ライフサイエンスコーパス: SUMO

1 SUMO (Small Ubiquitin-like Modifier) conjugation onto ta

2 SUMO and ubiquitin play important roles in the response

3 SUMO conjugation is a highly dynamic process that can be

4 SUMO does not modify Oct-1 directly, but regulates the e

5 SUMO E3 ligases enhance transfer of SUMO from the charge

6 SUMO homeostasis is important for many cellular processe

7 SUMO is a key posttranslational modification that modula

8 SUMO post-translational modification of proteins or SUMO

9 SUMO protease can rapidly reverse SUMO conjugation makin

10 SUMO/sentrin-specific proteases are able to remove SUMOs

11 of PIAS1 are counteracted by ICP0, the HSV-1 SUMO-targeted ubiquitin ligase, which disrupts the recru

12 egardless of the presence of ICP0, the HSV-1 SUMO-targeted ubiquitin ligase.

13 teract with small ubiquitin-like modifier 1 (SUMO-1) and Ubc9, and function as an intramolecular E3 l

14 or the small ubiquitin-like modifier type 1 (SUMO-1) as a regulator of SERCA2a and have shown that ge

15 fied by the small ubiquitin-like modifier-3 (SUMO-3) protein further demonstrates the generalizabilit

16 A SUMO E1 inhibitor, ginkgolic acid, decreases alpha-synuc

17 A SUMO E3 ligase named Wos1 (Wor1 SUMO-ligase 1) was ident

18 A SUMO-specific protease 4 (SUSP4) was shown to rescue p53

19 pposing actions of a STUbL (Slx5:Slx8) and a SUMO isopeptidase (Ulp2).

20 w a small viral protein can play a role as a SUMO E3 ligase and E4-like SUMO elongase to impact a var

21 nd proteomic analysis identified KLP-19 as a SUMO substrate in vivo.

22 RAP80 also contains a SUMO interacting motif (SIM) just upstream of the tandem

23 This finding distinguishes a SUMO ligase that may mediate signaling events important

24 Mice expressing a SUMO-defective K68R SHP mutant have increased liver BA l

25 presence of SIMs in RC components generate a SUMO-SIM network that facilitates assembly of the RC.

26 (i) A SUMO interaction motif located at ICP0 residues 362 to 3

27 We show that PIAS1 localizes at PML-NBs in a SUMO interaction motif (SIM)-dependent manner that requi

28 g that Tof2 is targeted for degradation in a SUMO- and STUbL-dependent manner.

29 Ubc9 (a SUMO-conjugating enzyme E2), PIAS (a SUMO-protein ligase E3), and Smt3 (the SUMO isoform in D

30 n promote SUMO modification by stabilizing a SUMO E3 ligase.

31 d modifier (SUMO) pathway components Ubc9 (a SUMO-conjugating enzyme E2), PIAS (a SUMO-protein ligase

32 We modulated expression of UBC9, a SUMO E2 ligase, using gain- and loss-of-function in neon

33 Preventing CRMP2 SUMOylation with a SUMO-impaired CRMP2-K374A mutant triggered NaV1.7 intern

34 3 binding to the phosphatase TC45 through an SUMO-interacting motif of TC45.

35 , PIAS1, that regulates HTT accumulation and SUMO modification in cells.

36 anGAP1*SUMO1/Ubc9 complex may link Crm1- and SUMO-dependent functions.

37 ction prevented the accumulation of mHTT and SUMO- and ubiquitin-modified proteins, increased synapto

38 be applied to any SUMOylation substrate and SUMO isoform.

39 by altering TDG sumoylation through SUMO and SUMO protease overexpression experiments.

40 Our findings indicate that sumoylation and SUMO binding are not essential for TDG-mediated excision

41 ct of proteasome inhibition on ubiquitin and SUMO-modified proteomes using parallel quantitation of u

42 some of the interaction surfaces on UBQ and SUMO overlap, each molecule has distinct features that a

43 recognition features of ubiquitin (UBQ) and SUMO observed in the PDB and the orientation of the UBQ

44 recover normal degradation when expressed as SUMO mimetics.

