ライフサイエンスコーパス: SPC

1 SPC activity in ONH lysate was significantly higher than

2 SPC and LPC bind to GPR4 in GPR4-transfected CHO cells w

3 SPC charts documented improvements in both outcomes.

4 SPC charts effectively monitor ongoing compliance and pa

5 SPC films plasticized with 40-50% glycerol showed a time

6 SPC flow prior to Fontan measured 1.5+/-0.9 L/min/m(2),

7 SPC number and intracellular content of hypoxia-inducibl

8 SPC recruitment and protein changes were inhibited by si

9 SPC was extracted from soybean flour, produced during th

10 SPCs and endothelial progenitor cells (EPCs) were isolat

11 SPCs exhibit testicular repopulating activity in vivo an

12 SPCs had high expression of beta1 integrin, moderate exp

13 SPCs performed only 18% of these operations (15,002).

14 tisfaction with SPC availability (P < .001), SPC acceptance of patients receiving chemotherapy (P < .

15 ediatric appendectomies were performed in 21 SPCs and 183 DGHs in England.

16 any and 7,560 in Sweden, overall 752 and 349 SPCs were recorded, respectively.

17 sexD3 was recruited for biosynthesis of 3UFA SPCs in M. sexta lineage via gene duplication and neofun

18 dreds (at baseline, 370 FPC kindreds and 468 SPC kindreds).

19 8.6 x 10,000 PY), and 22 of them developed a SPC (annual incidence: 3.9 x 10,000 PY).

20 The annual incidence of a SPC in the transplanted patients who developed a first c

21 ype and presence of a fenestration, absolute SPC flow was significantly associated with hospital dura

22 In addition, SPC treatment, but not genistin treatment, significantly

23 or gene Trp53(F/F) mice infected with Adeno5-SPC-Cre and Adeno5-CC10-Cre viruses displayed difference

24 sing a bleomycin model of lung injury and an SPC-driven inducible cre to fate-map AECs, we found the

25 s a homolog of the mammalian PC2 protein, an SPC that functions in the regulated secretory pathway in

26 han that of retinal lysate; however, when an SPC inhibitor was added, activity in ONH decreased more

27 with SPC service availability (P < .001) and SPC service acceptance of patients on chemotherapy (P <

28 of ClayFF, constant-valence force field, and SPC water model.

29 Mice treated with genistin and SPC had reduced final tumor weights by 56% (P < 0.05) an

30 -transformed duration of hospitalization and SPC flow as a proportion of total aortic (rho=0.31, P=0.

31 Da secretory protein (CC10+) airway-like and SPC+ saccular structures within 6 days.

32 integrin profile of vascular progenitors and SPC adhesion to extracellular matrix (ECM) proteins in v

33 athology results (rho = 0.87; P < .001), and SPCs correlated with histopathology results (rho = 0.88;

34 s to observe and characterize Dirac WGMs and SPCs, and speculate that these features can potentially

35 rranted to apply soy phytochemicals, such as SPC, as a potent prevention regimen for bladder cancer p

36 genotyping, an approach that we refer to as SPC-SBE.

37 thetic templates, an approach we refer to as SPC-sequencing.

38 participate in an anonymous survey assessing SPC referral practices.

39 ractor muscles and in the spicule-associated SPC and PCB cholinergic neurons.

40 ency included comprehensiveness of available SPC services (P = .004), satisfaction with SPC availabil

41 ck from mTORC1 to the GDNF receptor balances SPC growth with self-renewal.

42 e sought to evaluate the association between SPC flow and acute post-Fontan clinical outcomes using a

43 light of the functional similarities between SPC proteins, we developed a membrane protein fragmentat

44 BM SPC recruitment is a repair response to dimethylnitrosam

45 uitment of SPCs was analyzed by examining BM SPC proliferation, mobilization to the circulation, engr

46 soidal endothelial cell progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endoth

47 ays, 40% of all LSECs came from engrafted BM SPCs.

48 After partial hepatectomy, BM SPCs provide hepatocyte growth factor, promote hepatocyt

49 t, bone marrow progenitor cells of LSECs (BM SPCs), which are rich in HGF, are recruited to the liver

50 th factor (VEGF) regulates recruitment of BM SPCs and their effects on liver injury.

