ライフサイエンスコーパス: SNB

1 SNB is an appropriate initial alternative to routine sta

2 SNB motoneuron number was increased in female Bax-/- mic

3 SNB motoneurons were axotomized bilaterally and BDNF or

4 SNB motoneurons were retrogradely labeled with cholera t

5 SNB motoneurons were retrogradely labeled with cholera t

6 0 mm in thickness was improved if they had a SNB, with significantly improved disease-free and DMFS.

7 Adding SNB to ePLND improves BCR-free survival, although the pr

8 nificantly from the outcome after additional SNB.

9 eral nucleus (RDLN), nor did the drug affect SNB soma size in the absence of androgen treatment.

10 for the study; of these, 397 (62.8%) had an SNB.

11 Patients who did not have an SNB were at higher risk of locoregional recurrence (HR,

12 tly obtained in patients who did not have an SNB.

13 in UNC-104, a neuronal-specific kinesin, and SNB-1, a synaptic vesicle-associated protein termed syna

14 pathologically measured excision margins and SNB on local and locoregional disease control in patient

15 ), NCI-H23 (lung), SK-MEL-28 (melanoma), and SNB-7 (CNS).

16 ph node basins were evaluated by FDG-PET and SNB in 70 assessable patients.

17 naffected by the absence of Bax protein, and SNB motoneuron number is dissociated from target muscle

18 MZ resistant GBM cell lines, U373(TMZ-R) and SNB-19(TMZ-R) cells, in the presence of TMZ than unmodif

19 0, 0.25, and 0.15 in UWR2, UWR3, U251MG, and SNB-19 cells, respectively.

20 e glioma cell lines (UWR2, UWR3, U251MG, and SNB-19).

21 Transient transfections of U373MG and SNB-19 with wild-type p27 and a degradation-resistant p2

22 Using two glioma cell lines, U373MG and SNB-19, we have demonstrated that SF/HGF stimulation all

23 ampling procedure from hereon referred to as SNB.

24 n androgen receptor expression in axotomized SNB motoneurons, and examined whether delayed applicatio

25 elayed application of BDNF to the axotomized SNB motoneurons restored the AR-LI to the intact level.

26 Experience with sentinel node biopsy (SNB) after neoadjuvant chemotherapy is limited.

27 ndations on the use of sentinel node biopsy (SNB) for patients with early-stage breast cancer.

28 Sentinel node biopsy (SNB) has led to an increase in the detection of micromet

29 Worldwide, sentinel node biopsy (SNB) is now a standard staging procedure for most patien

30 The benefit of adding sentinel node biopsy (SNB) to extended pelvic lymph node dissection (ePLND) re

31 If sentinel node (SN) biopsy (SNB) is accurate in this setting, completion node dissec

32 hologic results (sentinel lymph node biopsy [SNB] or axillary lymph node dissection [ALND]) were comp

33 use the disease Stagonospora nodorum blotch (SNB) in wheat.

34 am68 colocalize in Sam68-SLM nuclear bodies (SNBs), while transfected Sik and Sam68 are localized dif

35 d the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats.

36 , the spinal nucleus of the bulbocavernosus (SNB) and the dorsolateral nucleus (DLN), and for the sex

37 f the spinal nucleus of the bulbocavernosus (SNB) and the dorsolateral nucleus (DLN), both sexually d

38 n the spinal nucleus of the bulbocavernosus (SNB) and their target muscles in the perineum, bulbocave

39 n the spinal nucleus of the bulbocavernosus (SNB) express androgen receptors and innervate striated m

40 rphic spinal nucleus of the bulbocavernosus (SNB) in male and female gerbils from known intrauterine

41 The spinal nucleus of the bulbocavernosus (SNB) is a medially located, bilaterally organized sexual

42 n the spinal nucleus of the bulbocavernosus (SNB) motoneurons of adult male rats.

43 rats, spinal nucleus of the bulbocavernosus (SNB) motoneurons shrink after castration and are restore

44 n the spinal nucleus of the bulbocavernosus (SNB) of rats extends postnatally and is controlled by an

45 n the spinal nucleus of the bulbocavernosus (SNB) of the Mongolian gerbil is achieved by two periods

46 n the spinal nucleus of the bulbocavernosus (SNB) than do females.

