ライフサイエンスコーパス: SPD

1 SPD has stereoselective PK and PD.

2 SPD stereoisomers (141 or 283 mg/kg) did not cause NTD.

3 SPD stereoisomers' anticonvulsant activity was comparati

4 SPD stereoisomers' PK-PD relationship was evaluated in r

5 SPD-1 differs from other midzone components in that it i

6 SPD-1 is a conserved microtubule-bundling protein that l

7 SPD-2 and SPD-5 are codependent for localization to the

8 SPD-304 may employ a similar mechanism of inhibition.

9 SPD-5 exists mostly as a monomer but also forms complexe

10 SPD-5 is required for the centrosomal localization of ga

11 carboranylbutyl) SPD/SPM derivatives (SPD-1, SPD-5, SPM-1, SPM-5); N1,N10-diethyl-N5-(4-carboranylbut

12 suggest that the interactions between SPD-2, SPD-5, and PLK-1 do not result in formation of cytoplasm

13 (2S,3S)-SPD, (2R,3R)-SPD, and racemic-SPD have similar anticonvulsant activit

14 (2R,3S)-SPD and (2S,3R)-SPD higher clearance led to a 50% lower plasma exposure

15 better than those of (2R,3S)-SPD and (2S,3R)-SPD, making them good candidates for development as new,

16 (2R,3S)-SPD and (2S,3R)-SPD higher clearance led to a 50% lower

17 rofile that are better than those of (2R,3S)-SPD and (2S,3R)-SPD, making them good candidates for dev

18 (2S,3S)-SPD, (2R,3R)-SPD, and racemic-SPD have similar anticonvu

19 r factor V Quebec, alpha delta-SPD, or alpha-SPD (gray platelet syndrome).

20 the centriole duplication factors ZYG-1 and SPD-2.

21 PCM assembly in vivo, Polo-like kinase-1 and SPD-2/Cep192.

22 SPD-2 and SPD-5 are codependent for localization to the PCM, but S

23 r in schizophrenic (1.22 +/- 0.24 cm(3)) and SPD (1.20 +/- 0.23 cm(3)) patients than controls (1.37 +

24 s between the coiled-coil proteins SPD-5 and SPD-2 and the kinase PLK-1 are critical for PCM assembly

25 We measured CC16 and SPD in sputum supernatants of 84 asthmatic patients and

26 CC16 and SPD levels are upregulated in SRA and correlate with rem

27 sthmatics, we additionally measured CC16 and SPD levels in BAL and assessed smooth muscle area (SMA),

28 BAL CC16 and SPD levels were also higher in SRA compared to mild-mode

29 Induced sputum CC16 and SPD were significantly higher in patients with severe as

30 acts genetically with dynein heavy chain and SPD-5, another coiled-coil protein required for centroso

31 levels of BrdU incorporation in the PUT and SPD microcosms, but not in the CTRs.

32 of FACS-sorted cells indicated that PUT- and SPD-transforming bacteria were composed similarly of a d

33 doxovir, elvucitabine, Racivir, Reverset and SPD 754 are nucleoside reverse transcriptase inhibitors

34 Schizophrenic and SPD patients have volume reduction in the pulvinar, but

35 Our observations suggest that the SPV and SPD and their associated dopamine-containing socket cell

36 We show that the SPV and SPD spicule-associated sensory neurons and the spicule s

37 , and HD were also apparent, whereas TTM and SPD were largely influenced by the same latent genetic f

38 orders, and another was exclusive to TTM and SPD.

39 second factor loaded exclusively on TTM and SPD.

40 ministration of the AMPA receptor antagonist SPD 502 significantly reduced the amount of AMPA-induced

41 as a member of a novel family of ASH (ASPM, SPD-2, Hydin) domains.

42 hich interact with the ASH-RhoGAP-like (ASPM-SPD-2-Hydin homology and Rho-GTPase Activating Domain-li

43 Only the assembled SPD-5 networks, and not unassembled SPD-5 protein, funct

44 esults suggest that the interactions between SPD-2, SPD-5, and PLK-1 do not result in formation of cy

45 henomenological and comorbid overlap between SPD and trichotillomania-these disorders likely share ov

46 We also show that SAS-7 binds SPD-2 and regulates SPD-2 centriolar recruitment, while

47 215, and Aurora A kinase family members, but SPD-5 accumulates at centrosomes in mutants lacking thes

48 codependent for localization to the PCM, but SPD-2 localizes to centrioles independently of SPD-5.