45 ck side binding site of Ubc9 and function as SUMO-based Ubc9 inhibitors (SUBINs).

46 lymers with ubiquitin-like modifiers such as SUMO (small ubiquitin-related modifier) or NEDD8 (neural

47 multiple targets suggest that the available SUMO is limiting, indicating a possible explanation for

48 opy, we demonstrate that the RAP80 SIM binds SUMO-2, and that both specificity and affinity are enhan

49 Here, we show that SLX4 binds SUMO-2/3 chains via SUMO-interacting motifs (SIMs).

50 Once covalently bound, SUMO can alter a conjugated protein's stability and/or f

51 Once covalently bound, SUMO conjugation can change the stability or functionali

52 nic alterations of PML-associated E1B-55K by SUMO-dependent PML-IV and PML-V interaction have so far

53 tivity of hypothalamic SF-1 was activated by SUMO, but this was attenuated during starvation.

54 on and thioester bond formation exhibited by SUMO E1 is indeed conserved in Ub E1.

55 Post-translational modification by SUMO (small ubiquitin-like modifier) plays important but

56 We show that GFI1 is modified by SUMO at K239.

57 by controlling the stability of OsbZIP23 by SUMO conjugation through manipulating specific SUMO prot

58 ated in vitro and in vivo, preferentially by SUMO-1.

59 ith the mutant and was modified primarily by SUMO-2.

60 ion and thioester bond formation revealed by SUMO E1 structures are thought to be conserved in Ub E1,

61 UBC9 may also promote Ikbalpha stability by SUMO-1 conjugation that further regulates NF-kappaB sign

62 including as a signal for ubiquitination by SUMO targeted ubiquitin ligases (STUbLs).

63 septin groups can be covalently modified by SUMOs.

64 st-translational modification of proteins by SUMOs (small ubiquitin-like modifier proteins; SUMOylati

65 ally opposite to that observed for canonical SUMO interaction motifs (SIMs).

66 In addition to canonical SUMOs, land plants encode a loosely constrained noncanon

67 lated proteins generates peptides containing SUMO-remnant diglycyl-lysine (KGG) at the site of SUMO m

68 re particularly prominent nutrient-dependent SUMO targets.

69 RNF212-dependent SUMO conjugation effected a checkpointlike process that

70 r proteins important for regulating discrete SUMO-regulated pathways.

71 Thus, dynamic SUMO modification and the presence of SIMs in RC compone

72 Specifically, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in

73 We reveal that the cellular E3 SUMO ligase PIAS3 is a novel and conserved target of E4-

74 We previously identified an HTT-selective E3 SUMO ligase, PIAS1, that regulates HTT accumulation and

75 inker and the SP-RING domain of PIAS3, an E3-SUMO (small ubiquitin-related modifier) ligase.

76 Each SUMO shifts the half-maximal activation voltage (V1/2) o

77 ometry, we identified 1209 unique endogenous SUMO modification sites.

78 also inhibited a purified, E. coli expressed SUMO protease, SENP1, in vitro, indicating the increase

79 tro biochemical studies of the P. falciparum SUMO E1 and E2 enzymes, resulting in the identification

80 complex reveals that the molecular basis for SUMO-2 specificity is due to isoform-specific sequence d

81 ite on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for

82 data highlight the continued importance for SUMO signaling throughout infection.

83 e, we delineate the molecular mechanisms for SUMO-dependent control of ribosomal DNA (rDNA) silencing

84 ith genetic data showing the requirement for SUMO and PCNA binding for the SDSA role of Srs2, Srs2 di

85 y K239 as the only high-probability site for SUMO modification.

86 two KCNE1 accessory subunits, and up to four SUMOs, one on Lys424 of each KCNQ1 subunit.

87 ponent, the kinase BUB-1, contain functional SUMO interaction motifs (SIMs), allowing them to recruit

88 Further, SUMO-RanGAP1 bound to the N-terminal lysine 56 of SLP-76

89 ely few known/effective inhibitors of global SUMO-conjugation.

