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1 SRF is also dispensable for the KLF3-mediated repression
2 SRF is an essential regulator of skeletal muscle differe
3 SRF is an essential transcription factor in hematopoiesi
4 SRF regulates neutrophil migration, integrin activation,
5 SRF split renal function was measured by using the area
6 SRF subsequently funded animal research to evaluate sucr
7 SRF terminated Project 259 without publishing the result
8 SRF thickness >118.25 mum at baseline predicted requirin
9 SRF-deficient macrophages fail to spread, transmigrate,
10 SRF-VP16iHep mHCC reveal convergent Ras/MAPK and Rho/act
11 SRF/MRTF-A-dependent gene transcription is activated whe
13 The main aim of this study was to compare 2D SRFs between neurons in the noise-selective region (NSR)
14 for retina (ICC = 0.84; 95% CI, 0.83-0.86), SRF (ICC = 0.88; 95% CI, 0.86-0.89), and subretinal tiss
15 2 reduced the nuclear accumulation of MRTF-A.SRF complexes and consequently inhibited alpha-SMA promo
17 ription factor/serum response factor (MRTF-A/SRF) transcription pathway as a potential novel therapeu
19 conditionally express constitutively active SRF-VP16 in hepatocytes, thereby controlling subsets of
21 ion resulting in reduced myogenically active SRF, but enhanced SRF activity on target genes involved
25 enrichment of RNase L and TTP targets among SRF-regulated genes suggesting that the RNase L/TTP axis
27 n proposed that coating the inner wall of an SRF cavity with superconducting thin films increases Hvp
28 ning, funding, and internal evaluation of an SRF-funded research project titled "Project 259: Dietary
29 essive DNA binding complexes and suppress an SRF-dependent transcriptional program that supports surv
30 transmigrate, and phagocytose bacteria, and SRF-deficient neutrophils show defective chemotaxis in v
33 differentiate, and quantify intraretinal and SRF using area under the receiver operating characterist
35 rrelations were computed between the IRC and SRF parameters and the baseline BCVA, final BCVA, and BC
36 s of fit of correlations between the IRC and SRF parameters and the baseline BCVA, final BCVA, and BC
37 rvention, exudative features such as IRC and SRF resolved rapidly in 74% of eyes, whereas PED respond
41 e" treatment (complete resolution of IRF and SRF) or ranibizumab "relaxed" treatment (resolution of I
43 us, despite the shared phenotype of KLF3 and SRF-deficient mice, cooperation of these factors appears
46 F), resulting in disruption of myocardin and SRF interactions and thereby attenuating expression of s
49 scription factors (MRTFs), which function as SRF coactivators, serve as sensors of actin polymerizati
50 rrative case study method was used to assess SRF Project 259 from 1967 to 1971 based on sugar industr
53 rs for BCVA change at month 12 were baseline SRF (P = 0.05), PVD (P = 0.03), IRC (P = 0.05), treatmen
54 No robust associations were found between SRF and baseline BCVA (R2 = 0.06; P = .14) or BCVA chang
55 resolution of all retinal fluid (i.e., both SRF and intra-retinal fluid [IRF]) in patients with nAMD
59 inal cysts resolved most rapidly followed by SRF, whereas PED decreased at a slower rate and intensit
62 ific role of the transcription factors CREB, SRF, and MEF2 in the depression and potentiation compone
63 In this study, we tested the role of CREB, SRF, and MEF2 in ocular dominance plasticity (ODP), a pa
64 to block the transcription function of CREB, SRF, and MEF2 in the visual cortex, and measured visuall
66 novel MRTF/SRF inhibitor, markedly decreased SRF reporter gene activity and showed a greater inhibito
67 gether, these results suggest that decreased SRF expression induces replicative stress and chromosoma
68 act as general antagonists of MRTF-dependent SRF target gene expression, competing directly with the
69 C data, we identified over 700 TCF-dependent SRF direct target genes involved in signaling, transcrip
71 Forty-six (90%) study participants developed SRF during the study period, with 9 (20%) experiencing s
72 kness of 39 study participants who developed SRF at the first visit increased from 280 (26) microm at
73 upon postnatal and adult depletion of either SRF or its cofactors Myocardin Related Transcription Fac
74 tiple cancer-related pathways including Elk1/SRF, AP1, NFkappaB and STAT, and reduces EGFR expression
75 observation), when exudative signs emerged (SRF in 3/6 eyes and retinal cystoid spaces in 5/6 eyes).
77 educed myogenically active SRF, but enhanced SRF activity on target genes involved in proliferation.
