ライフサイエンスコーパス: STR

1 STR <30% was associated with a greater likelihood of hyp

2 STR and STR2 are coexpressed constitutively in the vascu

3 STR genotyping is achieved utilizing RecA-mediated ligat

4 STR genotyping with short-read sequence data is confound

5 STR heterodimerizes with STR2, and the resulting transpo

6 STR in IGF1 promoter has been extensively studied for it

7 STR is a representative of a novel clade in the ABCG sub

8 STR occurred only in neutropenic patients transfused wit

9 STR profiling just fulfills the purpose of authenticatio

10 STR transcripts were quantified by RT-PCR, and plasma wa

11 STR was identified by positional cloning and encodes a h

12 STR-selective primers enable massively parallel, targete

13 STR-Seq employs in vitro CRISPR-Cas9-targeted fragmentat

14 STRs are especially valuable in conservation and ecologi

15 ed the mutation dynamics of close to 100,000 STR loci and observed more than 50,000 STR variations in

16 0,000 STR loci and observed more than 50,000 STR variations in a single genome.

17 We collected information for nearly 700,000 STR loci across more than 1000 individuals in Phase 1 of

18 quencing technology that analyses over 2,000 STRs in parallel, and provides the accurate genotyping o

19 to determine germline STR genotypes for 102 STR loci with high accuracy across diverse populations o

20 fied 138 individuals with risk alleles at 15 STR disease loci.

21 Dungans, and Karakalpaks using 35 SNP and 17 STR markers.

22 n and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184,

23 In summary, these 21 STR loci showed a high level of genetic polymorphisms fo

24 y increases to 99-100% when approximately 30 STRs are used.

25 ted by active surveillance and resulted in 5 STRs occurring 9 to 24 hours posttransfusion; none of th

26 oyed our approach to capture a panel of 5000 STRs from a test group of diademed sifakas (Propithecus

27 The primary end point was complete (>70%) STR after PCI.

28 In this large international study, absent STR 60 minutes after primary PCI was present in approxim

29 mmends minimal sequencing depth for accurate STR genotyping, depending on repeat length and sequencin

30 By multivariable analysis, STR<30% was an independent predictor of 3-year major adv

31 nerated from AC samples derived from CBA and STR/Ort mice at 3 different ages, corresponding to the s

32 Software tools such as lobSTR and STR-FM have been developed to address these demands, whi

33 recorded from multiple electrodes in PFC and STR while monkeys acquired new categories.

34 n of functional circuits between the PFC and STR.

35 of LFPs between, but not within, the PFC and STR.

36 Proteomic analysis of SN and STR tissues indicates that 3months of exercise induces c

37 nchrony was also seen between PFC spikes and STR LFPs, but not the reverse, reflecting the direct mon

38 chers investigating disease-related STRs and STR evolution.

39 omosome bi-allelic markers and 17 associated STR loci.

40 eate a framework for measuring constraint at STRs by comparing observed versus expected mutation rate

41 orensic parameters of 21 non-CODIS autosomal STR loci in Chinese Guanzhong Han population.

42 orroborates our earlier work using autosomal STR and Y-chromosome binary markers.

43 imates of the linkage disequilibrium between STRs and common SNPs.

44 ter model to examine the interaction between STRs and SNPs in IGF1 promoter.

45 which only a single allele was identified by STR analysis.

46 plotype consisting of three promoter SNPs (C-STR-T-T).

47 racy by measuring its consistency in calling STRs from whole-genome sequencing of two biological repl

48 conventional capillary electrophoresis (CE) STR fragment size analysis.

49 estimate the mutation rates of Y chromosome STRs (Y-STRs) with 2-6 bp repeat units that are accessib

50 iable segments I and II, and 36 Y-chromosome STRs from 24 Mesoamerican Totonacs and 23 South American

51 Complete STR profiles were obtained with as few as 25 copies of D

52 Complete STR was not significantly different between the 2 groups

53 Absent, incomplete, and complete STR were achieved in 514 (20.7%), 712 (28.7%), and 1258

54 P=0.03) than those with partial and complete STR, respectively.

55 be processed by the Sgs1-Top3-Rmi1 complex (STR).

