ライフサイエンスコーパス: SN

1 SN also reduced sarcoplasmic reticulum Ca(2+) leak, augm

2 SN are membrane vesicles containing pre- and post-synapt

3 SN DA-like burst activity increased integrated ICa durin

4 SN provided incremental prognostic information to establ

5 SN reclassified patients to their correct risk strata on

6 SN-38 is a very important and highly potent drug for sev

7 SN/VTA adaptation was not instantaneous but developed ac

8 pically very difficult to produce sub-100nm, SN-38-encapsulated nanoparticles without modification of

9 Therefore, these sub-100nm, SN-38-encapsulated photonic micelles show great promise

10 We report the discovery of ASASSN-15lh (SN 2015L), which we interpret as the most luminous super

11 n) in 46-91 % yield and in up to >98 % SN 2':SN 2 ratio, 96:4 diastereomeric ratio and 98:2 enantiome

12 all 40 completed nonadaptive WMT (20 HIV, 20 SN) and were assessed after 1 month, and 55 adaptive WMT

13 ort on the successful production of 20-30nm, SN-38-encapsulated photonic micelles for effectively tri

14 Results Preoperative imaging revealed 2.4 SNs (range, 1-6) per patient.

15 A total of 74 of 76 (34 HIV, 42 SN) completed adaptive WMT and all 40 completed nonadapt

16 showed that a weekly dosing schedule of 4mg SN-38/kg was the most efficacious regimen.

17 = 0.091, P = .72; pons: r = 0.106, P = .62; SN: r = -0.165, P = .45; GP: r = 0.111, P = .61; pulvina

18 -0.254, P = .31; pons: r = -0.097, P = .65; SN: r = -0.194, P = .38; GP: r = -0.175, P = .41; pulvin

19 Interestingly, the Pt subsetnUiO-66-SN containing both functional groups gave different prod

20 ing the VITOM-GP combination, we evaluated 9 SNs.

21 ing the VITOM-GP combination, we evaluated 9 SNs.

22 idation) in 46-91 % yield and in up to >98 % SN 2':SN 2 ratio, 96:4 diastereomeric ratio and 98:2 ena

23 Specifically, the chemotherapeutic agent SN-38 is incorporated into a central 'core' layer, betwe

24 was tested with the chemotherapeutic agents SN-38 and mitoxantrone (MX).

25 ting cases from all control subjects, and an SN of 95.7% and an SP of 67.8% for differentiating cases

26 and 6 patients with penile cancer during an SN biopsy procedure using indocyanine green-(99m)Tc-nano

27 CAPTURE exhibited an SN of 95.7% and an SP of 44.4% for differentiating cases

28 iatum (2.26 +/- 0.93 vs. 3.30 +/- 0.46), and SN (0.46 +/- 0.20 vs. 0.68 +/- 0.15).

29 n (1.7 and 1.4), ventral striatum (0.7), and SN (0.5 and 0.4).

30 r bottle types, SA and FA Plus (aerobic) and SN and FN Plus (anaerobic), was performed in a clinical

31 (CaMKIIdelta) activity via direct SN-CaM and SN-CaMKII binding and attenuated CaMKIIdelta-dependent p

32 The ratios of SN<--N versus SN<--Cy and SN<--Cy versus SN<--CS decreased with increasing ratio o

33 although eribulin exhibited greater DRG and SN penetration than paclitaxel, the neurotoxicity observ

34 rns between the three networks, with FPN and SN activity predominant in early windows and DN stimulat

35 oach to show that stimulation of the FPN and SN evoked a rapid (<70 ms) response that was predominant

36 in other nodes of the DN, as well as FPN and SN.

37 ded markedly increased myocardial levels and SN internalized into cardiomyocytes by endocytosis.

38 ohistochemistry (IHC) use was mandatory, and SN metastases of any size, including isolated tumor cell

39 vity toward daunorubicin (P-gp and MRP1) and SN-38 (BCRP) in A2780/ADR (P-gp), H69AR (MRP1), and MDCK

40 n, radical cyclization and ring opening, and SN 2.

