ライフサイエンスコーパス: SNP

1 SNP rs2227473 is located within a putative binding site

2 SNP rs2227473, in linkage disequilibrium with rs2227476,

3 SNP-SNP interaction was suggested (P<0.005) for 14 SNP p

4 SNPs in PPARG were significantly overrepresented (ranked

5 size of the SNP data set, with 25,000-50,000 SNPs required for accurate detection of population trend

6 errepresented (ranked 7-11 and 67 of 556,000 SNPs; P < 2.2 x 10(-7)), and were mostly in introns or r

7 s2478544 at AGT and rs11658531 at ACE) and 1 SNP in women (rs12451328 at ACE).

8 P interaction was suggested (P<0.005) for 14 SNP pairs, none of which had shown individual associatio

9 he reported direction of associations and 14 SNPs significantly generalized to the HCHS/SOL.

10 The 14-SNP GRS could distinguish the co-affected siblings (n =

11 a obesity-related traits, hsCRP, based on 16 SNPs from genes including CRP, was not associated with B

12 In the European cohorts, 186 SNPs had an interaction P < 1 x 10(-4) and a look-up eva

13 The h(2)SNP of anorexia nervosa was 0.20 (SE=0.02), suggesting t

14 A combination of PolyPhen-2, SNPs&GO, MutPred, MutationTaster2 and FATHMM was found t

15 d nine popular prediction tools (PolyPhen-2, SNPs&GO, MutPred, SIFT, MutationTaster2, Mutation Assess

16 Results were obtained for 10,641,224 SNPs and insertion-deletion variants with minor allele f

17 We examined the association of 291 SNPs with baseline serum 25(OH)D levels and 25(OH)D dose

18 Sex-specific associations were seen for 3 SNPs in men (rs2468523 and rs2478544 at AGT and rs116585

19 We use variation in 33 SNPs for the receptor genes for six well-known social ne

20 inium SNP array and mapped a total of 29,347 SNP markers onto the reference genome of Darmor-bzh.

21 ther decreased (p < 0.05) in a TLR5(392Stop) SNP rUTI subgroup.

22 In contrast, 4 SNPs were found based on standard GWAS analysis (P < 5 x

23 Based on 4 SNPs each 1 mg/dl increase in calcium was positively ass

24 We identified 70 publications reporting 45 SNPs in 36 genes significantly associated with disease-r

25 Among these, 50 SNPs were found within 39 transcripts highly homologous

26 e DeePAS was performed by correlating the 52 SNPs to all phenotypes using logistic and linear regress

27 dial infarction] and 123504 noncases), the 6 SNPs related to serum calcium levels and without pleiotr

28 previously known index SNPs at T2D loci, 66 SNPs showed consistency with the reported direction of a

29 Consistent associations between these 7 SNPs (particularly rs10399931 and rs4950928) and 5 CpG s

30 We selected 7,734 SNPs for linkage mapping, resulting in 27 linkage groups

31 nd a look-up evaluation of these disclosed 8 SNPs in 4 loci, with an interaction P < 0.05 in the larg

32 ltiple beta-defensin genes and containing 94 SNPs was significantly associated with fertility and fun

33 , the strongest temporal change is seen at a SNP in phosphatidylinositol 4-kinase, which is involved

34 Here we performed a SNP and gene-based association analysis of the RTK/ERK p

35 specific systems, comparing cleavage using a SNP-derived PAM to a guide specific approach.

36 Initial investigation of additional SNPs also highlighted correlations with gene expression.

37 afore-mentioned method so that more adjacent SNPs can be incorporated.

38 We found that samples for which all SNP loci were scored had no disagreements across the thr

39 tes by calculating the enrichment of allergy SNPs falling in gene regulatory regions in various cells

40 onally, we observed an enrichment of allergy SNPs falling within immune pathways and regions of chrom

41 An SNP near integrin alpha6 (ITGA6) reached genome-wide sig

42 twin studies ranges from 30 to 50% (2) , and SNP-based heritability ranges from 6 to 15% (3-6) .

43 ene Relationships Across Implicated Loci and SNP-SNP interaction analysis of selected gene pairs.

44 Both single SNP and SNP x SNP interaction association analyses with body mas

45 solution for rapid recovery of large STR and SNP datasets in any species without needing a reference

46 ic SNPs, including SNPs with wrong RS ID and SNPs with mismatched probe sequences.

