency startle responses (SLCs) in larval zebrafish and tested the hypothesis that

218 een short-latency and long-latency C-starts (SLCs vs. LLCs) in larval zebrafish.

219 een short-latency and long-latency C-starts (SLCs vs. LLCs) in larval zebrafish.

220 d to other gene families of similar stature, SLCs are relatively understudied.

221 An outbred mouse strain (SLC:ddY) previously reported to be naturally susceptible

222 hat the chemokine CCL21 (also known as TCA4, SLC, 6Ckine), a ligand for the chemokine receptor CCR7,

223 with islet expression of the chemokine TCA4/SLC.

224 Our results indicate that TCA4/SLC can induce the development and organization of lymph

225 Technically, SILC is more challenging than SLC.

226 appear to be more susceptible to injury than SLCs.

227 tic defect in the expression of SLC and that SLC mediates the entry of naive T cells and antigen-stim

228 This report demonstrates that SLC can both induce antitumor responses and enhance the

229 Thus, we provide direct evidence that SLC and CCR7 participate in the emigration of DCs from p

230 The finding that SLC is a potent chemokine for DC as well as naive T cell

231 We show here that SLC is a potent chemokine for mature DC but does not act

232 he Malvasia as the more effective one), that SLC led to the lowest level of TAC and that 8 buds/plant

233 Here, we show that SLC binds to alpha(v)beta8, an integrin expressed by nor

234 We also show that SLC-1 messenger RNA and protein is expressed in the vent

235 The SLC contains nonimmunoglobulin-like peptide extensions o

236 The SLC trypan blue uptake was increased but similar in both

237 t is determined by its Ig components and the SLC, we investigated the regulation of pre-BCR surface e

238 and activation stage-dependent manner by the SLC approach.

239 As in pre-B cells, the SLC in nonlymphoid cells supported only a limited degree

240 tify peptides in the capsid that contact the SLC, the B-box RNA, and the encapsidated RNA.

241 re of GAS strains associated with ARF in the SLC region, 964 mucoid and nonmucoid pharyngeal isolates

242 ) HEV segments in wild-type mice, and in the SLC-negative HEVs of DDD/1 mice.

243 tion represents a deletion that includes the SLC gene expressed in secondary lymphoid organs and the

244 of multispecific "drug" transporters of the SLC and ABC transporter families.

245 presents a well-characterized example of the SLC family.

246 ency and the precision in the latency of the SLC field potentials were linearly correlated to the lat

247 e pre-BCR also signals downregulation of the SLC genes (VpreB and lambda5), thereby limiting this exp

248 cause of the heat-sensitive phenotype of the SLC strain 7R4.

249 Expression of the SLC-related chemokine, Epstein Barr virus-induced molecu

250 this was due to an intrinsic property of the SLC.

251 sing this replicase, we demonstrate that the SLC-like structure in Fny-CMV plays a role similar to th

252 The plt mutation maps to the SLC locus; however, the sequence of SLC introns and exon

253 ow that the "smart" fields learned using the SLC method can achieve robust manipulation of supercondu

254 toplasts, we found that BMV RNA3s with their SLCs replaced with two different CMV SLCs were defective

255 s T cell-attracting chemokine (CTACK), three SLC, and four ELC genes or pseudogenes are present in so

256 chemotaxis of murine T cells and B cells to SLC but not to other homeostatic chemokines.

257 t L-selectin-mediated enhanced chemotaxis to SLC required intact intracellular kinase function.

258 lectin-mediated enhancement of chemotaxis to SLC was observed for all naive lymphocytes and effector/

259 1023-base pair cDNA and is 35% homologous to SLC-1.

260 pha14i-positive NKT cells did not migrate to SLC/CCL21.

261 lable methodology and results with regard to SLC sequencing and assembly.

262 wth factor beta was decreased in response to SLC treatment.

263 cells, and NK cells were also responsive to SLC.

264 tin-sensitive Na(+)-Li(+) counter-transport (SLC) activity, an established marker for hypertension.

265 of both major classes of drug transporters, SLC and ABC, in resting human blood neutrophils.

266 o both primary and MK cells, the tumorigenic SLC-1 cell line did not accumulate in a specific cell cy

267 otypes share a duplication that includes two SLC genes, which demonstrate different expression patter

268 n-like peptide extensions on each of the two SLC components.

269 The UD+SLC group had a decreased duration of inflow occlusion (

270 We next used SLC gene-modified DCs as a treatment of established tumo

271 Here, we used SLC as a treatment for tumors established from the poorl

272 ique for liver parenchymal transection using SLC and UD in noncirrhotic livers is safe and may provid

273 nstrate that mu(s)-chains can associate with SLC internally.

274 site immunization of tumor-bearing mice with SLC gene-modified DCs pulsed with tumor lysate elicited

275 we showed MHC class II-positive cells within SLC-staining lymphatic channels in the mouse dermis.