ライフサイエンスコーパス: SPARC

1 SPARC (Secreted Protein Acidic and Rich in Cysteine), is

2 SPARC (secreted protein acidic rich in cysteine) is an a

3 SPARC and myocilin mRNA expression were dramatically inc

4 SPARC and myocilin protein expression paralleled changes

5 SPARC binding does not distort the canonical triple heli

6 SPARC deficiency resulted in endoglin-mediated blockade

7 SPARC enhanced signaling by integrin-linked kinase (ILK)

8 SPARC expression in human adipose tissue correlated with

9 SPARC expression is increased in ACC samples by 1.56 +/-

10 SPARC expression was correlated with leptin independent

11 SPARC expression was measured by immunoblot.

12 SPARC in the stroma, but not in the tumor, was correlate

13 SPARC interacted directly with endoglin and reduced endo

14 SPARC is a matricellular protein often associated with f

15 SPARC is a matricellular protein that is highly expresse

16 SPARC is a matricellular protein that is involved in bot

17 SPARC is a regulatory node for IOP.

18 SPARC is known to be upregulated in the tumor microenvir

19 SPARC is not synaptogenic, but specifically antagonizes

20 SPARC is secreted at high levels by pancreatic stellate

21 SPARC is thus a novel regulator of microglial proliferat

22 SPARC levels were positively correlated with GSIS in isl

23 SPARC may be a downstream regulatory node of TGF-beta2-m

24 SPARC null/CX3CR1-GFP reporter mice reveal that SPARC re

25 SPARC overexpression decreased STAT3 phosphorylation; co

26 SPARC overexpression increased the IOP of perfused human

27 SPARC overexpression increases IOP in perfused cadaveric

28 SPARC production peaks when innervation of the rat super

29 SPARC recognizes the GVMGFO motifs of the middle and tra

30 SPARC reduced carcinogen-induced inflammation and accumu

31 SPARC retarded the morphological changes exhibited by pr

32 SPARC was expressed at measurable levels in human islets

33 SPARC was suppressed 31 +/- 13% (n = 5, P < 0.0001) by s

34 SPARC was upregulated by TGF-beta2 in the human TM cells

35 SPARC-like 1 (SC1) is a member of the SPARC family of ma

36 SPARC-null animals develop cataracts associated with a d

37 SPARC-null mice demonstrate a lower IOP resulting from i

38 SPARC-null mice demonstrated a more uniform outflow patt

39 SPARC-null mice had a 23% decrease in IOP.

40 SPARC-null mice have a 15% to 20% decrease in intraocula

41 SPARC-null mice have lower intraocular pressure (IOP).

42 SPARC-null mice have lower IOPs than do their WT counter

43 SPARC-Related Modular Calcium Binding Protein-2 (Smoc-2)

44 SPARC/Osteonectin (SP/ON) is implicated in the regulatio

45 ly poorer results (rmse 1.29 (ABSOLV), 1.25 (SPARC), and 1.62 (KOWWIN) log units).

46 he hematopoietic system is normal, HSCs in a SPARC-deficient niche show an accelerated return to quie

47 f cell lysates revealed enhanced levels of a SPARC-integrin beta1 complex during stress.

48 Monoclonal antibodies revealed a SPARC-like fragment generated from hevin that was co-loc

49 in 6 (IL-6) and supplemented IL-6-abrogated, SPARC-mediated suppression of Notch signaling and expres

50 ene target of Etv1 by luciferase assays, and SPARC and ETV1 proteins co-localized in vivo.

51 l gray and white matter in both controls and SPARC nulls.

52 Here, COSMOtherm and SPARC performed clearly better with an rmse of 0.35 and

53 and of lung metastasis mediators (FSCN1 and SPARC).

54 ecombinant leptin, insulin, and glucose, and SPARC mRNA and protein expression determined by Western

55 Hevin and SPARC are expressed by astrocytes in the superior collic

56 d two astrocyte-secreted proteins, hevin and SPARC, as regulators of excitatory synaptogenesis in vit

57 h regulation of relative levels of hevin and SPARC, astrocytes might control the formation, maturatio

58 tive models, ABSOLV, COSMOtherm, KOWWIN, and SPARC to calculate storage lipid-water partition coeffic

59 ese results identify hevin as a positive and SPARC as a negative regulator of synapse formation and s

60 We conclude that SC1 and SPARC may share significant homology, but are likely to

61 sive nephrotoxic nephritis in SPARC(+/+) and SPARC(-/-) mice.