47 Samples were genotyped via microarray, and SNPs that could not be genotyped were imputed.

48 We further demonstrated that 3 APOA5 SNPs with established functional impact could explain th

49 For flexibility in genotyping applications, SNPs polymorphic between tetraploid and diploid species

50 SNP rs11055880 and leukemia risk-associated SNP rs12142375-and demonstrate their endogenous regulato

51 brium (r(2) > 0.7) with the trait-associated SNP.

52 egions containing clusters of ABA-associated SNPs.

53 (IGAP Stage 1), we identified AD-associated SNPs (at p < 10-5).

54 These candidate genes and associated SNPs provide valuable resources for future studies to de

55 Ls provide a link between disease-associated SNPs and the regulatory genome that will improve the fun

56 to investigate the effect of MDD-associated SNPs within the regions.

57 We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping betwe

58 W chromosome, as well as 148 sex-associated SNPs showing significant differentiation (average FST=0.

59 To prioritize the associated SNPs, different layers of the public functional data wer

60 Association SNPs were then included as fixed effects into a GP model

61 literature data relative to 87,818 autosomal SNPs in 14 open populations and 10 geographic and/or lin

62 hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel mi

63 BC SNPs previously identified in Caucasian population showe

64 Effects of the intervention were modified by SNPs in VDR and CYP27B1.

65 In total 156,362 candidate SNPs are studied, and the phenotypes of 64 poplar trees

66 By modifying candidate SNPs in transgenic flies, we show that the largest effec

67 ng gene, but also that the effect of certain SNPs on expression of proteins can vary with diagnosis.

68 quencing (WES) and canine high-density (cHD) SNP genotyping of 28 dogs from 3 breeds to compare the S

69 Associations between 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites in whole

70 ese results indicate a functional non-coding SNP in EPHA2 promoter affects PAX2 binding and reduces E

71 mapping, we prioritized rs9349379, a common SNP in the third intron of the PHACTR1 gene, as the puta

72 improved model leads to estimates of common SNP heritability on average 43% (s.d. 3%) higher than th

73 A4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel.

74 cumulation of putative resistance-conferring SNPs, potentially in combination with specific resistanc

75 omic locus and rapidly identifying consensus SNPs with the highest deleteriousness scores making thos

76 Analyses of core SNP diversity and accessory genome variations showed tha

77 we report the development of a high-density SNP array 'Axiom_Arachis' with 58 K SNPs and its utility

78 In this work, we developed a high-density SNP array with 690,662 unique SNPs (herein 690 K array)

79 Therefore, availability of a high-density SNP array with uniform genome coverage can advance genet

80 We detected SNPs at USP25 with associations of genome-wide significa

81 These include many different SNP pipelines, wgMLST approaches, k-mer algorithms, whol

82 ring allele frequencies among many different SNPs that share similar biological functions in response

83 s4803217) were not superior to the discovery SNP rs12979860 with respect to liver inflammation or fib

84 INTERPRETATION: The exo-E415G SNP and plasmepsin 2-3 amplification are markers of pipe

85 sity at three SNP sites, before phasing each SNP allele to wild-type or mutant HTT.

86 Finally, SNP rs11265269 was identified as a risk factor of BPD (O

87 les with Asian and European origins for five SNPs in CHRNB3 showed significant associations with ND,

88 y statistics of the associations of the five SNPs with AD were obtained from the International Genomi

89 ime PCR to guide the choice of protocols for SNP amplification.

90 trate an alternative approach: we looked for SNPs associated with the expression of many genes simult

91 probe that can reliably distinguish all four SNP alleles in a single experiment.

92 ltivariate logistic regression analyses four SNPs were significantly associated with GAD.

93 Based on four SNPs, the odds ratio of AD per genetically predicted one

94 3 (rs147210663) and 3 established functional SNPs in APOA5.

95 e also identified the most likely functional SNPs at each locus.

96 Further, SNP variants showing frequency differences between fast-

97 he high beta-carotene accumulation in golden SNP melons was found to be due to a reduced further meta

98 e and predict the function of noncoding GWAS SNPs have been developed.

99 g SNPs, which represent the majority of GWAS SNPs, present a particular challenge.

100 Here, SNP's conditional FDR was estimated given its RES based

101 ce that associations between GWAS-identified SNPs and prostate cancer are modified by circulating con

102 gated the association of the GWAS-identified SNPs with BC risk in Indian population.