56 distinguish heterozygous alleles containing STRs with consecutive repeat numbers.

57 each STR in the human genome by correlating STR genotypes with local sequence heterozygosity.

58 Here, we demonstrate STR-Seq, a next-generation sequencing technology that an

59 nt fragment length analysis and demonstrated STR profiles highly concordant with those from the seque

60 is performed to transfer replicas of desired STR targets from the single-cell genomic DNA onto the co

61 s, failure of passive surveillance to detect STR, and lack of specificity of STR criteria.

62 appropriate statistical methods in detecting STR-phenotype associations.

63 This assay is capable of determining STR genotypes of human samples, is easily adapted to hig

64 Here, we developed STR-FM, short tandem repeat profiling using flank-based

65 Here, we present a pipeline for developing STR markers directly from high-throughput shotgun sequen

66 ork to estimate mutation parameters for each STR in the human genome by correlating STR genotypes wit

67 ously been leveraged for scalable, efficient STR recovery.

68 of abciximab in STEMI did not improve either STR or TIMI flow rate after PCI.

69 ression of nearby genes (known as expression STR, eSTR).

70 rvey identified 2,060 significant expression STRs (eSTRs).

71 With these new features, STR-Seq can identify a 0.1% minor genome fraction in a D

72 genome's representation of STR alleles, find STR loci with common loss-of-function alleles, and obtai

73 ormance of current mainstream algorithms for STR profiling.

74 ) because of limited microarray coverage for STR-conferring mutations, and specificity was 99.2% (129

75 The 1-year risk for mortality for STR compared with biopsy was reduced significantly (RR,

76 rates and built a model to predict rates for STRs across the genome.

77 applications-we find that 90-98% of forensic STR records can be connected to corresponding SNP record

78 ested that the polysynaptic connections from STR to the PFC exerted a stronger overall influence.

79 We show that putatively functional STRs may be identified by deviation from predicted STR v

80 ate the need for targeted assays to genotype STRs accurately, and call for more appropriate statistic

81 wever, it has proven problematic to genotype STRs from high-throughput sequencing data.

82 ted an error correction model for genotyping STRs that can distinguish heterozygous alleles containin

83 riments, we use MIPSTR to determine germline STR genotypes for 102 STR loci with high accuracy across

84 issue near the SN and fetal striatal grafts (STR) 2.5 mm rostral in the nigrostriatal pathway.

85 rozen vials from the same ATCC lot, however, STR markers did not differ from ATCC reference for any s

86 e report the largest-scale analysis of human STR variation to date.

87 In STR groups, the animals were subjected to restraint stre

88 A benefit in STR at 60 min (RR: 1.25; 95% CI: 1.06 to 1.47; p = 0.007

89 ngly retained in AC during OA development in STR/Ort mice.

90 TRH and six TRH-like peptide levels in STR fell by 0.5h consistent with leptin-induced release

91 We found that the OA in STR/Ort mice exhibited a molecular phenotype resembling

92 by tracing Mendelian inheritance patterns in STR alleles in whole-genome sequencing of a HapMap trio,

93 nd to address the specific noise patterns in STR calling.

94 rial contamination of platelets resulting in STR in neutropenic patients, failure of passive surveill

95 However, we still struggle to incorporate STR variation into genotype-phenotype maps.

96 ve evidence of genetic studies on individual STRs suggests that STR variation profoundly affects phen

97 we developed MUTEA, an algorithm that infers STR mutation rates from population-scale data by using a

98 ss than half of other reports for integrated STR analysis and allows a compact, inexpensive microchip

99 Intestinal STR transcript levels at baseline were unaffected by acu

100 calable solution for rapid recovery of large STR and SNP datasets in any species without needing a re

101 ively parallel, targeted sequencing of large STR sets.

102 of MICB) and additionally genotyped the MICA-STR in 2,023 type 1 diabetic case subjects and 1,748 con

103 equencing data, it becomes practical to mine STR profiles in silico from genome sequences.

