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1 SPA also significantly attenuated the growth of HPAF-II
2 SPA and the observed stable nonlinear spectral propagati
3 SPA inhibited CXCR2-mediated Ca(2+) mobilization and blo
4 SPA is known to be critical for proper assembly of the i
5 SPA loss-of-function phenotypes include excessive septat
6 SPA proteins are essential cofactors of COP1, but their
7 SPA proteins are not homologous at the primary sequence
8 SPA showed a capacity to appropriate circulating IgG, by
9 SPA uses a universal plasmid donor strain that contains
10 SPA versus PPA changes were significant at the SZ and TZ
11 SPA-1 localizes to the cytoplasm and to a lesser degree
12 SPA-LDA and PCA-LDA provided significantly better result
13 SPA-LN is optimized by maximizing both the affinity and
14 SPA-TT(2) elicited slightly higher, though not statistic
17 OMORPHOGENIC1 (COP1)/SUPPRESSOR OF phyA-105 (SPA) complex, which targets positive regulators of photo
18 1 and RUP2), and the SUPPRESSOR OF PHYA-105 (SPA) family as proteins copurifying with UVR8(W285A).
20 the COP1-interacting SUPPRESSOR OF PHYA-105 (SPA) proteins in seedling and adult facets of the shade-
22 Circular dichroism revealed that a 29mer SPA peptide shifts from a random coil to a helix in a co
24 apture 125I-labeled hIL-5-bound Sf9 cells, a SPA was developed and used to measure hIL-5 high-affinit
25 y the silanized fiber surface thus forming a SPA layer, which would greatly enhance the proportion of
26 icacy and safety of sulcus implantation of a SPA-IOL, designed for both in-the-bag and sulcus positio
27 H inhibitors can be readily detected using a SPA with BMACP and that the effectiveness of inhibitors
30 e release of the virulence factor protein A (SPA) from a strain of community-associated methicillin-r
31 RA, the ability of staphylococcal protein A (SPA) to interact with and modulate cells of the monocyti
35 of sinusitis-related subperiosteal abscess (SPA) of the orbit and their impact on patient outcomes u
37 rom increased spontaneous physical activity (SPA) and resting metabolic rate (RMR); and 3) if VMH BDN
38 nditure (EE), spontaneous physical activity (SPA), postintervention diet-induced thermogenesis (DIT),
41 hm (GA), a successive projections algorithm (SPA) and nonlinear techniques (BP-ANN, back propagation
43 ction effect, self-parametric amplification (SPA), which manifests itself as optical spectrum narrowi
46 be2L3 (UbcH5a and UbcH7) established that an SPA motif in loop 7 of E2 is required for binding to CHI
48 ssociated with Linear Discriminant Analysis (SPA-LDA) for simultaneous classification of the teas acc
50 cence complementation revealed that Brd4 and SPA-1 interact with each other in the nucleus of living
54 methyleneanilinouracil by the filtration and SPA methods gave comparable results, but the SPA assay u
55 , carbon dioxide production, food intake and SPA were measured for 24h in an indirect calorimeter.
58 hyB disrupt the interaction between COP1 and SPAs, resulting in reorganization of the COP1/SPA comple
59 he substance P receptor (NK(1)R) antagonist (SPA) L-000760735 altered cortical expression of multiple
60 completeness of the superficial palmar arch (SPA) was present in 46%, the deep palmar arch was comple
61 ep zone [DZ]) and regions (subpistonal area [SPA] and peripistonal area [PPA]) were defined as region
62 sent here a new two-hybrid smart pool array (SPA) system in which, instead of individual activation d
63 We developed a scoring function (named as SPA-PP, specificity and affinity of the protein-protein
64 and urine collected by suprapubic aspirate (SPA), regardless of whether the subjects had urinary sym
65 onfirmed in a scintillation proximity assay (SPA) and a DEAE membrane-based assay for [(3)H]AAG bindi
67 (WGA)-coated scintillation proximity assay (SPA) beads to capture 125I-labeled hIL-5-bound Sf9 cells
68 avidin-coated scintillation proximity assay (SPA) beads, and after addition of homopolymeric A templa
69 rst validated scintillation proximity assay (SPA) binding method for quantitation of (3)H-labeled d-l
70 of a coupled scintillation proximity assay (SPA) for 3 KDMs: KDM1A (LSD1), KDM3A (JMJD1A), and KDM4A
73 96-well plate scintillation proximity assay (SPA) for measuring small molecule interactions at IGFBP-
74 gh-throughput scintillation proximity assay (SPA) for parathyroid hormone (1-84) (PTH) has been devel
76 l homogeneous scintillation proximity assay (SPA) for the study of DnaB-stimulated E. coli primase ac
78 based on the scintillation proximity assay (SPA) technology that provides results equivalent to thos
79 s: the use of scintillation proximity assay (SPA) technology to measure aminoacyl-tRNA synthetase (aa