41 were blocked by tetrodotoxin, riluzole, and SN-6, implicating elevated persistent INa and reverse mo

42 compare DAT availability in the striatum and SN in PD patients and control subjects.

43 ncluding different parts of the striatum and SN/VTA.

44 vidence for a network comprising the VTA and SN, the habenula, and mesocorticolimbic structures that

45 mic areas (head and neck [28 patients]), and SNs that failed to accumulate blue dye (19 patients).

46 the substantia nigra/ventral tegmental area (SN/VTA) (+20%; p=0.02), ventral striatum (VST) (+14%; p<

47 the Substantia Nigra/Ventral Tegmental Area (SN/VTA) and ventral striatum were steeper for prediction

48 substantia nigra and ventral tegmental area (SN/VTA), medial temporal lobe, or subsequent memory perf

49 ntricular arrhythmia-induced cardiac arrest, SN levels were also associated with short-term mortality

50 er was superior compared with blue dye-based SN visualization.

51 ticorrelation between SN and DMN and between SN and ECN compared with patients with unfavorable outco

52 ectivity and greater anticorrelation between SN and DMN and between SN and ECN compared with patients

53 switching and transient connectivity between SN, CEN, and DMN.

54 nces, the data show that correlation between SN and nvPM mass concentration still adheres to the firs

55 The difference between SN@ and RRP separated ischaemic from non-ischaemic sympa

56 cking and hydrophobicity interaction between SN-38, and a unique class of photonic nanoporphyrin mice

57 vealed immature dynamic interactions between SN, CEN, and DMN in children, characterized by higher me

58 Aberrant cross-network interactions between SN, central executive network, and default mode network

59 he first synthetic analogue with biomimetic {SN/S2} ligation which could be structurally characterize

60 ude of the fuel-induced uncertainty for both SN within the Emissions Data Bank as well as nvPM mass w

61 daptive WMT, improved WM performance in both SN and HIV participants, and the accompanied decreased o

62 daptive WMT, improved WM performance in both SN and HIV participants, and the accompanied decreased o

63 d acrolein-induced cell death was delayed by SN-6, a Na(+)/Ca(++) exchange inhibitor.

64 ns of these highly substituted isoxazoles by SN Ar reactions and hydrogenolysis allows access to usef

65 owed that the extent of tumor penetration by SN-38 was significantly higher in mice receiving the tar

66 The canonical SN 2 behavior displayed by alcohols and activated alkyl

67 assessed the association between circulating SN levels and mortality in 2 patient cohorts and the fun

68 tantia nigra/ventral tegmental area complex (SN/VTA) and the hippocampus.

69 By conjugating SN-38 to the dendrimer via different linker technologies

70 This system contains SN-38-a prodrug of the topoisomerase I inhibitor irinote

71 mesolimbic DA VTA, but not nigrostriatal DA SN, neurons.

72 e II delta (CaMKIIdelta) activity via direct SN-CaM and SN-CaMKII binding and attenuated CaMKIIdelta-

73 of lipid metabolism was found in the distal SN that was not present in the corresponding cell bodies

74 e likely initiating molecular events driving SN-HPC tumorigenesis, which places SN-HPC among the grow

75 During SN DA-like pacemaking, only Cav1.3 variants conducted Ca

76 macological properties of human LTCCs during SN DA-like and arterial smooth muscle (aSM)-like activit

77 his observation by demonstrating that during SN DA-like neuronal activity LTCCs are less sensitive to

78 lower sensitivity to Cav1.3 variants during SN DA-like pacemaking compared with Cav1.2 during aSM-li

79 rise in cue-reactivity throughout the entire SN, indicating that the insula's role in smoking cue-rea

80 ually represent the engagement of the entire SN.