90 however the mechanisms regulating the global SUMO balance remain poorly defined.

91 sence of substrate, showing that E4-ORF3 has SUMO E4 elongase activity.

92 Like other SENP family members, SENP7S has SUMO isopeptidase activity but unlike full-length SENP7L

93 Cs, which resist chemoradiation, have higher SUMO activating enzyme (E1) and global SUMOylation level

94 graphy, we solved the structure of the human SUMO E1 ubiquitin fold domain in complex with the E2, Ub

95 ted by a flood of recent studies implicating SUMO in a wide range of cellular and molecular activitie

96 ic domain (POD)-associated factors including SUMO, Mre11, Daxx, as well as the integrity of these nuc

97 sOTS1 degradation, indicating that increased SUMO conjugation in rice plants during salt stress is in

98 rmis via Polycomb-dependent and -independent SUMO E3 ligase activities.

99 hese fragments and related compounds inhibit SUMO conjugation in biochemical assays with potencies of

100 ional NBD1 conformation, was followed by its SUMO modification; and (c) introduction of solubilizing

101 etion of the STUbL SLX5 or disruption of its SUMO-interacting motifs, confirming that Tof2 is targete

102 ations to stabilize F508del NBD1 reduced its SUMO modification.

103 formation of mutant NBD1, which leads to its SUMO-2 conjugation and degradation by the ubiquitin-prot

104 onjugating enzyme 9 (UBC9) is the only known SUMO conjugating enzyme.

105 The burden of deSUMOylating the large SUMO-proteome rests on 6 full-length mammalian SUMO-prot

106 play a role as a SUMO E3 ligase and E4-like SUMO elongase to impact a variety of cellular responses.

107 rate how the opposing actions of a localized SUMO isopeptidase and a STUbL regulate rDNA silencing by

108 LPS treatment lowers SUMO-1 and UBC9 mRNA levels in primary astrocytes.

109 studies define the organization of the maize SUMO system and imply important functions during seed de

110 MO-proteome rests on 6 full-length mammalian SUMO-proteases or SENP.

111 hydrolases for ubiquitin-like modifications (SUMO and NEDD8) in eukaryotes, reportedly serve as bacte

112 both ubiquitin (Ub) and the Ub-like modifier SUMO.

113 dified by the small ubiquitin-like modifier (SUMO) and functionally interacts with the PIAS3 SUMO E3

114 of CRMP2 with small ubiquitin-like modifier (SUMO) and further controlled by the phosphorylation stat

115 moylation and Small Ubiquitin-like Modifier (SUMO) binding and by altering TDG sumoylation through SU

116 sents a novel small ubiquitin-like modifier (SUMO) binding motif.

117 Small ubiquitin-like modifier (SUMO) conjugation is a reversible post-translational mod

118 ession of the small ubiquitin-like modifier (SUMO) E2 enzyme UBC9 improves cardiac protein quality co

119 RF3 acts as a small ubiquitin-like modifier (SUMO) E3 ligase.

120 Small ubiquitin-like modifier (SUMO) E3 ligases are known to have a major role in preve

121 f proteins by small ubiquitin-like modifier (SUMO) has received much attention, reflected by a flood

122 dification by small ubiquitin-like modifier (SUMO) is one such possible mechanism.

123 Small ubiquitin-like modifier (SUMO) is used by the intrinsic antiviral immune response

124 IZ1 as the E3 Small Ubiquitin-like Modifier (SUMO) ligase responsible for this modification.

125 Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes

126 cells by the Small ubiquitin-like modifier (SUMO) on two independent sites: K169, within a consensus

127 activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) an

128 The E3 small ubiquitin-like modifier (SUMO) protein ligase protein inhibitor of activated STAT

129 onjugation of small ubiquitin-like modifier (SUMO) proteins (SUMO1, SUMO2, and SUMO3) to lysine resid

130 ications with small ubiquitin-like modifier (SUMO) proteins regulate multiple aspects of host immunit

131 dification by small ubiquitin-like modifier (SUMO) proteins.

