ライフサイエンスコーパス: SPR

1 SPR assays also revealed that Abraxane, an FDA-approved

2 SPR coupled with SELEX from the first to the last round

3 SPR method can become a valuable addition to analytical

4 SPR offers several advantages in terms of label free det

5 SPR reflectance curves were recorded as a function of in

6 SPR sensors with different average surface densities of

7 SPR, ITC, and (19)F NMR analyses revealed that the most

8 heoretical and experimental realization of a SPR based fiber optic nicotine sensor having coatings of

9 Here we report the use of a SPR biosensor based on ultra-low fouling and functionali

10 We further demonstrate that a SPR biosensor based on a pCBAA brush with a thickness as

11 oach is here coupled for the first time to a SPR biosensor to simultaneously recognize albumen, yolk,

12 assays and ELISA feasibility; additionally, SPR imaging analysis of a supported membrane microarray

13 ect to sensitivity and dynamic range against SPR.

14 urface, leading to a significantly amplified SPR signal readout.

15 Real-time amplified SPR response is observed upon the introduction of nonlin

16 or POC, this is the first report of using an SPR biosensor for measuring DBS samples.

17 n important mycotoxin, was captured using an SPR gold chip containing an antifouling layer and monocl

18 In this work, an SPR immunosensor was developed to elucidate the reaction

19 nstants with literature values and analogous SPR measurements indicates that this approach is applica

20 RI)-based label-free methods such as BLI and SPR is the requirement to tether one of the interaction

21 eptide-spot array screening, competition and SPR assays, high-resolution crystallography, and mutatio

22 nding properties using NMR, SAXS, cryoEM and SPR.

23 ht be associated with H3K4 dimethylation and SPR-5 downregulation.

24 s interpretation, co-immunoprecipitation and SPR experiments indicated that EBI3 binds IL-6.

25 X-ray crystallography, HDX-MS and SPR analysis confirmed that the CDR regions of VHH6 inte

26 sors surpassed those of conventional QCM and SPR, closely approaching the most sensitive ELISAs.

27 Simulations and SPR experiments suggested that an Fn conformational chan

28 e-Ne laser beam using a laboratory assembled SPR setup.

29 enzoic acid (4-MBA) modified gold (4-MBA/Au) SPR chip was developed first time for the detection of B

30 olic acid protein (FAP) using graphene-based SPR chips.

31 In addition, the nonlinear HCR based SPR biosensing methodology is extended to the detection

32 ggest the potential of this GO-peptide-based SPR chip detection method in clinical application.

33 ein, the major advantage of GO-peptide-based SPR sensors was their reduced nonspecific adsorption and

34 method for fabricating novel M13 phage-based SPR sensor system which has a high sensitivity and high

35 Our M13 phage-based SPR sensor takes advantage of simplicity of self-assembl

36 more, the sensitivity of the M13 phage-based SPR sensor was enhanced due to the aligning of receptor

37 lectivity and sensitivity to M13 phage-based SPR sensor.

38 ed using a commercial propagating-wave based SPR.

39 ity molecular target, which was confirmed by SPR and crystallography.

40 es and proteins, which are not detectable by SPR alone.

41 86I (Kd(app) = 0.2-0.5 mum, as determined by SPR) compared with the lowest-affinity double-alanine pe

42 nsing surface (polymer) and is identified by SPR technique.

43 the SPRi surface was preserved and imaged by SPR and MALDI MS.

44 tored in real-time and multiplexed manner by SPR imaging.

45 y rounds confirmed the evolution observed by SPR and also revealed the selection of hairpins displayi

46 The evaluation of the pools was performed by SPR, simultaneously, during the association phase, each

47 anied by high sensitivity and selectivity by SPR immunosensor.

48 In the case of palladium, our calculated SPR wavelength for the planar geometry was 160 nm, demon

49 d through pi-stacking on the graphene coated SPR chip and the FAP analyte in serum.

50 Combined SPR/EIS and QCM-D/EIS measurements revealed that during

51 at our NanoBioAnalytical platform, combining SPR and AFM, is a suitable method for a sensitive, repro

52 nsitivity of 16 times that of a conventional SPR chip.

53 ed by up to 1.2 times that of a conventional SPR chip.

