ライフサイエンスコーパス: SLN

1 SLN and ALND groups and radiation fields were compared w

2 SLN binding to SERCA uncouples Ca(2+) transport from ATP

3 SLN biopsy is recommended for patients with intermediate

4 SLN biopsy may be considered for thin melanomas that are

5 SLN biopsy may be recommended for patients with thick me

6 SLN biopsy should be considered in patients with eyelid

7 SLN biopsy using dual-dye technique was performed in 16

8 SLN biopsy was performed using dual-dye technique (a com

9 SLN counts were performed in vivo and confirmed ex vivo.

10 SLN identification rates for dual-dye, radiotracer, and

11 SLN metastases were detected in 65 (5.2%) of 1,250 patie

12 SLN showed metastasis in 2 patients (12.5%).

13 SLN surgery is increasingly used for nodal staging after

14 SLN used for co-crystallization with SERCA1a is also pal

15 The median overall detection (>/=1 SLN in a patient) was 98.6% for SPECT/CT (range, 92.2%-1

16 he reported median bilateral detection (>/=1 SLN in each hemipelvis) was 69.0% for SPECT/CT (range, 6

17 At least 1 SLN was identified in 639 patients (92.7%: 95% CI: 90.5%

18 Only 1 SLN was excised in 78 patients (12.0%).

19 that SLN differs significantly from PLB: 1) SLN primarily affects the Vmax of SERCA-mediated Ca(2+)

20 We show that: 1) SLN values constrain models of cortical hierarchy, revea

21 In 75 cases, 136 SLNs were eligible for analysis, of which 13 (9.6%) cont

22 In these 80 surgical procedures, 147 SLNs were excised.

23 7%) patients with cN1 disease and at least 2 SLNs resected, clip location was confirmed in 141 cases.

24 des removed compared with a median of only 2 SLNs removed with SLND alone (P < 0.001).

25 ake but not the pump affinity for Ca(2+); 2) SLN can bind to SERCA in the presence of high Ca(2+), bu

26 g previously unsuspected areal relations; 2) SLN reflects the operation of a combinatorial distance r

27 indications for ALND were metastases in >/=3 SLNs or gross extracapsular extension.

28 In 484 SLN-only patients with known RT fields (103 prone, 280 s

29 Four of the 5 SLNs exhibited increased SUVs of 12.4-139.0 obtained fro

30 An alignment of 67 SLN sequences from the protein databases shows that 19 o

31 (2+)-ATPase assays showed that sAnk1 ablated SLN's inhibition of SERCA1 activity.

32 SLN caused the resulting chimera to acquire SLN-like function.

33 in muscle succinate dehydrogenase activity, SLN expression, mitochondrial content, and neovasculariz

34 view the evidence that regression may affect SLN status.

35 ith a single tumor-positive lymph node after SLN biopsy underwent CLND and were randomly assigned to

36 Five-year event-free survival after SLN alone was 93% with no isolated axillary recurrences.

37 in locoregional recurrence or survival after SLN biopsy alone or ALND.

38 An SLN could not be identified in 46 patients (7.1%).

39 The clipped node was not retrieved as an SLN in 23% (31 of 134) of patients, including six with n

40 tivity, which established a lymph node as an SLN.

41 .010) compared with patients who received an SLN biopsy.

42 Patients underwent an SLN procedure with preoperative (99m)Tc-nanocolloid SPEC

43 tle/abstract and considered eligible when an SLN procedure was performed using both imaging modalitie

44 f isosulfan blue dye to radioisotope when an SLN was identified on a preoperative lymphoscintigram.

45 Patients in whom an SLN biopsy was not performed had significantly reduced M

46 FNR of 9.8% with the combination of AUS and SLN surgery would be acceptable for the adoption of SLN

47 istologic regression of primary melanoma and SLN status.

48 e mutants, we additionally show that PLB and SLN can bind to the same groove but interact with a diff

49 utagenesis and generated chimeras of PLB and SLN.

50 Although the sequences of PLN and SLN are practically invariant among mammals, they vary i

51 the regulatory mechanisms imposed by PLN and SLN could have clinical implications for both heart and

52 PLN and SLN have significant sequence homology in their transmem

53 In contrast to PLN and SLN, which are expressed in cardiac and slow skeletal mu

54 Our results indicated that sAnk1 and SLN can associate in the sarcoplasmic reticulum membrane

55 o-reconstituted proteoliposomes of SERCA and SLN.

