ライフサイエンスコーパス: SNpc

1 urons in the substantia nigra pars compacta (SNPC).

2 urons of the substantia nigra pars compacta (SNpc).

3 urons in the substantia nigra pars compacta (SNpc).

4 ) neurons in substantia nigra pars compacta (SNpc).

5 adult number of dopaminergic neurons in the SNpc.

6 clein transgenic mice was conserved in human SNpc.

7 ad an increase in BrdU-positive cells in the SNpc.

8 euron numbers and BrdU-positive cells in the SNpc.

9 ns of all dopaminergic nuclei, including the SNpc.

10 y cause the selective death of DA neurons in SNpc.

11 nd astrocytes expressed iNOS in the lesioned SNpc.

12 We suggest that SNPC-4 binding establishes a positive expression environ

13 SNPC-4 exhibits an atypical widely distributed binding p

14 SNPC-4 localization is mutually dependent with localizat

15 We show that C. elegans SNPC-4, the Myb-like DNA-binding subunit of the small nu

16 n, -83%; P < .001), followed by the anterior SNpc (-49%; P < .001) and the locus coeruleus (-37%; P <

17 how that the substantia nigra pars compacta (SNpc), a brain region where dopamine (DA) cell degenerat

18 ice, there is an up-regulation of Bax in the SNpc after MPTP administration and a decrease in Bcl-2.

19 urons of the substantia nigra pars compacta (SNpc) against 6-OHDA and MPTP.

20 wever, in relationship to its potency in the SNPC, (+)-AJ76 was more potent than haloperidol in the C

21 rons of the substantia nigra, pars compacta (SNpc) akin to what is observed in Parkinson disease (PD)

22 lanin volume loss of the posterior and whole SNpc allowed the best differentiation of patients with P

23 s MPTP-induced dopaminergic neuronal loss in SNpc and nigrostriatal nerve-fiber loss.

24 nsient loss of the dopaminergic phenotype in SNpc and now report that this loss recovers by 90 d afte

25 s (LBs) are abnormal inclusions found in the SNpc and other neurons of these patients.

26 mixed genomes and analyzed number of DNs in SNpc and striatal axonal swellings in 120 F2-En1+/- 17 w

27 ents MPTP-induced activation of microglia in SNpc and striatum and the expression of the cytotoxic me

28 Cop-1 immune cells showed NAA levels, in the SNpc and striatum, nearly equivalent to PBS-treated anim

29 totic protein Bax is highly expressed in the SNpc and that its ablation attenuates SNpc developmental

30 ng rates in dopaminergic neurons in both the SNPC and the CN.

31 r N-methyl-d-aspartate microinjection in the SNpc and/or optogenetic stimulation of nigro-vagal termi

32 urons in the substantia nigra pars compacta (SNpc) and of noradrenergic neurons in the locus coeruleu

33 urons in rat substantia nigra pars compacta (SNPC) and postsynaptic type II neurons in the anterior c

34 ished in the substantia nigra pars compacta (SNpc) and striatum, regions most affected in human disea

35 opaminergic neurons in the substantia nigra (SNpc) and the subsequent loss of their projecting nerve

36 s in the rat substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA), and compared the

37 urons in the substantia nigra pars compacta (SNpc) and widespread aggregates of the protein alpha-syn

38 romising the substantia nigra pars compacta (SNpc) and, later, the cerebral cortex.

39 c neurons in substantia nigra pars compacta (SNpc), and there was no loss of dopaminergic neurites in

40 y in the activity of dopaminergic neurons in SNpc, and improvement in the motor function at the behav

41 gest that, just as in other species, the DH, SNpc, and POA might be involved in the expression of soc

42 connects the brainstem vagal nuclei and the SNpc, and to determine whether this pathway is compromis

43 (QA) dramatically enhances the magnitude of SNpc apoptosis and results in a lower number of adult SN

44 Bcl-2 attenuates both natural and QA-induced SNpc apoptosis.

45 Some, but not all of the SNpc apoptotic neurons still express their phenotypic ma

46 urons in the substantia nigra pars compacta (SNpc) are greatly needed to effectively change the debil

47 urons in the substantia nigra pars compacta (SNpc) as seen in Parkinson's disease.