132 1 for the Ubl small ubiquitin-like modifier (SUMO) revealed a single active site that is transformed

133 sponse is the small ubiquitin-like modifier (SUMO) signaling pathway.

134 gation of the small ubiquitin-like modifier (SUMO) to protein substrates is an important disease-asso

135 the Ub-like family, small Ub-like modifier (SUMO), has also been recognised as integral for efficien

136 onstrate that small ubiquitin-like modifier (SUMO)- and folate-dependent nuclear de novo thymidylate

137 ugation of small ubiquitin-related modifier (SUMO) and comprises an important regulator of protein fu

138 , in which small ubiquitin-related modifier (SUMO) is attaching by covalent bonds to substrate protei

139 own of the small ubiquitin-related modifier (SUMO) pathway components Ubc9 (a SUMO-conjugating enzyme

140 ion by the small ubiquitin-related modifier (SUMO) regulates numerous cellular pathways, including tr

141 dly attach small ubiquitin-related modifier (SUMO) to a large collection of nuclear proteins, with st

142 tein called 'small ubiquitin-like modifier' (SUMO) is post-translationally linked to target proteins

143 diated by the small ubiquitin-like modifier, SUMO.

144 modified by small ubiquitin-like modifiers (SUMOs) and what roles this modification may have in sept

145 fications by small ubiquitin-like modifiers (SUMOs) regulate many cellular processes, including genom

146 cation by small ubiquitin-related modifiers (SUMOs) is essential and conserved in the malaria parasit

147 n of a GR-small ubiquitin-related modifiers (SUMOs)-NCoR1/SMRT-HDAC3 repressing complex mandatory for

148 n of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1-HDAC3 repressing complex, which is ind

149 of protein are recruited through multivalent SUMO interactions.

150 ically requires ectopic expression of mutant SUMOs with introduced tryptic sites.

151 mapping and mutagenesis, we identified a new SUMO-interacting motif (SIM) in PIASy.

152 The E4-ORF3 protein displays no SUMO-targeted ubiquitin ligase activity in our assay sys

153 hat can be rapidly reversed by the action of SUMO proteases.

154 Attachment of SUMO moieties to internal lysines in Ubc9 itself can fur

155 This diGly signature is characteristic of SUMO(KGG) conjugation alone, as no other ubiquitin-like

156 reveal the ubiquitin-like protease class of SUMO protease gene family in rice (Oryza sativa) and dem

157 Conjugation of SUMO (Small Ubiquitin-like Modifier) protein to cellular

158 standing the target-specific consequences of SUMO modification requires knowledge of the location of

159 mediate the conjugation and deconjugation of SUMO molecules to/from target proteins.

160 Disruption of SUMO dynamics prompts various pathophysiological conditi

161 However, direct evidence of SUMO modification in ErbB4 signaling has remained elusiv

162 otein inhibitor of activated STAT) family of SUMO (small ubiquitin-like modifier) ligases has been im

163 itor of activated STAT (PIAS) RING family of SUMO E3 ligases, as essential for mitotic chromosomal SU

164 a new functional role for the PIAS family of SUMO ligases in the intrinsic antiviral immune response

165 inhibitor of activated STAT (PIAS) family of SUMO ligases is predominantly associated with the suppre

166 ocol for the proteome-wide identification of SUMO modification sites using mass spectrometry (MS).

167 are nonviable, underlining the importance of SUMO conjugation to plant survival.

168 Our results highlight the importance of SUMO-SIM networks in regulating the assembly of dynamic

169 tly inherited and caused by the inability of SUMO peptidase sentrin/SUMO-specific protease 2 (SENP2)

170 Knockdown of SUMO E1 or SUMO conjugating enzyme (E2) inhibits CC CSC

171 y currently lacks proteome-wide knowledge of SUMO pathway targets.

172 S-RNAi rice plants accumulate high levels of SUMO-conjugated proteins during salt stress and are high

173 PIASy adds to the growing list of SUMO E3 ligases containing multiple SIMs that play impor

174 Interdependent localization of SUMO, ubiquitin, and proteasomes along chromosome axes w

175 hese proteins, which is reflected by loss of SUMO at tRNA genes.