103 We also identify SNPs at novel loci including GCKR, CADM2 and FAM69C.

104 cord blood and peripheral blood to identify SNPs associated with DNA methylation (meQTL lists).

105 studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of assoc

106 analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leu

107 d can detect all problematic SNPs, including SNPs with wrong RS ID and SNPs with mismatched probe seq

108 nk study (n=116,279) revealed 16 independent SNPs with significant Bayes factor at a 5% false discove

109 etions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteo

110 The effective number of independent SNPs was calculated to correct for multiple testing.

111 ise selection, we identified two independent SNPs (i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A)

112 Among 80 previously known index SNPs at T2D loci, 66 SNPs showed consistency with the re

113 ndary signals with previously reported index SNPs in 1000G super populations suggested that the SCN5A

114 In addition, we utilized individual SNP lookups and polygenic score analyses to identify gen

115 ors with the Brassica 60 K Illumina Infinium SNP array and mapped a total of 29,347 SNP markers onto

116 arge, only a parsimonious set of influential SNPs are correlated with a particular complex trait and

117 ratio, where dI is the number of intergenic SNPs per intergenic site.

118 -density SNP array 'Axiom_Arachis' with 58 K SNPs and its utility in groundnut genetic diversity stud

119 disequilibrium patterns between the 13 lead SNPs and six secondary signals with previously reported

120 ions suggested that the SCN5A and KCNE1 lead SNPs were potentially novel and population-specific.

121 The doxorubicin (DOX)-loaded SNP (SNP/DOX) shows significant antitumor efficacy and n

122 Another MAGI3 SNP marker (rs6689879) contributed to increased ileal MA

123 le nucleotide polymorphisms (SNPs), but many SNPs have not been replicated in a separate cohort.

124 ssociation signal than the standard marginal SNP method.

125 association study we identified a novel miR-SNP (rs713065) in the 3'UTR region of FZD4 gene linked w

126 s-driven and microRNA-pathway-based SNP (miR-SNP) association study we identified a novel miR-SNP (rs

127 We identified a missense SNP (rs2075291, G > T, G185C) in APOA5 for CAD that reac

128 We identified a missense SNP, rs2075291, in APOA5 associated with CAD at a genome

129 Multi-SNP genetic risk scores (GRS) composed of the candidate

130 nt studies, in order to detect complex multi-SNP-multi-QT associations, bi-multivariate techniques su

131 The multi-SNP analysis described here was readily adopted by anoth

132 t, compared to stepwise conditional multiple-SNP analysis, SOJO provided better sensitivity and speci

133 Similarly, multiple-SNPs analysis revealed joint effects of rs2134655, rs172

134 We identified 25 new SNP-CAD associations (P < 5 x 10(-8), in fixed-effects m

135 et of variants (e.g. all variants or all non-SNPs).

136 Noncoding SNPs, which represent the majority of GWAS SNPs, present

137 anation for the observation of nonsynonymous SNPs in fnbA among clinical isolates of S. aureus that c

138 ex association signal, with additional novel SNPs modulating plasma FXI levels in both the F11 and KN

139 ibrated (average chi(2) = 1.00-1.02 for null SNPs), whereas the Armitage trend test (ATT), standard m

140 tivity sites were reported to explain 79% of SNP heritability; using our improved heritability model,

141 e validated with FISH and genetic mapping of SNP markers derived from BES.

142 The accumulation of SNPs in multiple isolates obtained over time from the sa

143 ere utilized to first quantify the amount of SNPs on the templates using a two-channel fluorescence m

144 We also evaluated the association of SNPs with BMI related factors such as sleep duration and

145 notation indicated a greater contribution of SNPs in protein-coding regions and within 3'-UTR regions

146 were used to assess the aggregate effect of SNPs on outcome.

147 Enrichment of SNPs associated with DNase I-hypersensitive sites was al

148 r more difficult to find because millions of SNPs must currently be compared to thousands of transcri

149 he hotspot loci and quantified the number of SNPs and/or genes, which if accumulated would confer ful

150 The choice of optimal number of SNPs is studied.

151 le of displaying and comparing large sets of SNPs in a genomic locus and rapidly identifying consensu

152 nal FDR was estimated given its RES based on SNP prior information including linkage disequilibrium (

153 /or predict diseases and traits dependent on SNP phasing.

154 s) associated with isoleucine levels and one SNP associated with both leucine and valine levels at ge

155 s6639786, rs2270112, and rs17268988) and one SNP in the SULT2A1 gene (rs182420) were genotyped.