81 was used, all 10 intraoperatively evaluated SNs could be visualized with the gamma-camera independen

82 entify a linker, dose and dosing regimen for SN-38 conjugated to polyoxazoline-modified dendrimer tha

83 e enzymatically active tandem repeat of four SN domains is crucial for targeting TSN to the cytoplasm

84 roups (frontal/temporal [SN-FT] and frontal [SN-F]), a semantic appraisal network-predominant group (

85 aoperatively, radio- and fluorescence-guided SN detection rates were scored at working distances of 0

86 Sinonasal hemangiopericytoma (SN-HPC) is an uncommon, site-specific, low-grade mesench

87 In 143 patients hospitalized for acute HF, SN levels were closely associated with mortality (n = 66

88 ced in treated HIV infection compared to HIV SN (p < 0.05).

89 were depleted in EFV and PI compared to HIV SN and negatively correlated with intestinal gut dysfunc

90 the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ L

91 f the 20 patients with HIV, 14 (70%) had HIV-SN.

92 rus (HIV)-associated sensory neuropathy (HIV-SN) is difficult but needed for diagnosis and monitoring

93 scopy could be used in the assessment of HIV-SN, but larger studies are required to confirm this find

94 0.31 to 4.65; P = .03) and in those with HIV-SN compared with those without (17.84 vs 14.18; median d

95 to -6.25; P < .001) and in patients with HIV-SN compared with those without (25.8/mm2 vs 30.7/mm2; me

96 th HIV but without SN, and patients with HIV-SN.

97 7.7 [7.75] years) than the group without HIV-SN (mean [SD] age, 42.3 [7.26] years) and the controls (

98 rhans cells in patients with and without HIV-SN.

99 toNEET model 5(2-) and a related homoleptic {SN/SN} capped [2Fe-2S] cluster 4(2-) are established, an

100 omical and functional heterogeneity of human SN, which underpins value versus salience coding, and im

101 ters (vGLUT1 and vGLUT2) in postmortem human SN in schizophrenia subjects (n=13) and matched controls

102 in micelles (NPM), the extremely hydrophobic SN-38 was successfully encapsulated into NPM with signif

103 delivery of 7-ethyl-10-hydroxycamptothecin (SN-38), in an expanded phase II trial of patients with r

104 y a higher number of tyrosine hydroxylase(+) SN neurons (increase of approximately 29%), compared to

105 If SN ypN0(i+)s had been considered negative, the FNR would

106 The CAPTURE plus PEF exhibited improved SN and SP for all cases versus all control subjects (89.

107 lar myoid cell neoplasms were also absent in SN-HPC; thus, the molecular pathogenesis of SN-HPCs rema

108 lished by comparing the effect of alcohol in SN and total homogenate preparations from the same sampl

109 Hence, ghrelin signaling through AMPK in SN dopamine neurons mediates CR's neuroprotective effect

110 onstruct a timeline of functional decline in SN dopaminergic neurons from MitoPark mice.

111 , and kinetics of dienamine intermediates in SN-type reactions are investigated.

112 contribute differentially to Ca(2+) load in SN DA neurons, with prominent Cav1.3-mediated ICa betwee

113 coordinated microRNA regulation of mRNAs in SN, a mechanism that may explain the aberrations in syna

114 sive degeneration of dopaminergic neurons in SN, neuritic swelling, reduced striatal DA release, and

115 rylation of Akt and ribosomal protein S6, in SN neurons.

116 Crucially, increased SN/VTA and ventral striatal adaptation was related to im

117 e encapsulated the topoisomerase-I inhibitor SN-38 in polymeric nanoparticles (NPs) surface-decorated

118 lantation ipsilateral to the vector-injected SN.

119 Intracellularly, SN reduced Ca(2+)/calmodulin (CaM)-dependent protein kin

120 h preoperative SN mapping and intraoperative SN identification in melanoma patients.

121 ed to evaluate differences in intraoperative SN visualization through FI and blue-dye detection.

122 Intraoperatively, SNs were initially pursued by using gamma tracing follow

123 tDNA in respiratory chain deficiency in IPD, SN neurons, isolated with laser-capture microdissection,

124 ionally lensed type Ia supernova, iPTF16geu (SN 2016geu), at redshift z = 0.409.