56 association with pathologic nodal status and SLN FNR.

57 These studies suggest that UCP1 and SLN are required to maintain optimal thermogenesis and t

58 e cold adaptation by employing UCP1(-/-) and SLN(-/-) mice.

59 ety of Surgical Oncology recommendations are SLN positive.

60 rformed with other axillary surgery, such as SLN dissection.

61 operative (99m)Tc-nanocolloid SPECT/CT-based SLN mapping.

62 suggest that domains can be switched between SLN and PLB without losing the ability to regulate SERCA

63 649 underwent chemotherapy followed by both SLN surgery and ALND.

64 lowing chemotherapy, patients underwent both SLN surgery and ALND.

65 In this study, we used both SLN knockout (Sln(-/-)) and skeletal muscle-specific SLN

66 subareolarly for localization of the breast SLN and isosulfan blue dye (5 mL) is injected in the ips

67 um Ca(2+) cycling and that its regulation by SLN can be the basis for muscle NST.

68 CA promotes uncoupling of SERCA, we compared SLN and SERCA1 interaction with that of PLB in detail.

69 ed node should be considered when conducting SLN surgery in this setting.

70 ets of the SPECT and MR images were created, SLNs could be identified on the MR image with accurate c

71 sonic imaging system to noninvasively detect SLNs based on the accumulation of methylene blue dye.

72 s into a therapeutic strategy, we knock down SLN expression in 1-month old mdx:utr (-/-) mice via ade

73 at can help improve surgical guidance during SLN biopsy procedures.

74 ease with removal of the clipped node during SLN surgery reduces the FNR of SLN surgery after neoadju

75 nguinal lymph nodes pathologically examined (SLN + MILND) was 12.0 (interquartile range 8.0, 14.0).

76 FireFly camera system to detect fluorescent SLNs after administration of a dual-labeled molecular im

77 d that Arg(27) and Tyr(31) are essential for SLN function.

78 the trunk), the use of indocyanine green for SLN detection is severely limited compared with SLNE usi

79 impact of AUS results to select patients for SLN surgery to reduce the FNR was assessed.

80 en together, establish an important role for SLN in muscle metabolism and energy expenditure.

81 normal nodes and guide patient selection for SLN surgery.

82 staging after NAC and optimal technique for SLN identification is important.

83 Blue dye technique can be used for SLN biopsy in settings where nuclear medicine facilities

84 swapping PLB N and C termini with those from SLN caused the resulting chimera to acquire SLN-like fun

85 antiated that it is the way the 4-(N)-GemC18-SLNs deliver the 4-(N)-GemC18 into tumor cells that allo

86 The 4-(N)-GemC18 in the 4-(N)-GemC18-SLNs entered tumor cells due to clathrin-mediated endocy

87 rin-mediated endocytosis of the 4-(N)-GemC18-SLNs into the lysosomes of the cells, whereas the 4-(N)-

88 e the mechanisms underlying the 4-(N)-GemC18-SLNs' ability to overcome gemcitabine resistance.

89 bine solid lipid nanoparticles (4-(N)-GemC18-SLNs) can overcome multiple acquired gemcitabine resista

90 ligible, 12 underwent ALND only, and 689 had SLN surgery attempted.

91 ients met Z0011 eligibility criteria and had SLN metastases.

92 Patients eligible for Z0011 had SLN biopsy alone.

93 ality studies had a lower likelihood to have SLN positivity (OR, 0.48; 95% CI, 0.32-0.72) compared wi

94 th regression had a lower likelihood to have SLN positivity (OR, 0.56; 95% CI, 0.41-0.77) than patien

95 with these respective characteristics having SLN disease.

96 0.75 mm, with 6.3% of these patients having SLN disease, whereas in melanomas < 0.75 mm, SLN metasta

97 However, the detailed mechanism of how SLN regulates muscle metabolism remains unclear.

98 echnique was the only factor found to impact SLN identification; with use of blue dye alone increasin

99 Detection of metastasis in SLNs in approximately 12% of cases emphasizes the utilit

100 to the histologic result of each individual SLN.

101 ssion modeling assessing factors influencing SLN identification was performed.

102 sequent verification of fluorescence-labeled SLNs during robotic-assisted surgery.