48 The binding studies show that DiC(6)SNPC binds cooperatively to two sites on group IA PLA(2)

49 laced tracers in the dorsal vagal complex or SNpc; brainstem and midbrain were examined for tracer di

50 cells in the substantia nigra pars compacta (SNpc), but this difference was significant only among ma

51 ress response in dopaminergic neurons of the SNpc, but not in other brain regions.

52 urons of the substantia nigra pars compacta (SNpc) by regulating the magnitude of the first phase of

53 Ghrelin binds to SNpc cells, electrically activates SNpc DA neurons, incr

54 h more potent than pramipexole in inhibiting SNPC cells, PNU-91356A, a D2-preferring agonist, did not

55 urons in the substantia nigra pars compacta (SNpc) compared with saline treatment.

56 volume of the anterior, posterior, and whole SNpc correlated with Unified Parkinson's Disease Rating

57 lin or the ghrelin receptor (GHSR) increased SNpc DA cell loss and lowered striatal dopamine levels a

58 Exogenous ghrelin administration decreased SNpc DA cell loss and restricted striatal dopamine loss

59 uce overt motor abnormalities or substantial SNpc DA neuron loss.

60 mice defective in NADPH-oxidase exhibit less SNpc DA neuronal loss and protein oxidation than their W

61 re, the localization of ERbeta and IGF-1R on SNpc DA neurons and astrocytes suggests a modulatory rol

62 LRRK2 G2019S on the function and survival of SNpc DA neurons are poorly understood.

63 gest that ALDH1A1 protects subpopulations of SNpc DA neurons by preventing the accumulation of dopami

64 the theory that D-amphetamine inhibition of SNPC DA neurons is dependent upon neuronal negative feed

65 and protein were similarly decreased in the SNpc DA neurons of aged G2019S mice.

66 F-1R mRNA and revealed that almost all TH-ir SNpc DA neurons were immunoreactive for IGF-1R, respecti

67 binds to SNpc cells, electrically activates SNpc DA neurons, increases tyrosine hydroxylase mRNA and

68 ial mechanisms by which LRRK2 G2019S acts in SNpc DA neurons, resulting in downregulation of its down

69 nucleus (CN), the major projection area for SNPC DA neurons.

70 ase-immunoreactive (TH-ir) SN pars compacta (SNpc) DA neurons are immunoreactive for estrogen recepto

71 In rodent SNpc, DA neurons can be divided into two subpopulations

72 on of DNs in substantia nigra pars compacta (SNpc), decreased striatal dopamine levels and swellings

73 thening the apoptotic nature of the observed SNpc developmental cell death, we demonstrate that overe

74 in the SNpc and that its ablation attenuates SNpc developmental neuronal apoptosis.

75 s within the substantia nigra pars compacta (SNpc) display a differential vulnerability to loss in Pa

76 minergic terminal density and modest loss of SNpc dopamine neurons after eight weeks, corresponding t

77 ation of EUK-189 decreases paraquat-mediated SNpc dopaminergic neuronal cell death in vivo.

78 s as to the occurrence of this phenomenon in SNpc dopaminergic neurons in the developing mouse.

79 tosis and results in a lower number of adult SNpc dopaminergic neurons.

80 ic synapses on VTA dopaminergic neurons than SNpc dopaminergic neurons.

81 s and cholinergic interneurons compared with SNpc dopaminergic neurons.

82 of midbrain substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons contributes to the main

83 by a loss of substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons, and can be modeled by t

84 DA lesion differed between regions, with the SNpc exhibiting the greatest loss of neurons (46%), but

85 cated in the substantia nigra pars compacta (SNpc), expression of monoamines and indolamines in brain

86 ventral tier substantia nigra pars compacta (SNpc) failed to demonstrate a preponderance of a particu

87 on were similar to those required to inhibit SNPC firing.

88 e other contained a phosphorylcholine (DiC(6)SNPC) headgroup.