125 The lateral SN connects with somatomotor regions of striatum and cor

126 supported a role for the value-coding medial SN network in decisional impulsivity, while the salience

127 The medial SN connects with limbic striatal and cortical regions an

128 and the ability to reverse the BCRP-mediated SN-38 resistance.

129 of distinguishing CPT-11 from its metabolite SN-38.

130 h SN-38-encapsulated nanoporphyrin micelles (SN-NPM) enhanced the in vitro antitumor activity by 78 a

131 PEF (males, <350 L/min; females, <250 L/min) SN and SP were 88.0% and 77.5%, respectively, for differ

132 amma-probe and SPECT/CT may be due to missed SNs during surgery, but with respect to pelvic hotspots,

133 Significantly more SNs were detected by SPECT/CT for breast cancer (2,165 v

134 duced the pacemaker precision of adult mouse SN DA neurons but did not affect their somatic Ca(2+) os

135 N (SN<--Cy), and -12.0% to 7.3% for CS to N (SN<--CS).

136 r N to N (SN<--N), 2.3% to 8.6% for Cy to N (SN<--Cy), and -12.0% to 7.3% for CS to N (SN<--CS).

137 (64)Cu ranged from -0.2% to 3.6% for N to N (SN<--N), 2.3% to 8.6% for Cy to N (SN<--Cy), and -12.0%

138 an increased risk for subsequent neoplasms (SNs), but the incidence beyond the age of 40 years and a

139 dorsal root ganglia (DRG) and sciatic nerve (SN) for up to 72 hours.

140 ics and metabolomics from the sciatic nerve (SN), the lumbar 4/5 dorsal root ganglia (DRG), and the t

141 arietal network (FPN), and salience network (SN) while recording evoked responses in other recording

142 The salience network (SN), anchored in the anterior insula and the dorsal ante

143 efault-mode network (DMN), salience network (SN), and executive control network (ECN) by using seed-b

144 k interactions between the salience network (SN), central executive network, and default mode network

145 ty involving the so-called salience network (SN), default-mode network (DMN), and frontoparietal task

146 arietal network (FPN), and salience network (SN), in seven subjects undergoing invasive neurosurgery.

147 dACC) are key nodes of the salience network (SN), which integrates internal and extrapersonal informa

148 le in bvFTD, including the salience network (SN), with key nodes in the frontoinsula and pregenual an

149 lt mode network (DMN), and salience network (SN).

150 ult mode network (DMN) and semantic network (SN) are two of the most extensively studied systems, and

151 ge 55 years, the cumulative incidence of new SNs and SMNs occurring after age 40 years was 34.6% (95%

152 opaminergic neurons in the substantia nigra (SN) and affected the integrity of the nigrostriatal syst

153 opaminergic neurons of the substantia nigra (SN) and cholinergic neurons of the dorsal motor nucleus

154 (DA) neuronal loss in the substantia nigra (SN) and ventral tegmental area (VTA), supporting an impo

155 ovides neuroprotection for substantia nigra (SN) dopamine neurons and increases BDNF in the nigrostri

156 d the MPTP-induced loss of substantia nigra (SN) dopamine neurons and striatal dopamine turnover in g

157 y by the selective loss of substantia nigra (SN) dopaminergic (DAergic) neurons.

158 l tegmental area (VTA) and substantia nigra (SN) has been examined at multiple levels.

159 The dopaminergic substantia nigra (SN) is implicated in the drive to explore novel stimuli

160 opaminergic neurons of the substantia nigra (SN) play a vital role in everyday tasks, such as reward-

161 neurons originating in the substantia nigra (SN) projecting to the dorsal striatum (DS) are tradition

162 The substantia nigra (SN) provides the largest dopaminergic input to the brain

163 pamine (DA) neurons in the substantia nigra (SN) to neurodegenerative stressors causes Parkinson's di

164 organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Hum

165 putamen, ventral striatum, substantia nigra (SN), and cerebellum were manually drawn on coregistered

166 fibril seeds into the rat substantia nigra (SN), in combination with adenoassociated virus (AAV)-med

167 area (VTA), but not in the substantia nigra (SN), of D2R-OE mice.