104 -32.7%) of these 284 reactions met 1 or more STR criteria, and sensitivity of STR criteria varied fro

105 lts showed that STRScan can profile 20% more STRs in the target set that are missed by lobSTR.

106 little is known about the variation of most STRs in the human population.

107 to the mutational dynamics of highly mutable STRs, the mutation rates of most others remain unknown.

108 ghlight the limitations of reported national STR data based on passive surveillance and the need to i

109 No STR locus was observed to deviate from the Hardy-Weinber

110 redictions indicate that the load of de novo STR mutations is at least 75 mutations per generation, r

111 nome-wide analysis and validation of de novo STR mutations.

112 In the absence of STR, the fluorescence intensity is weak.

113 Upon addition of STR, the aptamer binds to its target, leading to release

114 lyses were based on the PCR amplification of STR loci followed by gel electrophoresis.

115 MIPSTR uses targeted capture of STR loci by single-molecule Molecular Inversion Probes (

116 Patients were categorized by the degree of STR at 60 minutes: (1) complete (>70%); (2) partial (30%

117 r were successfully assessed by detection of STR in a spiked milk and blood serum without interferenc

118 our estimates, we identified determinants of STR mutation rates and built a model to predict rates fo

119 ize this call set to analyze determinants of STR variation, assess the human reference genome's repre

120 We also analysed the potential effect of STR and CNV variations, as well as the infection of the

121 p3 is required for the efficient function of STR.

122 Investigation of STR-based clusters of haplotypes and their ages revealed

123 TREDPARSE extends the limit of STR size detection beyond the physical sequence read len

124 erspectives with regard to the management of STR.

125 ately determining the length polymorphism of STR loci in the genome by next-generation sequencing (NG

126 w-complexity reads; and (2) the high rate of STR amplification stutter.

127 e human reference genome's representation of STR alleles, find STR loci with common loss-of-function

128 The results of STR analysis indicate that the 697 shMer1A and 697 shMer

129 me processing times and a biased sampling of STR alleles.

130 t 1 or more STR criteria, and sensitivity of STR criteria varied from 5.1% to 45.5%.

131 Five sets of STR criteria were evaluated, including recent AABB crite

132 ce to detect STR, and lack of specificity of STR criteria.

133 ipeline that can detect the full spectrum of STR alleles from short-read data, can adapt to emerging

134 However, per-locus studies of STR mutations have been limited to highly ascertained pa

135 gorithm to conduct a comprehensive survey of STR variations in a deeply sequenced personal genome.

136 is scalable to genotyping many thousands of STR loci in thousands of individuals.

137 otential to profile hundreds of thousands of STR loci.

138 wing in the physiopathology and treatment of STR.

139 determine the long-term prognostic value of STR after primary PCI in ST-segment-elevation myocardial

140 The long-term predictive value of STR after primary percutaneous coronary intervention (PC

141 ient recovery of targeted loci-97.3-99.6% of STRs characterized with >/=10x non-redundant sequence co

142 These results highlight the contribution of STRs to the genetic architecture of quantitative human t

143 c effects of the pharmacologic inhibition of STRs in response to an oral glucose load in healthy lean

144 on the OGTT.The pharmacologic inhibition of STRs in the gastrointestinal tract alters insulin respon

145 ppm lactisole, a human-specific inhibitor of STRs.

146 We review here the promise of STRs in contributing to complex trait heritability and h

147 t-generation sequencing approaches and other STR assays rely on a limited number of PCR amplicons, ty

148 We then tested our STR capture strategy on P. diadema fecal DNA, and report

149 Overall, STR-Seq has higher throughput, improved accuracy and pro

150 a valuable tool for prioritizing pathogenic STRs in medical genetics studies.

151 rticular, accurate detection of pathological STR expansion is limited by the sequence read length dur

152 This study suggests that the micro-patterned STR-functionalized SiNWs platform provides additional ad

153 probiotic (PROB), periodontal disease (PD), STR-PROB, STR-PD, STR-PROB-PD, and PROB-PD groups.

154 periodontal disease (PD), STR-PROB, STR-PD, STR-PROB-PD, and PROB-PD groups.