103 SPECT/CT accurately localized SLN in 11 out of 12 patients.

104 nal tail causes the chimeric protein to lose SLN-like function.

105 ities are not available, albeit with a lower SLN identification rate.

106 Detection of a technetium Tc 99m-marked SLN before surgery was possible in all cases.

107 By this mechanism, SLN promotes the futile cycling of SERCA, contributing t

108 Women with one to two metastatic SLNs planning to undergo breast-conserving surgery with

109 Women with one to two metastatic SLNs who are planning to undergo breast-conserving surge

110 SLN disease, whereas in melanomas < 0.75 mm, SLN metastasis rates are < 5%.

111 hood that the FNR in patients with 2 or more SLNs examined was greater than 10%, the rate expected fo

112 Of the remaining 525 patients with 2 or more SLNs removed, no cancer was identified in the axillary l

113 fused SPECT/MR images and scored morphologic SLN parameters on a standardized case report form.

114 Most SLN metastases (86.2%) occur in melanomas >/= 0.75 mm, w

115 After NAC, SLN surgery and axillary lymph node dissection (ALND) we

116 l applications of solid lipid nanoparticles (SLN) as oral delivery vehicles.

117 , (ii) tristearin solid lipid nanoparticles (SLN), and (iii) omega-3 fish oil-in-water emulsions was

118 al arrangement of solid lipid nanoparticles (SLN).

119 DRFS compared with patients with a negative SLN, unless an immediate completion lymph node dissectio

120 significantly between positive and negative SLN groups (all P < .05).

121 Among patients with tumor-negative SLN by conventional pathology but with melanoma detected

122 In Protocol B, patients with tumor-negative SLN by standard histopathology and immunohistochemistry

123 e for patients with positive versus negative SLNs (P = .001).

124 34) of patients, including six with negative SLNs but metastasis in the clipped node.

125 percentage of supragranular labeled neurons [SLN]).

126 th melanoma who undergo sentinel lymph node (SLN) biopsy based on American Society of Clinical Oncolo

127 ogy (SSO) guideline for sentinel lymph node (SLN) biopsy in melanoma.

128 Sentinel lymph node (SLN) biopsy provides a textbook example in which molecul

129 regarding the need for sentinel lymph node (SLN) biopsy when regression is present within the primar

130 with melanoma staged by sentinel lymph node (SLN) biopsy.

131 n overall and bilateral sentinel lymph node (SLN) detection in cervical cancer patients.

132 atients with a positive sentinel lymph node (SLN) had significantly reduced melanoma-specific surviva

133 accurate targeting for sentinel lymph node (SLN) mapping during robotic-assisted surgery has yet to

134 onclusion Women without sentinel lymph node (SLN) metastases should not receive axillary lymph node d

135 Women without sentinel lymph node (SLN) metastases should not receive axillary lymph node d

136 e factors predictive of sentinel lymph node (SLN) metastasis in thin melanoma.

137 negative rate (FNR) for sentinel lymph node (SLN) surgery after neoadjuvant chemotherapy (NAC) in cN1

138 ate (FNR) of 12.6% with sentinel lymph node (SLN) surgery after neoadjuvant chemotherapy in women pre

139 Sentinel lymph node (SLN) surgery provides reliable nodal staging information

140 ccuracy of the isotopic sentinel lymph node (SLN) technique correlated with hyperextensive pelvic res

141 signal emanating from sentinel lymph nodes (SLNs) approximately 2 d after injection and imaging of a

142 r with 1 or 2 positive sentinel lymph nodes (SLNs) are recommended to undergo axillary lymph node dis

143 essment of nonenlarged sentinel lymph nodes (SLNs) for diagnosing metastases in early-stage cervical

144 rs and 1 to 2 involved sentinel lymph nodes (SLNs) having breast-conserving therapy had no difference

145 ning nodes) as well as sentinel lymph nodes (SLNs) may provide more accurate assessment of the pathol

146 patients with positive sentinel lymph nodes (SLNs) randomized either to axillary lymph node dissectio

147 th one to two positive sentinel lymph nodes (SLNs) who undergo lumpectomy, radiotherapy (RT), and sys

148 , or SLN size, compared with the nearest non-SLN, showed no association with metastases (P= 0.055-0.7

149 araaortic lymph nodes, which represented non-SLNs, we assayed all lymph nodes for radioactivity and f

150 predicted metastatic invasion of nonenlarged SLNs, with quality-adjusted odds ratios of 1.42 (95% con

151 ion of one allele of the SLN gene normalizes SLN expression, restores SERCA function, mitigates skele

152 membranes indicating that the S-acylation of SLN or of other proteins is required for this effect on

153 Interestingly, adaptation of SLN(-/-) mice to mild cold conditions (16 degrees C) sig

154 gery would be acceptable for the adoption of SLN surgery for women with node-positive breast cancer t

155 negative rate; and complications, if any, of SLN biopsy.