54 times better detectability than conventional SPR.

55 SPR detection complementary to conventional SPR techniques.

56 and sensitivity, compared with conventional SPR.

57 The developed SPR sensor with the novel endotoxins nanoMIP showed the

58 e, we show how enhancement injections during SPR-measurements can be used to determine the ratio of t

59 Furthermore, the established SPR based assay and the screening approach can be adapte

60 By random selection of experimental SPRs from a large database for each individual pulse dur

61 The fabricated SPR biosensor allowed discrimination of anti-HBs positiv

62 The first SPR sensor for detection of bacteria was reported in 199

63 FO-SPR has enabled sensitive sensing capabilities in biomed

64 FO-SPR probes were homogeneously functionalized with ZIF-8

65 The two established MOF-FO-SPR sensors were then subjected to sensing experiments w

66 clusion, this paper demonstrates that our FO-SPR biosensor can be used as a true POC diagnostic tool

67 Finally, the POC FO-SPR immunoassay was validated by using matching serum an

68 The established point-of-care (POC) FO-SPR bioassay was also used to measure IFX in 100-fold di

69 a fiber-optic surface plasmon resonance (FO-SPR) biosensor for detection of IFX spiked in 100-fold d

70 ed fiber-optic surface plasmon resonance (FO-SPR) biosensor.

71 he Fiber Optic Surface Plasmon Resonance (FO-SPR) platform, which enabled simultaneous quantification

72 er optic based surface plasmon resonance (FO-SPR) sensors.

73 Furthermore, the assay time of the FO-SPR platform was significantly reduced compared to ELISA

74 Results from the FO-SPR platform were compared with an in-house developed, c

75 of the gold nanoparticles (Au NPs) on the FO-SPR sensor.

76 o solutions was directly monitored by the FO-SPR system.

77 IFX concentrations determined with FO-SPR were compared to a clinically validated enzyme-linke

78 in accumulation is a sensitive biomarker for SPR inhibition in vivo.

79 a good match with the experimental data for SPR wavelengths, 440 nm and 558 nm, respectively for sil

80 d and applied a novel mathematical model for SPR data treatment that enables determination of kinetic

81 acillus spp., highlighting the potential for SPR to detect any target bacterium in a mixed sample of

82 hly the same as that previously reported for SPR under the same biochemical conditions, whereas LOD i

83 s for use as a signal enhancement system for SPR sensors, as liposomes excel not only at versatility

84 we show physical evidence (i.e., NMR, FRET, SPR) that purine or pyrimidine-rich microRNAs of appropr

85 y imprinted polymer microarrays on bare gold SPR imaging chips.

86 bly blue-shift and significantly dampen gold SPR absorption.

87 This enhanced gold SPR can drive reduction of the iron oxide shell under br

88 evaluated surface plasmon resonance imaging (SPR imaging) as a DNA biosensor for the detection of met

89 shed between affinity constant determined in SPR and metal chelation capacity determined from UV-visi

90 ll-characterized by pronounced difference in SPR spectral band position (shifting up to 50nm).

91 This integrated SPR chip has been used to detect target complementary DN

92 engineering specific molecular interactions, SPR can rapidly quantify small aliquots of nanoRx formul

93 enzyme-free CHA amplification and non-label SPR biosensor, the established biosensor exhibited simpl

94 s work confirmed the suitability of the MIPs SPR sensor for the detection of viruses.

95 When model SPR detections of food-borne bacterial pathogens in homo

96 sp. in hamburger sample using a multichannel SPR biosensor having appropriate functional coatings.

97 ochemical, fluorescence-based, nanomonitors, SPR-based, and field-effect transistor biosensors for ea

98 mulated emission depletion (STED) nanoscopy, SPR, and NMR spectroscopy approaches.

99 Notably, SPR analysis indicated that constitution of WTA determin

100 The novel SPR sensor had a wide linear range over an RAC concentra

101 Up to now, SPR has been poorly exploited for tau detection by immun

102 es of SPR and basic quantitative analysis of SPR data, (2) previous applications of SPR in the study

103 complications that arise in the analysis of SPR measurements where temperature is varied.