176 is a major determinant in the modulation of SUMO-target function.

177 enome-wide changes in chromatin occupancy of SUMO-2/3-modified proteins in K562 and VCaP cells using

178 ce and self-renewal, while overexpression of SUMO E1 or E2 increases CC cell stemness.

179 Here, we investigate the role of SUMO in Srs2 regulation and show that the SUMO-interacti

180 , our findings provide support for a role of SUMO in the cytosolic response to aberrant proteins.

181 relatively little is known about the role of SUMO isopeptidases in genome maintenance and their role

182 Despite the important mechanistic role of SUMO proteases in model plants, until now the identity o

183 This study reveals an unexpected role of SUMO-1 and SAFB in the stimulatory coupling of promoter

184 tion, indicating a pro-recombination role of SUMO.

185 In this study, we investigated the roles of SUMO in IFN signaling, gene expression, protein stabilit

186 remnant diglycyl-lysine (KGG) at the site of SUMO modification.

187 ing protease sites in the C-terminal tail of SUMO proteins.

188 SUMO E3 ligases enhance transfer of SUMO from the charged E2 enzyme to the substrate.

189 SERCA2a and have shown that gene transfer of SUMO-1 in rodents and large animal models of heart failu

190 A major factor in the variation of SUMO-target function is the balance between the conjugat

191 ing enzyme Ubc9 catalyzes the conjugation of SUMOs to -amino groups of lysine residues in target prot

192 of Ulp1 deregulation, with a major impact on SUMO pathway function.

193 We identify a pocket on SUMO E1 likely to be responsible for N106's effect.

194 replication through mechanisms that rely on SUMO signaling.

195 Knockdown of SUMO E1 or SUMO conjugating enzyme (E2) inhibits CC CSC maintenance

196 tion of SUMOylated Smc5/6 (sgs1-SIMDelta) or SUMO-dead alleles (sgs1-KR) exhibit unprocessed HJs at d

197 tate, a single-unoccupied molecular orbital (SUMO), which turns rectification off and drops R to 6.

198 ) and demonstrate a critical role for OsOTS1 SUMO protease in salt stress.

199 We reveal that OsOTS1 SUMO protease directly targets the ABA and drought respo

200 SAP domains are common among many other SUMO E3s, and are implicated in substrate recognition an

201 O) and functionally interacts with the PIAS3 SUMO E3 ligase.

202 Here, we show that the PIAS3 SUMO ligase is important for activation of the ATR (atax

203 Here, we describe the plant SUMO system at the phylogenetic, biochemical, and transc

204 recruitment of RING finger protein 4, a poly-SUMO-dependent E3 ubiquitin ligase, and that PML acts as

205 O3 conjugation to TIF-1gamma as well as poly-SUMO chain elongation.

206 that distinct SUBINs primarily inhibit poly-SUMO chain formation, whereas mono-SUMOylation was not i

207 will enable a thorough investigation of poly-SUMO-mediated cellular processes, such as DNA damage res

208 n further lead to the formation of polymeric SUMO chains.

209 active UBCH5B-like E2 that polyubiquitinates SUMO chains in concert with RNF4.

210 Pli1 degradation causes the profound SUMO pathway defects and associated centromere dysfuncti

211 ely, Ulp1-mediated desumoylation can promote SUMO modification by stabilizing a SUMO E3 ligase.

212 Modification by the ubiquitin-like protein SUMO affects hundreds of cellular substrate proteins and

213 ich a small ubiquitin-like modifier protein (SUMO) is attached to the target.

214 tion motifs (SIMs), allowing them to recruit SUMO modified proteins, including KLP-19, into the RC.

215 The mechanistic role of these regulatory SUMO proteases in mediating stress responses has not bee

216 entrin-specific proteases are able to remove SUMOs from targets, contributing to a tight control of S

217 me is targeted to the nucleolus for removing SUMO from specific substrates and how curtailing sumoyla

218 SUMO protease can rapidly reverse SUMO conjugation making this modification system highly

219 -binding domains, and overlaps with RanBP2's SUMO E3 ligase region.