168 entate nucleus (DN), pons, substantia nigra (SN), pulvinar thalami, and globus pallidus (GP).

169 nergic (DA) neurons in the substantia nigra (SN), which may contribute to their selective degeneratio

170 ected unilaterally, in the substantia nigra (SN), with AAV1/2-A53T-aSyn or control vector.

171 (VTA) and the other in the substantia nigra (SN).

172 (DAT) in the striatum and substantia nigra (SN).

173 nuclein (alpha-syn) in the substantia-nigra (SN).

174 If sentinel node (SN) biopsy (SNB) is accurate in this setting, completion

175 escence image guidance during sentinel node (SN) biopsy procedures.

176 remity who were scheduled for sentinel node (SN) biopsy.

177 ar lymphoscintigraphy (PI) in sentinel node (SN) detection in malignancies with different lymphatic d

178 HR), DIE NEUTRALIS (DNE), and STERILE NODES (SN), have recently been shown to correspond to orthologs

179 nts has been shown to detect sentinel nodes (SNs) in patients with ovarian cancer.

180 ze of SN metastases and rate of positive non-SNs.

181 Whether single nucleotide (SN)-BER of a damaged base requires histone deposition or

182 en the emissions parameters of smoke number (SN) and mass concentration of nonvolatile particulate ma

183 inaccuracies in measuring low smoke numbers (SNs) produced by modern high bypass ratio engines.

184 These data suggest that activation of SN DA neurons and DS D1 receptors during fear extinction

185 Activation of SN DA neurons with designer Gq-coupled receptors exclusi

186 Anticorrelation of SN-DMN predicted outcomes with higher accuracy than flui

187 uggest that inflammation-induced blunting of SN responses to hippocampal novelty signals may represen

188 ugate did not produce a high initial Cmax of SN-38.

189 ces high initial and local concentrations of SN-38, which are associated with gastrointestinal toxici

190 Furthermore, no significant connection of SN with CEN and DMN was found in PTSD patients.

191 uperhydrophobicity, in vitro cytotoxicity of SN-38 loaded meshes, and compatibility provide key desig

192 targets Trop-2 for the selective delivery of SN-38, the active metabolite of irinotecan.

193 led administration of an efficacious dose of SN-38, achieving significant regression of the SW620 tum

194 are a likely target mediating the effects of SN DA activation.

195 rdiovascular biomarker and assess effects of SN on cardiomyocyte Ca(2+) handling.

196 These data extend previous findings of SN sensitivity to mild inflammation associated with chan

197 An ASOX-mediated hyperactivity of SN dopamine neurons, which was caused by oxidative dysfu

198 hicle for improving the therapeutic index of SN-38, the active metabolite of irinotecan.

199 ined by weaker state-dependent inhibition of SN DA LTCCs compared with aSM Cav1.2.SIGNIFICANCE STATEM

200 l gyrus of DMN, and right anterior insula of SN.

201 including progressive and selective loss of SN dopamine neurons, motor deficits that are improved by

202 This study sought to evaluate the merit of SN as a cardiovascular biomarker and assess effects of S

203 bolished STN DBS-mediated neuroprotection of SN neurons following progressive 6-hydroxydopamine lesio

204 ils to reduce somatic Ca(2+) oscillations of SN DA neurons.

205 ripartite connectivity-based parcellation of SN with a limbic, cognitive, motor arrangement.

206 SN-HPC; thus, the molecular pathogenesis of SN-HPCs remained unknown.

207 ent cohorts and the functional properties of SN in experimental models.