62 ediating detachment, cultured SPARC(+/+) and SPARC(-/-) podocytes were subjected to mechanical strain

63 ARC expression has prognosticative value and SPARC is a potential therapeutic target for AML.

64 Passive microbead affinity for WT and SPARC-null ECM did not differ.

65 Eyes of C57BL6-SV129 WT and SPARC-null mice were injected with fluorescent microbead

66 e not significantly different between WT and SPARC-null mice.

67 nce of SPARC, age-matched wild-type (WT) and SPARC-null mice underwent either transverse aortic const

68 This may become clinically relevant, as SPARC inhibition and its protective effect on HSCs could

69 he data supporting this relationship between SPARC and nab-paclitaxel remain largely correlative at t

70 The mechanistic relationship between SPARC and TGF-beta2 in trabecular meshwork (TM) is unkno

71 The link betwen SPARC stromal deficiency and enhanced myeloid cell expan

72 t with Lat-B dramatically downregulated both SPARC and myocilin on 75 kPa hydrogels.

73 by metabolic parameters in these cells, but SPARC expression was not detectable in beta cells.

74 NA levels were reduced by 4MU treatment, but SPARC and CSPG6 mRNA levels were unaffected.

75 ibronectin, and laminin were not affected by SPARC overexpression.

76 ic single-cell microcultures is inhibited by SPARC.

77 pression in IPF fibroblasts was regulated by SPARC-mediated activation of Akt, leading to inhibition

78 ke by J774A.1 macrophages and high uptake by SPARC(+) B16F10 melanoma cells).

79 and Anatomy's Role in Coronary Artery [CAD] [SPARC]; NCT00321399).

80 In human prostate cancer, SPARC immunoreactivity is highest in metastatic lesions

81 In leukemia cells, SPARC expression was mediated by the SP1/NF-kappaB trans

82 Throughout the CNS, SPARC is highly localized in mature ramified microglia,

83 In conclusion, SPARC triggers a cell-autonomous program of synapse elim

84 In contrast, SPARC was downregulated in CN-AML patients harboring mut

85 e had fewer excitatory synapses; conversely, SPARC-null mice had increased synaptic connections in th

86 stroke in the forelimb sensorimotor cortex, SPARC nulls demonstrate enhanced microgliosis in and aro

87 n primary prostate tumorigenesis, we crossed SPARC-null (SP(-/-)) with TRAMP (Transgenic Adenocarcino

88 for SPARC in mediating detachment, cultured SPARC(+/+) and SPARC(-/-) podocytes were subjected to me

89 ecreted protein acidic and rich in cysteine (SPARC) and collagen-I and induction of complement activa

90 ecreted protein acidic and rich in cysteine (SPARC) being one of the most significant ones.

91 creted protein, acidic and rich in cysteine (SPARC) family matricellular protein, during invasive pha

92 ecreted protein acidic and rich in cysteine (SPARC) has been implicated in multiple aspects of human

93 ecreted protein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extr

94 ecreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that is important for

95 Secreted protein acidic rich in cysteine (SPARC) is a matricellular protein that modulates the act

96 ecreted protein acidic and rich in cysteine (SPARC) is important for the normal growth and maintenanc

97 ecreted protein acidic and rich in cysteine (SPARC) is up-regulated and expressed intracellularly in

98 ecreted protein acidic and rich in cysteine (SPARC) participates in the regulation of morphogenesis a

99 ecreted protein acidic and rich in cysteine (SPARC) plays a key role in post-synthetic procollagen pr

100 creted protein, acidic and rich in cysteine (SPARC) were among those substrates we biochemically conf

101 ecreted protein acidic and rich in cysteine (SPARC), a matricellular protein with counteradhesive pro

102 ecreted protein acidic and rich in cysteine (SPARC), a molecule produced by glial cells, is involved

103 ecreted Protein Acidic and Rich in Cysteine (SPARC), a protein involved in mammalian cardiac function

104 ecreted protein acidic and rich in cysteine (SPARC), although the data supporting this relationship b

105 ecreted protein acidic and rich in cysteine (SPARC), and CA19-9 levels in relation to efficacy.