104 s implemented for a quantitative analysis of SPR under plane-wave illumination and a finite-differenc

105 Overall, our work extends the application of SPR beyond the realm of 1:1 stoichiometric ligand-recept

106 is of SPR data, (2) previous applications of SPR in the study of non-particulate therapeutics and nan

107 sis techniques: the biosensing capability of SPR and the chemical identification power of high resolu

108 n simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for

109 nsor, determined here using a combination of SPR and X-ray photoelectron spectroscopy (XPS) measureme

110 This effort reports development of SPR immunosensor for real-time and label-free detection

111 we discuss (1) the fundamental principles of SPR and basic quantitative analysis of SPR data, (2) pre

112 ific adsorption and improving the quality of SPR devices.

113 Holographic reconstructions of SPR images and real-time kinetic measurements are presen

114 y improve the sensitivity and selectivity of SPR sensor evidently.

115 addition of cerium indicated by red shift of SPR peak followed by complete precipitation.

116 xanthurenic acid bound to the active site of SPR reveals why among all kynurenine pathway metabolites

117 and (3) future opportunities for the use of SPR in the evaluation of nanoRx.

118 in tumor tissue and highlight the utility of SPR as a high throughput method to screen NPs for tumor

119 ving forward, we believe that utilization of SPR in the screening and design of nanoRx has the potent

120 lerae by developing an immunosensor based on SPR and compare the sensitivity of this method with form

121 l, which is up to 10 times better than other SPR imaging systems for multi-sensing applications.

122 Our SPR biosensor has proven to detect and identify gluten c

123 detection, indicating that our polarimetric SPR platform should be suitable for a cheap and efficien

124 The VP1 detection in the portable SPR biosensor had a detection limit of approximately 4.8

125 tructure-based design, we developed a potent SPR inhibitor and show that it reduces pain hypersensiti

126 abolites xanthurenic acid is the most potent SPR inhibitor.

127 Up to present, SPR application in stem cell biology and biomedical scie

128 nmol L(-1)) were presented with the proposed SPR immunosensor.

129 a potent inhibitor of sepiapterin reductase (SPR), the final enzyme in de novo BH4 synthesis.

130 effects, we targeted sepiapterin reductase (SPR), whose blockade allows minimal BH4 production throu

131 report the structure-property relationships (SPR) of 35 phenylpropionic acid derivatives, in which th

132 erlap between the surface plasmon resonance (SPR) absorption of PVP-AuNPs and the excitation of BSA-A

133 Surface plasmon resonance (SPR) analysis identified a strong correlation between HA

134 p50 subunit, and surface plasmon resonance (SPR) analysis showed that PL binds to p50 concentration-

135 l down assays and surface plasmon resonance (SPR) analysis, we demonstrate that Aar (AggR-activated r

136 Using surface plasmon resonance (SPR) analysis, we found that quinine binds with very hig

137 c approaches like surface plasmon resonance (SPR) and aptamer technology has also been discussed.

138 nt agreement with Surface Plasmon Resonance (SPR) and ELISA.

139 ofenofos based on surface plasmon resonance (SPR) and molecular imprinting is introduced.

140 imized by kinetic surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation (Q

141 were measured by surface plasmon resonance (SPR) and were found to be >10-fold higher for REG- than

142 crobalance (QCM), surface plasmon resonance (SPR) and X-ray photoelectron spectroscopy (XPS).

143 iosensors such as surface plasmon resonance (SPR) are an effective screening approach in drug discove

144 In a surface plasmon resonance (SPR) assay, the compound bound to recombinant DEPTOR but

145 tion systems like Surface Plasmon Resonance (SPR) assays, Impedance-based method, Quartz Crystal Micr

146 he characteristic surface plasmon resonance (SPR) band of Tyr-Au NPs was red-shifted to 596 and 616nm

147 evolution of the surface plasmon resonance (SPR) band.

148 proach based on a surface plasmon resonance (SPR) based assay combined with an enzyme inhibition assa

149 development of a surface plasmon resonance (SPR) based biosensor for the detection of Neisseria meni

150 id cost-effective surface plasmon resonance (SPR) based method for measuring the Rexocytosis for popu

151 Optical fibre surface plasmon resonance (SPR) based sensor for the detection of heavy metal ions

152 , and show unique surface plasmon resonance (SPR) behaviors.