79 of the CCTepsilon subunit by siRNA enhances SRF signaling in cultured mammalian cells by an actin as
81 genes controlled by the transcription factor SRF, and overexpression of SRF rescues impaired chromoso
83 transcription factor serum-response factor (SRF) along with its co-activator, myocardin-related tran
84 ial role of myocardin/serum response factor (SRF) and Notch signaling in the transcriptional regulati
85 transcription factor serum response factor (SRF) and set the chromatin state of SRF-targeted genes e
86 factor A (MRTF-A) and serum response factor (SRF) and the other using the transcriptional coactivator
88 al remodelling on the serum response factor (SRF) co-factors Megakaryoblastic Leukemia-1 and -2 (MKL1
90 tic leukemia-1 (MKL1)/serum response factor (SRF) during myofibroblast differentiation resulted in de
93 scriptional regulator serum response factor (SRF) is controlled by both Ras/MAPK (mitogen-activated p
94 We demonstrate that serum response factor (SRF) is induced by both platelet-derived growth factor (
99 lators and to promote serum response factor (SRF) signalling has raised the question of whether MRL p
101 -kappaB and myocardin/serum response factor (SRF) to convey hypertrophy signaling in cardiac myoblast
102 teraction between the serum response factor (SRF) transcription factor and one of its principal co-ac
103 levated expression of serum-response factor (SRF), a master regulator of mitogen-induced transcriptio
104 s where they activate serum response factor (SRF), a regulator of actin and other cytoskeletal protei
105 cardin for binding to serum response factor (SRF), resulting in disruption of myocardin and SRF inter
106 transcription factor Serum Response Factor (SRF), suffer from loss of BBB integrity and intracerebra
108 ator that activates a serum response factor (SRF)-dependent gene program required for cardiogenesis a
109 gnificantly inhibited serum response factor (SRF)-dependent reporter gene (SRE-LUC) activity and mRNA
110 tes the expression of serum-response factor (SRF)-dependent target genes in response to the Rho-actin
112 lastic leukemia (MKL)/serum-response factor (SRF)-mediated gene transcription is a highly conserved m
113 merization results in serum response factor (SRF)-mediated transcription through nuclear retention of
114 r TGF-beta1 and MYOCD/serum response factor (SRF)-regulated TSPANs in VSMC by using RNA-seq analyses
118 transcription factor, serum response factor (SRF); however, the mechanisms dynamically regulating SMC
119 CREB (cAMP response element binding factor), SRF (serum response factor), and MEF2 (myocyte enhancer
121 sue by quantifying spatial receptive fields (SRFs) in two functionally distinct cortical regions in t
122 incomplete resolution of sub-retinal fluid (SRF) </=200 mum at the foveal centre relative to a T&E p
123 as intra-retinal (IRF) or sub-retinal fluid (SRF) were evident on SD-OCT, followed by a gradual exten
125 uity (BCVA), resolution of subretinal fluid (SRF) demonstrated by optical coherence tomography (OCT),
126 F corresponded to areas of subretinal fluid (SRF) on spectral-domain OCT and was found to persist in
129 intraretinal cysts (IRCs), subretinal fluid (SRF), and pigment epithelial detachment (PED), presentin
131 intraretinal cysts (IRCs), subretinal fluid (SRF), and pigment epithelial detachments (PEDs), decreas
132 intraretinal fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (RPE) fluid and
133 id material and persistent subretinal fluid (SRF), but also a RPE-independent visual cycle for cone p
134 tinal cystoid fluid (IRC), subretinal fluid (SRF), pigment epithelial detachment, and vitreomacular i
135 intraretinal fluid (IRF), subretinal fluid (SRF), sub-retinal pigment epithelium (RPE) fluid, and su
138 ivation of SRF by GSK-3 that is critical for SRF-dependent axon growth in mammalian central neurons.
140 Thus, competition between TCFs and MRTFs for SRF determines the balance between antagonistic prolifer
141 This serine phosphorylation is necessary for SRF activity and for its interaction with MKL-family cof
142 ollectively, our results identify a role for SRF in proliferation and migration during craniofacial d
143 the most accurate CT volumetry technique for SRF and the prediction of postdonation kidney function (
144 In 1965, the Sugar Research Foundation (SRF) secretly funded a review in the New England Journal
145 ters commonly evaluate split renal function (SRF) with Tc-99m-mercapto-acetyltriglycin (MAG3) scintig
148 Only 2 participants (4%) were found to have SRF at the last study visit after discontinuation of tre
149 transcription factor depletion in the heart (SRF(HKO)) or of cardiac hypertrophy triggered by transve
152 inding supports previous reports implicating SRF and MEF2 in long-term depression (required for Dc-OD
153 ds achieving higher acceleration gradient in SRF cavity accelerator beyond the theoretical limit of b
155 pression of a wide range of genes, including SRF itself and many important structural and regulatory
156 h insulin alone, insulin+TNF-alpha increased SRF/SRE binding and beta-MHC expression, which was rever
157 ein 70-interacting protein (CHIP), increased SRF activity, as well as beta-myosin heavy chain (MHC) a
158 At the molecular level, direct and indirect SRF/MRTF target genes, encoding structural components of
159 Olfm2 expression inhibited TGF-beta-induced SRF binding to SM gene promoters in a chromatin setting,
163 utilized Nb ellipsoid to simulate an inverse SRF cavity and investigate the effect of coating it with
165 baseline, the proportions of eyes with IRC, SRF, and PED were balanced between the aflibercept and r
167 agreement between CT volumetry SRF and MAG3-SRF (bias, 95% limits of agreement: ROI vs MAG3 0.4%, -7
169 ic SRF was determined and compared with MAG3-SRF, postoperation donor kidney function, and graft func
170 wever, in severely dilated kidneys, the mean SRF split renal function measurement was underestimated
171 atypical actin-regulatory protein, mediates SRF/MRTF-A-dependent gene transcription elicited by nerv
174 study, we examined the possible role of MKL/SRF in the context of regulation of profilin (Pfn), a ma
176 tify the transcription factor binding motifs SRF and PRDM1 as important regulators of PIP3-sensitive
181 lore the impact of the actin-controlled MRTF-SRF (myocardin-related transcription factor-serum respon
188 that YAP-TEAD activity is sensitive to MRTF-SRF-induced contractility, while MRTF-SRF signaling resp
189 o MRTF-SRF-induced contractility, while MRTF-SRF signaling responds to YAP-TEAD-dependent TGFbeta sig
191 scription factor/Serum response factor (MRTF/SRF) pathway plays a key role in fibroblast activation a
192 scription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target t
196 d showed a greater inhibitory effect on MRTF/SRF target genes than the previously described MRTF-A in
198 ckness of the retina was Delta = 5+/-67 mum, SRF was Delta = 1.5+/-35 mum, and subretinal tissue comp
199 ls of HRT2 concomitantly disrupted myocardin/SRF and Notch transcription complex formation at respect
200 agged1 ligand- and Notch1-enhanced myocardin/SRF complex formation at the promoter CArG element.
