1 SUDEP excludes other forms of seizure-related sudden dea
2 SUDEP usually occurs when the seizures are not witnessed
3 SUDEP-prone Kcna1-/- mice with partial genetic ablation
4 Demographic and clinical information of
61 SUDEP cases were collected.
5 The
61 SUDEP cases were categorized as definite SUDEP (n = 54),
6 s of BECTS are present in the North
American SUDEP Registry (NASR).
7 ocampus, culminating in seizure activity
and SUDEP.
8 duced the incidence of ictal bradycardia
and SUDEP in DS mice.
9 ot cardiac, KO of Scn1a produced cardiac
and SUDEP phenotypes similar to those found in DS mice.
10 profound postictal cerebral dysfunction,
and SUDEP.
11 to mechanisms and prevention of epilepsy
and SUDEP.
12 us Scn8a(N1768D/+) mice exhibit seizures
and SUDEP, confirming the causality of the de novo mutation
13 disorder, including spontaneous seizures
and SUDEP.
14 iorespiratory findings related to SUDEP,
and SUDEP animal models.
15 the ryanodine receptor-2 (RyR2) gene in
both SUDEP and sudden cardiac death cases linked to catechola
16 = 54), probable SUDEP (n = 5), and
definite SUDEP plus (n = 2).
17 61 SUDEP cases were categorized as
definite SUDEP (n = 54), probable SUDEP (n = 5), and definite SUD
18 Two deaths were
definite SUDEP, and 1 was probable SUDEP.
19 In this review, we
discuss SUDEP population studies, case-control studies, witnesse
20 Sudden unexpected death in
epilepsy (
SUDEP) accounts for approximately 1 in 5 deaths in patie
21 Sudden unexpected death in
epilepsy (
SUDEP) can affect individuals of any age, but is most co
22 taneous sudden unexpected death in
epilepsy (
SUDEP) in two of our strain combinations.
23 Sudden unexpected death in
epilepsy (
SUDEP) is increasingly recognized as a common and devast
24 Sudden unexpected death in
epilepsy (
SUDEP) is the leading cause of death in patients with re
25 Sudden unexpected death in
epilepsy (
SUDEP) is the most common cause of death in intractable
26 Sudden unexpected death in
epilepsy (
SUDEP) is the most common cause of death in patients wit
27 Sudden unexpected death in
epilepsy (
SUDEP) is the most common cause of death in patients wit
28 Sudden unexplained death in
epilepsy (
SUDEP) is the most common cause of premature mortality i
29 Sudden unexpected death in
epilepsy (
SUDEP) refers to the sudden death of a seemingly healthy
30 dels of sudden unexpected death in
epilepsy (
SUDEP) that exhibit audiogenic generalized convulsive se
31 d with sudden unexplained death in
epilepsy (
SUDEP), we propose that dysfunctions of KCNQ channels ma
32 ice to sudden unexplained death in
epilepsy (
SUDEP), which we recorded fortuitously in one animal.
33 bute to sudden unexpected death in
epilepsy (
SUDEP).
34 isk for sudden unexpected death in
epilepsy (
SUDEP).
35 due to sudden unexpected death in
epilepsy (
SUDEP).
36 lity is sudden unexpected death in
epilepsy (
SUDEP).
37 risk of sudden unexpected death in
epilepsy (
SUDEP).
38 isms of Sudden Unexpected Death in
Epilepsy (
SUDEP).
39 use of sudden unexplained death in
epilepsy (
SUDEP).
40 ial for sudden unexpected death in
epilepsy (
SUDEP).
41 isk for sudden unexpected death in
epilepsy (
SUDEP).
42 ia, and sudden unexpected death in
epilepsy (
SUDEP).
43 ause of sudden unexpected death in
epilepsy (
SUDEP).
44 isk for sudden unexpected death in
epilepsy (
SUDEP).
45 nation, sudden unexpected death in
epilepsy (
SUDEP, 18% of all deaths) did not fully explain the earl
46 redictor of early death even after
excluding SUDEP (e.g. reduction in years of life for those who had
47 ltiple seizures was a strong risk factor
for SUDEP.
48 ic seizures are the greatest risk factor
for SUDEP; most often, SUDEP occurs after this type of seizu
49 l apnea, may be a pathogenetic mechanism
for SUDEP.
50 ous system and establish an animal model
for SUDEP.
51 Four SUDEP cases (7%) had mutations in common genes responsib
52 king Kcna1 a strong candidate gene for
human SUDEP.
53 To search for genetic risk factors
in SUDEP cases, we performed an exome-based analysis of rar
54 ppression (PGES) and apnea are implicated
in SUDEP.