153 or marker using a surface plasmon resonance (SPR) bio-sensing platform.

154 highly sensitive surface plasmon resonance (SPR) biochip and a simple portable imaging setup for lab

155 anoplasmonics and surface plasmon resonance (SPR) biosensing and probes distinctive colloidal propert

156 e and enzyme-free surface plasmon resonance (SPR) biosensing strategy has been developed for highly s

157 using a portable surface plasmon resonance (SPR) biosensor (SPIRIT 4.0, Seattle Sensor Systems).

158 thodology using a Surface Plasmon Resonance (SPR) biosensor for label-free monitoring of alternative

159 Here, a simple surface plasmon resonance (SPR) biosensor has been developed for highly sensitive d

160 in milk by using surface plasmon resonance (SPR) biosensor is reported.

161 have presented a surface plasmon resonance (SPR) biosensor technique for the detection of anti-PEG a

162 determined using surface plasmon resonance (SPR) biosensor technology are 262 +/- 4 nM for iMVP/INT,

163 novel and simple surface plasmon resonance (SPR) biosensor was developed for specific and highly sen

164 GO-peptide-based surface plasmon resonance (SPR) biosensor.

165 Surface plasmon resonance (SPR) biosensors are most commonly applied for real-time

166 onstrating that a surface plasmon resonance (SPR) can be excited in this case.

167 inding studies by surface plasmon resonance (SPR) confirmed it to be a high affinity ligand for Robo1

168 g systems rely on surface plasmon resonance (SPR) detection to quantify biomolecular interactions.

169 G) effect and the surface plasmon resonance (SPR) effects.

170 e a generation of surface plasmon resonance (SPR) for plasmonic sensing.

171 that measured by surface plasmon resonance (SPR) for the same binding reaction.

172 hydrolysate using Surface Plasmon Resonance (SPR) for their antioxidant properties.

173 alculation of the surface plasmon resonance (SPR) frequency of nanoparticles immersed in a medium, ne

174 be used with most surface plasmon resonance (SPR) imaging instruments.

175 ethod is based on surface plasmon resonance (SPR) imaging measurements made across a spatial temperat

176 ified coupling of surface plasmon resonance (SPR) immuno-biosensing with ambient ionization mass spec

177 Surface plasmon resonance (SPR) immunosensor enhanced by biocatalyzed precipitation

178 Surface plasmon resonance (SPR) immunosensor has been widely utilized for monitorin

179 Surface plasmon resonance (SPR) immunosensor using 4-mercaptobenzoic acid (4-MBA) m

180 Surface Plasmon Resonance (SPR) in combination with different amplification strateg

181 oxide (GO)-coated Surface Plasmon Resonance (SPR) interfaces.

182 Surface plasmon resonance (SPR) is a powerful analytical technique used to quantita

183 Surface Plasmon Resonance (SPR) is a powerful technique for studying 1:1 stoichiome

184 Surface plasmon resonance (SPR) is the current standard tool used for label-free ki

185 Real-time surface plasmon resonance (SPR) measurements showed that fibrinogen interacted with

186 Surface plasmon resonance (SPR) measurements showed that polymer conjugation did no

187 perature gradient surface plasmon resonance (SPR) measurements to quantitatively evaluate how the sta

188 nal calculations, surface plasmon resonance (SPR) measurements, and X-ray crystallography experiments

189 inally, by use of surface plasmon resonance (SPR) measurements, we show that the new disulfide bond d

190 the potential of surface plasmon resonance (SPR) method coupled to atomic force microscopy (AFM) to

191 which include the surface plasmon resonance (SPR) of Au nanoparticles, low overpotential of Pt nanopa

192 development of a surface plasmon resonance (SPR) optical fiber biosensor based on tilted fiber Bragg

193 ties of localized surface plasmon resonance (SPR) phenomenon to study non-covalent interactions not j

194 oin antibodies by surface plasmon resonance (SPR) revealed low nanomolar antiserum affinity for the k

195 ple and sensitive surface plasmon resonance (SPR) sensing system for rapid differentiation between ri

196 be determined by surface plasmon resonance (SPR) sensing using folic acid-functionalized gold nanopa

197 ealize label-free surface plasmon resonance (SPR) sensing.