202 identified the first VSMC-enriched and MYOCD/SRF and TGF-beta1/SMAD-dependent TSPAN family member, wh
203 2 is regulated by 2 parallel pathways, MYOCD/SRF and TGF-beta1/SMAD, via distinct binding elements wi
204 two regions: (1) compared with NSR neurons, SRF properties of FMSR neurons were more strongly depend
207 al a novel phosphorylation and activation of SRF by GSK-3 that is critical for SRF-dependent axon gro
209 ndingly, TRIM32 attenuated the activation of SRF signaling and hypertrophy due to dysbindin, whereas
217 PTEN interacts with the N-terminal domain of SRF and PTEN-SRF interaction promotes SRF binding to ess
220 t of CCG-1423, a small molecule inhibitor of SRF/MRTF-A-dependent transcription that exhibits efficac
224 xpression levels are maintained with loss of SRF, integrin activation and trafficking are disrupted.
225 and RS renal scintigraphy for measurement of SRF split renal function was shown in patients with mode
227 nscription factor SRF, and overexpression of SRF rescues impaired chromosome condensation and segrega
232 t on visual recovery; however, recurrence of SRF during follow-up showed a tendency for an additional
233 g SRF activity antagonizes Myc repression of SRF target genes, attenuates Myc-induced apoptosis, and
234 half-time PDT showed complete resolution of SRF within 6 months after PDT, but 3 eyes that received
237 genomics approach to investigate the role of SRF (serum response factor) in the serum response of fib
241 factor (SRF) and set the chromatin state of SRF-targeted genes early growth response 1 (egr1) and c-
242 y to ECM stiffness, and compare with that of SRF/MAL, which is another important regulator of differe
246 revealing essential requirements of ongoing SRF/MRTF activity for maintenance of cerebral small vess
247 ying peripheral areas of previous or ongoing SRF and choroidal hyperpermeability that can assist in t
248 A via their respective DNA-binding partners (SRF and TEAD) and is therefore indirect, arising as a co
249 t Q8wks), and 52% (ranibizumab) of patients; SRF resolved in 75% (both aflibercept Q4wks/Q8wks) and 6
250 ow-up period, but 1 eye exhibited persistent SRF, which was resolved progressively during the 12 mont
251 s that received half-dose PDT had persistent SRF before loss to follow-up at months 5, 7, and 8 (P =
253 technique for the evaluation of predonation SRF and allows a reliable prediction of donor's PDKF.
255 ain of SRF and PTEN-SRF interaction promotes SRF binding to essential promoter elements in SM-specifi
256 s with the N-terminal domain of SRF and PTEN-SRF interaction promotes SRF binding to essential promot
261 nd performed manual measurements of retinal, SRF, and subretinal tissue complex thicknesses at the fo
263 absence of either RNase L or TTP stabilized SRF mRNA, and a subset of established TTP targets was al
270 ly with increasing sound levels; and (3) the SRF size and centroid elevation were correlated with the
273 These data support a central role of the SRF/MRTF pathway in the pathobiology of lung fibrosis an
278 of Ras homolog family member A signaling to SRF, results in aberrant myeloid differentiation and hyp
284 orrelation between predonation CT volumetric SRF of the preserved kidney and PDKF at day 3 was r = 0.
286 alysis showed agreement between CT volumetry SRF and MAG3-SRF (bias, 95% limits of agreement: ROI vs
291 the SRF transcript and formed a complex with SRF mRNA in cells providing a mechanism by which RNase L
295 oters show enriched genome-wide overlap with SRF ChIP-seq peaks, PDGF selectively activates a network
299 tor for CRP2 that works synergistically with SRF and myocardin to regulate smooth muscle gene express
300 nt treatments compared with patients without SRF, without PVD, or without either who may require more
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