47 f the spinal nucleus of the bulbocavernosus (SNB), a sexually dimorphic motor nucleus in the lumbar s

48 n the spinal nucleus of the bulbocavernosus (SNB), an androgen-dependent population of motoneurons in

49 n the spinal nucleus of the bulbocavernosus (SNB), dorsolateral nucleus and retrodorsolateral nucleus

50 : the spinal nucleus of the bulbocavernosus (SNB), in which neuron number is greater in males; the re

51 itive spinal nucleus of the bulbocavernosus (SNB).

52 itive spinal nucleus of the bulbocavernosus (SNB).

53 ith fluorodeoxyglucose (FDG) PET followed by SNB.

54 lbocavernosus muscle, which is innervated by SNB motoneurons, was approximately 50% larger in 2M than

55 recurrence (14.3%) in a node basin missed by SNB.

56 at the time of FDG-PET imaging: 17 proved by SNB (24.3%) and one by follow-up examination (1.4%).

57 t, when performed by experienced clinicians, SNB appears to be a safe and acceptably accurate method

58 ization, we recorded ipsi- and contralateral SNB motor nerve activity following unilateral spinal sti

59 n caused regressive changes in contralateral SNB motoneurons: Soma size and dendritic length were bot

60 and examined the morphology of contralateral SNB motoneurons.

61 ether delayed application of BDNF to the cut SNB axons can completely reverse the axotomy-induced los

62 We depleted SNB motoneurons on one side only of the spinal cord by u

63 xtremely local effects within the developing SNB arbor, as well as transient alterations in somal gro

64 nce the morphology of the sexually dimorphic SNB neuromuscular system.

65 rvival rate was 80.5% and 69.9% in the ePLND+SNB and ePLND groups, respectively.

66 In the ePLND+SNB group, only the number of positive nodes was an inde

67 probability of BCR-free status in the ePLND+SNB group, whereas the ePLND group was performing as pre

68 ncer Center nomogram was higher in the ePLND+SNB than in the ePLND group.

69 obtained from multicenter studies evaluating SNB before systemic therapy and suggest that the sentine

70 distant metastasis-free survival (DMFS) for SNB patients with T2 and T3 melanomas (P = 0.041).

71 ups indicated a significantly better MSS for SNB patients with T2 and T3 melanomas (>1.0 to 4.0 mm th

72 vator ani (LA), which is a target muscle for SNB motoneurons.

73 Of 343 patients who had SNB and axillary dissection, the sentinel nodes were pos

74 male copulatory behavior via alterations in SNB motoneuron morphology, and thus support maternal lic

75 MT-MMP protein was detected in SNB-19 and U251 cell lines only after ConA treatment.

76 on retrograde tracing, the sex difference in SNB cell number is eliminated in Bax-/- mice.

77 R2A and R2B mRNA expression in SNB cells was not affected by androgen manipulations.

78 her NMDA receptor activation was involved in SNB dendritic growth and whether the estrogenic support

79 2M males did not differ from 2F males in SNB motoneuron number, but the bulbocavernosus muscle, w

80 tration reduced the expression of R1 mRNA in SNB motoneurons, an effect that was blocked by androgen

81 RNA resulted in enhanced exon recognition in SNB-19 glioblastoma cells.

82 The amount of MT-MMP mRNA was unchanged in SNB-19 after ConA treatment, and the MT-MMP mRNA level i

83 ver, MT-MMP mRNA expression was unchanged in SNB-19 cells.

84 Transfected Sik phosphorylates Sam68 in SNBs in HT29 cells and in the nucleoplasm of NMuMG cells

85 6 days of treatment did not further increase SNB motoneuron numbers.

86 Bcl-2 overexpression significantly increased SNB cell number in females, overall cell density of AVPV

87 Maternal licking influences SNB motoneuron number, with reductions in licking result

88 f BDNF was not different from that in intact SNB motoneurons.

89 cible ets-1 gene was stably transfected into SNB-19 cells using a tetracycline repressor system.

90 adish peroxidase conjugate (CT-HRP) to label SNB cells.