220 the availability of the new chain-selective SUMO inhibitors reported here will enable a thorough inv

221 d by the inability of SUMO peptidase sentrin/SUMO-specific protease 2 (SENP2) to desumoylate HSP90-SU

222 mall-molecule binding site on Ubc9, the sole SUMO E2 enzyme.

223 MO conjugation through manipulating specific SUMO protease levels.

224 tif described here and a globular-structured SUMO-binding catalytic domain, to stabilize p53.

225 We previously found that SUMO-1 marks chromatin at the proximal promoter regions

226 egradation of OsOTS1 protein indicating that SUMO conjugation is an important response to drought str

227 We propose that SUMO conjugation establishes a precondition for designat

228 We therefore propose that SUMO serves as a mark for nonfunctional mitochondrial pr

229 We show that SUMO E3 ligase GEI-17/PIAS is required for KLP-19 recrui

230 We show that SUMO modification of mitochondrial proteins does not rel

231 Together, our data suggest that SUMO modification is essential to restrain pathogenic ba

232 The SUMO E3 ligase complex RanBP2/RanGAP1*SUMO1/Ubc9 localiz

233 The SUMO protease Ulp2 modulates many of these SUMO-dependen

234 he FA ubiquitin ligase core complex, and the SUMO E3 ligases PIAS1/PIAS4 and is antagonized by the SU

235 lecular mechanism of a novel mutation at the SUMO motif on signal transducer and activator of transcr

236 eviously shown that interactions between the SUMO E1-activating and E2-conjugating enzyme in P. falci

237 that has been shown to specifically bind the SUMO-2 isoform.

238 tion of RB and Lamin A/C is modulated by the SUMO protease SENP1 and that sumoylation of both protein

239 igases PIAS1/PIAS4 and is antagonized by the SUMO protease SENP6.

240 These pathways are linked by the SUMO Targeted ubiquitin Ligase Rnf4 that catalyses trans

241 those with modified sequences containing the SUMO-acceptor site of target proteins.

242 zed role of INa in hypoxic brain damage, the SUMO pathway and NaV1.2 are identified as potential targ

243 lencing factor Sir4, NE-associated Esc1, the SUMO E3 ligase Siz2, and the nuclear pore complex (NPC)

244 Finally, the SUMO acceptor lysine was functionally required for ErbB4

245 eater for F508del NBD1 versus WT and for the SUMO-2 paralog.

246 We identified the SUMO E3 ligase PIASxbeta as a ligase for PKC-theta.

247 We identify the SUMO ligase PIAS1 as a constituent PML-NB antiviral prot

248 We identify the SUMO ligase protein inhibitor of activated STAT1 (PIAS1)

249 ylation of STAT3 and a rapid increase in the SUMO protease SENP3 that depended on a simultaneous incr

250 e will focus on conjugation machinery in the SUMO, NEDD8, ATG8, ATG12, URM1, UFM1, FAT10, and ISG15 p

251 DNA breaks, thus providing insights into the SUMO and ubiquitin interplay in genome maintenance.

252 By mapping the SUMO proteome in Saccharomyces cerevisiae, we discovered

253 preventing Drp1 SUMOylation by mutating the SUMO acceptor sites enhances binding to Mff.

254 by a calcium/calpain-induced cleavage of the SUMO E1 enzyme SAE2, thus leading to sumoylation inhibit

255 ave previously shown that acetylation of the SUMO E2 conjugase enzyme, Ubc9, at K65 downregulates its

256 RNAi depletion of the SUMO E2 ligase Ubc9 suppresses 3D growth of KRAS mutant

257 mitochondrial proteins as substrates of the SUMO pathway in yeast.

258 y mechanism that adapts cells to loss of the SUMO protease Ulp2.

259 In this study, we reveal the role of the SUMO protease, OsOTS1 in mediating tolerance to drought

260 adaptive mechanism to counteract loss of the SUMO protease.

261 tegrated picture of cardiac functions of the SUMO system under physiologic or pathologic conditions.