106 creted Protein, Acidic and Rich in Cysteine (SPARC), originally discovered in bone as osteonectin, is

107 ecreted protein acidic and rich in cysteine (SPARC), which significantly stimulated the expression of

108 ecreted protein acidic and rich in cysteine (SPARC)-deficient mice exhibited decreased pericyte-assoc

109 reted Protein, Acidic, and Rich in Cysteine (SPARC)-null mice have a lower intraocular pressure.

110 ecreted protein acidic and rich in cysteine (SPARC).

111 ose tissue explants, while glucose decreased SPARC protein.

112 Decreasing SPARC expression using siRNA has been shown to decrease

113 dels revealed that tumor- and stroma-derived SPARC reduced tumor growth and metastasis through inhibi

114 ration by targeting CTGF which downregulates SPARC expression.

115 our approach improves contrast because each SPARC-targeting molecule delivers a large number of nano

116 ibroblasts that is characterized by elevated SPARC, giving rise to activated beta-catenin, which regu

117 can be rescued by the addition of exogenous SPARC.

118 Similarly, exogenous SPARC prevents IGF-1-induced survival of primary mouse i

119 pper binding domain of SPARC is required for SPARC-mediated response to stress.

120 To establish a causal role for SPARC in mediating detachment, cultured SPARC(+/+) and S

121 h peptide 4.2, a 20-aa sequence derived from SPARC that mimics full-length protein effects.

122 es for alkyl PAHs deviated increasingly from SPARC log K(OW) values with increasing degree of alkylat

123 Microglia from SPARC nulls also intrinsically proliferate at a greater

124 However, when we subject muscle from SPARC-deficient mice to an in vitro fatigue stimulation

125 oteoglycans - including fibulin, hemicentin, SPARC, agrin, and type XVIII collagen - are present in B

126 The matricellular SPARC family member hevin (SPARC-like 1/SPARCL-1/SC1/Mast9) contributes to neural d

127 distribution of hevin in human TM and hevin/SPARC in mouse anterior segments.

128 Furthermore, high SPARC promoter methylation negatively correlated with di

129 An adenoviral vector containing human SPARC was used to increase SPARC expression in human TM

130 ystal structure at 3.2 A resolution of human SPARC bound to a triple-helical 33-residue peptide harbo

131 nvasion of breast carcinoma cells identified SPARC, or secreted protein acidic and rich in cysteine.

132 4 integrin expression and signaling impacted SPARC expression and that SPARC facilitates beta4-mediat

133 The data implicate SPARC in the noncell autonomous control of cardiac funct

134 In SPARC knockout mice, we performed an injury study to inv

135 In SPARC-null mice, TAC increased LV mass to an extent simi

136 In addition, in SPARC-null mice, TAC increased fibrillar collagen conten

137 ations form an intramolecular salt bridge in SPARC and are essential for the binding of SPARC to coll

138 Collagen fibril diameter decreased in SPARC-null (28.272 nm) versus WT tissue (34.961 nm, P <

139 PEFL increased in SPARC-null (70.61 +/- 11.36%) versus WT mice (54.68 +/-

140 e alpha-, beta-, and gamma-actin isoforms in SPARC knockout myoblasts reveals a changed expression pa

141 myocardial diastolic stiffness was lower in SPARC-null TAC mice (0.075+/-0.005) than in WT TAC mice

142 servations show that homozygous mutations in SPARC can give rise to severe bone fragility in humans.

143 by inducing passive nephrotoxic nephritis in SPARC(+/+) and SPARC(-/-) mice.

144 Moreover, the preserved podocyte number in SPARC(-/-) mice correlates with reduced urinary levels o

145 ments suggest that aqueous turnover rates in SPARC-null mice are equal to if not greater than rates i

146 s ameliorated, and proteinuria is reduced in SPARC(-/-) mice as compared with SPARC(+/+) littermates.

147 ion of the SP1/NF-kappaB complex resulted in SPARC downregulation and leukemia growth inhibition.

148 IV, we identified two homozygous variants in SPARC (GenBank: NM_003118.3; c.497G>A [p.Arg166His] in i

149 containing human SPARC was used to increase SPARC expression in human TM endothelial cells and perfu

150 Increased SPARC can be detected in the serum of type 2 diabetes pa

151 d that leptin and insulin potently increased SPARC production dose dependently in visceral adipose ti

152 ture amoeboid myeloid precursors only induce SPARC expression after they cease proliferation and migr

153 TGF-beta2-induced SPARC expression was suppressed by inhibitors against p3

154 In islets, SPARC expression is highest in young mice, and is also e

155 kers, including laminin, J6(Hsp 47), and J31(SPARC, osteonectin) were expressed at lower levels in RA

156 capacity of this CRAd is driven by a 0.5-Kb SPARC promoter fragment (named F512).