208 The ratios of SN<--N versus SN<--Cy and SN<--Cy versus SN<--CS decreas

209 However, the normal bilateral reactivity of SN to stimulus novelty was significantly attenuated foll

210 There was no correlation between size of SN metastases and rate of positive non-SNs.

211 due to the ultra-flat aromatic structure of SN-38, it is typically very difficult to produce sub-100

212 MMU-132), a Trop-2 ADC, for the targeting of SN-38.

213 ld explain the differential vulnerability of SN dopamine and DMV neurons in PD and could promote neur

214 Cumulative incidence of SNs, standardized incidence ratios (SIRs), excess absolu

215 aging lymphadenectomy including resection of SNs related to the ovary, SPECT/CT was performed within

216 s of soft tissue and sinonasal tract origin, SN-HPCs were recently shown to lack recurrent NAB2-STAT6

217 n of near-injection-site SNs (two patients), SNs located in complex anatomic areas (head and neck [28

218 N ACYL-COA SYNTHETASE2, GLYCEROL-3-PHOSPHATE SN-2-ACYLTRANSFERASE4, and the ATP-BINDING CASSETTE11 cu

219 s driving SN-HPC tumorigenesis, which places SN-HPC among the growing family of beta-catenin-driven m

220 The hybrid tracer enables both preoperative SN mapping and intraoperative SN identification in melan

221 ically relevant isradipine levels to protect SN DA neurons can be explained by weaker state-dependent

222 rnovae, such as the Type Iax-class prototype SN 2002cx, are described by a variety of models such as

223 Root:Shoot ratios (R:S), averaged 0.30 for R:SN , 0.36 for R:SP , 0.32 for R:SK , 0.27 for R:SCa , an

224 ons through leaching with a separation ratio SNd/Dy =359.

225 effective in the thermally induced reductive SN bond cleavage of N,N-dialkylsulfonamides, and reducti

226 main at increased risk for treatment-related SNs.

227 fically in the distal axon/Schwann cell-rich SN.

228 properties of interactions between salience (SN), default mode (DMN), and central executive (CEN) net

229 iratory flow (PEF) with optimal sensitivity (SN) and specificity (SP).

230 (HIV) participants compared to seronegative (SN) controls.

231 s mitochondrial mass was unchanged in single SN neurons from IPD patients, we observed a significant

232 ue for identification of near-injection-site SNs (two patients), SNs located in complex anatomic area

233 of an index case, we analyzed a total of six SN-HPCs for mutations within the amino-terminal region o

234 Due to the relatively small size, SN-NPM possessed superior long tumor retention time (>5d

235 for the caudate, putamen, ventral striatum, SN, and cerebellum were drawn on coregistered MR images.

236 the thrombin-specific, fluorogenic substrate SN-59 (100 muM).

237 rmality and the time to peak supernormality (SN@).

238 Here we report that a supernova (SN 2011kl) was associated with the ultra-long-duration g

239 release half-life of 21h achieved sustained SN-38 exposure in blood, above the target concentration.

240 iled the transcriptome of synaptoneurosomes (SN) obtained from the amygdala of mice that consumed 20%

241 ork-predominant subgroups (frontal/temporal [SN-FT] and frontal [SN-F]), a semantic appraisal network

242 nts also had greater frontal activation than SN at baseline, but brain activation decreased in both g

243 tensive alpha-synucleinopathies earlier than SN dopamine neurons while exhibiting milder cell loss in

244 rer self-reported executive functioning than SN, but both groups reported improvements after adaptive

245 r cognitive performance and start index than SN at baseline, both groups improved on improvement inde

246 To determine the possibility that SNs are missed, this feasibility study compared their de

247 can be measured in both the striatum and the SN, supporting the utility of (18)F-FE-PE2I as an imagin

248 ng-state functional connectivity between the SN/VTA and hippocampus predicted preferential retention

249 s offline post-learning dynamics between the SN/VTA and hippocampus, providing novel evidence for a p

250 persistent radicals 3 and 4 obtained by the SN(F) synthetic strategy includes X-ray crystal structur

251 First, the SN demonstrated the highest levels of flexibility in tim

252 FA in the SN and CBF in the caudate nucleus were inversely correla

253 ses in dopamine and GABA transmission in the SN in schizophrenia, with a potential relation to treatm

254 However, whether BDNF signaling in the SN participates in the neuroprotective effects of DBS re

255 controls, 29% in PD patients, whereas in the SN the underestimation was 22% in controls and 15% in PD

256 e-fold cross-validation identified FA in the SN(FA-SNAv), CBF in the PFC(CBF-PFCAv) and FA in the par

257 iabetes in the nervous system present in the SN, the region most affected by neuropathy.