155 th leptin-induced release of these peptides: STR (7 downward arrow).

156 After learning, different pairs of PFC-STR electrodes showed stronger synchrony for one or the

157 d method for robustly genotyping and phasing STRs from Illumina sequencing data, and we report a geno

158 The 9-plex STR profiles of single cells from both pure and mixed po

159 ies, and DNA profiles generated using 9-plex STR samples displayed approximately 14- to 19-fold highe

160 mutation-rate estimates for 702 polymorphic STRs by tracing each locus over 222,000 meioses, resulti

161 ted the mutation rates of highly polymorphic STRs by using capillary electrophoresis and pedigree-bas

162 ay be identified by deviation from predicted STR variation and by association with quantitative pheno

163 (PROB), periodontal disease (PD), STR-PROB, STR-PD, STR-PROB-PD, and PROB-PD groups.

164 present lobSTR, a novel method for profiling STRs in personal genomes.

165 Yet profiling STRs from short-read sequencing data is challenging beca

166 ges in non-OA-prone CBA mice versus OA-prone STR/Ort mice, which develop disease that bears significa

167 bidopsis thaliana genome encodes 20 putative STR proteins.

168 Septic transfusion reactions (STRs) resulting from transfusion of bacterially contamin

169 a natural ligand for sweet taste receptors (STRs) that are expressed on the tongue and in the gastro

170 d that the intestinal sweet taste receptors (STRs), T1R2 and T1R3, were expressed in distinct epithel

171 tional or secondary tricuspid regurgitation (STR) is the most frequent etiology of tricuspid valve pa

172 to researchers investigating disease-related STRs and STR evolution.

173 termining the length of short tandem repeat (STR) alleles.

174 s were authenticated by short tandem repeat (STR) analysis before publication, the transduced progeny

175 d by direct sequencing, short tandem repeat (STR) assay and Southern blotting.

176 tion for rapid forensic short tandem repeat (STR) forensic profiling in a single disposable plastic c

177 ped across 15 autosomal short tandem repeat (STR) loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH0

178 any advantages over the short tandem repeat (STR) loci currently used to assay genetic variation.

179 tionally genotyped four short tandem repeat (STR) loci that flank the lactase enhancer region.

180 cell authentication by short tandem repeat (STR) markers.

181 lished by genotyping of short tandem repeat (STR) microsatellite markers.

182 A short tandem repeat (STR) typing method is developed for forensic identificat

183 Short tandem repeat (STR) variants are highly polymorphic markers that facili

184 Short tandem repeat (STR) variation has been proposed as a major explanatory

185 nd a highly polymorphic short tandem repeat (STR) within its breakpoints.

186 rphisms in 15 out of 25 short-tandem-repeat (STR) loci previously selected by in silico analyses of t

187 n, but only one method (short tandem repeat [STR] profiling) has been the subject of a comprehensive

188 s in the test data are short tandem repeats (STR) and are multi-allelic (sometimes as high as 30 dist

189 Functional short tandem repeats (STR) are polymorphic in the population, and the number o

190 Short tandem repeats (STRs) are found in many prokaryotic and eukaryotic genom

191 Short tandem repeats (STRs) are highly mutable genetic elements that often res

192 Short tandem repeats (STRs) are highly variable elements that play a pivotal r

193 Short tandem repeats (STRs) are hyper-mutable sequences in the human genome.

194 Short tandem repeats (STRs) are implicated in dozens of human genetic diseases

195 Short tandem repeats (STRs) are mutation-prone loci that span nearly 1% of the

196 Short tandem repeats (STRs) have a wide range of applications, including medic

197 Length variation in short tandem repeats (STRs) is an important family of DNA polymorphisms with n

198 and the other with 13 short tandem repeats (STRs) used in forensic applications-we find that 90-98%

199 kers and 19 chromosome short tandem repeats (STRs) were genotyped to produce a high-resolution datase

200 llelic and composed of short tandem repeats (STRs) with individual motifs composed of mononucleotides

201 Short tandem repeats (STRs), also known as microsatellites, are among the larg

202 data sets derived from short tandem repeats (STRs), insertion deletion polymorphisms (indels) and sin

203 ng large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral scle

204 of the contribution of short tandem repeats (STRs), which constitute one of the most polymorphic and

205 Short terminal repeats (STRs) were performed simultaneously on DNA obtained from

206 s total resection (GTR), subtotal resection (STR), and biopsy.