91 (GI(5)(0) = 0.018 muM), CNS cancer cell line SNB-75 (GI(5)(0) = 0.0159 muM), ovarian cancer cell line

92 LM/SNB is a safe, low-morbidity procedure for staging the r

93 LM/SNB should become standard care for staging the regional

94 30-case learning phase and 25 additional LM/SNB cases, the accuracy of LM/SNB continues to increase

95 The low (10.1%) complication rate after LM/SNB increased to 37.2% with the addition of CLND; CLND a

96 mphatic mapping and sentinel node biopsy (LM/SNB) for staging the regional nodal basin of patients wi

97 The rate of false-negative LM/SNB during the trial phase, as measured by nodal recurre

98 additional LM/SNB cases, the accuracy of LM/SNB continues to increase with a center's experience.

99 Since our introduction of LM/SNB in 1990, this technique has been widely adopted and

100 The accuracy of LM/SNB was determined by comparing the rates of SN identifi

101 Early morbidity of LM/SNB was evaluated by comparing complication rates betwee

102 CLND for nodal recurrence, or to WE plus LM/SNB with immediate CLND for SN metastasis.

103 tment approaches: wide excision (WE) plus LM/SNB with immediate complete lymphadenectomy (CLND) for s

104 and the incidence of SN metastases in the LM/SNB group versus the subsequent development of nodal met

105 node-positive breast cancer after NAC, a low SNB FNR (8.4%) can be achieved with mandatory use of IHC

106 F alpha-receptor had fewer than half as many SNB motoneurons than did wild-type males and no more tha

107 NB dendritic morphology is normally mature), SNB motoneurons were retrogradely labeled with cholera t

108 ll lines, such as DBTRG MG, Hs 683, U-87 MG, SNB-19, and A-172, are very susceptible to hIL13-PE38QQR

109 nd that adult 2M female gerbils had 16% more SNB motoneurons than did 2F females.

110 New SNB motoneurons appeared within 2 days of delayed TP rep

111 tomy reflects the decrease in the ability of SNB motoneurons to accumulate androgens.

112 est whether axotomy decreases the ability of SNB motoneurons to accumulate androgens.

113 ion and compared with histologic analyses of SNB specimens and clinical follow-up examination.

114 r patients, stratified by the application of SNB.

115 sought to assess the therapeutic benefit of SNB in a large, nonrandomized patient cohort.

116 re, that the estrogen-sensitive component of SNB dendritic development requires their activation.

117 ence is caused by hormone-regulated death of SNB motoneurons and their target muscles.

118 ct of maternal licking on the development of SNB dendritic morphology.

119 nvolved in sexually dimorphic development of SNB motoneuron number and that target muscle survival pe

120 Dendritic development of SNB motoneurons requires the action of both androgens an

121 olved in the normal postnatal development of SNB motoneurons, and whether the effect of estradiol on

122 Sexual dimorphism of SNB motoneuron number developed completely normally in C

123 effects are limited to the initial growth of SNB dendrites through 4 weeks of age.

124 Somal area and dendritic length of SNB motoneurons in MK-801-treated, intact males were bel

125 atment significantly increased the number of SNB motoneurons with AR-positive nuclei at P7.

126 ionate (TP) treatment resulted in numbers of SNB motoneurons comparable to those seen in intact males

127 The percentage of SNB motoneurons expressing medium or high AR-LI was the

128 my significantly decreased the percentage of SNB motoneurons to accumulate tritiated testosterone or

129 nter trials in which the test performance of SNB was evaluated with respect to the results of ALND (c

130 trophic factors in the androgenic rescue of SNB motoneurons and further suggest that trophic factor

131 identified patients with negative results of SNB, when done under the direction of an experienced sur

132 Sensitivity of SNB for detection of occult regional lymph node metastas

133 ivered either into the perineum (the site of SNB target muscles) or systemically.

134 ts suggest that androgen affects the size of SNB motoneurons by influencing their expression of the N

135 TFRalpha prevented the androgenic sparing of SNB motoneurons when antagonists were delivered to the p

136 growth and whether the estrogenic support of SNB dendritic growth was dependent on the activation of

137 and levator ani muscles, the main targets of SNB motoneurons, was not affected in either CNTF or CNTF

138 included in future guidelines on the use of SNB after NAC in this setting.

139 vailable through February 2004 on the use of SNB in early-stage breast cancer.

140 /neoadjuvant systemic therapy may be offered SNB.

141 /neoadjuvant systemic therapy may be offered SNB.

142 rons, and whether the effect of estradiol on SNB dendritic growth could be explained by an indirect a

143 ients with axillary metastases identified on SNB.