80 d optimized a scintillation proximity assay (SPA) to replace the more costly, wasteful and cumbersome
82 e developed a scintillation proximity assay (SPA) where use of biotinylated MACP (BMACP) allows the g
83 measured in a scintillation proximity assay (SPA)-based high-throughput screen using [gamma-(33)P]bio
87 intillation proximity high throughput assay (SPA) to identify inhibitors of DNA methyltransferases wa
89 is based on a novel short peptide assembler (SPA) that assembles protein sequences from their constit
90 the form of synchronous plateau assemblies (SPAs) that are initiated by sparse groups of gap-junctio
91 These 24 residues comprise the SP assembly (SPA) domain, and we propose that neighboring SPA units i
92 ), databases, service provision assessments (SPAs), Demographic and Health Surveys, Multiple Indicato
93 cter, we identify 17 septal pore-associated (SPA) proteins that localize to the septal pore in rings
94 ecosystem model (the Soil-Plant-Atmosphere (SPA) model) were evaluated against measurements from two
95 n microscopy with single-particle averaging (SPA-SIM) approach to study the localization of all 18 SP
100 suggest that cry2 stability is controlled by SPA and phyA, thus providing more information on the mol
101 Histone deacetylase activity measured by SPA was concordant with that determined via the traditio
102 , cell-surface ATP concentration measured by SPA-luc transiently reached approximately 1 microm indep
103 the regulation of innate immune responses by SPA with key roles for specific components of the extrac
104 y polyvinyl toluene-polyethyleneimine-coated SPA beads and quantified by counting by beta-scintograph
107 yellow-colored compounds, than conventional SPA beads or scintillation fluid (emitting at 400 to 480
108 dark by the synergistic actions of CUL4(COP1-SPA) E3 ubiquitin ligase and a subset of basic helix-loo
110 EBF1/2), CUL3(LRB), CUL3(BOP), and CUL4(COP1-SPA)) that regulate PIF abundance both in dark and light
111 enic factor targeted for degradation by COP1/SPA, correlates temporally with the accumulation of phyA
114 the Arabidopsis (Arabidopsis thaliana) COP1/SPA E3 ubiquitin ligase causes the degradation of multip
115 The Arabidopsis (Arabidopsis thaliana) COP1/SPA ubiquitin ligase is a central repressor that suppres
117 r mechanism for the inactivation of the COP1/SPA complex by phyA- and phyB-mediated light perception.
119 pa mutants, thus demonstrating that the COP1/SPA complex is only required for elongation responses to
124 ow R:FR, in a fashion that involves the COP1/SPA ubiquitination target LONG HYPOCOTYL IN FR LIGHT1 bu
127 atistical values also indicate that the DGAT SPA is a robust assay, with a Z' of more than 0.60 and a
128 n kinetic parameters determined by this DGAT SPA method agreed well with the values determined with t
131 Instead, the spacer peptide assembly domain (SPA), a putative 24-residue helical sequence comprising
132 X-2 of nonsteroidal anti-inflammatory drugs, SPA successfully discriminates the drugs from the divers
137 Patients in the DSA-SPA-positive and DSA-SPA-negative groups received similar immunosuppression,
138 Patients in the DSA-SPA-positive and DSA-SPA-negative groups received similar immunosuppression,
144 ese studies suggest that the presence of DSA-SPA, despite a negative flow cytometry crossmatch result
145 hese included 62 patients with preformed DSA-SPA detected by Luminex at the time of transplantation.
146 hese included 62 patients with preformed DSA-SPA detected by Luminex at the time of transplantation.
151 ll allograft survival was similar in the DSA-SPA-positive and DSA-SPA-negative groups (log-rank test=
152 ll allograft survival was similar in the DSA-SPA-positive and DSA-SPA-negative groups (log-rank test=
160 These data support the proposal that the E2 SPA motif provides specificity for binding to CHIP, wher
162 LTR poly(A) signal with a synthetic element (SPA) permits gene loop formation, suggesting that these
167 nce P antagonist-receptor quantifier ([(18)F]SPA-RQ) [2-fluoromethoxy-5-(5-trifluoromethyl-tetrazol-1
171 ct classification rate) were 96% and 98% for SPA-LDA and PLS-DA, respectively, indicating that the NI
174 ad a 33% sensitivity and 86% specificity for SPA incompleteness with a cutoff value of >10 seconds an
176 GABAergic interneurons as they progress from SPAs to GDPs marks the emergence of synapse-driven netwo
178 is method, a Saccharomyces cerevisiae genome SPA increases yeast two-hybrid screening efficiency by a
179 [gamma-(33)P]biotin-11 GTP as substrate (GTP-SPA); the format is sensitive, accurate, robust, and com
187 , to membranes is cooperative and identifies SPA as a major factor that controls this cooperativity.