157 While podocytes lacking SPARC were more resistant to stretch-induced detachment,

158 oss induced by very-low-calorie diet lowered SPARC expression by 33% and increased by 30% in adipose

159 subjects for analysis of metabolic markers, SPARC, and various cytokines (RT-PCR).

160 In WT mice, TAC increased LV mass, SPARC expression, myocardial diastolic stiffness, fibril

161 The matricellular SPARC family member hevin (SPARC-like 1/SPARCL-1/SC1/Mas

162 We measured SPARC expression by qRT-PCR in human primary pancreatic

163 FBI), interaction with the microenvironment (SPARC), retinoic acid signaling (RBP1), and the response

164 capable of processing and thereby modulating SPARC, a protein implicated in bone metastasis and infla

165 The selected mRNAs (IL-6, IL-8, myocilin, SPARC [secreted protein, acidic and rich in cysteine], m

166 The mRNAs of myocilin, SPARC, and MMP-3, which do not have AREs, were more stab

167 At night, SPARC-null mice also exhibited a blunted increase in IOP

168 The absence of SPARC reduced pressure overload-induced alterations in e

169 olic function are affected by the absence of SPARC, age-matched wild-type (WT) and SPARC-null mice un

170 t SC1 does not compensate for the absence of SPARC.

171 in K in regulation of biological activity of SPARC in bone metastasis.

172 The amount of SPARC secreted by skin fibroblasts was reduced in indivi

173 n TCP produced greater or similar amounts of SPARC and myocilin mRNA after Lat-B treatment.

174 n SPARC and are essential for the binding of SPARC to collagen type I.

175 nificantly reduced secretion and cleavage of SPARC.

176 The complexity of SPARC family proteins is further revealed by the detecti

177 es including cancer, but the contribution of SPARC to malignant growth remains controversial.

178 The degree of SPARC expression in BM stromal elements, including CD146

179 s segmental, and that transgenic deletion of SPARC causes a more uniform pattern that correlates with

180 indicated that the copper binding domain of SPARC is required for SPARC-mediated response to stress.

181 tein and the result of a gene duplication of SPARC.

182 herefore aimed to characterise the effect of SPARC on beta-cell function and features of diabetes.

183 S) in primary human islets and the effect of SPARC overexpression on GSIS in beta cell lines.

184 The profibrotic effects of SPARC may contribute to metabolic dysregulation in obesi

185 gether, our data indicate that evaluation of SPARC expression has prognosticative value and SPARC is

186 Furthermore, expression of SPARC decreased the production of interleukin 6 (IL-6) a

187 -induced detachment, stable re-expression of SPARC restored detachment rates to levels comparable wit

188 ned therapy attenuates in vivo expression of SPARC, increases microvessel density, and enhances drug

189 F silencing also decreased the expression of SPARC, phospho-FAK and FAK and overexpression of SPARC a

190 -regulated DNMTs and increased expression of SPARC, which led to tumor growth suppression in bone in

191 hs post-instillation to assess the impact of SPARC on multiple stages in the development of fibrosis.

192 tion, an effect which appears independent of SPARC's modulation of obesity-induced insulin resistance

193 Our results highlight a complex influence of SPARC over the stromal and hematopoietic BM response in

194 sminogen-mediated apoptosis by inhibition of SPARC or beta-catenin.

195 umor tissues, the frequency and intensity of SPARC expression were inversely correlated with disease-

196 During the day, the mean IOP of SPARC-null mice (n = 142, 16.9 +/- 2.4 mm Hg) was lower

197 The IOPs of SPARC-null mice, their corresponding wild-type (WT), and

198 injury study to investigate whether lack of SPARC would compromise the ability to repair muscle.

199 sa26(YFP);Cre;Etv1(fl/fl)) reduced levels of SPARC and hyaluronic acid in the stroma.