89 Stimulation of the SNpc increased gastric tone and motility via activation

90 s within the substantia nigra pars compacta (SNpc), locus coeruleus, and ventral tegmental area in Pa

91 elated volumes of the anterior and posterior SNpc, locus coeruleus, and ventral tegmental area were d

92 e in PD was most pronounced in the posterior SNpc (median, -83%; P < .001), followed by the anterior

93 nes and indolamines in brain, alterations in SNpc microglia number and morphology, and expression of

94 ouse strains exhibit dramatic differences in SNpc neuron survival, ranging from 63% cell loss in C57B

95 mb akinesia, striatal denervation or loss of SNpc neuron, nor did STN DBS elevate p-rpS6 levels furth

96 of morphologic techniques, we show that many SNpc neurons fulfill the criteria for apoptosis and that

97 The majority of SNpc neurons undergoing apoptotic-like cell death did no

98 One case had no LB-containing SNpc neurons undergoing apoptotic-like cell death.

99 Three cases demonstrated that SNpc neurons with LBs in the perikarya had the same prop

100 r apoptotic-like changes were more common in SNpc neurons with somal LBs compared to those without so

101 same proportion of apoptotic-like changes as SNpc neurons without somal LBs.

102 rylation of ribosomal protein S6 (p-rpS6) in SNpc neurons, a readout of trkB activation.

103 doses above those inhibiting firing rates of SNPC neurons.

104 zyme during inflammation, is up-regulated in SNpc of human PD and MPTP mice.

105 some of the neuronal death occurring in the SNpc of Lewy body-associated disorders resembles apoptos

106 dent increases of autophagic vacuoles in the SNpc of LRRK(-/-) mice before the onset of DA neuron los

107 a morphology of apoptosis does occur in the SNpc of mice and that this process plays a critical role

108 ve reactive microgliosis was observed in the SNpc of MPTP-lesioned IL-6 (+/+) mice.

109 ylase-positive and total cell numbers in the SNpc of MPTP-lesioned mice, even though this did not inc

110 kin expression in cultured cells; and in the SNpc of PD patients, Parkin levels are reduced in a subs

111 were evident for dopaminergic neurons in the SNpc of Wistar vs. Sprague-Dawley rat strains.

112 urons of the substantia nigra pars compacta (SNpc) of human PD patients.

113 ccurs in the substantia nigra pars compacta (SNpc) of patients with Parkinson's disease and other Lew

114 shown in the substantia nigra pars compacta (SNpc) of PD models when there has been a decrease in tyr

115 S10 into the substantia nigra pars compacta (SNpc) of rats reduced microgliosis and protected against

116 (PD), in the substantia nigra par compacta (SNpc) of the brain in a PD mouse model.

117 effect on the firing rates of DA neurons in SNPC, on type II anterior CN neurons, or on the effects

118 to the somata of dopaminergic neurons in the SNpc or dorsal striatal cholinergic interneurons.

119 the ventral substantia nigra pars compacta (SNpc) preferentially degenerate in Parkinson's disease (

120 n dopaminergic neurons (mDAs) in the VTA and SNpc project to different regions and form distinct circ

121 Quantification of DA neurons in the SNpc show that mice allowed to run unrestricted for 1 or

122 Quantification of DA neurons in the SNpc show that mice whose running was restricted lost si

123 o either the substantia nigra pars compacta (SNpc), the lateral ventricle (LV) or the striatum (or co

124 urons in the substantia nigra pars compacta (SNpc) undergo natural cell death during development in r

125 that the number of apoptotic neurons in the SNpc vary in a time-dependent manner from postnatal day

126 cells in the substantia nigra pars compacta (SNpc), ventral tegmental area (VTA), and retrorubral fie

127 entially affects dopaminergic neurons in the SNpc, VTA, and RRF; however, the resulting changes in nu

128 ng CR in the substantia nigra pars compacta (SNpc) were relatively spared compared to those that did

129 Binding of DiC(6)SNPC with 2.0 mM Triton X-100 showed positive cooperativ