ライフサイエンスコーパス: SREBP cleavage-activating protein

1 g proteins Insig1 or the cytosolic domain of SREBP cleavage-activating protein.

2 cleaving SREBP-2 in a fashion that requires SREBP cleavage-activating protein.

3 tivating point mutation in the gene encoding SREBP cleavage-activating protein.

4 [sterol-regulatory element-binding protein (SREBP) cleavage-activating protein] acts as a cholestero

5 the enzyme; and 2) sterol-induced binding to SREBP cleavage-activating protein, an action that blocks

6 rmal SREBP-processing pathway, including the SREBP cleavage-activating protein and the Site 1 proteas

7 l regulation of the mammalian proteins SCAP (SREBP cleavage activating protein) and HMG-CoA reductase

8 hrough their sterol-induced binding to Scap (SREBP cleavage-activating protein) and 3-hydroxy-3-methy

9 pathway, including a single SREBP (dSREBP), SREBP cleavage-activating protein (dSCAP), and the two p

10 SCAP (SREBP cleavage-activating protein) forms a complex with

11 Ps in the lung, we conditionally deleted the SREBP cleavage-activating protein gene, Scap, in respira

12 inding proteins (SREBPs) by binding to SCAP (SREBP cleavage-activating protein) in a sterol-regulated

13 SCAP (SREBP cleavage-activating protein) is a sterol-regulated

14 transgenic SREBP-1a, transgenic SREBP-2, and SREBP cleavage-activating protein knockout mice recently

15 Overexpression of either dominant-negative SREBP cleavage-activating protein or 25-hydroxycholester

16 endoplasmic reticulum-to-Golgi transport of SREBP cleavage-activating protein requires the actin-bas

17 erol levels are high, Insig proteins bind to SREBP cleavage-activating protein, retaining it in the E

18 SREBP cleavage activating protein (SCAP), a membrane-bou

19 yos injected with a morpholino to knock down Srebp cleavage activating protein (scap).

20 D and the putative sterol-sensing regions of SREBP cleavage-activating protein (SCAP) and 3-hydroxy-3

21 tein that binds the sterol-sensing domain of SREBP cleavage-activating protein (SCAP) and facilitates

22 Mammalian proteins SREBP cleavage-activating protein (SCAP) and HMG-CoA red

23 sig's exert this action in the ER by binding SREBP cleavage-activating protein (SCAP) and preventing

24 through a mechanism that required an intact SREBP cleavage-activating protein (SCAP) pathway.

25 SREBP cleavage-activating protein (SCAP) stimulates the

26 Release of membrane-bound SREBP requires SREBP cleavage-activating protein (SCAP) to escort SREBP

27 Sequence analysis of SREBP cleavage-activating protein (SCAP) transcripts fro

28 a proteolytic process that is stimulated by SREBP cleavage-activating protein (SCAP), a membrane pro

29 es by proteases whose activities depend upon SREBP cleavage-activating protein (SCAP), a polytopic en

30 clear SREBPs as a result of gene knockout of SREBP cleavage-activating protein (SCAP), a protein requ

31 This response is mediated by SREBP cleavage-activating protein (SCAP), a regulatory p

32 lglutaryl coenzyme A (HMG-CoA) reductase and SREBP cleavage-activating protein (SCAP), and to the NPC

33 cells and elicits a conformational change in SREBP cleavage-activating protein (SCAP), as revealed by

34 VEGF-induced SREBP activation depended on SREBP cleavage-activating protein (SCAP), because knocki

35 c(-/-) mice was greater than in mice lacking SREBP cleavage-activating protein (SCAP), in which all n

36 evels are high, Insig proteins bind and trap SREBP cleavage-activating protein (SCAP), retaining it i

37 s to the membranous sterol-sensing domain of SREBP cleavage-activating protein (SCAP), retaining the

38 In the SREBP cleavage-activating protein (SCAP), sterols inhibi

39 erexpression of the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), suggesting tha

40 , and -2) or a dominant positive form of the SREBP cleavage-activating protein (SCAP), which facilita

41 nt-binding proteins (SREBPs) is regulated by SREBP cleavage-activating protein (SCAP), which forms co

42 cently discovered as a specific inhibitor of SREBP cleavage-activating protein (SCAP), which is requi

43 ion cloning we have isolated a cDNA-encoding SREBP cleavage-activating protein (SCAP), which regulate

44 but is restored by increasing the levels of SREBP cleavage-activating protein (SCAP).

45 ite 1, due to mutations in the gene encoding SREBP cleavage-activating protein (SCAP).

46 with a polytopic membrane protein designated SREBP cleavage-activating protein (SCAP).

47 rane protein of 1276 amino acids, designated SREBP cleavage-activating protein (SCAP).

48 nt SREBP-1c by enhancing the affinity of the SREBP cleavage-activating protein (SCAP).SREBP-1c comple

49 SREBP) pathway by preventing movement of the SREBP cleavage-activating protein (SCAP)/SREBP complex f

50 , sterol regulatory element-binding protein (SREBP) cleavage activating protein (SCAP), and SREBP-2.

51 : sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-

52 f sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and consequent

53 f sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), a sterol-sens

54 f sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP), an essential

55 s subsequently leads to the transport of the SREBP cleavage-activating protein.SREBP complex from the

56 lular sterol levels in mammalian cells in an SREBP cleavage-activating protein-stimulated fashion.