ライフサイエンスコーパス: STIM

1 STIM proteins are Ca(2+) sensors in the endoplasmic reti

2 STIM proteins are endoplasmic reticulum (ER) luminal Ca(

3 STIM proteins are known to mediate Ca(2+) store-sensing

4 STIM proteins are sensors of endoplasmic reticulum (ER)

5 STIM proteins contain an EF-hand in their N-termini that

6 STIM(EF)-expressing cells had normal ER Ca(2+) levels bu

7 r than the distance that can be spanned by a STIM-Orai complex, and STIM1 function should therefore n

8 efects induced by intestinal expression of a STIM-1 Ca(2+)-binding mutant, indicating that the protei

9 A multicenter observational study (A-STIM [According to Stop Imatinib]) evaluating MMR persis

10 on generated sufficient tidal volumes in all STIM animals.

11 6 mumol L(-1) after 5:20 hrs between CMV and STIM; p < 0.0001), but not the lactate/pyruvate ratio.

12 Orai and STIM have been implicated in the growth and metastasis o

13 he signalling pathways regulated by Orai and STIM in normal and malignant cells, we expose discrepanc

14 More recently Orai and STIM proteins have been proposed to underlie the well-de

15 s little information on the role of Orai and STIM proteins in smooth muscle.

16 ding of the interacting partners of Orai and STIM proteins in the regulation of CRAC channel activity

17 Recently, Orai and STIM proteins were identified as the molecular identitie

18 ted Ca(2+) entry (SOCE) mediated by ORAI and STIM proteins.

19 of key Ca(2+) signalling components, such as STIM proteins and TRP channels.

20 i is an essential intracellular link between STIM and the CRAC channel, an accessory protein in the p

21 renic nerves to mimic spontaneous breathing (STIM).

22 t activation of CRAC current is initiated by STIM proteins, which sense ER Ca2+ levels through an EF-

23 activated Ca(2+) (CRAC) channels mediated by STIM and ORAI proteins is a fundamental signaling pathwa

24 ed calcium (Ca(2+)) entry (SOCE) mediated by STIM/Orai proteins is a ubiquitous pathway that controls

25 ruitment of Orai and TRPCs to lipid rafts by STIM, we develop the hypothesis that Orai:TRPC complexes

26 -operated Ca(2+) channel (SOCC) regulated by STIM-1.

27 endoplasmic reticulum (ER) Ca(2+) stores by STIM proteins and coupling to Orai1 channels is well und

28 channels that migrate and become tethered by STIM within the ER-PM junctions, where they mediate exce

29 terminal STIM1 antibody blocked constitutive STIM(EF)-mediated Ca(2+) entry, but only in cells expres

30 e that different agonists activate different STIM proteins to sustain Ca(2+) signals and downstream r

31 at organize ER-plasma membrane junctions for STIM-ORAI-dependent calcium signaling.

32 t studies have indicated a critical role for STIM (stromal interacting molecule) proteins in the regu

33 onless (AMN) associates with ORAIs and forms STIM/ORAI/AMN complexes after Ca(2+) store depletion.

34 Hence, STIM N termini are powerful coupling modifiers, function

35 While the escape probability at high STIM:Orai expression ratios is <1%, it is significantly

36 ease increased in CMV transiently whereas in STIM lactate dropped during this same time point (2.6 vs

37 However, the precise mechanisms involving STIM-dependent Ca(2+) signaling in the heart are not cle

38 ticulum stores, and a second phase involving STIM 1 (stromal interaction molecule 1) clustering and C

39 Ist2 lysine-rich tail are found in mammalian STIM proteins that reversibly induce the formation of cE

40 1, and a few proteins that directly modulate STIM-ORAI function.

41 Stromal interacting molecule (STIM) 1 acts as a sensor for the level of Ca(2+) stored

42 Stromal interacting molecule (STIM) and Orai proteins constitute the core machinery of

43 ed deletion of Stromal Interaction Molecule (STIM) 1 and STIM2 [double-knockout (DKO)] mice develop s

44 Stromal cell-interaction molecule (STIM) 1 and STIM2 serve as endoplasmic reticulum Ca(2+)

45 d activated by stromal interaction molecule (STIM) 1 and STIM2.

46 e activated by stromal interaction molecule (STIM) 1 and STIM2.