51 ethylnitrosamine-induced proliferation of BM SPCs and their mobilization to the circulation, reduced

52 Hepatic VEGF regulates recruitment of BM SPCs to liver and reduces this form of liver injury.

53 s in the bone marrow, and mobilization of BM SPCs to the circulation increased 2- to 4-fold by 24 hou

54 Proliferation of BM SPCs, the number of SPCs in the bone marrow, and mobiliz

55 er regeneration from the perspective that BM SPCs that have been recruited to the liver, rather than

56 mong week-to-week assessments of blood-borne SPC HIF factors.

57 demonstrated that the number of blood-borne SPCs and the cellular content of HIFs at study entry and

58 We conclude that both SPC-expressing alveolar type 2 cells and CC10-expressing

59 , migration, and tube formation through both SPC-dependent and -independent pathways.

60 Furthermore, both SPCs and MASCs express GPR125, an orphan adhesion-type G

61 ce reduces processing time for genotyping by SPC-SBE and allows direct spotting of sample for rapid a

62 trating the significant advantage offered by SPC-sequencing for the accurate identification of frames

63 Oxidative stress from lactate metabolism by SPCs accelerated further SPC recruitment and differentia

64 ly in the lungs from a surfactant protein C (SPC) promoter (SPC-GM(+/+)/GM(-/-)).

65 ng epithelium from the surfactant protein C (SPC) promoter were generated to investigate the role of

66 -RasG12D expression in Surfactant Protein C (SPC)(+) alveolar type 2 cells and in Clara cell antigen

67 -dipole recoupling sequences-DRAWS, POST-C7, SPC-5, R1, and R2-are compared.

68 atic cancer, and sporadic pancreatic cancer (SPC) kindreds as families without such an affected pair.

69 ed the incidence of a second primary cancer (SPC) in 7,636 patients who underwent a kidney, liver, lu

70 ribution and risk of second primary cancers (SPCs) in multiple myeloma (MM) survivors in Germany and

71 uencing method using solid-phase capturable (SPC) dideoxynucleotides and MALDI-TOF mass spectrometry

72 otyping method using solid phase capturable (SPC) dideoxynucleotides and single base extension (SBE),

73 feasibility of using solid phase capturable (SPC) dideoxynucleotides to generate single base extensio

74 CD34(+) SPCs from lactate-supplemented Matrigel exhibited signif

75 There were over one million CD34(+) SPCs per Matrigel plug 18 h after Matrigel implantation,

76 Using spermatogonial progenitor cells (SPCs) as a model system, we show that mTORC1 impairs ste

77 ative adult spermatogonial progenitor cells (SPCs) can be efficiently obtained by cultivation on mito

78 circulating smooth muscle progenitor cells (SPCs) in human peripheral blood.

79 iation of circulating stem/progenitor cells (SPCs) in subcutaneous Matrigel in mice was assessed.

80 sized that studies of stem/progenitor cells (SPCs) in the early weeks of standard wound management co

81 We observed that CML stem/progenitor cells (SPCs) produce tumor necrosis factor-alpha (TNF-alpha) in

82 rvival signals to CML stem/progenitor cells (SPCs) with contradictory results.

83 f postnatal spermatogonial progenitor cells (SPCs).

84 circulating smooth muscle progenitor cells (SPCs).

85 BAL cells, SPC, and PC were stimulated either with live attenuated

86 , failed to induce this effect on BAL cells, SPC, and PC.

87 models [i.e., extended simple point charge (SPC/E) vs. four-site transferrable intermolecular potent

88 ding yeast, the spindle position checkpoint (SPC) delays mitotic exit until the mitotic spindle moves

89 The spindle position checkpoint (SPC) ensures correct mitotic spindle position before all

90 ay known as the spindle position checkpoint (SPC) to ensure the arrival of one end of the mitotic spi

91 ircuit components, including the cholinergic SPC and PCB and the glutamatergic PCA sensory-motor neur

92 Evidence for circulating SPCs in human subjects does not exist, and the mechanism

93 The tunable binary citrem/SPC nanoplatform holds promise for future development of

94 hway as a relevant therapeutic target in CML SPCs and endorse the current use of nilotinib in combina

95 Furthermore, we demonstrate that in CML SPCs, inhibition of autocrine TNF-alpha signaling via a

96 highlight a novel survival mechanism of CML SPCs and suggest a new putative therapeutic target for t

97 a and found that it supports survival of CML SPCs by promoting nuclear factor kappaB/p65 pathway acti

98 s correlated with increased apoptosis of CML SPCs in vitro and a reduction in primitive quiescent CML

99 f systemic-to-pulmonary arterial collateral (SPC) vessels in single ventricle patients are poorly und

100 Systemic-pulmonary collateral (SPC) flow occurs commonly in single ventricle patients a

101 We have compared SPC-sequencing with electrophoresis-based sequencing in

102 ic subunits is the signal peptidase complex (SPC) in the mammalian endoplasmic reticulum.