156 formed a genome-wide scan and identified one SNP with significantly different frequencies in 5,724 su

157 s with low LLD have significantly larger per-SNP heritability and that roughly half of this effect ca

158 Across all five GBS analysis platforms, SNP calls showed unexpectedly low convergence but genera

159 Total 2420 and 2396 polymorphic SNPs were detected on the A and the B genome chromosomes

160 Single-single nucleotide polymorphism (SNP) and haplotype-based association tests were used to

161 Single nucleotide polymorphism (SNP) associations were stratified by study site and were

162 genome-wide single-nucleotide polymorphism (SNP) data and air pollution exposure.

163 analysis of single-nucleotide polymorphism (SNP) data for Spanish teosinte, sympatric populations of

164 lex PCR with single nucleotide polymorphism (SNP) detection using highly selective BiDz sensors targe

165 y included a single nucleotide polymorphism (SNP) genome-wide association study (GWAS), the selection

166 sed first on single nucleotide polymorphism (SNP) genotyping and then with whole-genome data and show

167 high density single nucleotide polymorphism (SNP) genotyping array (Illumina MegaEx).

168 f a promoter single-nucleotide polymorphism (SNP) in IL32 on lipid profiles in RA patients and indivi

169 The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significa

170 s-associated single-nucleotide polymorphism (SNP) located in the intron of the long noncoding RNA (ln

171 show that a single-nucleotide polymorphism (SNP) mutation in the GL4 gene resulted in a premature st

172 f at a human single-nucleotide polymorphism (SNP) of the gene encoding the immunomodulatory receptor

173 t type (e.g. single nucleotide polymorphism (SNP) or indel) within a broader set of variants (e.g. al

174 tes per-base single nucleotide polymorphism (SNP) pathogenicity scores across relevant genomic interv

175 CmOr) golden single-nucleotide polymorphism (SNP) through a yet to be discovered mechanism.

176 solates, and single nucleotide polymorphism (SNP) variants emerging over time were detected.

177 allele and a single-nucleotide polymorphism (SNP), are associated with diurnal preference and higher

178 Genome-wide single nucleotide polymorphism (SNP)-based haplotyping has been used to determine popula

179 Single nucleotide polymorphism (SNP)-based heritability and genetic correlations were ca

180 owerful than single-nucleotide polymorphism (SNP)-set kernel association tests and burden tests.

181 omatic mutations, or germline polymorphisms (SNP) are associated with immune metagene expression in b

182 investigate single nucleotide polymorphisms (SNP) located in genes encoding interacting TJ proteins a

183 with a mean single nucleotide polymorphisms (SNP) rate of approximately 1 per 50 bases suggestive of

184 igh-quality Single Nucleotide Polymorphisms (SNP) were identified.

185 correlated single-nucleotide polymorphisms (SNPs) (r(2)>0.9) located in an intergenic region on chro

186 on of human single-nucleotide polymorphisms (SNPs) alter pri-miRNA processing, and confirm several pr

187 ately 7.4 M single nucleotide polymorphisms (SNPs) and 1.9 M indels.

188 630 exonic single-nucleotide polymorphisms (SNPs) and 43 copy number variations (CNVs) with in-vitro

189 ormation of single nucleotide polymorphisms (SNPs) and combining two relevant existing tools, relativ

190 2 diabetes single nucleotide polymorphisms (SNPs) and genome-wide methylation (methylation quantitat

191 urthermore, single-nucleotide polymorphisms (SNPs) and insertions/deletions (indels) can result in al

192 of non-HLA single-nucleotide polymorphisms (SNPs) and outcomes after blood or marrow transplant (BMT

193 he 10 novel single nucleotide polymorphisms (SNPs) and performed an association study.

194 examine the single nucleotide polymorphisms (SNPs) associated with family history (FH) of upper gastr

195 independent single nucleotide polymorphisms (SNPs) associated with isoleucine levels and one SNP asso

196 dvantage of single-nucleotide polymorphisms (SNPs) distributed across the genome to discriminate dono

197 No single-nucleotide polymorphisms (SNPs) exceeded genome-wide significance in the transethn

198 ate, common single-nucleotide polymorphisms (SNPs) explained between 20% and 29% of the variance in M

199 rols for 93 single nucleotide polymorphisms (SNPs) from 7 genes.