47 ervations, the stromal interaction molecule (STIM) 1 and the calcium release-activated calcium modula

48 domain in the stromal interaction molecule (STIM) 1 is distinct in that it is ordered in the monomer

49 Ca(2+) sensor stromal interaction molecule (STIM) 1.

50 Ca(2+) sensor stromal interaction molecule (STIM) 1.

51 Stromal interaction molecule (STIM) 2, but not STIM1, was arranged in puncta in restin

52 ntification of stromal interaction molecule (STIM) and ORAI, two essential regulators of CRAC channel

53 Ca(2+)-sensing stromal interaction molecule (STIM) proteins are crucial Ca(2+) signal coordinators.

54 nding protein, stromal interaction molecule (STIM), plays an essential role in the activation of thes

55 nflux mediator stromal interaction molecule (STIM), the plasma membrane Ca(2+) pump plasma membrane C

56 The stromal interaction molecule (STIM)-ORAI calcium release-activated calcium modulator (

57 d activated by stromal interaction molecule (STIM)1 and STIM2 in the endoplasmic reticulum.

58 Orai1 and stromal interaction molecule (STIM)1 are critical components of Ca(2+) release-activat

59 activated by stromal interaction molecules (STIM) 1 and 2 in response to depletion of endoplasmic re

60 ct fragments operate independently of native STIM proteins.

61 from this domain induces the aggregation of STIM to regions of the ER immediately adjacent to the pl

62 not in DT40 STIM1 knock-out cells devoid of STIM(WT).

63 s of store-operated Ca2+ entry downstream of STIM.

64 However, the possible effects of STIM on other modes of receptor-activated Ca2+ entry hav

65 In PC2-defective cells, the interaction of STIM-1 with Orai channels is uncoupled, whereas coupling

66 Current models emphasize the role of STIM located in the endoplasmic reticulum membrane, wher

67 e models, which reveal the essential role of STIM proteins in Ca(2+) homeostasis and their crucial ro

68 is little or no information on the roles of STIM and Orai proteins in primary cells.

69 l discuss results pertaining to the roles of STIM and Orai proteins in smooth muscle Ca(2+) entry pat

70 the immune system, focusing on the roles of STIM and ORAI proteins in store-operated Ca(2+) entry.

71 tion of ER calcium triggers translocation of STIM proteins, which serve as calcium sensors in the ER,

72 se line drawings for 3s ('stimulus phase' or STIM).

73 n cancer is presently indisputable, how Orai-STIM-controlled Ca(2+) signals affect malignant transfor

74 Here, we review recent studies linking Orai-STIM Ca(2+) channels with cancer, with a particular focu

75 s physiological/pathological functions, Orai/STIM channels may be an important mediator for various p

76 In a recently discovered signaling process, STIM (stromal-interacting molecule) proteins sense a dro

77 lex and the microtubule cytoskeleton promote STIM 1 clustering at sites of plasma membrane apposition

78 The proteins STIM and ORAI were discovered through limited and genome

79 ling between two distinct membrane proteins, STIM and Orai.

80 d directly by endoplasmic reticulum-resident STIM proteins to generate the Ca(2+)-selective, Ca(2+) r

81 The endoplasmic reticulum Ca(2+)-sensing STIM proteins mediate Ca(2+) entry signals by coupling t

82 termembrane coupling with the Ca(2+)-sensing STIM proteins.

83 s mediated by the ubiquitous calcium-sensing STIM proteins.

84 Both actions are mediated by the short STIM-Orai activating region (SOAR) of STIM1.

85 cal differences in the function of the short STIM-Orai-activating regions (SOAR) of STIM1 and STIM2.

86 The dimeric STIM1 protein contains a small STIM-Orai-activating region (SOAR)--the minimal sequence

87 was without detectable phenotype, the STIM1/STIM double-KO was perinatally lethal, revealing an esse

88 Targeted STIM deletion impairs calcium homeostasis, NFAT activati

89 entry into T cells and fibroblasts and that STIM proteins are required for the development and funct

90 Our results provide direct evidence that STIM-Orai complexes are trapped by their physical connec

91 ticity is indicated by the observations that STIM-1, the sensor of calcium concentration in stores, a

92 New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca(2+)

93 We reveal that STIM-Orai coupling is rapidly blocked by hypoxia and the

94 Our study suggests that STIM proteins function as Ca(2+) store sensors in the si

95 Dissecting the STIM-Orai coupling process is restricted by the abstruse

96 Despite extensive sequence homology, the STIM proteins are functionally distinct.

97 o recent studies independently implicate the STIM protein family as essential components in this coup

98 pstream and downstream of Ca(2+) influx (the STIM/ORAI and calcineurin/NFAT pathways, respectively).

99 key role in SOCE activation and inhibits the STIM-dependent activation of AC6 by ER Ca(2+) depletion.

100 such entry, the recent identification of the STIM and Orai proteins has focused attention on the chan

101 ER luminal Ca(2+) concentrations through the STIM proteins and facilitates import of the ion from the

102 e this problem, we studied coupling by using STIM chimera and cytoplasmic C-terminal domains of STIM1

103 ORAI-1 GFP reporters are co-expressed with STIM-1 in the gonad and intestine.