55 es is common and suspected to play a role
in SUDEP.
56 euptake inhibitor (SSRI), blocks GCS-
induced SUDEP in both DBA/2 and DBA/1 mice.
57 luding epilepsy, sudden death syndromes
like SUDEP and SIDS, and cardiac arrhythmia.
58 In cases with an LQTS gene
mutation,
SUDEP may occur as a result of a predictable and prevent
59 ve seizures and often associated with (
near)
SUDEP.
60 Understanding the genetic basis
of SUDEP may inform cascade testing of at-risk family membe
61 of SUDEP, while searching for biomarkers
of SUDEP risk embedded in electroencephalography (EEG) and
62 Cases
of SUDEP among children who received a diagnosis of BECTS a
63 tonic-clonic seizures precede most cases
of SUDEP, patients must be better educated about prevention
64 The cause
of SUDEP remains unknown.
65 ng video-EEG recording and who later died
of SUDEP.
66 A crucial element
of SUDEP is brainstem dysfunction, for which postictal gene
67 The frequency
of SUDEP varies depending on the severity of the epilepsy,
68 in-heart association as potential indices
of SUDEP susceptibility.
69 the Kcna1 knockout mouse (Kcna1-/-) model
of SUDEP, while searching for biomarkers of SUDEP risk embe
70 etion acts as protective genetic modifier
of SUDEP and suggest measures of brain-heart association as
71 nd increase in duration of PGES, the odds
of SUDEP increased by a factor of 1.7%(p < 0.005).
72 res indicated significantly elevated odds
of SUDEP with PGES durations of >50 seconds (p < 0.05).
73 rtant contributors to the pathophysiology
of SUDEP, and serotonin (5-HT) system dysfunction may be in
74 greater importance to the pathophysiology
of SUDEP.
75 ave important implications for prevention
of SUDEP in DS patients.
76 A sizeable proportion
of SUDEP cases have clinically relevant mutations in cardia
77 The substantial lifetime risk
of SUDEP and the lack of a clear pathophysiological connect
78 gher the risk of SUDEP; furthermore, risk
of SUDEP is also elevated in male patients, patients with l
79 entifying which patients are most at risk
of SUDEP is hindered by a complex genetic etiology, incompl
80 Risk
of SUDEP may be increased in direct proportion to duration
81 o clinicians on ways to minimise the risk
of SUDEP, information to pass on to patients, and medicoleg
82 ractory epilepsy patients who are at risk
of SUDEP.
83 ery might contribute to reducing the risk
of SUDEP.
84 IEE13 (OMIM 614558), which has a 10% risk
of SUDEP.
85 onic-clonic seizures, the higher the risk
of SUDEP; furthermore, risk of SUDEP is also elevated in ma
86 were found dead in circumstances typical
of SUDEP.
87 greatest risk factor for SUDEP; most
often,
SUDEP occurs after this type of seizure in bed during sl
88 n of sudden unexpected death in epilepsy,
or SUDEP.
89 udden unexpected death in epilepsy
patients (
SUDEP).
90 tropine-sensitive ictal bradycardia
preceded SUDEP.
91 ath, which may lead to novel ways to
prevent SUDEP.
92 could be a promising strategy for
preventing SUDEP.
93 gorized as definite SUDEP (n = 54),
probable SUDEP (n = 5), and definite SUDEP plus (n = 2).
94 aths were definite SUDEP, and 1 was
probable SUDEP.
95 en repository established in 2011 to
promote SUDEP research.
96 , exposure to toxic substances, or
suicide);
SUDEP classification was determined by the consensus of
97 Video monitoring demonstrated
that SUDEP occurred immediately following generalized tonic-c
98 Given
that SUDEP often occurs in association with generalised seizu
99 These findings suggest
that SUDEP is caused by apparent parasympathetic hyperactivit
100 ger in the generalized motor seizures of
the SUDEP group (p < 0.001).
101 t tested that blocks RA selectively in
these SUDEP models, which may be clinically relevant.
102 effects of the 5-HT(2B/2C) agonist in
these SUDEP models.
103 sfunction in these systems may contribute
to SUDEP associated with mutations of Scn8a.
104 hypoxemia and hypercapnia may contribute
to SUDEP.
105 are, and thus has potential to contribute
to SUDEP.
106 s, but physiological mechanisms that lead
to SUDEP are unknown.
107 model might be shared with those leading
to SUDEP.
108 eizure cardiorespiratory findings related
to SUDEP, and SUDEP animal models.
109 Understanding the mechanisms
underlying SUDEP is paramount to developing preventative strategies
110 gest the most probable mechanisms
underlying SUDEP.
111 psy and respiratory problems associated
with SUDEP.