200 btained for single-nucleotide polymorphisms (SNPs) identified from a genome-wide association meta-ana

201 ,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autosomal genes with CM-specifi

202 informative single nucleotide polymorphisms (SNPs) in 305 individuals with Haplogroup O2a1c-002611 id

203 hip between single nucleotide polymorphisms (SNPs) in nonsteroidal anti-inflammatory drug (NSAID) met

204 NVs) due to single nucleotide polymorphisms (SNPs) in the genome, or RNA editing events within the RN

205 nts through single-nucleotide polymorphisms (SNPs) in the primary miRNA outside the mature miRNA sequ

206 known index single nucleotide polymorphisms (SNPs) indicated an additional independent signal at KCNQ

207 (2) Single nucleotide polymorphisms (SNPs) known to be involved in human eye colour variation

208 e 2,271,584 single nucleotide polymorphisms (SNPs) on the panel from previous studies, and genome-wid

209 pleiotropic single nucleotide polymorphisms (SNPs) possibly acting via obesity-related traits, hsCRP,

210 notyping of single nucleotide polymorphisms (SNPs) representing linkage blocks of the SLC2A14 gene.Bo

211 ion between single nucleotide polymorphisms (SNPs) rs1800544 ADRA2A (odds ratio: 1.69; confidence int

212 Single-nucleotide polymorphisms (SNPs) that surpassed a significance threshold of P<1x10(

213 t of 14 559 single-nucleotide polymorphisms (SNPs) to identify the likely source population for this

214 ore whether single nucleotide polymorphisms (SNPs) were associated with functional and anthropometric

215 genome-wide single nucleotide polymorphisms (SNPs) were selected to develop a large-scale SNP genotyp

216 lopment and single nucleotide polymorphisms (SNPs), but many SNPs have not been replicated in a separ

217 Single nucleotide polymorphisms (SNPs), the most common genetic markers in genome-wide as

218 associated single-nucleotide polymorphisms (SNPs), whereas the markers on the other chromosomes were

219 (SSRs) and single nucleotide polymorphisms (SNPs).

220 consecutive single-nucleotide polymorphisms (SNPs).

221 re than 300 single-nucleotide polymorphisms (SNPs).

222 trains were single nucleotide polymorphisms (SNPs).

223 ielded nine single-nucleotide polymorphisms (SNPs): G-1106A, A-1018T, T-1014C, T-988G, G-513A, G-462A

224 nd two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality

225 We prioritized SNPs in IFITM3 on the basis of putative biological funct

226 manifest file and can detect all problematic SNPs, including SNPs with wrong RS ID and SNPs with mism

227 GWA analysis identified a putative SNP on Bos taurus autosomes (BTA) 2 associated with phen

228 The proportion of extremely rare SNPs disrupting SREs is significantly higher in European

229 hes to determine the potential of regulatory SNPs depend on inadequate knowledge of cell-specific DNA

230 he association with the most well-replicated SNP (rs964184) for triglycerides identified by genome-wi

231 panic whites between the previously reported SNP rs1229984 in ADH1B and both alcohol consumption phen

232 We found none of these eight reported SNPs were significant associated with urolithiasis risk

233 We describe updates to the Rice SNP-Seek Database since its first release.

234 h two regulatory variants-breast cancer risk SNP rs11055880 and leukemia risk-associated SNP rs121423

235 We also modeled a known functional risk SNP of colorectal cancer, rs6983267, in HCT-116 cells.

236 studies to date using a score of 62 RA risk SNPs (p < 5 * 10(-8)) as instrumental variable (IV).

237 physical interactions among all 44 TGCT risk SNPs and candidate causal genes.

238 d a significant association of the rs3750846 SNP at the ARMS2/HTRA1 locus with subretinal/sub-retinal

239 SNPs) were selected to develop a large-scale SNP genotyping array.

240 ly significant associations between sentinel SNPs and case-control status have been replicated by gen

241 We identified several SNPs with p < 10(-5), including regions of multiple supp

242 GCTA analyses found a significant SNP-based heritability of self-reported alcohol consumpt

243 ant SNPs for SET, and 22 and 142 significant SNPs for SDW, in glasshouse and field conditions, respec

244 The GWAS uncovered five and 32 significant SNPs for SET, and 22 and 142 significant SNPs for SDW, i

245 ohort, a total of 15 independent significant SNPs were identified (conditional FDR < 0.05).