156 The application of SLN surgery for staging the axilla following chemotherap

157 To better define how binding of SLN to SERCA promotes uncoupling of SERCA, we compared S

158 R) or data on expected and observed cases of SLN positivity and histologic regression were included.

159 n this study we demonstrate that deletion of SLN N-terminal residues (2)ERSTQ leads to loss of the un

160 The primary end point was the FNR of SLN surgery after chemotherapy in women who presented wi

161 d node during SLN surgery reduces the FNR of SLN surgery after neoadjuvant chemotherapy.

162 rtant to ensure successful identification of SLN(s) after NAC.

163 /CT aids in intraoperative identification of SLN.

164 sed to develop a model for the likelihood of SLN metastasis from molecular, clinical, and histologic

165 Accurate preoperative localization of SLN in relation to adjacent anatomic structures using SP

166 Localization of SLN in the regional node basin by hybrid SPECT/CT scan;

167 Preoperative localization of SLN was performed using SPECT/CT in 12 patients.

168 SLN expression in UCP1-KO mice, and loss of SLN is compensated by increased expression of UCP1 and b

169 Debate remains as to the optimal method of SLN detection.

170 meta-analyses were used to summarize ORs of SLN positivity and histologic regression.

171 rative AUS results are considered as part of SLN surgery.

172 To determine the structural regions of SLN that mediate uncoupling of SERCA, we employed mutage

173 is study show that there is up-regulation of SLN expression in UCP1-KO mice, and loss of SLN is compe

174 ras of PLN with the five luminal residues of SLN added to its C terminus.

175 lts of this analysis showed that the risk of SLN positivity was significantly lower in patients with

176 rthermore, molecular dynamics simulations of SLN and SERCA interaction showed a rearrangement of SERC

177 auricular region was the most common site of SLN.

178 ults, we propose that the C-terminal tail of SLN is a distinct, essential domain in the regulation of

179 ed alanine mutants of the C-terminal tail of SLN using co-reconstituted proteoliposomes of SERCA and

180 our studies highlight that the N termini of SLN and PLB influence their respective unique functions.

181 nd an updated randomized controlled trial of SLN biopsy, as well as two randomized controlled trials

182 udy contributes to a better understanding of SLN as a function of the bioactive lipid.

183 ity would be necessary to support the use of SLN surgery as an alternative to ALND.

184 ately 12% of cases emphasizes the utility of SLN biopsy in accurate staging and treatment of eyelid m

185 tested the effect of a truncated variant of SLN (Arg(27)stop) and extended chimeras of PLN with the

186 ng and real-time intraoperative detection of SLNs during robotic surgery.

187 tigraphy or intraoperative identification of SLNs.

188 The number of SLNs identified using the near infrared fluorescence tec

189 Presence of ENE on SLN dissection is associated with N2 disease.

190 , and 38 (18.3%) had ENE larger than 2 mm on SLN dissection.

191 ncement, cortical thickness, round shape, or SLN size, compared with the nearest non-SLN, showed no a

192 we sought to understand how loss of UCP1 or SLN is compensated during cold exposure and whether they

193 This corresponded to a pooled overall SLN detection OR of 2.5 (95% CI, 1.2-5.3) in favor of SP

194 ng with SPECT/CT results in superior overall SLN detection in comparison with planar lymphoscintigrap

195 Pig SLN is also fully palmitoylated/oleoylated on its Cys-9

196 und Ca(2+)-free E2 state; and 3) unlike PLB, SLN interacts with SERCA throughout the kinetic cycle an

197 However, unlike PLN, SLN has a conserved C-terminal luminal tail composed of

198 inal tail, zfPLN appears to use a hybrid PLN-SLN inhibitory mechanism.