258 ghrelin significantly increased pAMPK in the SN.

259 ly associated with D2/3R availability in the SN/VTA (r=0.34, p=0.03), VST (r=0.36, p=0.02), and palli

260 rmore, functional connectivity involving the SN, which is predominantly composed of the anterior insu

261 tinct dynamic functional architecture of the SN and demonstrates how this network is uniquely positio

262 w that the large-scale brain dynamics of the SN are characterized by several distinctive and robust p

263 Fifth, temporal flexibility of the SN uniquely predicted individual differences in cognitiv

264 cond, dynamic functional interactions of the SN were among the most spatially varied in the brain.

265 h, time-varying connectivity profiles of the SN were distinct from all other prefrontal control syste

266 e dynamic spatiotemporal organization of the SN.

267 ng-term memory through the activation of the SN/VTA-Hippocampal loop, possibly via dopaminergic modul

268 rain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop) when successfully grasping the

269 profound reduction in FN passing through the SN in PD.

270 nse that was predominantly higher within the SN sites, whereas stimulation of the DN led to sustained

271 escent, while only 61.7% (116 of 188) of the SNs stained blue (P < .0001).

272 of this study, optical identification of the SNs through the fluorescent signature of the hybrid trac

273 were radioactive, 96.7% (295 of 305) of the SNs were fluorescent, while only 61.7% (116 of 188) of t

274 Intraoperatively, 93.8% (286 of 305) of the SNs were radioactive, 96.7% (295 of 305) of the SNs were

275 ugh localization (10- to 30-cm range) of the SNs, the GP for providing convenient real-time acoustic

276 ton coupled electron transfer (PCET) at the {SN} ligated site, pointing at a potential functional rol

277 Third, SN nodes maintained a consistently high level of network

278 e demonstrate that the decreased FNs through SN in combination with changes in FA-SNAv, CBF-PFCAv and

279 rescence guidance allowed detailed real-time SN visualization.

280 photoperiod response in a similar manner to SN and DNE, and recessive ppd mutants on a spring-flower

281 reverse the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity.

282 ded in human cells by the endonuclease Tudor-SN (TSN).

283 Tudor Staphylococcal Nuclease (TSN or Tudor-SN; also known as SND1) is an evolutionarily conserved p

284 pulsivity, while the salience-coding ventral SN network was associated with motor impulsivity.

285 than losses during fMRI), while the ventral SN connects with associative regions of cortex and stria

286 of SN<--N versus SN<--Cy and SN<--Cy versus SN<--CS decreased with increasing ratio of the N of the

287 The ratios of SN<--N versus SN<--Cy and SN<--Cy versus SN<--CS decreased with increa

288 ericoxide and pericosine A readily react via SN 2' mechanisms against a variety of nucleophilic subst

289 ted with enhanced context sensitivity in VTA/SN.

290 ventral tegmental area/substantia nigra (VTA/SN) shows context-sensitivity, an effect enhanced with a

291 With respect to sites where SNs were resected, remaining hotspots may have been caus

292 tified hotspots in 4 patients at sites where SNs were resected.

293 Moreover, a synergistic activity of 5c with SN-38 (the active metabolite of irinotecan) and 5-fluoro

294 Perfusing hearts with SN yielded markedly increased myocardial levels and SN i

295 light irradiation, combination therapy with SN-38-encapsulated nanoporphyrin micelles (SN-NPM) enhan

296 rmal-, photodynamic- and chemo-therapy) with SN-NPM demonstrated dramatically enhanced in vivo antitu

297 78 and 350 times over single treatment with SN-38 and phototherapy alone, respectively.

298 d for and hence uncertainty associated with (SNs), instead relying upon engine conditions in order to

299 trols and patients with HIV with and without SN.

300 ups: controls, patients with HIV but without SN, and patients with HIV-SN.