49 cy for the 5' HOXD genes causes not SHFM but SPD and point to the presence of a novel locus for SHFM

50 usly reported for N5-[4-(o-carboranyl)butyl] SPD/SPM derivatives (SPD-5 and SPM-5) but similar to tho

51 the most relevant amine was PUT, followed by SPD, HIS, TYR, CAD, SPM, PHE, and SER, with the total BA

52 fee brews, the order was PUT, SPM, TYR, CAD, SPD, PHE, HIS, and SER, but at a very low level in compa

53 synthesized: N1- and N5-(4-carboranylbutyl) SPD/SPM derivatives (SPD-1, SPD-5, SPM-1, SPM-5); N1,N10

54 iated in some cases with features of classic SPD and in all cases with a novel foot phenotype.

55 n each of these parameters (CPT-AC, MTH-CVc, SPD-CVc) was used to identify NCD independently.

56 Surfactant protein D (SPD) plays an important role in surfactant homeostasis a

57 protein was made from surfactant protein D (SPD), HIV-1 Gag as a test antigen, and CD40L, where SPD

58 instrument--the Survey of the Previous Day (SPD)--to quantify MMM as well as media-nonmedia and nonm

59 is 1 of 13 platelet storage pool deficiency (SPD) mouse mutants.

60 es on patients with storage pool deficiency (SPD) who are specifically deficient in platelet dense gr

61 ha delta, and delta storage pool deficiency (SPD), thrombasthenia, and in two new patients with isola

62 ing due to platelet storage pool deficiency (SPD).

63 via changing the severe plastic deformation (SPD) processing pathway.

64 t described for factor V Quebec, alpha delta-SPD, or alpha-SPD (gray platelet syndrome).

65 hesion defect by RBCs was specific for delta-SPD; it was not observed in either von Willebrand's dise

66 deficient in platelet dense granules (delta-SPD) have suggested a role for dense granule substances,

67 sponse to all agonists was impaired in delta-SPD and was associated with an inability of these platel

68 effect of RBCs on platelet adhesion in delta-SPD appears to be chemical rather than physical in natur

69 impaired prothrombinase activation in delta-SPD platelets were corrected by the addition of adenosin

70 ysis of the type of adhesion defect in delta-SPD suggest that ADP may be involved in the process requ

71 e more complicated Previous studies in delta-SPD suggested an adhesion defect that was strongly influ

72 in platelet adhesion in patients with delta-SPD, most significantly at Hct values of 30% to 40%.

73 n normal subjects and in patients with delta-SPD.

74 e study of selective peripheral denervation (SPD) in cervical dystonia (CD) patients with primary or

75 N5-(4-carboranylbutyl) SPD/SPM derivatives (SPD-1, SPD-5, SPM-1, SPM-5); N1,N10-diethyl-N5-(4-carbor

76 [4-(o-carboranyl)butyl] SPD/SPM derivatives (SPD-5 and SPM-5) but similar to those of native SPD and

77 Substance P derivatives (SPDs) induced apoptosis and inhibited growth of lung can

78 istory within the solar protoplanetary disk (SPD).

79 s released by Shockley partial dislocations (SPDs) accompanied by the formation of stacking faults.

80 n men with schizotypal personality disorder (SPD) compared with healthy control (HC) subjects.

81 Schizotypal personality disorder (SPD) shares social deficits and cognitive impairment wit

82 s, 12 with schizotypal personality disorder (SPD), and 12 normal control subjects.

83 as having schizotypal personality disorder (SPD).

84 ients with schizotypal personality disorder (SPD).

85 Skin picking disorder (SPD) is characterized by the repetitive and compulsive p

86 Excoriation (skin-picking) disorder (SPD) is a disabling, underrecognized condition in which

87 platelet storage pool deficiency disorders (SPD).

88 s conducted through short path distillation (SPD) of an acylglycerol mixture (containing 67% MAGs) pr

89 eins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4.

90 However, the molecular basis for SPD-2 centriolar localization remains unknown.

91 pharmacologic or psychological treatment for SPD.

92 Furthermore, SPD-5 interacts genetically with a dynein heavy chain.

93 in schizophrenia, the similar patterns of HC-SPD age-related GMV reduction suggest that SPD showed no

94 lly and molecularly accurate model for human SPD.

95 ; the same type of expansion occurs in human SPD mutations.