200 Our data suggest that levels of SPARC are reduced in islets from donors with diabetes an

201 tutively expressed increased basal levels of SPARC, plasminogen activator inhibitor-1 (PAI-1), and ac

202 wild-type littermates, we found that loss of SPARC accelerated the development of urothelial preneopl

203 Loss of SPARC was associated with an inflammatory phenotype of t

204 in Drosophila and suggest that modulation of SPARC gene expression may ameliorate cardiac dysfunction

205 C, phospho-FAK and FAK and overexpression of SPARC abrogated the inhibitory effect of CTGF silencing

206 w that adenoviral-mediated overexpression of SPARC cDNA (Ad-DsRed-SP) elevated the expression of the

207 Overexpression of SPARC in cultured beta-cells resulted in a 2.4-fold incr

208 h signaling is suppressed in the presence of SPARC, as well as the Notch effector basic helix-loop-he

209 action increased secretion and processing of SPARC, as did co-cultures of bone marrow stromal cells w

210 The coincident up-regulation of SPARC and cathepsin K occurred both in vivo in experimen

211 We then examined the relation of SPARC with glucose stimulated insulin secretion (GSIS) i

212 ed to the stromal compartment reminiscent of SPARC.

213 ray data, confirmed the expected reversal of SPARC gene suppression after treating HT-29 cells with 5

214 nteraction with actin suggests a new role of SPARC during tissue remodeling.

215 is protective effect is not due to a role of SPARC in HSCs, but rather is due to its function in the

216 ow, and IOP, indicating a modulatory role of SPARC in IOP regulation.

217 Accordingly, we elucidate the role of SPARC in mediating experimental crescentic glomeruloneph

218 To determine the role of SPARC in primary prostate tumorigenesis, we crossed SPAR

219 The role of SPARC in the in vivo lung response to crocidolite asbest

220 of this study was to investigate the role of SPARC in the regulation of beta cell growth and survival

221 The VWF-binding site overlaps those of SPARC (also known as osteonectin) and discodin domain re

222 eta4 ligation facilitates the translation of SPARC through a TOR-dependent mechanism.

223 6, P = 0.01 for mRNA), while upregulation of SPARC had no effect on TGF-beta2.

224 ving further support to the potential use of SPARC as a therapeutic candidate for medulloblastoma tre

225 g and/or activity of ILK, integrin beta1, or SPARC resulted in increased apoptosis of stressed LEC.

226 ar fragment approaches (EPISuite's KOCWIN or SPARC), poly parameter linear free energy relationship (

227 idolite asbestos in a series of wild-type or SPARC-null mice.

228 discriminates between hevin and its ortholog SPARC.

229 rotein, acidic, cysteine-rich (osteonectin) (SPARC) gene, which encodes a matricellular protein that

230 rophin, along with required binding partners SPARC/SPARCL1 and HSP90B, as key mediators of this chemo

231 Primary SPARC-deficient pericytes exhibited increased basal TGF-

232 es the stromal-derived matricellular protein SPARC as a novel regulator of islet survival and beta ce

233 We show that the matricellular protein SPARC contributes to the BM stromal response to myelopro

234 e implication of the multifunctional protein SPARC (Secreted protein acidic and rich in cysteine)/ost

235 Purified SPARC inhibits growth factor-induced signaling in both I

236 regulated tumor modulating genes GPX3, RBP1, SPARC, and TGFBI.

237 Specifically, recombinant SPARC inhibited (a) adipocyte differentiation of stromal

238 Finally, reducing SPARC gene dosage ameliorated the cardiomyopathy that de

239 is study demonstrate that beta4 can regulate SPARC expression and that SPARC is an effector of beta4-

240 c microglia rapidly downregulate and release SPARC at the lesion, concomitant with reactive, hypertro

241 n; constitutive expression of STAT3 reversed SPARC-mediated expression of neuronal markers.

242 of secreted protein, acidic, cysteine rich (SPARC), myocilin, angiopoietin-like factor (ANGPTL)-7, a

243 Secreted protein, acidic, cysteine-rich (SPARC) is a glycoprotein that binds to collagen type I a

244 , FBLN1, FHL1, FN, NKTR, OGN, PARVA, S100A6, SPARC, STC1 and ZEB1 proteins showed specific and varied

245 Furthermore, secreted SPARC activated the integrin-linked kinase/AKT (ILK/AKT)

246 ings demonstrate that both tumor and stromal SPARC are limiting for primary prostate tumorigenesis an

247 istinct contributions of tumoral and stromal SPARC to tumorigenesis and progression are unclear.

248 To determine the contribution of stromal SPARC, we evaluated subcutaneous tumor growth of TRAMP c

249 tor: nongerminal center B cell-like subtype, SPARC (secreted protein, acidic, and rich in cysteine) <

250 f a specific microRNA (miR-29a) that targets SPARC and impedes invasion.