103 bjected to a supervised principal component (SPC) analysis to predict progression-free survival (PFS)

104 RCC-specific supervised principal component (SPC) risk score prognostic gene signature was constructe

105 y the molecular basis of novel SP component (SPC) acquisition, we used the tobacco hornworm (Manduca

106 Availability of comprehensive SPC, especially for patients receiving chemotherapy, and

107 oflavone-rich soy phytochemical concentrate (SPC) on the growth and metastasis of 253J B-V tumors in

108 coacervation of soybean protein concentrate (SPC) by using calcium salts and spray-drying.

109 l properties of soybean protein concentrate (SPC) films, plasticized with varying levels of glycerol

110 Baseline statistical process control (SPC) charts were created and mean errors per administrat

111 proach based on statistical process control (SPC), which is able to monitor the response to a treatme

112 luated by using statistical process control (SPC).

113 an subtilisin-related proprotein convertase (SPC), is emerging as an important pharmaceutical target

114 by a subtilisin-like proprotein convertase (SPC).

115 Subtilisin-like proprotein convertases (SPCs) are a family of calcium-dependent cleavage enzymes

116 t by subtilisin-like proprotein convertases (SPCs) in constitutive or regulated secretory pathways.

117 y of subtilisin-like proprotein convertases (SPCs).

118 d by subtilisin-like proprotein convertases (SPCs).

119 y of subtilisin-like proprotein convertases (SPCs).

120 opsy samples using stereologic point counts (SPCs).

121 e an emerging class of soft porous crystals (SPCs) with potential for high working capacity for gas s

122 ), also referred to as soft porous crystals (SPCs), show reversible structural transitions dependent

123 enceforth the term superpersistent currents (SPCs).

124 p-angle cycled (SFC), rf pulse phase cycled (SPC), and pulsed field gradient (PFG) strength cycled (S

125 GPR4 in GPR4-transfected CHO cells with K(d)/SPC = 36 nm, and K(d)/LPC = 159 nm, respectively.

126 thesized that embolization acutely decreases SPC flow and increases systemic blood flow (Q(S)).

127 In differentiating SPCs, Sall4 levels transiently increase and Sall4 physic

128 substrate-based assay was used to elucidate SPC enzyme activity within human retina and optic nerve

129 garding compliance with guidelines employing SPC charts.

130 olish the effects of extracellular D-erythro-SPC (10 microM) or liposomes containing 100 microM D-ery

131 D-erythro-SPC (dissolved in dimethyl sulfoxide but not coupled to

132 ever, administration of 100 microM D-erythro-SPC and IP3 entrapped in the same liposomes enhanced the

133 D-erythro-SPC and L-threo-SPC at the concentration of 100 microM i

134 o the same magnitude as 100 microM D-erythro-SPC entrapped in liposomes.

135 D-erythro-SPC treatment did not significantly change the median am

136 or liposomes containing 100 microM D-erythro-SPC.

137 cle embolization of angiographically evident SPC vessels.

138 d solid phase capture-single base extension (SPC-SBE) method.

139 vitro assays indicated that MMP8 facilitated SPC migration across endothelial cells and through Matri

140 arrows of ApoE(-/-)/MMP8(-/-) mice had fewer SPCs in atheromas and smaller lesions than ApoE(-/-)/MMP

141 ned by intracoronary infusion of fluorescent SPCs into porcine coronary arteries containing a fibrone

142 In addition, a fluorogenic SPC substrate-based assay was used to elucidate SPC enzy

143 sponse to GDNF, a growth factor critical for SPC self-renewal, via negative feedback at the level of

144 g Plzf, a transcription factor essential for SPC maintenance, have enhanced mTORC1 activity.

145 Similar associations exist for SPC flow as a percentage of total aortic (OR=1.09, P=0.0

146 mologue GPR4 is a high affinity receptor for SPC with low affinity for lysophosphatidylcholine (LPC).