207 I) improves ST-segment elevation resolution (STR) after primary percutaneous coronary intervention (P

208 ST-segment resolution (STR) at 60 min (RR: 1.31; 95% CI: 1.16 to 1.48; p < 0.00

209 herapy, the degree of ST-segment resolution (STR) correlates with long-term cardiovascular mortality.

210 y recording the scotopic threshold response (STR) and photopic negative response (PhNR) of the electr

211 ynaptic pathways as shown for left and right STR, which do not share direct anatomical connections, b

212 The evolutionarily conserved Sgs1/Top3/Rmi1 (STR) complex plays vital roles in DNA replication and re

213 Several STR loci that are entirely guanine or cytosines (G or C)

214 that MIPSTR can detect low-frequency somatic STR variants.

215 or due to amplification stutter from somatic STR mutations.

216 Lastly, we suggest that somatic STR variation within individuals may serve as a read-out

217 The unstable expansion of some STRs was associated with various genetic disorders (e.g.

218 FCD loci were completed with closely spaced STR markers, whereas genes associated with early- and la

219 ptures using a micro-patterned streptavidin (STR)-functionalized silicon nanowire (SiNW) platform, wh

220 Streptomycin (STR), isoniazid (INH), rifampin (RIF), ethambutol (EMB)

221 For the second-line drug streptomycin (STR), overall concordance between the agar proportion me

222 ive and sensitive detection of streptomycin (STR) based on Exonuclease III (Exo III), SYBR Gold and a

223 four rats were divided into control, stress (STR), probiotic (PROB), periodontal disease (PD), STR-PR

224 en the prefrontal cortex (PFC) and striatum (STR) is thought critical for cognition and has been link

225 (AY), posterior cingulate (PCNG), striatum (STR), hippocampus (HC), medulla oblongata (MED) and ante

226 articular, we demonstrate that the striatum (STR) can be segregated according to differential rs-fMRI

227 opamine and its metabolites in the striatum (STR), followed by neurodegeneration of dopaminergic (DAe

228 We used STR-FM to study STR error rates and patterns in publicly available human

229 Sulfurtransferases (STRs) catalyze the transfer of a sulfur atom from a dono

230 ddresses the pressing challenges surrounding STR genotyping, and thus is of wide interest to research

231 , and an approach for highly parallel target STR recovery.

232 rticularly useful for the NGS-based targeted STR profiling, e.g., in genetic and human identity testi

233 an that uses a greedy algorithm for targeted STR profiling in next-generation sequencing (NGS) data.

234 te recent advances in sequencing technology, STR variation has remained largely inaccessible across m

235 iscriminating Indian and Chinese rhesus than STR loci.

236 We argue that STR variants are more likely than single-nucleotide vari

237 tic studies on individual STRs suggests that STR variation profoundly affects phenotype and contribut

238 ritability and highlight the challenges that STRs pose due to their repetitive nature.

239 We discovered that STRs sequenced with a PCR-free protocol have up to ninef

240 The STR clade is unusual in that it lacks the taxon-specific

241 The STR profiles demonstrated that the samples originated fr

242 Additionally, the STR profile of GM09947 cells could be deduced even in th

243 lso clarify the roles played by Top3 and the STR complex as a whole during the resolution of replicat

244 Our method will be valuable for the STR analysis of samples containing mixtures of cells/DNA

245 ocated outside the STR were required for the STR to function as eSTR.

246 ergic neurons of the SNc and neurites in the STR.

247 nd late after the natural onset of OA in the STR/Ort mice.

248 leads to recruitment of Sgs1 as part of the STR (Sgs1-Top3-Rmi1) complex, mediated by two SUMO-inter

249 ctra can be obtained for close to 90% of the STR loci in the genome.

250 e mechanism how the number of repeats of the STR regulates gene transcription.