198 mobilisation on a surface plasmon resonance (SPR) sensor as affinity receptor for adenovirus detectio

199 A Surface Plasmon Resonance (SPR) sensor chip consisting of four sensing arrays enabl

200 A Surface Plasmon Resonance (SPR) sensor for the quantitation of lysozyme dimer in mo

201 ed ultrasensitive surface plasmon resonance (SPR) sensor in a checkerboard nanostructure on plastic s

202 A novel surface plasmon resonance (SPR) sensor that uses molecular imprinted polymers (MIPs

203 on the surface of surface plasmon resonance (SPR) sensors present potential for a significant improve

204 Moreover, surface plasmon resonance (SPR) showed that longer chain of synthetic alpha(1-6)man

205 Surface plasmon resonance (SPR) spectroscopy is an advanced tool to measure binding

206 using a portable surface plasmon resonance (SPR) system.

207 major goal in the surface plasmon resonance (SPR) technique is the reliable detection of small molecu

208 de application of surface plasmon resonance (SPR) to a broad area of interests, from environment to f

209 were screened by surface plasmon resonance (SPR) to determine the binding dissociation constant (off

210 microscopy (AFM), surface plasmon resonance (SPR), and molecular simulations were used to investigate

211 P specific ELISA, surface plasmon resonance (SPR), and virus neutralization assays.

212 pectrometry (MS), surface plasmon resonance (SPR), biolayer interferometry (BLI), and backscattering

213 (OXA-48) through surface plasmon resonance (SPR), dose-rate inhibition assays, and X-ray crystallogr

214 man spectroscopy, surface plasmon resonance (SPR), electrochemiluminescence and colorimetric readouts

215 rimetry (ITC) and surface plasmon resonance (SPR), respectively.

216 Using surface plasmon resonance (SPR), we found that IL-1RAcP also does not bind IL-36R w

217 With surface plasmon resonance (SPR), we present this diversified collection to collagen

218 or change, due to surface plasmon resonance (SPR), which occurs in about 30min of total assay time wh

219 s was assessed by surface plasmon resonance (SPR), which revealed excellent correlation with the part

220 films for use in surface plasmon resonance (SPR)-based immunoaffinity biosensors.

221 fabrication of a surface plasmon resonance (SPR)-based nucleic acid sensor for quantification of DNA

222 A surface plasmon resonance (SPR)-based SELEX approach has been used to raise RNA apt

223 Lastly, a surface plasmon resonance (SPR)-based technique was established enabling drug-speci

224 Surface plasmon resonance (SPR)-biosensor experiments show that the drug can displa

225 loped using a new surface plasmon resonance (SPR)-biosensor which provides an alternative technology

226 h AP and AS using surface plasmon resonance (SPR).

227 rum samples using surface plasmon resonance (SPR).

228 limitations with surface plasmon resonance (SPR).

229 -P5CDH complex by surface plasmon resonance (SPR).

230 emonstrated using surface plasmon resonance (SPR).

231 PMS measurement (via single pulse responses [SPR]).

232 eports the operation principles for reusable SPR biosensors utilizing nanoscale-specific electrostati

233 o construct a highly sensitive and selective SPR chip for folate biomarker sensing in serum.

234 have developed a simple and highly sensitive SPR biosensor for the detection of gluten peptides in ur

235 Using this highly sensitive SPR method, it was possible to sense the early stage of

236 For the development of the optical sensor, SPR-2 biosensor system was used by functionalising the g

237 ene yield a broad, significanlty red-shifted SPR band with a peak at 230 nm.

238 Since SPR principle relies on the refractive index modificatio

239 a model, we identified by NMR spectroscopy, SPR, analytical ultracentrifugation, and microcalorimetr

240 for the first time, the presence of a stable SPR signal recorded in soft matters.

241 dia with increased sensitivity over standard SPR analyses.