199 In the case of a positive SLN biopsy, CLND or careful observation are options for

200 A positive SLN was identified in 12.3% of all patients.

201 zed controlled trials of CLND after positive SLN biopsy, were included.

202 Melanomas < 0.75 mm had positive SLN rates of < 5% regardless of Clark level and ulcerati

203 uvant HDI in patients with a single positive SLN was found.

204 Of these patients, 329 had a tumor-positive SLN.

205 of the NSLN status in patients with positive SLN.

206 nodal burden, patients with 1 or 2 positive SLNs and ENE 2 mm or smaller demonstrated recurrence and

207 T1 or T2 breast cancer with 1 or 2 positive SLNs.

208 All cSCCs with positive SLNs were greater than 2 cm in diameter.

209 >/= IV, and ulceration significantly predict SLN disease in thin melanoma.

210 spectively, using a 10% cutoff for predicted SLN metastasis risk).

211 ulceration (P = .01) significantly predicted SLN metastasis with 6.3%, 7.0%, and 11.6% of the patient

212 ic PET/CT scan was acquired for preoperative SLN mapping.

213 In cervical cancer patients, preoperative SLN imaging with SPECT/CT results in superior overall SL

214 We find that native rabbit SLN is modified by a fatty acid anchor on Cys-9 with a p

215 The radioisotope SLN identification method up to the common iliac region

216 ectly and in complex with SERCA1 and reduces SLN's inhibitory effect on SERCA1 activity.

217 The AAV treatment markedly reduces SLN expression, attenuates muscle pathology and improves

218 Here we show that reducing SLN levels ameliorates dystrophic pathology in the sever

219 ew of the literature was conducted regarding SLN biopsy and completion lymph node dissection (CLND) a

220 tion, S-acylation/deacylation also regulates SLN activity.

221 The time between injection and robotic SLN mapping ranged from 32 to 38 h.

222 Approximately 36 h later, robotic SLN mapping was performed using a fluorescence-capable c

223 Recommendations Routine SLN biopsy is not recommended for patients with thin mel

224 Sarcolipin (SLN) is a novel regulator of sarcoplasmic reticulum Ca(2

225 Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic ret

226 Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum

227 lated by phospholamban (PLB) and sarcolipin (SLN) in cardiac and skeletal muscle.

228 PLB), an affinity modulator, and sarcolipin (SLN), an uncoupler.

229 ity with phospholamban (PLN) and sarcolipin (SLN), which inhibit SERCA, the membrane pump that contro

230 proteins phospholamban (PLN) and sarcolipin (SLN).

231 proteins phospholamban (PLN) and sarcolipin (SLN).

232 based) and skeletal muscle (i.e. sarcolipin (SLN)-based) thermogenesis processes play important roles

233 n in a manner similar to that of sarcolipin (SLN).

234 We recently showed that sarcolipin (SLN), an uncoupler of the sarco(endo)plasmic reticulum C

235 regional node basin by hybrid SPECT/CT scan; SLN identification rate using dual-dye technique; SLN po

236 PLB gets dislodged from Ca(2+)-bound SERCA, SLN continues to bind SERCA throughout its kinetic cycle

237 Significantly, SLN promoted the interaction between sAnk1 and SERCA1 wh

238 kout (Sln(-/-)) and skeletal muscle-specific SLN overexpression (Sln(OE)) mice to explore energy meta

239 d in the node, the clip location at surgery (SLN or ALND) was evaluated.

240 Unilateral surgical SLN detection did not validate bilateral pelvic lymph no

241 dentification rate using dual-dye technique; SLN positivity rate; false-negative rate; and complicati

242 These results further confirm that SLN-based thermogenesis is a key player in muscle non-sh

243 On the basis of these data we propose that SLN is a novel target for enhancing whole-body energy ex

244 Our studies reveal that SLN differs significantly from PLB: 1) SLN primarily aff

245 We recently showed that SLN plays an important role in cold- and diet-induced th

246 Earlier studies have shown that SLN and phospholamban, the other well studied small SERC

247 Recent data suggest that SLN could play a role in muscle thermogenesis by promoti

248 These data collectively suggest that SLN is functionally distinct from PLB; its ability to in

249 Taken together, our findings suggest that SLN reduction is a promising therapeutic approach for DM

250 The SLN FNR was not different based on AUS results; however,

251 The SLN identification rate after NAC was higher when mappin

252 The SLN identification rate was 78.6% with blue dye alone; 9

253 y treatment did not significantly affect the SLN identification rate.