246 ific survival and then validated significant SNPs in another genome-wide association study from Harva

247 reater enrichment in genome-wide significant SNPs from the GWAS catalog, and are also more likely to

248 We identified 41 genome-wide significant SNPs that mapped to 13 previously identified QT loci.

249 Both single SNP and SNP x SNP interaction association analyses with

250 The doxorubicin (DOX)-loaded SNP (SNP/DOX) shows significant antitumor efficacy and nearly

251 Last, we show that some SNPs allosterically modulate PCSK9's substrate sequence

252 Species-specific SNP position (230 bp) in the matK region that is charact

253 5), including regions of multiple supporting SNPs on chromosomes 13 (minimum p = 7.5 x 10(-7)) and 14

254 and validation of deleterious non-synonymous SNPs (nsSNPs) in the interleukin-8 gene using three step

255 termined in 100 Han Chinese subjects and tag SNPs were selected.

256 3 "tag" single nucleotide polymorphisms (tag SNPs) in 367 challenge-proven food allergic cases, 199 f

257 Tag-SNP markers identified in this study can be used for mar

258 We determined that SNPs with low LLD have significantly larger per-SNP heri

259 The SNP Annotator adds traits, ontology terms, effects and i

260 The SNP association was also replicated in a depressive symp

261 sociated with 25(OH)D concentration, and the SNP-prostate cancer associations did not differ by these

262 not found through genetic correlation at the SNP level.

263 at this regulation is impaired either by the SNP c.*61 T > C or by diminished levels of miR-16 and mi

264 ping of 28 dogs from 3 breeds to compare the SNP and linkage disequilibrium characteristics together

265 d chimeric probe DNA can be realized for the SNP genotyping by optimizing the operation condition and

266 Moreover, the SNP rs12815313-T allele associated with increased suscep

267 stead was most influenced by the size of the SNP data set, with 25,000-50,000 SNPs required for accur

268 More than half of the SNPs associated with altitude were within large structur

269 r allowing for multiple testing, none of the SNPs examined was significantly associated with 25(OH)D

270 We then studied one of the SNPs, rs31746, in an independent sample of smokers who p

271 These SNPs can result in altered levels of expression of some

272 These SNPs reside in a region on chromosome 6q13 comprising th

273 We also found that the frequency of these SNPs in a cohort of healthy Dutch individuals is very lo

274 The effect of these SNPs is independent of classical prognostic factors and

275 , the pathogenic mechanisms of most of these SNPs remain elusive.

276 This SNP is also predicted to modify binding scores for sever

277 uggesting a possible protective role of this SNP against CVD.

278 iding direct evidence for the impact of this SNP in tumor development.

279 preliminary evidence for association of this SNP with elevated TEWL also.

280 Analysis of existing data suggests that this SNP may have transcription factor regulatory functions.

281 s were genotyped for heterozygosity at three SNP sites, before phasing each SNP allele to wild-type o

282 at coding amino acids encoded at these three SNP sites were conserved evolutionarily and associated w

283 Three SNPs in the STS gene (rs6639786, rs2270112, and rs172689

284 Three SNPs within adenylate cyclase 2 (ADCY2) showed the same

285 These three SNPs are located in intronic regions of CADM2, LINGO2 an

286 of them were individually validated through SNP typing.

287 A subset of the genes adjacent to SNP hotspots showed statistically significant enrichment

288 rsatile, functional pipeline and apply it to SNPs at 1p22, a locus identified in several GWAS for non

289 a high-density SNP array with 690,662 unique SNPs (herein 690 K array) that were relatively evenly di

290 lation only and an imputation approach using SNP and DArT markers on the entire population.

291 frequency) copy-number variants (CNVs) using SNP microarray data.

292 TL mapping approaches were carried out using SNP markers on about half of the population only and an

293 rived at largely complementary sets of valid SNP calls on the low-coverage data analyzed.

294 rphisms in-silico, of which 8,967 high value SNPs were incorporated into a commercially available Ill

295 ignificance with PA (P=1.80x10(-8)), whereas SNPs associated with Src kinase-associated phosphoprotei

296 m heterozygous patients and transfected with SNP-targeted siRNA, using glucan particles taken up by p

297 to increase power to detect association with SNPs, and thus may enable improved detection of novel lo

298 Both single SNP and SNP x SNP interaction association analyses with body mass inde

299 The high-resolution Y-SNP haplogroup and Y-STR haplotype can be obtained with

300 romosomal single nucleotide polymorphisms (Y-SNPs).