251 n by direct binding to a repeat motif of the STR.

252 that these adjacent SNPs located outside the STR were required for the STR to function as eSTR.

253 ranscriptional complexes located outside the STR, rather than by direct binding to a repeat motif of

254 cent oligonucleotides are base paired to the STR region without any overlap or gap.

255 Additionally, we validated the STR calls against known allele sizes in a set of GeT-RM

256 9 to 24 hours posttransfusion; none of these STRs had been reported by passive surveillance.

257 We have also shown this STR to bind to an unknown nuclear protein with high spec

258 In addition to STR targets, this approach also generates large, genome-

259 or of a more aggressive surgical approach to STR.

260 ect monosynaptic connections from the PFC to STR.

261 aptasensor showed a high selectivity toward STR with a limit of detection (LOD) as low as 54.5 nM.

262 Traditional STR analyses were based on the PCR amplification of STR

263 ymes (FatM and RAM2) and an ABC transporter (STR) that are required for symbiosis and conserved uniqu

264 ration of two PAM-resident ABC transporters, STR and STR2, is limited.

265 These pipelines treat STR mapping as gapped alignment, which results in cumber

266 e several disease-related long trinucleotide STRs.

267 We used STR-FM to study STR error rates and patterns in publicly

268 Here we determined whether STR expression was 1) acutely regulated by changes in lu

269 Whether STRs directly contribute to the regulation of glucose ho

270 single Holliday junction (HJ) explaining why STR is unable to process them.

271 A genome-wide STR and SNP based linkage analysis was performed in one

272 the first time we determined the genome-wide STR germline mutation rate from a deeply sequenced human

273 ed decreased mortality for GTR compared with STR at 1 year (RR, 0.62; 95% CI, 0.56-0.69; P < .001; nu

274 ression was decreased with GTR compared with STR at 6 months (RR, 0.72; 95% CI, 0.48-1.09; P = .12; N

275 Compared with STR, GTR substantially improves overall and progression-

276 The required read depth increases with STR length and is lower for a PCR-free protocol.

277 At 3 years, patients with STR<30% experienced a higher rate of major adverse cardi

278 in a large number of untreated patients with STR.

279 Y-STR haplotypes on the C2 (M38), C2a (M208), O1a (M119),

280 the allele and haplotype frequencies of 17 Y-STR (Y-filer) loci in the populations of Haiti, Jamaica

281 We also demonstrated that the 26 Y-STR loci system was potentially useful in forensic scien

282 Using the high-resolution 26 Y-STR loci system, we investigated genetic and phylogeneti

283 ur males living in southern Xinjiang at 26 Y-STR loci.

284 The high-resolution Y-SNP haplogroup and Y-STR haplotype can be obtained with NGS+.

285 none of pedigree samples shares identical Y-STR haplotype.

286 romosomes of father-son pairs, and imputed Y-STR genotypes.

287 identification of pedigree from mismatched Y-STR haplotypes.

288 es, resulting in the largest collection of Y-STR mutation rates to date.

289 Y-SNPs) and seventeen short tandem repeat (Y-STR) loci.

290 hes with Y-chromosome short tandem repeat (Y-STR) profiling in large-scale crime investigations.

291 Moreover, when the Y-STR profiles of haplogroup H derived individuals in our

292 However, when two Y-STR haplotypes have a few mismatched loci, it is difficu

293 for more than 100 biallelic markers and 17 Y-STRs.

294 We genotyped 4,500 Y-STRs by using data from the 1000 Genomes Project and the

295 e genotyped using a panel of autosomal and Y-STRs, and Y-SNPs.

296 short tandem repeats on the Y chromosome (Y-STRs) and querying recreational genetic genealogy databa

297 Finally, we identified Y-STRs with potential applications in forensics and geneti

298 neage because of the high mutation rate of Y-STRs.

299 e the mutation rates of Y chromosome STRs (Y-STRs) with 2-6 bp repeat units that are accessible to Il

300 equencing under the term 'NGS+' for typing Y-STRs and Y-chromosomal single nucleotide polymorphisms (