254 ere used to model the parameters against the SLN status.

255 dian overall survival was 178 months for the SLN-only positive group and 42.2 months for the NSLN pos

256 Median MSS was not reached for the SLN-only positive group and was 60 months for the NSLN p

257 Although this domain is distinct from the SLN luminal tail, zfPLN appears to use a hybrid PLN-SLN

258 ng the likelihood of failure to identify the SLN relative to using radiolabeled colloid +/- blue dye

259 id and/or methylene blue dye to identify the SLN, which is most likely to contain metastatic cancer c

260 ing, followed by immunohistochemistry if the SLN was free of metastasis.

261 pathology but with melanoma detected in the SLN by RT-PCR, there was no OS benefit for CLND or CLND+

262 ts had lymph node metastases, 19 only in the SLN.

263 Intraoperative visualization of the SLN by indocyanine green before skin incision was succes

264 Germline inactivation of one allele of the SLN gene normalizes SLN expression, restores SERCA funct

265 to radioisotope in the identification of the SLN in the presence of a positive preoperative lymphosci

266 moves the fatty acids from a majority of the SLN pool.

267 CA and that the functional properties of the SLN tail can be transferred to PLN.

268 transfer of the PLB cytosolic domain to the SLN transmembrane (TM) and luminal tail causes the chime

269 t of SERCA residues that is altered when the SLN N terminus is deleted.

270 tients where the clipped node was within the SLN specimen, the FNR was 6.8% (confidence interval [CI]

271 9 patients, cancer was not identified in the SLNs but was found in lymph nodes obtained with ALND, re

272 All of the SLNs defined by the ex vivo gamma-well assay of (99m)Tc

273 he clip-containing lymph node was one of the SLNs.

274 ymph nodes, selective evaluation of only the SLNs-for size and absence of sharp demarcation-can be us

275 ion, popliteal lymph nodes, representing the SLNs, were dissected with the assistance of the FireFly

276 injected dose; the amount of dye within the SLNs ranged from 8.5 to 88 pmol, which was equivalent to

277 emoval of the clip-containing lymph nodes to SLN dissection may identify patients for limited nodal s

278 educe the FNR in Z1071 patients with >/= two SLNs removed from 12.6% to 9.8% when preoperative AUS re

279 Toward this goal, we generated a UCP1;SLN double knock-out (DKO) mouse model and challenged th

280 where only patients with normal AUS undergo SLN surgery would potentially reduce the FNR in Z1071 pa

281 10%, the rate expected for women undergoing SLN surgery who present with cN0 disease.

282 a >/= 1.0 mm Breslow thickness and underwent SLN biopsy.

283 nical T0-T4,N1-N2,M0 breast cancer underwent SLN surgery and axillary dissection (ALND) after neoadju

284 A total of 4223 patients underwent SLN biopsy from 1986 to 2012.

285 Five patients underwent SLN dissection in addition to removal of the clip-contai

286 icant difference in the number of visualized SLNs was observed at a pooled ratio of 1.2 (95% CI, 0.9-

287 Outcome of interest was SLN biopsy metastasis within 90 days of melanoma diagnos

288 There were no complications associated with SLN biopsy.

289 AT, and TP53 expression were associated with SLN metastasis.

290 r new molecular risk factors associated with SLN positivity in thin and intermediate-thickness melano

291 As sAnk1 is coexpressed with SLN in muscle, we sought to determine whether these two

292 1 cm surgical excision margin) combined with SLN biopsy (followed by an immediate completion lymph no

293 r determining residual disease compared with SLN identification alone.

294 hologic characteristics were correlated with SLN status and outcome.

295 se results suggest that sAnk1 interacts with SLN both directly and in complex with SERCA1 and reduces

296 y examined overall survival of patients with SLN metastases undergoing breast-conserving therapy rand

297 improves the identification of patients with SLN metastases within 90 days of melanoma diagnosis.

298 Women with SLN metastases who will undergo mastectomy should be off

299 Women with SLN metastases who will undergo mastectomy should be off

300 alifornia, was queried for all patients with SLNs positive for cutaneous melanoma who subsequently un