251 engineered to display a peptide that targets SPARC glycoprotein, which is overexpressed in various ca

252 signaling impacted SPARC expression and that SPARC facilitates beta4-mediated invasion.

253 beta4 can regulate SPARC expression and that SPARC is an effector of beta4-mediated invasion.

254 -) mice and BM chimeras, we demonstrate that SPARC contributes to the development of significant stro

255 These results demonstrate that SPARC promotes pericyte migration by diminishing TGF-bet

256 Here we demonstrate that SPARC-deficient mice display higher resistance to serial

257 ct protein-protein interaction, we find that SPARC binds to actin.

258 We found that SPARC deficiency in the radioresistant BM stroma compart

259 Here, we found that SPARC overexpression is associated with adverse outcome

260 Importantly, we found that SPARC was epigenetically silenced in aggressive cells by

261 Therefore, we tested the hypothesis that SPARC in human adipose tissue is influenced by glucose m

262 These data support the hypothesis that SPARC plays a key role in post-synthetic procollagen pro

263 on these observations, we hypothesized that SPARC expression is clinically relevant in AML.

264 We hypothesized that SPARC overexpression would alter IOP by affecting extrac

265 We show using immunohistochemistry that SPARC is expressed by stromal cells within islets and ca

266 These results indicate that SPARC is produced by benign and malignant compartments o

267 Taken together, this study proves that SPARC plays a causal role in mediating podocyte detachme

268 In this paper, we report that SPARC promotes pericyte migration by regulating the func

269 We previously reported that SPARC expression significantly impairs medulloblastoma t

270 We previously reported that SPARC was among the most upregulated genes in cytogeneti

271 We have reported that SPARC-null mice accumulate significantly more fat than w

272 RC null/CX3CR1-GFP reporter mice reveal that SPARC regulates the distribution and branching of mature

273 We now show that SPARC inhibits adipogenesis in vitro.

274 Findings show that SPARC-induced neuronal differentiation can sensitize med

275 Our data suggest that SPARC expression is predominant in subcutaneous fat and

276 Taken together, our results suggest that SPARC induces expression of neuronal markers in medullob

277 in bone in vivo These findings suggest that SPARC plays a key role in maintaining the dormancy of pr

278 model of pancreatic cancer, suggesting that SPARC influences pericyte behavior.

279 in myopathies, which together suggests that SPARC might serve a specific role within muscle cells.

280 The hypothesis for the study was that SPARC contributes to the regulation of intraocular press

281 n levels and patterns are not altered in the SPARC null mouse, suggesting that SC1 does not compensat

282 collagen that was soluble was greater in the SPARC-null TAC mice (14+/-2%) than in WT TAC mice (1+/-2

283 collagen that was insoluble was less in the SPARC-null TAC mice (86+/-2%) than in WT TAC mice (99+/-

284 portance of addressing the complexity of the SPARC family and provides a new framework to explain the

285 SPARC-like 1 (SC1) is a member of the SPARC family of matricellular proteins that has been imp

286 LM of the SPARC-null iridocorneal angle revealed morphology that i

287 Therefore, SPARC appears to be an important modulator of the actin

288 Hevin is expressed in TM but, in contrast to SPARC, does not appear to be regulated by TGF-beta2.

289 In direct contrast to SPARC, however, FSTL-1 expression is reduced in pancreat

290 t activity, and have been directly linked to SPARC regulation.

291 creased STAT3 phosphorylation in response to SPARC expression.

292 TGF-beta2 upregulates SPARC expression in human TM through Smad-dependent (Sma

293 We hypothesized that TGF-beta2 upregulates SPARC expression in TM.

294 ertrophic perilesion astrocytes upregulating SPARC.

295 e upregulated genes were SNAI2, FGFBP1, VIM, SPARC (osteonectin), and SERPINE1, while the downregulat

296 TGF-beta2 did not induce hevin, whereas SPARC expression was induced in a dose-dependent manner

297 d detachment rates to levels comparable with SPARC(+/+) podocytes.

298 reduced in SPARC(-/-) mice as compared with SPARC(+/+) littermates.

299 6-ring parent PAHs, and correlated well with SPARC octanol/water coefficients (K(OW)) (correlation co

300 nal and nocturnal IOPs of C57Bl/6x129SvJ WT, SPARC-null, and heterozygous mice were measured.