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1 folding of the serotonin transporter (SERT; SLC6A4).
2 ymorphism in the serotonin transporter gene (SLC6A4).
3 GS2, two in HTR2A, one in SLC6A2, and one in SLC6A4).
4 y to ASD are PTEN and Serotonin transporter (SLC6A4).
5 terial artificial chromosome drivers Pet1 or Slc6a4.
6 variants of two functional polymorphisms of SLC6A4 (5-HTTLPR, intron 2 variable number tandem repeat
7 variants of the serotonin transporter gene (SLC6A4), a long-standing OCD candidate, have so far been
9 er region of the serotonin transporter gene (SLC6A4; also known as 5-HTT) and its contribution to str
10 ted with altered transcriptional activity of SLC6A4; an earlier study reported an association of the
15 nges in mice and rats), it seems likely that SLC6A4 and SERT will remain areas of high interest in ou
16 llustrate significant variation worldwide at SLC6A4 and that the functionally implicated alleles at t
17 Restraint stress was applied to pregnant Slc6a4 (+/+) and Slc6a4 (+/-) mice and post-stress embry
18 nsiently express the 5-HT transporter (SERT; Slc6a4) and accumulate 5-HT, suggesting that the SERT ac
19 ions between the serotonin transporter gene (SLC6A4) and alcohol, heroin, cocaine, or methamphetamine
21 er protein (SERT or soluble carrier protein, SLC6A4) and p11 (S-100A10, or calpactin I light chain).
22 variants at the serotonin transporter gene (SLC6A4) and serotonin 2A receptor gene (HTR2A) predict c
23 of interest--the serotonin transporter gene (SLC6A4) and the integrin beta 3 gene (ITGB3) on chromoso
26 am region of the serotonin transporter gene (SLC6A4) are associated with individual differences in st
28 there was no consistent association between SLC6A4*C and any Tridimensional Personality Questionnair
29 analysis revealed a positive linkage between SLC6A4*C and the 2 anxiety-related subdimensions of Harm
30 We have attempted to confirm the role of SLC6A4*C in anxiety-related personality traits by sibpai
31 association, raising the question of whether SLC6A4*C locus is itself affecting anxiety or is linked
32 sent study we replicated the relationship of SLC6A4*C to anxiety by sibpair linkage analysis but foun
33 ter of the human serotonin transporter gene (SLC6A4*C) was identified and found to be linked to an an
35 membrane serotonin (5-HT) transporter (SERT, SLC6A4) clears 5-HT after release at nerve termini and i
36 escribed in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SE
37 hism, 5HTTLPR, in the serotonin transporter, SLC6A4, coupled with prenatal stress is reported to incr
38 of p38alpha MAPK in serotonergic neurons (by Slc6a4-Cre or ePet1-Cre) or astrocytes (by Gfap-CreERT2)
41 ontrast, the response of embryos of stressed Slc6a4 (+/-) dams was found to be attenuated, shown by s
42 idate genes for neuropsychiatric phenotypes: SLC6A4, encoding the serotonin transporter; and SLC18A2,
43 ults contribute to a better understanding of SLC6A4 expression genetics and provide a functional hapl
44 hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatmen
45 nalysis supports that the association of the SLC6A4 gene with substance use disorder varies depending
46 T) transporter SERT (which is encoded by the SLC6A4 gene) to platelet 5-HT stores suggests an importa
50 ion of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of n
53 er region of the serotonin transporter gene (SLC6A4) has been found to moderate several categories of
54 promoter of the serotonin transporter gene (SLC6A4) has been proposed as a pharmacogenetic marker fo
55 Variation at the serotonin transporter gene, SLC6A4, has been associated with a variety of neuropsych
57 e found normal colonic mucosal expression of SLC6A4 in diarrhea (IBS-D)- or constipation-predominant
59 ssion and activity of 5-HT Transporter (SERT/Slc6a4) in 5-HT neurons leading to an increase of 5-HT u
60 he serotonin (5-HT) transporter gene (5-HTT, SLC6A4) in modulating amygdala and prefrontal activation
62 amine (5-HT)] transporters (hSERT, 5HTT, and SLC6A4) inactivate 5-HT after release and are prominent
63 lymorphism of the serotonin transporter gene SLC6A4, influences cerebral cortical structure volumes i
65 , including the human serotonin transporter (SLC6A4), is critical for efficient synaptic transmission
66 er region of the serotonin transporter gene (SLC6A4), is implicated in speech encoding in the human s
69 B in the same sample that they genotyped for SLC6A4-LL/TT in the previous randomized, double-blind, 1
70 rted that the 5'-HTTLPR-LL and rs1042173-TT (SLC6A4-LL/TT) genotypes in the serotonin transporter gen
73 pothesis that the S allele of 5HTTLPR at the SLC6A4 locus is associated with a poor outcome after tre
75 ess was applied to pregnant Slc6a4 (+/+) and Slc6a4 (+/-) mice and post-stress embryonic brains were
79 ubsequent exposure to adult social defeat on slc6a4 mRNA expression in the dorsal raphe nucleus (DR)
80 sed to social defeat as adults had increased slc6a4 mRNA expression throughout the DR compared to bot
81 to a novel cage control condition, increased slc6a4 mRNA expression was observed in the dorsal part o
84 ween these factors on serotonin transporter (slc6a4) mRNA expression, we investigated in rats the eff
85 human primates indicate that combinations of SLC6A4 non-coding 5', 3' UTRs and intronic regions plus
88 In Necdin-KO pups, the genetic deletion of Slc6a4 or treatment with Fluoxetine, a 5-HT reuptake inh
89 on serotonin (5-HT) transporter (5-HTT/SERT, SLC6A4) polymorphism is believed to confer lower 5-HTT e
90 gical mechanisms underlying the link between SLC6A4 polymorphisms and the emotionally vulnerable phen
92 influenced ability to detect association of SLC6A4 polymorphisms with personality measures; populati
99 ociation between the serotonin protein gene (SLC6A4) promoter variant (5-HTTLPR) and risk of current
100 ansmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects transcription and may be invo
101 sm and serotonin transporter genotype at the SLC6A4 promotor VNTR polymorphism in 30 healthy subjects
102 PR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transpor
104 ter (SLC6A2, NET) and serotonin transporter (SLC6A4, SERT) genes and remission in depressed older adu
105 sopressin receptor 1a) gene and STin2 in the SLC6A4 (solute carrier family 6 [neurotransmitter transp
106 17q11.2 region that harbors the SERT locus (SLC6A4) supports a genetic effect at or near this gene.
107 ed copy of the 5-HT transporter (i.e., SERT, slc6a4) that bears a single amino acid substitution, I17
108 cleotide polymorphisms (SNPs) for AVPR1A and SLC6A4 to determine whether other variants in these gene
109 location of the serotonin transporter (SERT, SLC6A4) to the synaptic terminals of serotonergic neuron
110 P1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effe
111 Because the L(A) allele confers increased SLC6A4 transcription, increased serotonin transporter le
112 sm in the serotonin transporter gene (locus, SLC6A4; variant, serotonin 5-HTTLPR) moderates risk of p
114 32 and all other known non-coding functional SLC6A4 variants revealed a highly significant omnibus as
116 To determine the extent of variation at SLC6A4, we genotyped 23 markers on approximately 2500 in
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