147 tor 1 (OGR1) is a high affinity receptor for SPC, and its closely related homologue GPR4 is a high af

148 an intrachain disulfide bond is required for SPC-mediated cleavage and that SPC-mediated cleavage is

149 n ER-retention signal, a target sequence for SPCs in the reactive site loop, and the in vitro inhibit

150 The biological effects resulting from SPC/GPR4 interactions involve the activation of both pho

151 re smooth muscle outgrowth cells (SOCs) from SPCs in human peripheral blood and characterize surface

152 of such cells with culture supernatant from SPCs without MMP8 knockdown, and this compensatory effec

153 ctate metabolism by SPCs accelerated further SPC recruitment and differentiation through Trx1-mediate

154 Long-term cultures of GPR125+ SPCs (GSPCs) also converted into GPR125+ MASC colonies.

155 All patients who had SPC flow quantified by CMR imaging before Fontan were re

156 An important question is how SPC activity is coordinated with mother-daughter polarit

157 that, in contrast to the tested hypothesis, SPC catalytic subunits exhibit overlapping substrate spe

158 These results identify SPC and its receptor, GPR4, as critical regulators of th

159 creased bronchioles and dilated airspaces in SPC-PDGFA transgenic mice.

160 dditionally, this proliferative capacity (in SPC and PC populations) was significantly enhanced upon

161 ion, demonstrating a significant decrease in SPC flow and Q(P):Q(S) and increase in Q(SVC) and Q(S).

162 lization, we found a significant decrease in SPC flow of 0.9 (range, 0.6-1.3) L/(min.m(2)) (P=0.03);

163 he spontaneous lung inflammation observed in SPC-TSLP mice reflects a TSLP-driven predisposition towa

164 metalloproteinase-8 (MMP8) played a role in SPC migration and their recruitment into atheromas.

165 MMP8 plays an important role in SPC migration and their recruitment into atherosclerotic

166 Postoperative length of stay was double in SPCs compared with DGHs (median, 4 vs 2 days).

167 ve appendectomy rates than those operated in SPCs.

168 ons, and 11% more readmissions than those in SPCs.

169 ERK1/2 induced by several stimuli, including SPC, sphingosine-1-phosphate, and even EGF.

170 Increasing SPC flow before Fontan, as measured by CMR imaging, is a

171 own-regulation of GPR4 specifically inhibits SPC-, but not sphingosine-1-phosphate-, or vascular endo

172 forms a noncovalent latent complex with its SPC-cleaved prodomain and that this latent complex is ac

173 xtracellular application of SPC mixture (D,L-SPC) at 1, 10, and 25 microM increased the MEPP frequenc

174 Primary GPR125-LacZ SPC lines retained GPR125 expression, underwent clonal e

175 on of mouse oocytes with the GPR3/12 ligands SPC and S1P delayed spontaneous oocyte maturation.

176 mbedded human posterior sections to localize SPC family members.

177 More detailed analysis of Adora2b(loxP/loxP) SPC Cre(+) mice confirmed elevated lung inflammation and

178 disease susceptibility in Adora2b(loxP/loxP) SPC Cre(+) mice.

179 lveolar epithelial cells (Adora2b(loxP/loxP) SPC Cre(+)) revealed a selective increase in disease sus

180 epithelial cell-specific Cre transgenic mice SPC-rtTA/TetO-Cre and floxed-Alk3 mice.

181 liposomes, in which 10, 100, or 1000 microM SPC mixture was entrapped in liposomal aqueous phase, in

182 More SPCs entered the bloodstream in the first 2 weeks of car

183 Moreover, SPCs showed increased adherence to fibronectin and colla

184 type MMTV mice and a triple transgenic mouse SPC-rtTA(+/-)TetoCre(+/-)LoxP-VEGF-A(+/+) to conditional

185 In addition, neither SPC nor LPC stimulated the binding of GTPgammaS to membr

186 ity of ligand binding, we found that neither SPC nor LPC, or other related lysophospholipids, induced

187 A degree of toxicity toward normal SPCs was observed with the combination treatment, althou

188 of a Sca1 promoter yielded CC10(+), but not SPC(+), hyperplasias, and adenomas.

189 njugation of low-molecular-mass O-SP-core (O-SPC) fragments.

190 ced in young outbred mice by the S. sonnei O-SPC conjugates were significantly higher then those elic

191 The O-SPC conjugates used oxime linkages between the terminal

192 The O-SPC fragments were bound by their reducing ends similar

193 ECT 475) in order to evaluate the ability of SPC to encapsulate and protect bacteria from stress cond

194 ction of GPR4 fully restores the activity of SPC.

195 hesis of the first photoaffinity analogue of SPC.

196 Extracellular application of SPC mixture (D,L-SPC) at 1, 10, and 25 microM increased

197 Here, we report the application of SPC-sequencing in characterizing frameshift mutations by

198 e amino group at C2 of the sphingoid base of SPC analogue 2.