144 Gap junctions on SNB and DLN motoneurons are androgen sensitive; the numb

145 The optimal SNB identification rate (IR) >/= 90% and false-negative

146 A for predicting positive results at ALND or SNB was 71%-75%.

147 Compared with OBS patients, SNB patients demonstrated improved disease-free survival

148 he outcomes for those who underwent WLE plus SNB (n = 2909) were compared with the outcomes for patie

149 In male rats, SNB motoneurons exhibit a biphasic pattern of dendritic

150 seen previously, among saline-treated rats, SNB somata of T-treated castrates were significantly lar

151 tor antagonists did not significantly reduce SNB motoneuron number when higher doses were injected sy

152 ays for serum/plasma (IMMULITE and SimulTRAC-SNB) for B12 analysis in human milk.

153 25 +/- 108% (range 116-553%) using SimulTRAC-SNB, most likely due to the presence of excess HC.

154 25 +/- 108% (range 116-553%) using SimulTRAC-SNB, most likely due to the presence of excess HC.

155 act by means of supraspinal input to support SNB motoneuron development.

156 he trophic effect of estradiol on supporting SNB dendritic growth, indicating that estrogens do not a

157 Ngamma) on the glioblastoma cell lines T98G, SNB-19 and U-373, focusing on the ability of IFNgamma to

158 We found that SNB motoneurons developed AR immunoreactivity at first a

159 In situ hybridization indicated that SNB motoneurons express mRNA for the NMDA receptor subun

160 Data suggest that SNB is associated with less morbidity than ALND, but the

161 The SNB IR was 87.6% (127 of 145; 95% CI, 82.2% to 93.0%), a

162 The SNB IR was 87.6%, and in the presence of a technical fai

163 the DLN shared characteristics with both the SNB and the RDLN.

164 significantly different for patients in the SNB and OBS groups.

165 atment, more motoneurons were labeled in the SNB following injection of a retrograde tract tracer int

166 er motoneurons, dendritic development in the SNB involves NMDA receptors and, furthermore, that the e

167 at androgen receptor immunoreactivity in the SNB motoneurons decreases after axotomy and returns to n

168 ation of androgen receptor expression in the SNB motoneurons; and (iii) treatment with brain-derived

169 Mean soma size in the SNB of Bax-/- females is reduced, however, and there is

170 cline in the density of soma labeling in the SNB of castrated males but did not reverse any other eff

171 s a subpopulation of very small cells in the SNB of female knock-outs.

172 Thus, new motoneurons appeared in the SNB of prepubertally castrated male Mongolian gerbils wi

173 In contrast, a sex difference in the SNB was absent in CNTFRalpha -/- animals: male mice lack

174 ed a 23% reduction in dendritic arbor in the SNB, an effect that was especially pronounced in the ros

175 r sexually dimorphic motoneuron death in the SNB, and motoneurons rescued by Bax deletion project the

176 interneurons; coupling was bilateral in the SNB.

177 e first was to determine the response of the SNB in prepubertally castrated male gerbils receiving de

178 We exploited these features of the SNB system to identify endogenously produced trophic fac

179 role of gap junctions in the activity of the SNB.

180 ng electrodes were placed bilaterally on the SNB motor nerves.

181 01 treatment blocked this effect of T on the SNB.

182 is study demonstrates that (i) silencing the SNB neuromuscular system with tetrodotoxin did not affec

183 esults indicate that unilateral input to the SNB may be differentially modulated to produce functiona

184 by means of descending spinal tracts to the SNB was involved in the normal postnatal development of

185 Their SNB and ramus heights were also significantly improved a

186 e highly invasive, but the sense-transfected SNB-19 clones were much less invasive; the antisense-tra

187 Four weeks after saporin treatment, SNB motoneurons contralateral to the saporin injection w

188 planned) or are pregnant should not undergo SNB.

189 planned) or are pregnant should not undergo SNB.

190 At either postnatal day (P) 28 (when SNB dendritic length is normally maximal) or P49 (when S

191 the best local and locoregional control when SNB was coupled with a more than 16-mm histologic excisi

192 tic length is normally maximal) or P49 (when SNB dendritic morphology is normally mature), SNB motone

193 nts indicate an extensive syncytium in which SNB motoneurons are coupled with each other and neighbor

194 pective randomized controlled trial in which SNB was compared with axillary lymph node dissection (AL

195 ical prostatectomy and ePLND with or without SNB (184 and 736 patients, respectively).