96 Thus, we have identified SPD-2 as a factor critical for the two basic functions o

97 in these responses in thrombasthenia, as in SPD, further show the close association between the gene

98 etry showed that the neocortical deficits in SPD were especially prominent in the left superior and m

99 Neurocognitive findings in SPD implicate difficulty with response inhibition (suppr

100 e, pulvinar and MDN together were reduced in SPD (0.14%) and schizophrenic (0.15%) patients vs contro

101 An adenovirus 5 (Ad5) vaccine incorporating SPD-Gag-CD40L was much stronger than Ad5 expressing Gag

102 macokinetic (PK) analysis of four individual SPD stereoisomers.

103 Interestingly, SPD-2 interacts genetically with dynein heavy chain and

104 ment, while SAS-7 centriolar localization is SPD-2-independent.

105 To our knowledge, SPD-3 is the first example of a link between mitochondri

106 l)-o-carboranyl]butyl inverted question mark SPD/SPM derivatives (ASPD-5, ASPM-5, DHSPD-5, and DHSPM-

107 During maturation, SPD-2 gradually accumulates at the centrosome in a manne

108 -5 and SPM-5) but similar to those of native SPD and SPM.

109 We show that SPD-2 is monomeric, and neither SPD-2 nor SPD-5 exists in complex with PLK-1.

110 No SPD has been localized to these regions of either the mo

111 nm), the stacking faults still exist, but no SPDs are found.

112 at SPD-2 is monomeric, and neither SPD-2 nor SPD-5 exists in complex with PLK-1.

113 n, competition study showed the impotence of SPD to replace with histone H1 in histone H1-DNA complex

114 D-2 localizes to centrioles independently of SPD-5.

115 ng mitosis in mutants with reduced levels of SPD-5, microtubules assemble but radiate from condensed

116 The midzone localization of SPD-1 is perturbed in embryos depleted of other midzone

117 t difference in the biological mechanisms of SPD and schizophrenia.

118 on and suppression in the pathophysiology of SPD, findings remarkably similar to those previously rep

119 symptoms, we carried out the first study of SPD to assess the caudate and putamen for comparison wit

120 which are affected in a specific subgroup of SPD.

121 Teratogenicity of SPD stereoisomers was evaluated in SWV mice strain, susc

122 wn using a plasmid lacking the N terminus of SPD that produced a single trimer fusion protein.

123 ) boron compounds, are greater than those of SPD/SPM.

124 efects in Ap-3, our findings suggest that pa SPD mutants are defective in a more downstream event of

125 Whereas the mocha and pearl SPD mutants have defects in Ap-3, our findings suggest t

126 ession of the AP-3 complex leads to platelet SPD.

127 Meanwhile, the polyamines SPD and SPM were found in all soya milks, being stable t

128 t (CPT-AC), and CVc with spatial processing (SPD-CVc).

129 13-subjects meeting proposed SPD criteria for DSM-5 free from other current psychiatr

130 e show that the microtubule-bundling protein SPD-1/MAP-65 and BMK-1/kinesin-5 act as a brake opposing

131 te involves the conserved centrosome protein SPD-2/CEP192 and CDK activity from the mitotic cell.

132 CM assembly requires the coiled-coil protein SPD-5.

133 nteractions between the coiled-coil proteins SPD-5 and SPD-2 and the kinase PLK-1 are critical for PC

134 Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daugh

135 s of three pericentriolar material proteins: SPD-5, the kinase aurora-A, and gamma-tubulin.

136 (2S,3S)-SPD, (2R,3R)-SPD, and racemic-SPD have similar anticonvulsant activity and a PK profil

137 sec-Butylpropylacetamide (racemic-SPD) is a chiral CNS-active amide derivative of valproic

138 We found that recombinant SPD-5 could polymerize to form micrometer-sized porous n

139 so show that SAS-7 binds SPD-2 and regulates SPD-2 centriolar recruitment, while SAS-7 centriolar loc

140 CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD)).

141 mpound, i.e. putrescine (PUT) or spermidine (SPD), or with no addition as controls (CTRs).