199 Moreover, the effects of SPC on EC require SPC induced trans-phosphorylation and

200 R4 is required for the biological effects of SPC on endothelial cells (EC).

201 erve-muscle preparations, and the effects of SPC on neurosecretion in the form of miniature endplate

202 The acute efficacy of SPC embolization has not been demonstrated in a quantifi

203 We sought to assess the acute efficacy of SPC embolization on blood flow as quantified by phase co

204 We report on the acute efficacy of SPC embolization, demonstrating a significant decrease i

205 and adenomas, but not for the generation of SPC(+) ATII lesions.

206 as undertaken to evaluate the involvement of SPC in transmitter release process.

207 he simple rapid screening of a wide range of SPC mediated organic reactions.

208 study does not indicate an increased risk of SPC in transplanted subjects who already suffered a firs

209 lveolar hyperplasias, exclusively made up of SPC(+) ATII cells, progressed to yield malignant adenoca

210 hat MMP8 deficiency inhibited the ability of SPCs to migrate from the arterial lumen and the adventit

211 The decrease in migratory ability of SPCs with MMP8 knockdown was reduced by incubation of su

212 he expression, localization, and activity of SPCs in the human retina and optic nerve head.

213 tance of integrins in mediating adherence of SPCs to specific ECM both in vitro and in vivo.

214 We conclude that assays of SPCs during the first weeks of care in patients with DFU

215 Homing of SPCs in vivo to specific ECM protein was determined by i

216 actate concentration increased the number of SPCs by 3.6-fold.

217 Proliferation of BM SPCs, the number of SPCs in the bone marrow, and mobilization of BM SPCs to

218 uman testis could enrich for a population of SPCs for derivation of GPR125+ MASCs, which may be emplo

219 Recruitment of SPCs was analyzed by examining BM SPC proliferation, mob

220 that Spn4.1 is an intracellular regulator of SPCs.

221 eden to provide etiological understanding of SPCs and insight into their incidence rates and recordin

222 sintegrin-and-metalloproteinase-domain-10 on SPCs.

223 r GI254023X decreased E-cadherin shedding on SPCs.

224 However, only SPC(+) alveolar type II (ATII) cells were able to form h

225 However, in adult mice, only SPC(+) ATII cells were able to yield malignant adenocarc

226 xture of citrem and soy phosphatidylcholine (SPC) at different weight ratios, we describe a library o

227 The semiconductor photocatalyzed (SPC) oxidation of toluene is performed inside an NMR spe

228 micked in its biological effects by ATX plus SPC.

229 Aberrant mTORC1 activation in Plzf(-/-) SPCs inhibits their response to GDNF, a growth factor cr

230 eta4, but little or no pro-surfactant C (pro-SPC), is endowed with regenerative potential.

231 ession of the type II epithelial marker, pro-SPC.

232 LP transgene (surfactant protein C promoter (SPC)-TSLP) develop a spontaneous and progressive asthma-

233 from a surfactant protein C (SPC) promoter (SPC-GM(+/+)/GM(-/-)).

234 Prospective SPC charts were used to measure the effect of guideline

235 adhesion, and integrin profile from putative SPC in human blood.

236 ist, and the mechanism whereby such putative SPCs may home to sites of plaque formation is presently

237 outcomes using a novel method of quantifying SPC flow by cardiac magnetic resonance (CMR) imaging.

238 and that MMP8 knockout significantly reduced SPC numbers in atherosclerotic lesions in apolipoprotein

239 Moreover, the effects of SPC on EC require SPC induced trans-phosphorylation and activation of the

240 Allogeneic resident SPCs, infused 24 hours after injection of dimethylnitros

241 Results SPC analysis allowed stratification based on 11 features

242 SIRs) were used to assess risk of a specific SPC compared to risk of the same first cancer in the cor

243 A SOMA for the CCRCC-specific SPC prognostic gene signature that is predictive of dise

244 nder the control of lung epithelial-specific SPC promoter was produced.

245 Significantly elevated SIRs of specific SPCs were observed for acute myeloid leukemia (AML; SIR

246 -phosphate, and sphingosylphosphorylcholine (SPC), are bioactive lipid molecules that regulate divers

247 pids, including sphingosylphosphorylcholine (SPC), that are putative signaling molecules.

248 that the lipid sphingosylphosphorylcholine (SPC) induces angiogenesis in vivo and GPR4 is required f

249 lipid mediator sphingosylphosphorylcholine (SPC) has not yet been identified.