262 The NMR structure of the SUMO-2.phospho-RAP80 complex reveals that the molecular

263 d degradation of PIM1 via recruitment of the SUMO-targeted ubiquitin ligase, RNF4.

264 nds on Cdc13 localization at DSBs and on the SUMO ligase Siz1, which is required for de novo telomere

265 Here we show the SUMO isopeptidase Ulp2 in Saccharomyces cerevisiae does

266 AS (a SUMO-protein ligase E3), and Smt3 (the SUMO isoform in Drosophila) by RNAi prevents Smo accumul

267 tential therapeutic approaches targeting the SUMO machinery to combat heart disease.

268 We found that the SUMO (small ubiquitin-like modifier)-modification and ub

269 We found that the SUMO (small ubiquitin-related modifier) ligase ZATT (ZNF

270 ion, provides evidence for the idea that the SUMO ligase activity of the E1B-55K viral oncoprotein is

271 We show that the SUMO ligase protein inhibitor of activated STAT 4 (PIAS4

272 of SUMO in Srs2 regulation and show that the SUMO-interacting motif (SIM) of Srs2 is important for th

273 to selectively degrade F508del CFTR via the SUMO-targeted ubiquitin E3 ligase, RNF4 (RING finger pro

274 ngs reveal a conserved mechanism whereby the SUMO pathway promotes Hh signaling by regulating Smo sub

275 While the SUMO system appears to predominantly target nuclear prot

276 tion of FXR blocked its interaction with the SUMO ligase PIASy and inhibited SUMO2 modification at K2

277 AT1 mutation (c.2114A>T, p.E705V) within the SUMO motif ((702)IKTE(705)) in a patient with disseminat

278 e SUMO protease Ulp2 modulates many of these SUMO-dependent processes in budding yeast.

279 UMOylated TOP2A CTD binding activity through SUMO-interaction motifs and the phosphorylation of Haspi

280 s associated with HSV-1 genome entry through SUMO interaction motif (SIM)-dependent mechanisms that a

281 ding and by altering TDG sumoylation through SUMO and SUMO protease overexpression experiments.

282 ssing a novel diSUMO polypeptide bearing two SUMO beta-grasp domains in tandem.

283 TR (Sgs1-Top3-Rmi1) complex, mediated by two SUMO-interacting motifs (SIMs) on Sgs1 that specifically

284 nnels formed without KCNE1 carry at most two SUMOs despite having four available KCNQ1-Lys424 sites.

285 interaction between the RanBP2-RanGAP1-UBC9 SUMO E3 ligase complex and NUSAP1.

286 We show that unconjugated SUMO levels are largely maintained throughout infection

287 ysine residue 714 in the ErbB4 ICD undergoes SUMO modification, which was reversed by sentrin-specifi

288 e and other cereals also synthesize a unique SUMO-conjugating enzyme variant with more restricted exp

289 al. (2017) report how a DNA translocase uses SUMO as a cue to save Top2 from ubiquitin-mediated degra

290 we show that SLX4 binds SUMO-2/3 chains via SUMO-interacting motifs (SIMs).

291 axes are hubs for regulated proteolysis via SUMO-dependent control of the ubiquitin-proteasome syste

292 As for FL CFTR and NBD1 in vivo, SUMO modification using purified components in vitro was

293 n the absence of ICP0, high-molecular-weight SUMO-conjugated proteins do not accumulate if HSV-1 DNA

294 e inhibitory effect of AR SUMOylation (where SUMO indicates small ubiquitin-like modifier) by mutatin

295 ingly, all intermediates are compatible with SUMO E3 ligase activity, suggesting that the RanBP2/RanG

296 ation; it not only mediates interaction with SUMO-PCNA to promote the anti-recombination function but

297 with Rac1 and inhibits its interaction with SUMO-specific protease 1 (SENP1), which in turn inhibits

298 RAP80 and the SIM recognition module within SUMO-2.

299 A SUMO E3 ligase named Wos1 (Wor1 SUMO-ligase 1) was identified to interact with Wor1 and

300 The ZATT SUMO ligase activity further promotes TDP2 interactions