142 enic polyamines; spermine (SPM), spermidine (SPD) and putrescine (PUT), or electrochemical investigat

143 of new boron-containing spermidine/spermine (SPD/SPM) analogues have been synthesized: N1- and N5-(4-

144 New boron-containing spermidine/spermine (SPD/SPM) analogues have been synthesized: N5-[4-(2-amino

145 4.17 x 10(5) and 1.46 x 10(5)M(-1) for SPM, SPD and PUT, respectively, which correlated well with th

146 The fabricated biosensor responded to SPM, SPD and PUT over an extended dynamic range of 0.04-100 m

147 A stepwise SPD process in a UIC KDL 5 system (vacuum 10(-3)mbar, fe

148 specially those with terminal N-substituted (SPD-1, SPM-1) boron compounds, are greater than those of

149 Synpolydactyly (SPD) is a dominantly inherited congenital limb malformat

150 Synpolydactyly (SPD) is a limb malformation that shows a characteristic

151 Human synpolydactyly (SPD) is an inherited congenital limb malformation caused

152 inherited limb malformation synpolydactyly (SPD).

153 e potent with a longer plasma half-life than SPDs.

154 We conclude that SPD is an effective treatment for patients with secondar

155 This work also demonstrated that SPD is able to concentrate n-3 PUFAs in MAG form by dist

156 Surprisingly, we also find that SPD-2 is required for centrosome duplication and genetic

157 Surprisingly, we found that SPD-3GFP localized to mitochondria.

158 It was hypothesized that SPD would be associated with reduced fractional anisotro

159 We propose that SPD-5, along with dynein, is required for centrosome mat

160 We show that SPD-2 is monomeric, and neither SPD-2 nor SPD-5 exists i

161 C-SPD age-related GMV reduction suggest that SPD showed no progressive GMV loss, pointing to an impor

162 one components are depleted, suggesting that SPD-1 may play an early role in the pathway of midzone a

163 In the SPD group, larger lateral ventricle volumes correlated w

164 Lung-specific overexpression of D/A in the SPD(-/-) mouse resulted in hetero-oligomer formation wit

165 In the SPD, participants first recalled (typed) what they did d

166 ming of formation of their precursors in the SPD.

167 In later parts of the SPD, participants analysed activities and their timing a

168 rms the SPD sheath cell into its sister, the SPD neuron.

169 ed by the Wnt receptor LIN-17 transforms the SPD sheath cell into its sister, the SPD neuron.

170 ms into the Pd shell layers to eliminate the SPDs.

171 c NPs were annealed at 523 K for 10 min, the SPDs at the surface of the NPs coated with a single atom

172 However, these SPDs had low potency and short half-lives.

173 This SPD-Gag-CD40L protein activated CD40-bearing cells and b

174 em may prove a beneficial target in treating SPD and other compulsive behaviors.

175 ssembled SPD-5 networks, and not unassembled SPD-5 protein, functioned as a scaffold for other PCM pr

176 In two unrelated SPD families, this duplication was directly transmitted

177 ingressing furrow in wild-type embryos; when SPD-1 is depleted, there is no visible midzone, and only

178 IV-1 Gag as a test antigen, and CD40L, where SPD serves as a scaffold for the multitrimer protein com

179 CC16 BAL levels correlated with ED, while SPD BAL levels correlated with SMA and RBM.

180 o June 26, 2015) and included 66 adults with SPD.

181 Here we report a father and daughter with SPD who carry a 117-kb microdeletion at the 5' end of th

182 study involved 54 neuroleptic-naive men with SPD and 54 male HC subjects aged 18 to 55 years recruite

183 Men with SPD showed global and widespread smaller regional GMV.

184 lated GMV reductions are greater in men with SPD than HC subjects, providing presumptive evidence on

185 voxelwise analysis showed participants with SPD had significantly smaller GMV in the left superior t

186 ophrenic patients (n = 10) and patients with SPD (n = 10) both of whom never received medication were

187 Patients with SPD (n = 16), schizophrenic patients (n = 42), and age-

188 ver 30 min) in medication-free patients with SPD (n=16) who met the criteria for cognitive impairment

189 was significantly elevated in patients with SPD and reduced in schizophrenic patients.

190 s significantly larger than in patients with SPD and significantly smaller than in schizophrenic pati

191 All of the patients with SPD and subsamples of the schizophrenic patients (n = 27

192 for the putamen being found in patients with SPD for the ventral slice and the lowest value for the r

193 y be related to the sparing of patients with SPD from frank psychosis.

194 Patients with SPD showed reduced volume and elevated relative glucose

195 sotropy did not correlate significantly with SPD disease severity, or depressive or anxiety scores.

196 Subjects with SPD exhibited significantly reduced fractional anisotrop

197 ve relationships with age in both those with SPD and HC subjects, without any group by age interactio

198 SF relative volumes were found in women with SPD compared with controls.