250 specificity to sphingosylphosphorylcholine (SPC), which ATX hydrolyzes to sphingosine-1-phosphate (S

251 dent peritoneal cells (PC), and splenocytes (SPC).

252 n for the production of S1P has a substrate (SPC) K(m) = 0.23 +/- 0.07 mM.

253 inner membrane peptidase catalytic subunits, SPC catalytic subunits exhibit nonoverlapping substrate

254 required for SPC-mediated cleavage and that SPC-mediated cleavage is essential to protein function.

255 preexisting type II AECs, demonstrating that SPC- progenitor cells replenished type II AECs during re

256 the first electrophysiological evidence that SPC can modulate transmitter release by an extra- or int

257 ally HIF-1 null myeloid cells indicated that SPC recruitment and lactate-mediated effects were depend

258 Ninety-four percent reported that SPC was available to them, but only 37% reported that th

259 Results show that SPC is a feasible material for the development of probio

260 Collectively, our results suggest that SPC and LPC are not the ligands for GPR4 and that this r

261 like growth factor-I levels, suggesting that SPC may contain other bioactive ingredients that have an

262 We find that SPCs lacking Plzf, a transcription factor essential for

263 We found that SPCs in atheromas expressed MMP8 and that MMP8 knockout

264 The SPC motor neurons trigger prolonged contraction through

265 med the relationship between the RRS and the SPC gene signature (R = 0.45, P < .001, classification a

266 we identified bud2Delta as deficient for the SPC.

267 based on the X -S charts generated from the SPC charts.

268 d-type males, GAR-3(mAChR) expression in the SPC and PCB neurons is required for the male to sustain

269 ings reveal a novel function for Elm1 in the SPC and suggest how checkpoint activity may be linked to

270 nce interval (CI), 4.5-16.1], but not in the SPC kindreds (1.8; 95% CI., 0.22-6.4).

271 protraction can be suppressed by killing the SPC motor neurons and the anal depressor muscle: cells t

272 s and single base extension (SBE), named the SPC-SBE, has been developed for mutation detection.

273 The performance of the SPC analysis (OS: IBS, 0.149; C index, 0.654; PFS: IBS,

274 The performance of the SPC analysis model was further improved when combined wi

275 mRNA expression of the SPC family in the human retina and optic nerve head tiss

276 ell-characterized, much less is known of the SPC receptors.

277 This result shows that the incidence of the SPC was the same as the incidence of a first cancer.

278 kinase Elm1 is an obligate regulator of the SPC, and this function requires localization of Elm1 to

279 Expression of the SPC-PDGFA transgene resulted in an enlarged, nonfunction

280 We report here the expanding of the SPC-SBE method as a single-tube assay to simultaneously

281 o explore the high multiplexing scope of the SPC-SBE method.

282 ength polymorphism method indicated that the SPC-SBE method is superior for detecting nucleotide vari

283 t dataset to confirm its relationship to the SPC gene signature (n = 70) and determination of patient

284 of the human p53 gene in one tube using the SPC-SBE method.

285 te IR and isotropic Raman spectra, using the SPC/E simulation model, and the results are in good agre

286 of a Cox proportional hazards model with the SPC analysis predictor was assessed with C index and int

287 , Spn4.1 forms SDS-stable complexes with the SPC furin and directly inhibits it.

288 The RRS scaled with the SPC gene signature (R = 0.57, P < .001, classification a

289 These results indicate that the SPCs are expressed in distinct patterns throughout the h

290 A striking finding is that the SPCs can be attributed to a robust type of relativistic

291 orm noncovalent, latent complexes with their SPC-cleaved prodomains.

292 D-erythro-SPC and L-threo-SPC at the concentration of 100 microM increased the MEP

293 ed to bovine serum albumin), but not L-threo-SPC, was active extracellular; the former (at 10 microM)

294 hat GPR4 is a receptor with high affinity to SPC and low affinity to LPC, and that multiple cellular

295 Oncologists referred patients frequently to SPC, but generally late in the disease course for patien

296 One third would refer to SPC earlier if it was renamed supportive care.

297 cavopulmonary connection patients underwent SPC flow quantification by phase contrast magnetic reson

298 e SPC services (P = .004), satisfaction with SPC availability (P < .001), SPC acceptance of patients

299 ather than later, included satisfaction with SPC service availability (P < .001) and SPC service acce

300 d to interact directly and specifically with SPC and in the definition of the ligand-binding sites.

301 e correlated the (1)H-MRS PDFF findings with SPCs (r = 0.92; P < .001).