242 a novel surface plasmon resonance technique (SPR) is developed and used, along with hepatocyte (with

243 The SPR absorption of PVP-AuNPs was enhanced with an increas

244 The SPR biochip consists of several capped nanoslit arrays w

245 The SPR biosensor demonstrated high specificity and long she

246 The SPR disk surface has been modified with octadecanethiol

247 The SPR partition data obtained for the antibody fragment F6

248 The SPR performance is consistent with that of previous repo

249 The SPR sensor instrument was configured to run on low power

250 The SPR signal processing using integration area under the r

251 The SPR signals increased with the increase of the amount of

252 The SPR system was applied to analyzes of actual clinical sa

253 The SPR technique developed may be used for the future study

254 The SPR-assay was reproducible and sensitive for different R

255 structures (metallic or not) may amplify the SPR signal and improve the limit of detection to the des

256 er obtained by cross-linking and confirm the SPR results.

257 e of immune-reactive biochips and during the SPR analysis.

258 binding of recombinant DEPTOR to mTOR in the SPR assay.

259 es, causing a characteristic decrease in the SPR signal.

260 bioassay with the capability to increase the SPR signal of about 10(2) folds compared to direct detec

261 omplete thermodynamic cycle to be 74 mum The SPR analysis also indicated that the IL-36R antagonist I

262 rformed during the dissociation phase of the SPR analysis by recovering the aptamer candidates direct

263 With respect to the shifts of the SPR angles of the chips, the affinity immunoassay intera

264 the dynamic range (10(-3)-10(3)ng/ml) of the SPR biosensor.

265 the dynamic range (10(-3)-10(3)ng/ml) of the SPR biosensor.

266 the penetration depth and sensitivity of the SPR instrument were experimentally determined for the ca

267 s suitable as the recognition element of the SPR sensorfor rapid screening and detection of beta-agon

268 Currently, most of the SPR sensors rely on the detection of amplitude or phase

269 er film led to a significant increase of the SPR signal.

270 , resulting in a significant increase of the SPR signal.

271 ations to best match the requirements of the SPR system.

272 ific capture antibody was immobilized on the SPR chip which allowed a direct label-free detection of

273 ofolate reductase (hDHFR) immobilized on the SPR sensor chip.

274 the encapsulant has a major influence on the SPR signal and outweighs the influence of the thin lipid

275 ty for detecting IFX in patients' serum, the SPR signal was amplified by employing gold nanoparticles

276 hip to become four times as sensitive to the SPR angle shift and to have the lowest antibody detectio

277 spectra are recorded simultaneously with the SPR sensorgram, and the detected Raman bands provide che

278 the direct and label-free detection with the SPR technique and neutralized chimeric probe DNA can be

279 This SPR shift correlates remarkably well with biochemical es

280 Thus, this SPR-based biosensor might become a potential alternative

281 versatile imaging method for high-throughput SPR detection complementary to conventional SPR techniqu

282 re than 2 orders of magnitude as compared to SPR, thus facilitating measurements of highly potent (Kd

283 In contrast to SPR and QCM-D, repeatable EIS measurements were not poss

284 Besides high sensitivity due to SPR technique and selectivity due to molecular imprintin

285 O-COOH chip, an Au/GO chip and a traditional SPR chip are 35.5m degrees , 9.128m degrees and 8.816m d

286 The platform has advantages over traditional SPR in terms of insensitivity of signal responses to pH

287 Transmission SPR measurements of free prostate specific antigen (f-PS

288 diazonium salts was facilitated by a tripad SPR sensor design.

289 To address this problem, we use SPR spectroscopy correlated with surface enhanced Raman

290 peptides were screened in hydrolysates using SPR and a correlation was established between affinity c

291 stics on molecular and cellular levels using SPR, ELISA, and flow cytometry.

292 Moreover, using SPR and isothermal calorimetry techniques, we establish

293 Binding studies using SPR confirmed that affinity for Grb7-SH2 domain is impro

294 rug-target residence time was determined via SPR.

295 hitecture is a typical complex system, where SPR response is formed by the stochastic interactions wi

296 t using immobilized probe 1 and probe 2 with SPR which showed the applicability of this methodology a

297 hat microelectrospotting in combination with SPR imaging can offer a versatile platform for label-fre

298 SELEX coupled with SPR is expected to speed up the selection process becaus

299 e differential detection of B. globigii with SPR in a mixed sample containing at least one additional

300 ol), benign and ovarian cancer patients with SPR has also been done to validate the process.