189 The classification models were based in SPA-LDA (Linear Discriminant Analysis coupled with Succe
192 red affinity tags that are often required in SPA, and is capable of detecting either radiolabeled RNA
196 olved in GDPs, interneurons participating in SPAs possess immature intrinsic properties, receive syna
198 ke and increasing EE consequent to increased SPA and RMR, suggesting that the VMH is an important sit
200 of a single-piece-acrylic intraocular lens (SPA-IOL) in the ciliary sulcus during phacoemulsificatio
202 Staphylococcus aureus protein A-luciferase (SPA-luc) was bound to endogenous antigens on primary hum
203 ng antibody blockade and murine macrophages, SPA-stimulated macrophage chemotaxis was dependent on TL
206 Comparable IC(50) values of 160 microM (SPA) and 125 microM were also obtained with the antibiot
209 SPA) domain, and we propose that neighboring SPA units in a Gag hexamer coalesce to form a six-helix
211 periencing flow degenerate in the absence of SPA-19, suggesting that eddy-trapped nuclei function to
214 RV from an animal with a spontaneous case of SPA (JSRV(21)) and showed that it harbors an infectious
215 tide substrate, ATP ([33P]ATP in the case of SPA), and tyrosine kinase in a 96-well assay format.
216 ameter changes in the entire sample depth of SPA versus PPA were found for delta1/2 (T1rho, 14% +/- 1
221 fication with PCT and sulcus implantation of SPA-IOL designed for both in-the-bag and sulcus position
223 n the nucleus in the absence and presence of SPA proteins, indicating that SPA proteins are not requi
224 that this novel dual-inhibitory property of SPA could be of significant therapeutic value in pancrea
227 Thus we describe the tertiary structure of SPA in the presence of sodium dodecylsulfate micelles at
228 hese turns juxtapose the N- and C-termini of SPA and may form the basis of this peptide's unique abil
230 o found that several lectins, when coated on SPA beads, were even more effective than WGA-coated SPA
232 3+), Lu(3+), and Sc(3+), were immobilized on SPA beads via metal chelate and utilized as affinity lig
233 eformed DSAs, defined by positive results on SPA but negative complement-dependent cytotoxicity and f
238 -Arg(1), D-Trp(5,7,9), Leu(11)] substance P (SPA) belongs to a family of peptides including antagonis
240 t formed in the reaction binds to polylysine SPA beads, producing a signal that is measured in a TopC
241 the Rap1-specific GTPase-activating protein, SPA-1, or inactivated form of Rap1 (N17Rap1) blocked pho
242 ), including JIA, SLE, CEL, T1D, UC, CD, PS, SPA and CVID, attributable to common genomic variations
243 o streptavidin-coated polyvinyltoluene (PVT) SPA microbeads and using [(125)I]IGF-1 as the endogenous
245 lling transition states wherein a chiral (R)-SPA protonates a dirhodium-bound enol intermediate.
246 ears requiring surgery for sinusitis-related SPA has remained a minority (15%-32.5%), without a clear
247 nts</=18 years of age with sinusitis-related SPA treated from 2002 to 2012; comparable cohorts from e
248 he cell membrane of CA-MRSA, and the related SPA-releasing chemokine CXCL10 bound to both cell wall a
249 evidence that the light signaling repressors SPA proteins contribute to COP1-mediated phyA degradatio
254 including [D-Arg(1),D-Trp(5,7,9),Leu(11)]SP (SPA) are broad-spectrum G protein-coupled receptor (GPCR
257 The remarkable performance demonstrates that SPA has significant potential applications in identifyin
259 nd presence of SPA proteins, indicating that SPA proteins are not required for nuclear localization o
260 eature of the results presented here is that SPA markedly reduced tumor-associated angiogenesis in th
261 ailed study of chemokine CXCL9 revealed that SPA release occurred through a post-translational mechan
263 isons with other scoring functions show that SPA-PP performs remarkably on both predictions of bindin
264 ell line as our model system, we showed that SPA inhibited multiple neuropeptide-induced Ca(2+) mobil
265 fetime imaging microscopy analyses show that SPAs and phytochromes colocalize and interact in nuclear
269 sembled VLPs showed strong protection at the SPA region, consistent with a higher-order structure.
270 SPA methods gave comparable results, but the SPA assay uses less radioactive label, is less time-cons
271 tibodies in the recipient, identified by the SPA, even in the presence of a negative flow cytometry c
272 V2 MAbs were thoroughly dissociated from the SPA layer by treatment with urea, and recombined to the
273 proximity to the scintillant embedded in the SPA beads, thereby allowing the radioactivity to be quan
274 s using intact CHO-Dukx/5-HT(6) cells in the SPA format was similar to data obtained from a filtratio
275 and rank order of potencies obtained in the SPA format were consistent with published filtration dat
276 that the effectiveness of inhibitors in the SPA is comparable to that obtained using MACP and a stan
277 , as determined by Z'=0.81+/-0.017, make the SPA format amenable to automation and higher throughput;
279 ive, sensitive high-throughput nature of the SPA format has advanced our knowledge of isoform-specifi
282 hese findings demonstrate the utility of the SPA technique to introduce plasmids into the haploid gen
284 y treatment with urea, and recombined to the SPA layer on the sensor surface for repeated immunoassay
291 2(-/-) mice failed to migrate in response to SPA but responded normally to TGFbeta1 and HA, effects t
292 and CD44(-/-) mice had similar responses to SPA, whereas those from RHAMM(-/-) mice had decreased ch
294 e of monomer nucleosomes as substrates using SPA technology could lead to more robust screening assay
296 r SPA-stimulated macrophage chemotaxis where SPA stimulation via TLR2 drives JNK- and ERK-dependent T
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